Patents by Inventor Jiacheng Zhou

Jiacheng Zhou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS
    Publication number: 20100190981
    Abstract: The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.
    Type: Application
    Filed: January 14, 2010
    Publication date: July 29, 2010
    Inventors: Jiacheng Zhou, Pingli Liu, Qiyan Lin, Brian W. Metcalf, David Meloni, Yongchun Pan, Michael Xia, Mei Li, Tai-Yuen Yue, James D. Rodgers, Haisheng Wang
  • Biaryl heterocyclic compounds and methods of making and using the same
    Patent number: 7705026
    Abstract: The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.
    Type: Grant
    Filed: November 21, 2008
    Date of Patent: April 27, 2010
    Assignee: Rib-X Pharmaceuticals, Inc.
    Inventors: Jiacheng Zhou, Ashoke Bhattacharjee, Shili Chen, Yi Chen, Jay J. Farmer, Joel A. Goldberg, Roger Hanselmann, Rongliang Lou, Alia Orbin, Adegboyega K. Oyelere, Joseph M. Salvino, Dane M. Springer, Jennifer Tran, Deping Wang, Yusheng Wu
  • PROCESS FOR THE SYNTHESIS OF BIARYL OXAZOLIDNONES
    Publication number: 20100022772
    Abstract: The present invention relates to processes for the preparation of biaryl oxazolidinones. These compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.
    Type: Application
    Filed: July 28, 2004
    Publication date: January 28, 2010
    Applicant: RIB-X PHARMACEUTICALS, INC.
    Inventors: Yusheng Wu, Chen Shili, Yi Chen, Roger Hanselmann, Rongliang Lou, Jiacheng Zhou
  • 1,2,5-OXADIAZOLES AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE
    Publication number: 20100015178
    Abstract: The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.
    Type: Application
    Filed: July 7, 2009
    Publication date: January 21, 2010
    Inventors: Andrew P. Combs, Eddy W. Yue, Richard B. Sparks, Wenyu Zhu, Jiacheng Zhou, Qiyan Lin, Lingkai Weng, Tai-Yuen Yue, Pingli Liu
  • SALTS OF 2-FLUORO-N-METHYL-4-[7-(QUINOLIN-6-YL-METHYL)-IMIDAZO[1,2-b][1,2,4]TRIAZIN-2-YL]BENZAMIDE AND PROCESSES RELATED TO PREPARING THE SAME
    Publication number: 20090291956
    Abstract: The present invention is directed to dihydrochloric acid and dibenzenesulfonic acid salts of the c-Met kinase inhibitor 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and pharmaceutical compositions thereof, useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways. The present invention further relates to processes and intermediates for preparing 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and salts thereof.
    Type: Application
    Filed: May 20, 2009
    Publication date: November 26, 2009
    Inventors: Lingkai Weng, Lei Qiao, Jiacheng Zhou, Pingli Liu, Yongchun Pan
  • AZETIDINE AND CYCLOBUTANE DERIVATIVES AS JAK INHIBITORS
    Publication number: 20090233903
    Abstract: The present invention relates to azetidine and cyclobutane derivatives, as well as their compositions, methods of use, and processes for preparation, which are JAK inhibitors useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.
    Type: Application
    Filed: March 10, 2009
    Publication date: September 17, 2009
    Applicant: INCYTE CORPORATION
    Inventors: James D. Rodgers, Stacey Shepard, Yun-Long Li, Jiacheng Zhou, Pingli Liu, David Meloni, Michael Xia
  • BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20090118502
    Abstract: The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.
    Type: Application
    Filed: November 21, 2008
    Publication date: May 7, 2009
    Applicant: Rib-X Pharmaceuticals, Inc.
    Inventors: Jiacheng Zhou, Ashoke Bhattacharjee, Shili Chen, Yi Chen, Jay J. Farmer, Joel A. Goldberg, Roger Hanselmann, Rongliang Lou, Alia Orbin, Adegboyega K. Oyelere, Josseph M. Salvino, Dane M. Springer, Jennifer Tran, Deping Wang, Yusheng Wu
  • Biaryl heterocyclic compounds and methods of making and using the same
    Patent number: 7456206
    Abstract: The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.
    Type: Grant
    Filed: July 14, 2006
    Date of Patent: November 25, 2008
    Assignee: Rib-X Pharmaceuticals, Inc.
    Inventors: Jiacheng Zhou, Ashoke Bhattacharjee, Shili Chen, Yi Chen, Jay J. Farmer, Joel A. Goldberg, Roger Hanselmann, Rongliang Lou, Alia Orbin, Adegboyega K. Oyelere, Joseph M. Salvino, Dane M. Springer, Jennifer Tran, Deping Wang, Yusheng Wu
  • Biaryl heterocyclic amines,amides, and sulfur-containing compounds and methods of making and using the same
    Publication number: 20070197541
    Abstract: The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of biaryl heterocyclic amines, amides, and sulfur-countering compounds that are useful as such agents agents.
    Type: Application
    Filed: July 28, 2004
    Publication date: August 23, 2007
    Inventors: Adegboyega Oyelere, Joel Goldberg, Alia Orbin, Joseph Salvino, Jiacheng Zhou
  • SYNTHESIS OF 4,5-DIHYDRO-PYRAZOLO[3,4-C]PYRID-2-ONES
    Publication number: 20070027186
    Abstract: A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. These compounds are useful as factor Xa inhibitors.
