Abstract: Among other things, the present invention is related to devices and methods of performing biological and chemical assays, particularly an easy sample manipulation and/or a rapid change or a rapid thermal cycling of a sample temperature is needed (e.g. Polymerase Chain Reaction (PCR) for amplifying nucleic acids).

Abstract: The present disclosure relates to devices, apparatus and methods of improving the accuracy of image-based assay, that uses imaging system having uncertainties or deviations (imperfection) compared with an ideal imaging system. One aspect of the present invention is to add the monitoring marks on the sample holder, with at least one of their geometric and/optical properties of the monitoring marks under predetermined and known, and taking images of the sample with the monitoring marks, and train a machine learning model using the images with the monitoring mark.

Abstract: Among other things, the present invention is related to devices and methods of performing biological and chemical assays, particularly an easy sample manipulation and/or a rapid change or a rapid thermal cycling of a sample temperature is needed (e.g. Polymerase Chain Reaction (PCR) for amplifying nucleic acids).

Abstract: Disclosed are a data processing method and apparatus, a computing device, and a storage medium, which belongs to the field of big data technologies. The method includes: determining, based on a query algorithm, a first query output (601) corresponding to an input data set; determining, based on a second query output of an unsampled data record in the input data set and the query algorithm, a perturbation of each of a target quantity of sampled data records in the input data set to the first query output, to obtain sensitivity (602) corresponding to the input data set, where the unsampled data record and the target quantity of data records constitute the input data set; and adding noise to the first query output based on the sensitivity and outputting a noised first query output (603).

Abstract: The present invention relates to provide, among other things, the methods, devices, and systems that can simply and quickly collecting and analyzing a tiny amount of vapor condensates (e.g. exhaled breath condensate (EBC)).

Abstract: A multi-mode illumination system, including: a first illumination module; a second illumination module; and a third illumination module, as disclosed herein.

Abstract: A device and a method of using the device for improving sensitivity, speed, and easy-to-use of a colorimetric assay of a liquid sample are provided. The device includes a first plate and a second plate, spacers, and a textured surface. The two plates each have a sample contact surface and are movable relative to each other into an open configuration or a closed configuration. The sample is deposited on one or both plates in the open configuration. Thereafter, the closed configuration is formed where the plates compress at least part of the deposited sample into a continuous layer. The textured surface is disposed on the sample contact surface of the second plate and has a textured structure that scatters light, from which an optical signal such as a colorimetric or fluorescent signal can be obtained for analyzing the sample.

Abstract: Given an input image in a high dynamic range (HDR) which is mapped to a second image in a second dynamic range using a reshaping function, to improve coding efficiency, a reshaping function generator may adjust the codeword range of the HDR input under certain criteria, such as for noisy HDR images with a relatively-small codeword range. An example of generating a scaler for adjusting the HDR codeword range based on the original codeword range and a metric of the percentage of edge-points in the HDR image is provided. The adjusted reshaping function allows for more efficient rate control during the compression of reshaped images.

Abstract: Catalysts containing a support and a metal oxide, and reactors and methods of using the catalysts in a carbonylation reaction, such as alcohol carbonylation and ester carbonylation, are described herein. The support is typically chemically inert and has a high surface area. The metal oxide typically contains a transition metal or a mixture of metals, such as rhenium, aluminum, tungsten, molybdenum, or a combination thereof. Typically, the metal oxide is mainly atomically dispersed on the surface of the support, as indicated by STEM. For example, at least 10% of the metal oxide is atomically dispersed on the surface of the support. The method includes (i) exposing a mixture of one or more alcohols or one or more esters and carbon monoxide to the catalyst. Typically, the one or more alcohols or one or more esters and carbon monoxide are in a gas phase.

Abstract: A multi-mode illumination system, including: a first illumination module; a second illumination module; and a third illumination module, as disclosed herein.

Abstract: A device, including: an end-emitting optical fiber including a first end and a second end; a light extraction plate including a light scattering structure; and a light diffuser film disposed above the light scattering structure. Also disclosed are systems including the device.

Abstract: The present disclosure relates to devices, apparatus and methods of improving the accuracy of an image-based assay. One aspect of the present invention is to sandwich a sample between two plates and add reference marks in the sample areas of the plates, with at least one of the geometric and/optical properties of the reference marks being predetermined and known, and taking images of the sample with the reference marks, and applying a machine learning model in the analysis of the image-based assay.

Abstract: A microscopy imaging system and methods for improving an assaying of a sample is disclosed.

Abstract: The present invention relates to provide, among other things, the methods, devices, and systems that can simply and quickly collecting and analyzing a tiny amount of vapor condensates (e.g. exhaled breath condensate (EBC)).

Abstract: The disclosure provides an apparatus, a device, and methods for improving optical analysis of a thin layer of a sample between two plates, particularly for multiple wavelengths.

Abstract: The present invention relates to an automatic history matching system for an oil reservoir based on transfer learning, comprising a data reading module, a population reinitializing module, an optimization module, a simulated calculation module, a comparative judgment module and an output module, wherein the data reading module reads an optimized result of an existing oil reservoir, outputs the optimized result to the population reinitializing module, obtains an initial population of a new oil reservoir by calculation and outputs the initial population to the optimization module; the optimized result is outputted to the simulated calculation module to obtain oil reservoir production simulated data, and the oil reservoir production simulated data is outputted to the comparative judgment module; when an error between the simulated data and observed data meets the requirement, the optimized result is outputted to the output module, and the system operation is completed; and if the error does not meet the requirem

Abstract: Among other things, the present invention is related to devices and methods for improving optical analysis of a thin layer of a sample sandwiched between containing between two plates.

Abstract: The present disclosure relates to devices, apparatus and methods of improving the accuracy of an image-based assay. One aspect of the present invention is to sandwich a sample between two plates and add reference marks in the sample areas of the plates, with at least one of the geometric and/optical properties of the reference marks being predetermined and known, and taking images of the sample with the reference marks, and applying a machine learning model in the analysis of the image-based assay.

Abstract: Among other things, the present invention is related to devices and methods for improving optical analysis of a thin layer of a sample sandwiched between two plates.

Abstract: Provided herein is a method and device for performing a homogeneous nucleic acid detection assay. The device can contain a pair of plates where one of the plates comprises (i) surface amplification surface; and (ii) target-specific nucleic acid probes that are immobilized on said amplification surface and that specifically binds to a part of the target nucleic acid; and the second plate comprises a sample contact area comprising a reagent storage site that comprises target-specific nucleic acid detection agents that specifically binds to another part of the target nucleic acid. In some embodiments, the device can be read without a washing unbound label from the surface of the device.