Patents by Inventor Jia Xie

Jia Xie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12338937
    Abstract: A robot applicable to synchronous patrol of a long branch pipeline and a main pipeline includes a walking apparatus and detection apparatuses located on a top of the walking apparatus, where the detection apparatuses accompany the walking apparatus to patrol the main pipeline. The robot further includes a sub-walking apparatus located at a front end of the walking apparatus, where front wheel obstacle-crossing apparatuses of the walking apparatus are also capable of limiting the sub-walking apparatus while crossing an obstacle in the main pipeline, and when the branch pipeline is encountered, the front wheel obstacle-crossing apparatuses are lifted to a certain height, a bin outlet of the sub-walking apparatus is released, and the sub-walking apparatus is separated from the walking apparatus and independently patrols the branch pipeline.
    Type: Grant
    Filed: July 29, 2024
    Date of Patent: June 24, 2025
    Assignee: State Grid Anhui Electric Power Research Institute
    Inventors: Jiaqing Zhang, Yi Guo, Jia Xie, Liufang Wang, Taiyun Zhu, Jian Sun, Shuping Wang, Yubiao Huang, Yang He, Fengju Shang, Rui Liu, Tiantian Tan, Xin Liu, Tao Xie, Tao Sun
  • Publication number: 20250186494
    Abstract: The invention provides chimeric antigen receptor T (CAR-T) cell compositions for targeting tumor cells. The compositions contain (a) a CAR-T cell having in the extracellular domain of its CAR a catalytic antibody (e.g., a scFv molecule derived from catalytic antibody 38C2), and (b) an adapter compound containing a substrate moiety of the catalytic antibody that is linked to a targeting moiety that specifically recognizes a surface molecule of a target tumor cell. The compositions allow formation of a covalent bond between the catalytic antibody in the CAR and the targeting moiety. The targeting moieties employed in the compositions can be obtained via screening DNA-encoded compound library for specific binding to the target tumor surface molecules. Also provided in the invention are therapeutic methods of using the CAR-T cell compositions of the invention to in the treatment of various tumors of interest.
    Type: Application
    Filed: February 7, 2023
    Publication date: June 12, 2025
    Inventors: Richard A. LERNER, Jia XIE, Alexey STEPANOV
  • Publication number: 20250164058
    Abstract: A robot applicable to synchronous patrol of a long branch pipeline and a main pipeline includes a walking apparatus and detection apparatuses located on a top of the walking apparatus, where the detection apparatuses accompany the walking apparatus to patrol the main pipeline. The robot further includes a sub-walking apparatus located at a front end of the walking apparatus, where front wheel obstacle-crossing apparatuses of the walking apparatus are also capable of limiting the sub-walking apparatus while crossing an obstacle in the main pipeline, and when the branch pipeline is encountered, the front wheel obstacle-crossing apparatuses are lifted to a certain height, a bin outlet of the sub-walking apparatus is released, and the sub-walking apparatus is separated from the walking apparatus and independently patrols the branch pipeline.
    Type: Application
    Filed: July 29, 2024
    Publication date: May 22, 2025
    Inventors: Jiaqing ZHANG, Yi GUO, Jia XIE, Liufang WANG, Taiyun ZHU, Jian SUN, Shuping WANG, Yubiao HUANG, Yang HE, Fengju SHANG, Rui LIU, Tiantian TAN, Xin LIU, Tao XIE, Tao SUN
  • Publication number: 20250076197
    Abstract: Provided are a fault diagnosis apparatus and method based on fluorescence multivariate correction analysis of transformer oil, relating to the field of transformer fault diagnosis technology. Thus, the problem of large volume and weight of the apparatus, high costs, and inconvenience to use caused when in the related art, a fluorescence spectrometer is directly used to acquire the fluorescence spectrum of transformer oil is solved. The monochromatic excitation light of an optimal excitation wavelength generated by a fluorescence excitation source is used to excite the transformer oil in a fluorescence excitation detection apparatus to generate fluorescence. The fluorescence excitation detection apparatus generates the fluorescence according to the input monochromatic excitation light and inputs the fluorescence to a fluorescence signal acquisition and analysis apparatus.
