Abstract: The present invention relates to a cylinder pump including: a body part having a main body with a coupling groove formed thereon and a front body coupled to the main body by means of hinges; a cartridge detachably attached to the coupling groove of the body part; a driving part located inside the main body to operate the cartridge; a display part located on the front body to provide an interface necessary for the operation thereof; a controller for controlling the operation of the driving part; and an operating part for transmitting a user's operating signal or input information to the controller.

Abstract: An embodiment relates to a method for constructing a graph for approximate nearest neighbor (ANN) search by dynamically adjusting parameters according to data density and dimensional characteristics. The method comprises: (a) receiving a dataset composed of a plurality of data points represented as multidimensional vectors and initial parameters; (b) calculating a density of each data point in the received dataset; (c) determining a range of parameters in consideration of variations in the densities; (d) dynamically adjusting the parameters according to the density of a specific data point based on the determined parameter range; and (e) inserting the specific data point into a graph using the adjusted parameters through a dynamic graph construction step, wherein the parameters include a ‘maximum number of connections (Mq)’ and a ‘search depth (efq)’.

Abstract: A display apparatus including a light-emitting device and a pixel lens is provided. The light-emitting device can be covered by the optical insulating layer. A lens planarization layer can be disposed on the optical insulating layer. The pixel lens can be disposed between the optical insulating layer and the lens planarization layer. The pixel lens can be surrounded by a lens passivation layer. The lens passivation layer can block oxygen and moisture moving toward the pixel lens. Thus, in the display apparatus, the deterioration in the quality of the image provided to a user due to oxygen and/or moisture can be prevented.

Abstract: This invention relates to a drug delivery vehicle for penetrating the Blood-Brain Barrier (BBB). Said drug delivery vehicle is a cube-structured nanostructure formed from a double-stranded deoxyribonucleic acid (DNA) framework, specifically D-form DNA. This drug delivery vehicle forms a protein corona on its surface within the serum, and through this, it passes the BBB via receptor-mediated transcytosis. The present invention provides a drug delivery vehicle for the purpose of being loaded with drugs, such as antisense oligonucleotides (ASOs), to deliver them to brain tissue for the treatment of brain tumors like glioblastoma.

Abstract: A method of analyzing a cerebrovascular image based on cerebrovascular chunk features is disclosed, the method including receiving, by an analysis device, a cerebrovascular image of a subject; extracting, by the analysis device, a plurality of vascular unit structures from the cerebrovascular image based on geometric features of a 3D model; extracting, by the analysis device, feature values for each of the plurality of vascular unit structures; inputting, by the analysis device, the feature values of each of the plurality of vascular unit structures into a learning model trained in advance, classifying chunks to which each of the plurality of vascular unit structures belongs, and generating chunk features for the cerebrovascular image; and evaluating, by the analysis device, a condition of the subject based on the chunk features.

Abstract: A binder solution for an all-solid-state battery, an electrode slurry for an all-solid-state battery including the same and a method of manufacturing an all-solid-state battery using the same, and more particularly to a binder solution for an all-solid-state battery, in which a polymer binder configured such that a non-polar functional group is bonded to the end of a polar functional group is used, whereby the polar functional group is provided by a deprotection mechanism of the polymer binder through a thermal treatment, thus increasing adhesion between electrode materials to thereby improve battery capacity and enabling a wet process to thereby reduce manufacturing costs, an electrode slurry for an all-solid-state battery including the same and a method of manufacturing an all-solid-state battery using the same.

Abstract: Methods and devices for providing a user-preferred route are described. According to one embodiment, the method comprises receiving, from a user terminal, information on a route search request including information on a departure point and information on a destination point, acquiring first data on a plurality of actual driving routes of a user for reaching the destination point and second data on a number of times each of the plurality of actual driving routes has been driven, the plurality of actual driving routes being associated with the departure point, generating a preferred route from the departure point to the destination based on the first data and the second data, and providing the preferred route to the user terminal.

Abstract: The present specification relates to a compound as a UBR box domain ligand. The present specification provides a small molecule compound that binds to the UBR box domain. Further, the present specification provides a composition for inhibiting UBR box domain substrate binding, including a ligand compound that binds to a UBR box domain, a pharmaceutical composition for treating UBR-related disease, and a use thereof.

Abstract: A method of preparing a protein conjugate contains linking a mono-PEGylated immunoglobulin Fc region to a dual agonist exhibiting activity on both glucagon-like peptide-1 (GLP-1) and glucagon. The mono-PEGylated immunoglobulin Fc region is prepared by linking a linker of Formula 1 to the N-terminus of an immunoglobulin Fc region comprising a hinge sequence: CHO-L1-(OCH2CH2)nO-L2-R??[Formula 1].

Abstract: A method of providing content translation that includes transmitting, by a management server, a translation target manuscript for an episode of content created based on a first language to a translation server; providing, by the translation server, the translation target manuscript to a first terminal, and receiving, from the first terminal, translated language corresponding to a second language, where the second language is different from the first language; generating, by the translation server, a translation file for the translation target manuscript using the received translated language; providing, by the translation server, the translation file to a second terminal; and receiving, from the second terminal, an image file corresponding to the episode, which is translated into the second language using the translation file.

