Abstract: A transaxle of a rail vehicle includes: a power assembly; an axle body; a running wheel; a guiding frame; a horizontal wheel; and a connecting rod component, including a first transverse pull rod and a second transverse pull rod, where when the rail vehicle turns left, the horizontal wheel cooperates with a rail beam to drive the guiding frame to swing and drive the first transverse pull rod to move together, and the second transverse pull rod is driven by the first transverse pull rod to drive the running wheel to swing to the left, and when the rail vehicle turns right, the horizontal wheel cooperates with the rail beam to drive the guiding frame to swing and drive the first transverse pull rod to move together, and the second transverse pull rod is driven by the first transverse pull rod to drive the running wheel to swing to the right.

Abstract: A method for establishing an optocoupler SPICE model includes: establishing at least three performance-state optocoupler SPICE models respectively from optocoupler circuits that correspond to at least three performance states; establishing, according to a maximum performance state, a minimum performance state, and a typical performance state of the at least three performance states that correspond to the at least three performance-state optocoupler SPICE models, three selection circuits for each of an input end and an output end; and correspondingly connecting an input-end first selection circuit, an input-end second selection circuit, an input-end third selection circuit, an output-end first selection circuit, an output-end second selection circuit, and an output-end third selection circuit to two sides of the at least three performance-state optocoupler SPICE models, so as to establish the optocoupler SPICE model.

Abstract: The invention provides a reaction system for preparing butyraldehyde by propylene carbonylation, comprising: a reactor; a side wall of the reactor is sequentially provided with a catalyst inlet, a propylene inlet and a synthesis gas inlet from top to bottom; the bottom of the reactor is provided with a solvent inlet; two micro-interface generators are arranged inside of the reactor from top to bottom, and the micro-interface generator located at a top end is connected to the propylene inlet to break the propylene gas into micron-scale micro-bubbles; the micro-interface generator located at a bottom is connected to the synthesis gas inlet for breaking the synthesis gas into micron-scale micro-bubbles; the outlets of the two micro-interface generators are opposite, and the outlets are connected with a gas distributor for evenly distributing raw materials.

Abstract: For in mold spraying, a double-inclined mixing nozzle is connected obliquely and fixedly with a side surface of a third half-mold through a lateral sealing structure and connected with a side surface of a first half-mold in an inclined and sealing manner, side faces of a first half-mold and the third half-mold are respectively provided with installation inclined surfaces. A lateral sealing structure includes a mounting plate and a sealing member. The sealing member is sleeved on the double-inclined mixing nozzle and is in transition fit with the double-inclined mixing nozzle and the mounting plate respectively. A butt sealing groove provided on the installation inclined surface of the first half-mold and is in sealing fit with the mounting plate.

Abstract: Embodiments are directed to novel GPR52 activators. In particular, a series of novel 1-(pyrimidin-4-yl)indoline-4-carboxamide analogs that have been identified as potent and selective GPR52 agonists. The optimized GPR52 agonist that, for example, can be used as a valuable pharmacological tool or a drug candidate for investigating the physiological and therapeutic potential of GPR52 activation for various human diseases.

Abstract: Use of a TGF-? small molecule inhibitor in the field of nerve regeneration, for in vitro regeneration and directed differentiation of a variety of nerve cells and brain-like organs. By adding the TGF-? small molecule inhibitor to a set of basal media having clear chemical compositions, pluripotent stem cells can be induced into adult cells derived from a variety of neural stem cells, and the number of induced nerve cells can be greatly increased.

Abstract: Provided is an ultrasonographic device. The ultrasonographic device includes a mounting housing, an ultrasonic transducer, and a puncture support. The ultrasonic transducer is rotatably disposed in an inner cavity of the mounting housing and spaced apart from the mounting housing. The puncture support is provided on an outer side of the mounting housing, where a puncture guide hole through which a puncture needle penetrates is provided on the puncture support, and the puncture support is capable of rotating synchronously with the ultrasonic transducer so that an axis of the puncture guide hole is coplanar with a real-time scanning plane of the ultrasonic transducer.

Abstract: Provided are a high-intensity focused ultrasound apparatus (10) and a control method. According to the high-intensity focused ultrasound apparatus (10), by providing a focusing transducer (120) having a freely transformable shape, after an entire transducer assembly (100) extends into an inner cavity of an object to be treated, the transducer assembly (100) can extend through a narrow part into the inner cavity of an object to be treated, and after extending into the inner cavity of the object to be treated, the shape of the focusing transducer (120) in the transducer assembly (100) changes, so that the effective area of the focusing transducer (120) increases, and the ultrasonic energy produced increases, thereby enhancing the irradiation intensity for a region to be treated, and satisfying normal operation requirements of the transducer assembly (100).