    Type: Application
    Filed: September 8, 2023
    Publication date: March 6, 2025
    Applicants: STATE GRID ANHUI ELECTRIC POWER RESEARCH INSTITUTE, STATE GRID ANHUI ELECTRIC POWER CO., LTD., HEFEI INSTITUTES OF PHYSICAL SCIENCE, CHINESE ACADEMY OF SCIENCES
    Inventors: Yue Zhao, Jia Xie, Fengxiang Ma, Yumei Song, Feng Zhu, Anjing Wang, Wei Liu, Shan Zhu, Jiong Qi, Zien Liu, Taiyun Zhu, Jun Cao, Jianlin Li, Chao Luo, Qingtao Chen, Chen Hang
  • Patent number: 12186610
    Abstract: An operation control method suitable for a fire extinguishing system of an extra-high voltage converter station is provided. The method includes: after an upper computer control system receives a sound-light alarm signal, an alarm position signal, and a switch position dividing signal, starting a spray range prediction analysis subsystem for a fixed fire monitor; determining, by the spray range prediction analysis subsystem for the fixed fire monitor based on an external wind direction and an external wind speed, whether a range of a fire monitor effectively covers an entire area of a converter transformer; and if yes, automatically presetting a first fire monitor to which a first compressed air foam generation subsystem belongs and a second fire monitor to which a second compressed air foam generation subsystem belongs; or if no, replacing a fire monitor with a mobile fire-fighting robot to extinguish a fire.
    Type: Grant
    Filed: June 18, 2021
    Date of Patent: January 7, 2025
    Assignees: STATE GRID ANHUI ELECTRIC POWER RESEARCH INSTITUTE, STATE GRID CORPORATION OF CHINA, STATE POWER ECONOMIC RESEARCH INSTITUTE
    Inventors: Jiaqing Zhang, Yubiao Huang, Yong Huang, Jinzhong Li, Pengcheng Yang, Jing Tan, Liufang Wang, Dengfeng Cheng, Yu Tian, Yanguo Ke, Sha Luo, Jia Xie, Minghao Fan, Wei Li, Yi Guo, Fengju Shang, Rui Liu, Wen Su
  • Patent number: 12159972
    Abstract: The present invention relates to the technical field of lithium metal batteries, and relates to a lithium metal battery electrolyte containing an aromatic compound as a diluent. The electrolyte contains a lithium salt, a solvent for dissolving the lithium salt, and a diluent; the diluent is an aromatic compound, and the diluent is used for inhibiting lithium dendrites generated due to uneven deposition of a lithium metal anode in the lithium metal battery during a cycle process, and is used for inhibiting the lithium metal anode in the lithium metal battery from reacting with the electrolyte.
    Type: Grant
    Filed: May 15, 2020
    Date of Patent: December 3, 2024
    Assignee: HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Jia Xie, Zhipeng Jiang, Ziqi Zeng, Zhilong Han
  • Publication number: 20240350848
    Abstract: An operation control method suitable for a fire extinguishing system of an extra-high voltage converter station is provided. The method includes: after an upper computer control system receives a sound-light alarm signal, an alarm position signal, and a switch position dividing signal, starting a spray range prediction analysis subsystem for a fixed fire monitor; determining, by the spray range prediction analysis subsystem for the fixed fire monitor based on an external wind direction and an external wind speed, whether a range of a fire monitor effectively covers an entire area of a converter transformer; and if yes, automatically presetting a first fire monitor to which a first compressed air foam generation subsystem belongs and a second fire monitor to which a second compressed air foam generation subsystem belongs; or if no, replacing a fire monitor with a mobile fire-fighting robot to extinguish a fire.
    Type: Application
    Filed: June 18, 2021
    Publication date: October 24, 2024
    Applicants: STATE GRID ANHUI ELECTRIC POWER RESEARCH INSTITUTE, STATE GRID CORPORATION OF CHINA, STATE POWER ECONOMIC RESEARCH INSTITUTE
    Inventors: Jiaqing ZHANG, Yubiao HUANG, Yong HUANG, Jinzhong LI, Pengcheng YANG, Jing TAN, Liufang WANG, Dengfeng CHENG, Yu TIAN, Yanguo KE, Sha LUO, Jia XIE, Minghao FAN, Wei LI, Yi GUO, Fengju SHANG, Rui LIU, Wen SU
  • Patent number: 12111319
    Abstract: Described are methods for providing personalized medicine for the treatment of B cell malignancies including lymphoma. The methods make use of Chimeric Antigen Receptor (CAR) technology.
    Type: Grant
    Filed: July 26, 2021
    Date of Patent: October 8, 2024
    Assignees: HESPERIX SA, THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Alexey Vyacheslavovich Stepanov, Dmitry Dmitrievich Genkin, Alexander Gabibovich Gabibov, Richard A. Lerner, Alexey Anatolievich Belogurov, Jia Xie
  • Publication number: 20240074442
    Abstract: The present application provides an Uvaria grandiflora extract as a botanical fungicide, a preparation method therefor, and an application thereof. The broad-spectrum plant-derived fungicide provided in the present application comprises: Uvaria grandiflora whole plant extract and compound zeylenone obtained through separation and purification, which have the advantages of a broad antibacterial spectrum and a simple separation process. By means of a potted fungicidal activity test, it is proven that Uvaria grandiflora extracts have excellent control effects on Phytophthora capsici, cucumber downy mildew, potato late blight, and cowpea powdery mildew. Furthermore, Uvaria grandiflora extracts promote cucumber growth. Furthermore, a field efficacy test proves that the fungicidal activity of Uvaria grandiflora extracts against cucumber powdery mildew is better than that of the commercial fungicide Luna Sensation.