Abstract: A battery cell module assembly is provided. The battery cell module assembly includes a lower case having a lower cooling flow passage, battery modules seated in a cell area of the lower case, a side case disposed along a periphery of the cell area and coupled to the lower case, an upper case to cover the battery modules and an upper surface of the side case, the upper case including an upper cooling flow passage, a lower coolant tube connected to the lower cooling flow passage over a tube area of the lower case disposed outside the side case, and an upper coolant tube connected to the upper cooling flow passage under a tube area of the upper case disposed outside the side case. Coolant flows through the lower cooling flow passage and the upper cooling flow passage to control a temperature deviation in the battery modules.

Abstract: The present invention relates to a composition for promoting collagen production comprising amidated amino acids, and more specifically, to a composition that promotes collagen production in various cells such as fibroblasts, follicular cells, dermal papilla cells, endothelial cells, chondrocytes, muscle cells, and osteoblasts, thereby preventing, improving, or treating various diseases and lesions that may result from collagen reduction in the skin, hair, blood vessels, cartilage, tendons, connective tissues, muscles, bones, teeth, and periodontal tissues.

Abstract: A semiconductor memory device is provided. The semiconductor memory device may include a first electrode and a second electrode spaced apart from each other, a dielectric film structure between the first electrode and the second electrode, a first interfacial film between the first electrode and the dielectric film structure, and a second interfacial film between the second electrode and the dielectric film structure. The dielectric film structure may include a first dielectric film and a second dielectric film sequentially stacked on the first interfacial film. The first dielectric film may include an oxide of at least one of titanium (Ti) or strontium (Sr) having a first dielectric constant greater than 20. The second dielectric film may include a material having a second dielectric constant that is smaller than the first dielectric constant by at least 20.

Abstract: The present specification relates to a compound as a UBR box domain ligand. The present specification provides a small molecule compound that binds to the UBR box domain. Further, the present specification provides a composition for inhibiting UBR box domain substrate binding, including a ligand compound that binds to a UBR box domain, a pharmaceutical composition for treating UBR-related disease, and a use thereof.

Abstract: Provided is a novel method for preparing a long-acting drug conjugate and a long-acting drug conjugate prepared using the method.

Abstract: A chimeric antibody receptors with anti-cotinine antibodies linked, and uses thereof are disclosed. A T cell presenting the chimeric antibody receptor on the surface secretes interferon gamma specifically for a target molecule of a cotinine-conjugated binding molecule that is added together therewith and induces cell death of the cell expressing the target molecule by the T cell. On the contrary, by administering a cytotoxic agent conjugated with cotinine, cell death of the chimeric antigen receptor T cell is induced. Therefore, if necessary, a cytotoxic agent conjugated with cotinine can be administered to remove the chimeric antigen receptor T cells that have been already administered, thereby suppressing immune side effects due to hyperactivity of T cells. Thus, the chimeric antigen receptor to which the anti-cotinine antibody is linked can be effectively and safely used for the treatment of cancer.

Abstract: A secondary battery according to an embodiment of the present disclosure may include an electrode assembly and a pouch-type batter. The battery case may include a cup part to accommodate electrode assembly. A sealing part may extend outward from an edge of the cup part and may be sealed. A venting device may be inserted into the sealing part through which a gas inside the cup part may be discharged to the outside. The sealing part may include a vent sealing portion into which the venting device may be inserted, and a weak sealing portion which may be positioned between the vent sealing portion and the cup part and sealed more weakly than the periphery thereof.

Abstract: A sign visibility test system includes a virtual reality provision unit for providing a virtual driving environment to a driver, a unit for acquiring bio signal information and gaze information of the driver; and a unit for providing the driver with a questionnaire about an awareness level of a sign, and for receiving answers to the questionnaire from the driver. The virtual reality provision unit provides the driver with the virtual driving environment in which the sign that is a visibility test target is installed, and at a moment when the driver passes the sign in a virtual reality, the questionnaire is provided to the driver within a virtual reality environment, and awareness level information on the sign about which the driver answers the questionnaire is stored as annotation data in the bio signal information and the gaze information.

Abstract: One aspect of the disclosure relates to a cargo delivery system comprising an autophagy targeting ligand and a target-binding ligand. In one aspect of the disclosure, by comprising an autophagy targeting ligand, cargo, which is a target-binding ligand that specifically binds to a target, is delivered to the p62 protein and autophagy is activated, so that depending on the type of target-binding ligand used, a target to be degraded can be selectively and directly removed. Accordingly, the cargo delivery system according to an aspect of the disclosure may be used in pharmaceutical compositions or food compositions for preventing, alimerating, and treating various diseases.

Abstract: A semiconductor device includes a substrate including an N-type region and a P-type region, a first active pattern on the N-type region, a first gate structure on the N-type region, the first gate structure crossing the first active pattern and including fluorine (F), a second active pattern on the P-type region, and a second gate structure on the P-type region, the second gate structure crossing the second active pattern and including fluorine (F), where the first gate structure includes a first gate dielectric film on the first active pattern, and a first gate electrode on the first gate dielectric film, the second gate structure includes a second gate dielectric film on the second active pattern and a second gate electrode on the second gate dielectric film, and a fluorine (F) concentration of the second gate dielectric film is smaller than a fluorine (F) concentration of the first gate dielectric film.