Abstract: Provided is a new use of a TGF-? small molecule inhibitor in the field of neuroregeneration, which can be used for the in vitro regeneration and directed differentiation of various nerve cells and brain-like organs. By adding same to a set of basal media having clear chemical compositions. pluripotent stem cells can be induced into adult cells derived from a variety of neural stem cells, and the number of induced nerve cells and the size of organoids can be greatly increased. The induction system provided in the present invention expands new functions of a single small molecule in the field of ectodermal cell induction and differentiation and at the same time avoids the use of B27 and other serum substitutes, thereby completely avoiding the potential risks caused by the presence of animal-derived components in cell culture processes, and greatly expanding the clinical prospects of a variety of nerve cell transplantations.

Abstract: Embodiments are directed to novel GPR52 activators. In particular, a series of novel 1-(pyrimidin-4-yl)indoline-4-carboxamide analogs that have been identified as potent and selective GPR52 agonists. The optimized GPR52 agonist that, for example, can be used as a valuable pharmacological tool or a drug candidate for investigating the physiological and therapeutic potential of GPR52 activation for various human diseases.

Abstract: For in mold spraying, a double-inclined mixing nozzle is connected obliquely and fixedly with a side surface of a third half-mold through a lateral sealing structure and connected with a side surface of a first half-mold in an inclined and sealing manner, side faces of a first half-mold and the third half-mold are respectively provided with installation inclined surfaces. A lateral sealing structure includes a mounting plate and a sealing member. The sealing member is sleeved on the double-inclined mixing nozzle and is in transition fit with the double-inclined mixing nozzle and the mounting plate respectively. A butt sealing groove provided on the installation inclined surface of the first half-mold and is in sealing fit with the mounting plate.

Abstract: The present disclosure relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof. The present disclosure further relates to methods of inhibiting viral replication including contacting one or more cells that have been infected with a virus with an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein the virus comprises a flavivirus. Also disclosed is a method of treating and/or preventing a flavivirus infection and/or a condition resulting from a flavivirus infection including administering an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof under conditions effective to treat and/or prevent a flavivirus infection and/or a condition resulting from a flavivirus infection.

Abstract: The present disclosure relates to a Prp8 intein splicing inhibitor. The present disclosure further relates to a method of treating and/or preventing a fungal infection, said method comprising administering a Prp8 intein splicing inhibitor under conditions effective to treat and/or prevent a fungal infection. Also disclosed is a method of inhibiting Prp8 intein expression or activity in a cell or tissue, said method comprising administering a compound under conditions effective to inhibit Prp8 intein expression or activity in a cell or tissue. Further disclosed are methods for screening for compounds that inhibit Prp8 intein splicing comprising an assay and a kit for predicting the likelihood of Prp8 inhibition.

Abstract: The current invention provides a method of activating fibroblast and myofibroblast apoptosis in a tissue of a mammal, comprising administering to the tissue a therapeutically effective amount of a composition comprising an siRNA molecule that binds to an mRNA that codes for TGFB1 protein in a mammalian cell, an siRNA molecule that binds to an mRNA that codes for COX-2 protein in a mammalian cell, and a pharmaceutically acceptable carrier comprising a pharmaceutically acceptable histidine-lysine polymer. The invention also provides additional methods for using this composition.

Abstract: The invention relates generally to novel EPAC1 activators, such as Formula I and II and the preparation thereof as well as the use of EPAC1 activators disclosed herein as to selectively activate EPAC1 in cells.

Abstract: Certain embodiments describe antiviral compounds and related methods of using such compounds.

Abstract: The present invention relates to a method of inhibiting or control wax formation during stimulation treatment of a well. More specifically, the present invention proposes the use of aqueous polymer dispersions suitable as wax inhibitor compositions which are compatible with aqueous fracturing fluids.

Abstract: According to a high-intensity focused ultrasonic apparatus and a control method, an image of a region to be treated is obtained by means of an imaging device, a working assembly and a target coordinate point in the region to be treated are located by means of an optical tracking device, so that a positioning device can clamp the working assembly to quickly and accurately move to a working position corresponding to the target coordinate point, thereby enabling the working assembly to quickly and accurately release a high-intensity focused ultrasonic pulse to the target coordinate point, which improves not only the treatment accuracy but also the treatment efficiency of the high-intensity focused ultrasonic apparatus.

Abstract: A series of substituted 4,6-dihydrospiro[[1,2,3]triazolo[4,5-b]pyridine-7,3'-indoline]-2',5(3H)-dione analogues, the use thereof and the preparation thereof.