    Type: Application
    Filed: October 16, 2023
    Publication date: March 7, 2024
    Inventors: RANFENG SUN, JIANGUO HE, ZHAN HU, JIA XIE
  • Patent number: 11731280
    Abstract: A cable trench inspection robot. The cable trench inspection robot includes a base spreading system, and a camera lifting system disposed on the base spreading system, where the base spreading system includes a base plate, a linear action unit, a cantilever plate, a walking assembly, and a jacking assembly, and the camera lifting system includes a travel block, an imitated four-bar assembly, a support rod, and a camera assembly. Such inspection can realize a through-wall operation by using a cable trench, thereby avoiding many use problems caused by a firewall, and efficiently completing a predetermined inspection task.
    Type: Grant
    Filed: August 20, 2021
    Date of Patent: August 22, 2023
    Assignees: STATE GRID ANHUI ELECTRIC POWER RESEARCH INSTITUTE, State Grid Corporation of China
    Inventors: Tao Sun, Minghao Fan, Jiaqing Zhang, Jia Xie, Bo Yan, Daoyou Huang, Songyuan Cao, Liangpeng Ye
  • Publication number: 20220347854
    Abstract: The present disclosure relates to the technical field of cable inspection, and specifically, to a cable trench inspection robot. The cable trench inspection robot includes a base spreading system, and a camera lifting system disposed on the base spreading system, where the base spreading system includes a base plate, a linear action unit, a cantilever plate, a walking assembly, and a jacking assembly, and the camera lifting system includes a travel block, an imitated four-bar assembly, a support rod, and a camera assembly. The present disclosure can realize a through-wall operation by using a cable trench, thereby avoiding many use problems caused by a firewall, and efficiently completing a predetermined inspection task.
    Type: Application
    Filed: August 20, 2021
    Publication date: November 3, 2022
    Inventors: Tao Sun, Minghao Fan, Jiaqing Zhang, Jia Xie, Bo Yan, Daoyou Huang, Songyuan Cao, Liangpeng Ye
  • Publication number: 20220216521
    Abstract: The present invention relates to the technical field of lithium metal batteries, and relates to a lithium metal battery electrolyte containing an aromatic compound as a diluent. The electrolyte contains a lithium salt, a solvent for dissolving the lithium salt, and a diluent; the diluent is an aromatic compound, and the diluent is used for inhibiting lithium dendrites generated due to uneven deposition of a lithium metal anode in the lithium metal battery during a cycle process, and is used for inhibiting the lithium metal anode in the lithium metal battery from reacting with the electrolyte.
    Type: Application
    Filed: May 15, 2020
    Publication date: July 7, 2022
    Applicant: HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Jia XIE, Zhipeng JIANG, Ziqi ZENG, Zhilong HAN
  • Publication number: 20220118297
    Abstract: Disclosed are a fire extinguishing system and method for an ultra-high voltage (UHV) converter station, and a UHV converter station. The fire extinguishing system includes a spray fire extinguishing system and a fire monitor-based fire extinguishing system, where the spray fire extinguishing system includes a first fire pipe and a spray pipe; the fire monitor-based fire extinguishing system includes a second fire pipe and a fire monitor; one fire monitor is disposed right above a firewall on both sides of each converter transformer in the UHV converter station, and each fire monitor is connected to one second fire pipe; a spray pipe is disposed on the firewall on both sides of each converter transformer; and the fire monitor corresponding to each converter transformer, and an outlet of the spray pipe connected to the first fire pipe corresponding to each converter transformer face the converter transformer.
    Type: Application
    Filed: December 31, 2021
    Publication date: April 21, 2022
    Inventors: Jiaqing Zhang, Yubiao Huang, Yong Huang, Dengfeng Cheng, Liufang Wang, Shengli Song, Jinzhong Li, Yifu Zhou, Pengcheng Yang, Yu Tian, Yanguo Ke, Sha Luo, Jia Xie, Minghao Fan, Wei Li, Yi Guo, Fengju Shang, Rui Liu
  • Publication number: 20220018845
    Abstract: Described are methods for providing personalized medicine for the treatment of B cell malignancies including lymphoma. The methods make use of Chimeric Antigen Receptor (CAR) technology.
