Abstract: The present invention relates to antibody-drug conjugates (ADCs) wherein a plurality of active agents are conjugated to an antibody through at least one branched linker. The branched linker may comprise a branching unit, and two active agents are coupled to the branching unit through a secondary linker and the branching unit is coupled to the antibody by a primary linker. The active agents may be the same or different. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g., 2-4 branched linkers, which may each be coupled to a different C-terminal cysteine of a heavy or light chain of the antibody. The branched linker may comprise one active agent coupled to the branching unit by a first branch and a second branch that comprises a polyethylene glycol moiety coupled to the branching unit. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g.

Abstract: A button-type secondary battery includes a lower can having a bottom surface; an upper can having a top, the upper can and the lower can being coupled to define a space therein; an electrolyte in the space; an electrode assembly in the space and including a negative electrode, a separator, and a positive electrode wound together; a gasket between the upper can and the lower can to electrically insulate the upper and lower cans; a top insulator that is electrically insulating and covering a top surface of the electrode assembly; and a bottom insulator that is electrically insulating and covering a bottom surface of the electrode assembly. The top and bottom insulators are each configured to expand in volume by absorbing the electrolyte. Surfaces of at least one of the top insulator and the bottom insulator are coated with a protective layer to prevent thermal shrinkage from occurring.

Abstract: A button type secondary battery includes a wound electrode assembly; a lower can with the electrode assembly and an electrolyte in the lower can; a top plate to close the lower can; a positive electrode terminal coupled to the top plate through a gasket to be electrically insulated from the top plate with a portion of the positive electrode terminal passing through a hole in the top plate to be bonded to a positive electrode tab; a top insulator covering a top surface of the electrode assembly; and a bottom insulator covering a bottom surface of the electrode assembly. The top insulator and the bottom insulator are each configured to expand in volume by absorbing the electrolyte. Surfaces of at least one or more of the top insulator and the bottom insulator are coated with a protective layer configured to prevent thermal shrinkage from occurring.

Abstract: A display device includes: a first substrate including a pixel area and a transmissive area; a thin-film transistor on the first substrate; a planarization layer on the thin-film transistor; a first light emitting electrode on the planarization layer; a bank covering a part of the first light emitting electrode; a light emitting layer on the first light emitting electrode; and a second light emitting electrode on the light emitting layer and the bank. The transmissive area includes a transmissive hole penetrating the bank and the planarization layer.

Abstract: The present invention relates to a polysubstituted imidazolo[4,5-c][1,2]thiazine derivative and a use of an agent comprising same as an active agent, which is useful for infectious diseases associated with vascular inflammation caused by HMGB1 protein activity. It has been found that the polysubstituted imidazolo[4,5-c][1,2]thiazine derivative of the present invention increases the sepsis survival rate as a result of searching for antiseptic effects through CLP-induced sepsis animal experiments. Accordingly, the agent comprising the polysubstituted imidazolo[4,5-c][1,2]thiazine derivative or a pharmaceutically acceptable salt thereof as an active agent may be advantageously used as a therapeutic agent for infectious diseases and vascular inflammatory diseases including sepsis caused by HMGB1 protein activity.

Abstract: An apparatus and a method for estimating a road surface friction coefficient relate to an apparatus of estimating a road surface friction coefficient including an additional power control module that arbitrarily adds a braking force, which causes a wheel speed difference, to an axle of the vehicle to which the braking force is applied, and together adds a driving force that cancels the braking force to an axle of the vehicle to which the driving force is applied, when it is determined that a driving state of the vehicle is an inertial driving state, and a road surface friction coefficient estimation module that estimates the road surface friction coefficient by the wheel speed difference caused by a newly added braking force.

Abstract: An object of the present disclosure is to provide a method for preparing fine particles having enclosed voids with improved stain resistance and composition comprising the particles by preventing free radicals from interfering with core swelling due to the cross-linking monomer upon polymerization of a secondary hard-shell and by removing the residual initiator by additional polymerization of the phosphoric acid monomer and the hard-shell monomer.

Abstract: The present disclosure relates to an integrated control apparatus for a vehicle, a system including the same, and a method thereof, and an exemplary embodiment of the present disclosure provides an integrated control apparatus for a vehicle, including: a processor configured to perform braking control in an initial stage of steering control of a driver, to control a damping force of an electronic controlled suspension, to release the braking control in a later stage of steering control of the driver, and to increase the damping force of the electronic controlled suspension; and a storage configured to store data obtained by the processor and an algorithm for driving the processor.

Abstract: An apparatus and a method for estimating a road surface friction coefficient relate to an apparatus of estimating a road surface friction coefficient including an additional power control module that arbitrarily adds a braking force, which causes a wheel speed difference, to an axle of the vehicle to which the braking force is applied, and together adds a driving force that cancels the braking force to an axle of the vehicle to which the driving force is applied, when it is determined that a driving state of the vehicle is an inertial driving state, and a road surface friction coefficient estimation module that estimates the road surface friction coefficient by the wheel speed difference caused by a newly added braking force.

Abstract: The present disclosure relates to an integrated control apparatus for a vehicle, a system including the same, and a method thereof, and an exemplary embodiment of the present disclosure provides an integrated control apparatus for a vehicle, including: a processor configured to perform braking control in an initial stage of steering control of a driver, to control a damping force of an electronic controlled suspension, to release the braking control in a later stage of steering control of the driver, and to increase the damping force of the electronic controlled suspension; and a storage configured to store data obtained by the processor and an algorithm for driving the processor.

Abstract: The present invention relates to a vacuum cleaning suction head for a vacuum cleaner where the dumping function is added, more particularly to a vacuum cleaning suction head capable of beating the cleaning object such as the bed mattress, the blanket, the carpet and the clothe in elastic and removing the dust (and/or the dirt, the bacteria such as the rat mites, and etc.) infiltrated into the cleaning object in efficiency.

Abstract: A shift register minimizing bias stress applied to transistors is disclosed.

Abstract: A liquid crystal display device includes a plurality of pixel electrodes to which a data voltage is supplied, a plurality of common electrodes arranged to form electric fields with the pixel electrodes, a plurality of common wire lines commonly connected to the common electrodes in each horizontal line, a plurality of common voltage drive circuits to supply a common voltage to each of the corresponding common wire lines, and a controller for generating clock signals to control the common voltage drive circuits to invert an electric potential of the common voltage to be output from each of the common voltage drive circuits for each frame period.

Abstract: An apparatus and method for driving a liquid crystal display device are disclosed. The apparatus includes a liquid crystal panel with pixels defined by data and gate lines. A gate driver provides different gate pulses to the odd-column pixels than to the even-column pixels. The gate pulses have different voltages and/or widths. Data drivers provide data voltages having a positive or negative polarity to the data lines. A timing controller controls the gate and data drivers and supplies gate clock pulses that have different voltages and/or widths to the gate driver.