Patents by Inventor Jhon Cores

Jhon Cores has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mammalian Lung Spheroids and Lung Spheroid Cells and Uses Thereof
    Publication number: 20240350554
    Abstract: This invention relates generally to the discovery of novel mammalian lung spheroids and lung spheroid cells and uses thereof.
    Type: Application
    Filed: April 26, 2024
    Publication date: October 24, 2024
    Inventors: Ke Cheng, Eric T. Henry, Jhon Cores
  • Mammalian lung spheroids and lung spheroid cells and uses thereof
    Patent number: 11998570
    Abstract: Using lung tissues as a source, mammalian lung progenitor cells lung spheroids and lung spheroid cells (LSCs) were prepared. In one embodiment mammalian LSCs were prepared by (i) culturing mammalian lung tissue explant cells under adherent culture conditions to form a first lung cell outgrowth culture; (ii) culturing the first lung cell outgrowth culture under low-adherence conditions to form lung spheroids; and (iii) culturing the lung spheroids under adherent culture conditions so as to form LSCs. The low-adherence conditions may be a cell culture or suspension. The lung spheroids or LSCs may be formulated into pharmaceutical compositions. Uses such as treatment of lung diseases or diagnostics are also provided. Lung spheroids and LSCs represents a simple and highly reproducible method to generate therapeutic lung cells.
    Type: Grant
    Filed: October 15, 2020
    Date of Patent: June 4, 2024
    Assignee: North Carolina State University
    Inventors: Ke Cheng, Eric T. Henry, Jhon Cores
  • Mammalian Lung Spheroids and Lung Spheroid Cells and Uses Thereof
    Publication number: 20210100849
    Abstract: Using lung tissues as a source, mammalian lung progenitor cells lung spheroids and lung spheroid cells (LSCs) were prepared. In one embodiment mammalian LSCs were prepared by (i) culturing mammalian lung tissue explant cells under adherent culture conditions to form a first lung cell outgrowth culture; (ii) culturing the first lung cell outgrowth culture under low-adherence conditions to form lung spheroids; and (iii) culturing the lung spheroids under adherent culture conditions so as to form LSCs. The low-adherence conditions may be a cell culture or suspension. The lung spheroids or LSCs may be formulated into pharmaceutical compositions. Uses such as treatment of lung diseases or diagnostics are also provided. Lung spheroids and LSCs represents a simple and highly reproducible method to generate therapeutic lung cells.
    Type: Application
    Filed: October 15, 2020
    Publication date: April 8, 2021
    Inventors: Ke Cheng, Eric T. Henry, Jhon Cores
  • Mammalian Lung Spheroids and Lung Spheroid Cells and Uses Thereof
    Publication number: 20170296595
    Abstract: This invention relates generally to the discovery of novel mammalian lung spheroids and lung spheroid cells and uses thereof.
    Type: Application
    Filed: September 18, 2015
    Publication date: October 19, 2017
    Applicant: North Carolina State University
    Inventors: Ke Cheng, Eric T. Henry, Jhon Cores