    Type: Application
    Filed: July 26, 2021
    Publication date: January 20, 2022
    Applicants: HESPERIX SA, THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Alexey Vyacheslavovich Stepanov, Dmitry Dmitrievich Genkin, Alexander Gabibovich Gabibov, Richard A. Lerner, Alexey Anatolievich Belogurov, Jia Xie
  • Patent number: 11215618
    Abstract: Described are methods for providing personalized medicine for the treatment of B cell malignancies including lymphoma. The methods make use of Chimeric Antigen Receptor (CAR) technology.
    Type: Grant
    Filed: August 3, 2020
    Date of Patent: January 4, 2022
    Assignees: HESPERIX SA, The Scripps Research Institute
    Inventors: Alexey Vyacheslavovich Stepanov, Dmitry Dmitrievich Genkin, Richard A. Lerner, Alexey Anatolievich Belogurov, Alexander Gabibovich Gabibov, Jia Xie
  • Publication number: 20210333282
    Abstract: Described are methods for providing personalized medicine for the treatment of B cell malignancies including lymphoma. The methods make use of Chimeric Antigen Receptor (CAR) technology.
    Type: Application
    Filed: August 3, 2020
    Publication date: October 28, 2021
    Applicants: HESPERIX SA, The Scripps Research Institute
    Inventors: Alexey Vyacheslavovich Stepanov, Dmitry Dmitrievich Genkin, Richard A. Lerner, Alexey Anatolievich Belogurov, Alexander Gabibovich Gabibov, Jia Xie
  • Patent number: 10975152
    Abstract: The invention provides TrkB agonist antibodies or antigen-binding fragments that specifically enhance TrkB signaling activities. The invention also provides therapeutic methods of using such antibodies for promoting survival and regeneration of retinal ganglion cells, and for treating or preventing subjects suffering from or at risk of developing various neurodegenerative conditions such as glaucoma.
    Type: Grant
    Filed: May 2, 2017
    Date of Patent: April 13, 2021
    Assignees: The Scripps Research Institute, Zebra Biologies, Inc.
    Inventors: Richard A. Lerner, Ronald M. Lindsay, Jia Xie
  • Publication number: 20200400676
    Abstract: Described are methods for providing personalized medicine for the treatment of B cell malignancies including lymphoma. The methods make use of Chimeric Antigen Receptor (CAR) technology.
    Type: Application
    Filed: August 3, 2020
    Publication date: December 24, 2020
    Applicants: OPKO Pharmaceuticals, LLC, The Scripps Research Institute, Shemyakin-Ovchinnikov institute of Bioorganic Chemistry, Russian Academy of Sciences, PJSC Pharmsynthez
    Inventors: Alexey Vyacheslavovich Stepanov, Dmitry Dmitrievich Genkin, Richard A. Lerner, Alexey Anatolievich Belogurov, Alexander Gabibovich Gabibov, Jia Xie
  • Publication number: 20200398227
    Abstract: The present invention relates to a dye-salt separation membrane and a preparation method thereof. The method includes the following steps: firstly pouring an aqueous phase solution containing tannic acid and anhydrous piperazine on a surface of a polysulfone-based ultrafiltration base membrane at a mass ratio of the tannic acid to the anhydrous piperazine of 1:2 to 2:1, followed by complete infiltration, and draining the aqueous phase solution; and then pouring an organic phase solution of trimesoyl chloride on the surface of the base membrane, and draining the organic phase solution to obtain the dye-salt separation membrane. The method of the present invention is simple and easy to implement, and the dye-salt separation membrane prepared by the method has a relatively high solution permeability, an efficient dye retention and permeability of inorganic salts, thereby achieving an excellent dye-salt separation effect.
    Type: Application
    Filed: June 20, 2020
    Publication date: December 24, 2020
    Applicant: Nanjing University of Science and Technology
    Inventors: Jiansheng LI, Qin LI, Junwen QI, Xiaofeng FANG, Zhipeng LIAO, Dapeng WANG, Jia XIE, Linhan Ni, Xiuyun SUN, Lianjun WANG
  • Publication number: 20200363420
    Abstract: Described are methods for providing personalized medicine for the treatment of B cell malignancies including lymphoma. The methods make use of Chimeric Antigen Receptor (CAR) technology.
    Type: Application
    Filed: August 3, 2020
    Publication date: November 19, 2020
    Applicants: OPKO Pharmaceuticals, LLC, The Scripps Research Institute, Shemyakin-Ovchinnikov institute of Bioorganic Chemistry, Russian Academy of Sciences, PJSC Pharmsynthez
    Inventors: Alexey Vyacheslavovich Stepanov, Dmitry Dmitrievich Genkin, Richard A. Lerner, Alexey Anatolievich Belogurov, Alexander Gabibovich Gabibov, Jia Xie