Abstract: The present invention relates to a pharmaceutical composition for preventing or treating cancer, wherein the pharmaceutical composition comprises a thiazole derivative or a pharmaceutically acceptable salt thereof. Specifically, the present invention relates to a pharmaceutical composition that selectively inhibits the activity of CDK7 to reduce side effects, and treats and prevents cancer by inhibiting the proliferation of all cancer cells, rather than being limited to specific cancer cells.

Abstract: The present disclosure relates to an artificial metabolon formed by selective self-assembly, production and use thereof, specifically, an artificial metabolon formed by de novo, in vivo assembly of multi-step metabolic pathway enzymes without using any external scaffold, production and use thereof.

Abstract: Provided is a novel method for preparing a long-acting drug conjugate and a long-acting drug conjugate prepared using the method.

Abstract: Disclosed are quantum dots including a luminescent dopant. More particularly, each of the quantum dots according to an embodiment of the present invention includes a core and a shell surrounding the core, wherein at least one of an interior of the core and an interface between the core and the shell is doped with a luminescent group I dopant.

Abstract: A lithium ion secondary battery includes: an anode including an anode current collector and an anode coating layer coating a region of the anode current collector; a cathode including a cathode current collector, a cathode coating layer coating a region of the cathode current collector, and an inactive coating layer disposed on a surface of a region of the cathode current collector on which the cathode coating layer is not disposed, the inactive coating layer extending from one or more of both end portions of the cathode coating layer toward an end portion of the anode; and a separation membrane arranged between the cathode and the anode.

Abstract: A display panel includes a first panel region (FPR) including (n?1)-th and n-th pixel rows ((n?1)PR and nPR), and a second panel region (SPR) dividing the nPR to propagate an optical signal. The display panel includes a circuit element layer (CEL) and a display element layer (DEL). The CEL includes a signal line (SL), a pixel driving circuit (PDC), and first to third regions. The SL and the PDC are in the first region. The second region (SR) corresponds to the SPR. The SL and the PDC are not in the SR. The third region (TR) corresponds to the SPR and is along a periphery of the SR. The SL is in the TR, and includes an (n?1)-th scan line ((n?1)SL) connected to the (n?1)PR, an n-th reset line (nRL) connected to the nPR, and a first row connection line in the TR and connecting the (n?1)SL and the nRL.

Abstract: A home appliance includes an electrical equipment compartment disposed in an upper portion of the home appliance, and including an upper side that is open, an electrical equipment compartment cover to cover the open upper side of the electrical equipment compartment, and including a speaker hole, a microphone accommodating portion which protrudes upward from an upper side of the electrical equipment compartment cover and including an accommodating space and a front portion that includes microphone holes laterally spaced apart from each other and which face toward a front of the home appliance, a microphone unit including a printed circuit board (PCB) disposed in the accommodation space behind the microphone holes and including microphone chips mounted on the PCB, and a speaker unit disposed in the electrical equipment compartment to correspond to the speaker hole.

Abstract: A display device includes: a substrate; a display area including pixels arranged on the substrate; a first area disposed at one side of the display area; a second area including pads arranged on the substrate; a bending area disposed between the first area and the second area; and a fan-out line disposed in the first area, the bending area, and the second area. The fan-out line includes: a plurality of sub-routing lines arranged in the first area and electrically connected to each other; and a plurality of sub-pad lines arranged in the second area and electrically connected to each other. The number of the plurality of sub-routing lines is greater than the number of the plurality of sub-pad lines.

Abstract: The present disclosure relates to a system for detecting an anomaly and a method for setting a threshold thereof. The method includes setting a minimum true positive rate (TPR) and a differentiation slope based on a user input, creating a receiver operating characteristic (ROC) curve using anomaly data and normal data, estimating a true negative rate (TNR) from the ROC curve based on the minimum TPR and the differentiation slope, and estimating and setting the threshold based on the estimated TNR.

Abstract: The present invention relates to a composition comprising plant extracts. The composition according to the present invention has a skin whitening effect by reducing the total amount of melanin and tyrosinase activity in melanocytes of the skin, promotes skin regeneration and increases skin elasticity or reduces skin wrinkles by promoting collagen synthesis and inhibiting collagenase activity in fibroblasts of the skin, has an anti-inflammatory effect or a skin soothing effect by inhibiting NO generation, increases the amount of moisture in the skin and has a moisturizing effect by promoting generation of hyaluronic acid in fibroblasts, and has an antioxidant effect by scavenging free radicals. In addition, since the composition of the present invention exhibits a broad antibacterial effect against various bacteria, the composition may be used as a cosmetic composition, a pharmaceutical composition, a skin external preparation, or a food composition.

Abstract: A display device includes: a substrate including first areas and second areas alternately arranged in a first direction in a plane view; a first electrode and a second electrode on the substrate and spaced apart from each other in a second direction crossing the first direction; a first insulation layer on the substrate and covering the first electrode and the second electrode; and a light emitting element on the first insulation layer and electrically connected to the first electrode and the second electrode, the first insulation layer having a first thickness in the first area and a second thickness thicker than the first thickness in the second area, and the light emitting element being located in the first area.

