Abstract: Fused bicycle indol, indoline, azoindole, or azoindoline compounds of Formula (I) set forth herein. Also disclosed are pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing the same. Further disclosed is a method for treating cancer, e.g., glioma, prostate cancer, and colorectal cancer, with these compounds.

Abstract: Fused bicycle indol, indoline, azoindole, or azoindoline compounds of Formula (I) set forth herein. Also disclosed are pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing the same. Further disclosed is a method for treating cancer, e.g., glioma, prostate cancer, and colorectal cancer, with these compounds.

Abstract: A novel use of a neuropeptide for treating brain injury in a subject in need thereof is provided. The present invention also provides various amenable routes of administering urocortin, that is, via injection intracerebroventricularly and intraperitoneally, and via intravenous bolus administration.

Abstract: The invention provides a novel medical use of Baicalein, and in particular, a use of baicalein in the preparation of a pharmaceutical composition useful for treating traumatic brain injury. The baicalein pharmaceutical composition in this invention includes a treating effective amount of baicalein and a suitable pharmaceutically acceptable excipient or carrier. The baicalein pharmaceutical composition is applicable for improving the behaviour function deficit in traumatic brain injury, reducing the contusion volume of traumatic brain injury, improving the brain neuronal degeneration in traumatic brain injury, reducing proinflammatory cytokines such as tumor necrosis factor-? (TNF-?), interleukin-1? (IL-1?), interleukin-6 (IL-6) or other relative inflammation factor induced in traumatic brain injury.

Abstract: According to one embodiment of the invention, a method for integrated decision support is disclosed. The method includes receiving decision inputs. The method also includes converting the received decision inputs to graph representations and mathematical representations. The method further includes decomposing the converted decision inputs to sub-problems. The method further includes detecting strongly-connected components associated with the sub-problems. The strongly-connected components represent the sub-problems that are coupled. The method further includes solving the sub-problems.

Abstract: The invention provides a novel medical use of Baicalein, and in particular, a use of baicalein in the preparation of a pharmaceutical composition useful for treating traumatic brain injury. The baicalein pharmaceutical composition in this invention includes a treating effective amount of baicalein and a suitable pharmaceutically acceptable excipient or carrier. The baicalein pharmaceutical composition is applicable for improving the behaviour function deficit in traumatic brain injury, reducing the contusion volume of traumatic brain injury, improving the brain neuronal degeneration in traumatic brain injury, reducing proinflammatory cytokines such as tumor necrosis factor-? (TNF-?), interleukin-1? (IL-1?), interleukin-6 (IL-6) or other relative inflammation factor induced in traumatic brain injury.

Abstract: An integrated decision support framework is disclosed, in which different types of decision-drivers from numerous sources can be converted into a unified decision network including, for example, both mathematical and node-edge graph representations. A graph-theoretic algorithm may be applied to the large problem (unified decision network) to detect and separate strongly-connected components. The strongly-connected components represent sub-problems that can be solved simultaneously. A dependency propagation technique may be used to properly order the sub-problems so they can be processed and solved sequentially and correctly. Each strongly-connected component (small sub-problem) can be delegated to a suitable decision generator depending on the types of relations included in the component.