    Type: Application
    Filed: September 7, 2006
    Publication date: February 1, 2007
    Inventors: Jiacheng Zhou, Lynette Oh, Philip Ma, Hui-Yin Li, Pasquale Confalone
  • Synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
    Patent number: 7153960
    Abstract: A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. These compounds are useful as factor Xa inhibitors.
    Type: Grant
    Filed: June 8, 2005
    Date of Patent: December 26, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jiacheng Zhou, Lynette M. Oh, Philip Ma, Hui-Yin Li, Pasquale Confalone
  • Biaryl heterocyclic compounds and methods of making and using the same
    Patent number: 7148219
    Abstract: The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.
    Type: Grant
    Filed: April 29, 2005
    Date of Patent: December 12, 2006
    Assignee: Rib-X Pharmaceuticals, Inc.
    Inventors: Rongliang Lou, Jiacheng Zhou, Ashoke Bhattacharjee, Shili Chen, Yi Chen, Jay J. Farmer, Joel A. Goldberg, Roger Hanselmann, Alia Orbin, Adegboyega K. Oyelere, Joseph M. Salvino, Dane M. Springer, Jennifer Tran, Deping Wang, Yusheng Wu
  • Sulfonamide compounds and methods of making and using the same
    Publication number: 20060270680
    Abstract: The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.
    Type: Application
    Filed: June 2, 2004
    Publication date: November 30, 2006
    Inventors: Joel Goldberg, Shili Chen, Jay Farmer, Alia Orbin, Joseph Salvino, Jiacheng Zhou
  • Biaryl heterocyclic compounds and methods of making and using the same
    Publication number: 20060264426
    Abstract: The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.
    Type: Application
    Filed: July 14, 2006
    Publication date: November 23, 2006
    Inventors: Jiacheng Zhou, Ashoke Bhattacharjee, Shili Chen, Yi Chen, Jay Farmer, Joel Goldberg, Roger Hanselmann, Rongliang Lou, Alia Orbin, Adegboyega Oyelere, Joseph Salvino, Dane Springer, Jennifer Tran, Deping Wang, Yusheng Wu
  • Halogenated biaryl heterocyclic compounds and methods of making and using the same
    Patent number: 7129259
    Abstract: The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having at least one halogenated hydrocarbon moiety, a biaryl moiety, and at least one heterocyclic moiety, that are useful as such agents.
    Type: Grant
    Filed: December 1, 2004
    Date of Patent: October 31, 2006
    Assignee: Rib-X Pharmaceuticals, Inc.
    Inventors: Shili Chen, Jiacheng Zhou, Yusheng Wu, Deping Wang, Joseph M. Salvino, Adegboyega K. Oyelere, Rongliang Lou
  • Convergent synthesis of ?-aryl-?-ketonitriles
    Patent number: 7112679
    Abstract: The present invention relates to processes for the production of ?-aryl-?-ketonitriles, which serve as synthetic intermediates in the preparation of a series of biologically important molecules such as corticotropin releasing factor (CRF) receptor antagonists.
    Type: Grant
    Filed: February 25, 2004
    Date of Patent: September 26, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jiacheng Zhou, Lynette May Oh, Philip Ma
  • Halogenated biaryl heterocyclic compounds and methods of making and using the same
    Publication number: 20060148869
    Abstract: The present invention relates generally to the field of anti-infective anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having at least one halogenated hydrocarbon moiety, a biaryl moiety, and at least one heterocyclic moiety, that are useful as such agents.
    Type: Application
    Filed: February 23, 2006
    Publication date: July 6, 2006
    Inventors: Shili Chen, Jiacheng Zhou, Yusheng Wu, Deping Wang, Joseph Salvino, Adegboyega Oyelere, Rongliang Lou, Ashoke Bhattacharjee, Yi Chen
  • Biaryl heterocyclic compounds and methods of making and using the same
    Patent number: 6969726
    Abstract: The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.
    Type: Grant
    Filed: June 2, 2004
    Date of Patent: November 29, 2005
    Inventors: Rongliang Lou, Jiacheng Zhou, Ashoke Bhattacharjee, Shili Chen, Yi Chen, Jay J. Farmer, Joel A. Goldberg, Roger Hanselmann, Alia Orbin, Adegboyega K. Oyelere, Joseph M. Salvino, Dane M. Springer, Jennifer Tran, Deping Wang, Yusheng Wu
  • Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones
    Publication number: 20050245566
    Abstract: A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. These compounds are useful as factor Xa inhibitors.
    Type: Application
    Filed: June 8, 2005
    Publication date: November 3, 2005
    Inventors: Jiacheng Zhou, Lynette Oh, Philip Ma, Hui-Yin Li, Pasquale Confalone
  • Biaryl heterocyclic compounds and methods of making and using the same
    Publication number: 20050203147
    Abstract: The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.
    Type: Application
    Filed: April 29, 2005
    Publication date: September 15, 2005
    Inventors: Jiacheng Zhou, Ashoke Bhattacharjee, Shili Chen, Yi Chen, Jay Farmer, Joel Goldberg, Roger Hanselmann, Rongliang Lou, Alia Orbin, Adegboyega Oyelere, Joseph Salvino, Dane Springer, Jennifer Tran, Deping Wang, Yusheng Wu