Abstract: Disclosed are a superjunction semiconductor device and a method of manufacturing the same. More particularly, the present disclosure relates to a superjunction semiconductor device and a method of manufacturing the same including one or more first conductivity type pillars in a ring region at least partially extending along a first direction, whereby it is possible to reduce electric field concentrations at a surface of the device, and thereby improve breakdown voltage characteristics and achieve an even or more even electric field distribution.

Abstract: A wireless battery management system includes a plurality of slave BMSs coupled to a plurality of battery modules in one-to-one correspondence. Each slave BMS is configured to operate in active mode and sleep mode. Each slave BMS is configured to wirelessly transmit a detection signal indicating a state of the battery module. The wireless battery management system further includes a master BMS configured to wirelessly receive the detection signal from each of the plurality of slave BMSs. The master BMS is configured to set a scan cycle and a scan duration for each of the plurality of slave BMSs based on the detection signal, and wirelessly transmit a control signal to the plurality of slave BMSs. The control signal includes a wireless balancing command indicating the scan cycle and the scan duration set for each of the plurality of slave BMSs.

Abstract: The present disclosure relates to a production medium for microorganisms converting methanol to an organic acid and a culture process, wherein the converted organic acid is oxalic acid, and the production medium for microorganisms comprises 1 to 5% of methanol, 1 to 5% of xylose, and 0.01 to 0.05% of calcium chloride relative to 1 L of the total medium, and further comprises potassium dihydrogen phosphate (KH2PO4), ammonium sulfate ((NH4)2SO4), magnesium sulfate (MgSO4), iron sulfate (FeSO4), manganese sulfate (MnSO4), zinc sulfate (ZnSO4), or boric acid (H3BO3). According to the present disclosure, provided is an organic acid production process using microorganisms of the genus Aspergillus (Aspergillus. sp), which enables a high-throughput production of high-value-added value organic acids such as oxalic acid by utilizing methanol obtained as a product from refining Cl gas such as methane.

Abstract: A display device and a manufacturing method thereof are provided. The display device includes a first substrate; a first color filter, a second color filter, and a third color filter that are on the first substrate; a plurality of roof layers that cover spaces that overlap the first color filter, the second color filter, and the third color filter, respectively; a first color conversion layer that is positioned in a space overlapping the first color filter; a second color conversion layer that is positioned in a space overlapping the second color filter; a transmissive layer that is positioned in a space overlapping the third color filter; and a capping layer that is positioned on the plurality of roof layers.

Abstract: Provided are a color converting substrate and a display device including same. The color converting substrate includes: a base portion in which a first light transmission area, a first light blocking area, and a second light transmission area, which are sequentially and closely arranged in a first direction, are defined; a first wavelength converting pattern located on the base portion and configured to wavelength-covert a first color light into a second color light; a second wavelength converting pattern located on the base portion and configured to wavelength-convert the first color light into a third color light; and a light transmission pattern located on the base portion and configured to transmit the first color light.

Abstract: A display device including a base layer, a circuit layer, a light emitting device layer, an organic layer, and a touch sensing unit. The base layer includes a display area and a non-display area. A plurality of insulation patterns overlaps the non-display area. The organic layer is disposed on the light emitting device and overlaps the plurality of insulation patterns and the organic light emitting diode. At least a portion of the plurality of touch signal lines overlaps the plurality of insulation patterns.

Abstract: A cell extruder of the present invention comprises: a pressure vessel in which a sample is dispensed; a regulator for adjusting a set pressure of nitrogen gas injected into the pressure vessel and then maintaining a constant pressure; an input valve for opening and closing the injection of nitrogen gas into the pressure vessel; an exhaust valve for removing the internal pressure of the pressure vessel; a filter holder which is provided with a membrane filter soaked with a reagent, so that the sample in the pressure vessel is fed through by the nitrogen gas and crushed into extracellular vesicles; and a collection container in which the extruded sample is stored. According to the present invention, pressure can be freely adjusted by the regulator. That is, the flow rate of the membrane according to pressure can be controlled, thus allowing the validation of a biopharmaceutical production method using an extracellular vesicle extruder.

Abstract: A foldable device includes first and second bodies that respectively support a first part and a second part of a flexible display device and are foldably connected to each other between a folded position and an unfolded position, and a movable support member that continuously near-supports a third part of the flexible display device between the first part and the second part when the first body and the second body change from the folded position to the unfolded position.

Abstract: A blockchain-based data distribution management method according to an embodiment is performed by a computing device. The method includes generating a plurality of shards by fragmenting a first information, requesting a first block event for distributed storage of the plurality of shards in a plurality of off-chain storages to a blockchain network, and transmitting the plurality of shards to the plurality of off-chain storages, wherein a second information indicating a history of the plurality of shards distributed and stored in the plurality of off-chain storages is recorded in the blockchain network through the first block event, wherein when a predetermined number or more of shards among the plurality of shards are collected, the first information is restored from the collected predetermined number or more of shards.