Abstract: The present invention is of using contact lenses for photodynamic inactivation of germs, a product, and a method of treating fungal keratitis by applying the same. The contact lens is to continuously release a photoactive solution containing a photosensitizer such as rose bengal and hydrogen peroxide to the ocular surface. The photosensitizer would be activated while these contact lenses are applied and exposed to daylight or other artificial lights in the environment. After activation, the photosensitizer will produce singlet oxygen and reactive oxygen species to inhibit the growth of fungi, thereby treating fungal keratitis without having the patient experiences eye pain or discomfort. Moreover, since the photoactive solution excludes any antifungal agents, the contact lenses for photodynamic inactivation of germs of the present invention can not only improve drug-resistant fungal keratitis but also prevent the germs from developing antimicrobial resistance.