Patents by Inventor Ji Ae Kook
Ji Ae Kook has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11572341Abstract: The present invention relates to a guanidine compound and a use thereof, and more specifically, to a guanidine derivative showing excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence; a preparation method thereof; and a pharmaceutical composition containing the same as an active ingredient. Compared to existing drugs, the guanidine derivative according to the present invention shows excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence even with small doses, and may thus be effectively used in preventing or treating various cancers such as uterine cancer, breast cancer, stomach cancer, brain cancer, rectal cancer, colorectal cancer, lung cancer, skin cancer, blood cancer, liver cancer, etc., inhibiting cancer cell proliferation and cancer metastasis.Type: GrantFiled: March 17, 2020Date of Patent: February 7, 2023Assignee: ImmunoMet Therapeutics Inc.Inventors: Hong Woo Kim, Jae Kap Jeong, Ji Sun Lee, Hye Jin Heo, Hong Bum Lee, Ji Ae Kook, Sung Wuk Kim
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Patent number: 11465989Abstract: The present invention relates to guanidine compounds for inhibiting mitochondrial oxidative phosphorylation (OXPHOS) and use thereof. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating a OXPHOS-related disease, particularly cancer, by inhibiting mitochondrial oxidative phosphorylation and reprogramming cellular metabolism.Type: GrantFiled: April 17, 2015Date of Patent: October 11, 2022Assignee: ImmunoMet Therapeutics, Inc.Inventors: Sung Wuk Kim, Hong Woo Kim, Sang Hee Yoo, Ji Sun Lee, Hye Jin Heo, Hong Bum Lee, Ji Ae Kook, Young Woo Lee, Mi Jeong Kim, Woong Cho
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Publication number: 20200277255Abstract: The present invention relates to a guanidine compound and a use thereof, and more specifically, to a guanidine derivative showing excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence; a preparation method thereof; and a pharmaceutical composition containing the same as an active ingredient. Compared to existing drugs, the guanidine derivative according to the present invention shows excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence even with small doses, and may thus be effectively used in preventing or treating various cancers such as uterine cancer, breast cancer, stomach cancer, brain cancer, rectal cancer, colorectal cancer, lung cancer, skin cancer, blood cancer, liver cancer, etc., inhibiting cancer cell proliferation and cancer metastasis.Type: ApplicationFiled: March 17, 2020Publication date: September 3, 2020Inventors: Hong Woo KIM, Jae Kap JEONG, Ji Sun LEE, Hye Jin HEO, Hong Bum LEE, Ji Ae KOOK, Sung Wuk KIM
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Patent number: 10626085Abstract: The present invention relates to a guanidine compound and a use thereof, and more specifically, to a guanidine derivative showing excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence; a preparation method thereof; and a pharmaceutical composition containing the same as an active ingredient. Compared to existing drugs, the guanidine derivative according to the present invention shows excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence even with small doses, and may thus be effectively used in preventing or treating various cancers such as uterine cancer, breast cancer, stomach cancer, brain cancer, rectal cancer, colorectal cancer, lung cancer, skin cancer, blood cancer, liver cancer, etc., inhibiting cancer cell proliferation and cancer metastasis.Type: GrantFiled: November 20, 2015Date of Patent: April 21, 2020Assignee: ImmunoMet Therapeutics Inc.Inventors: Hong Woo Kim, Jae Kap Jeong, Ji Sun Lee, Hye Jin Heo, Hong Bum Lee, Ji Ae Kook, Sung Wuk Kim
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Patent number: 10590081Abstract: The present invention relates to guanidine compounds for inhibiting mitochondrial oxidative phosphorylation (OXPHOS) and use thereof. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating a OXPHOS-related disease, particularly cancer by inhibiting mitochondrial oxidative phosphorylation and reprogramming cellular metabolism.Type: GrantFiled: April 30, 2015Date of Patent: March 17, 2020Assignee: ImmunoMet Therapeutics Inc.Inventors: Sung Wuk Kim, Hong Woo Kim, Sang Hee Yoo, Ji Sun Lee, Hye Jin Heo, Hong Bum Lee, Ji Ae Kook, Young Woo Lee
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Patent number: 10058558Abstract: The present invention provides a novel use of N1-cyclic amine-N5-substituted biguanide derivatives for preparing a medicine for preventing or treating fibrosis. The N1-cyclic amine-N5-substituted biguanide derivatives according to the present invention are capable of effectively inhibiting fibrosis by effectively suppressing the EMT.Type: GrantFiled: May 20, 2014Date of Patent: August 28, 2018Assignee: ImmunoMet Therapeutics Inc.Inventors: Sung Wuk Kim, Soon Im Lee, Yeon Jung Song, Min Jae Shin, Kook Hwan Oh, Kyung Don Ju, Eun Kyoung Shin, Ji Sun Lee, Hye Jin Heo, Hong Bum Lee, Ji Ae Kook, Min Jeong Kim, Hye Soun Eum
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Publication number: 20180093953Abstract: The present invention relates to guanidine compounds for inhibiting mitochondrial oxidative phosphorylation (OXPHOS) and use thereof. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating a OXPHOS-related disease, particularly cancer by inhibiting mitochondrial oxidative phosphorylation and reprogramming cellular metabolism.Type: ApplicationFiled: April 30, 2015Publication date: April 5, 2018Inventors: Sung Wuk KIM, Hong Woo KIM, Sang Hee YOO, Ji Sun LEE, Hye Jin HEO, Hong Bum LEE, Ji Ae KOOK, Young Woo LEE
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Publication number: 20180044283Abstract: The present invention relates to a guanidine compound and a use thereof, and more specifically, to a guanidine derivative showing excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence; a preparation method thereof; and a pharmaceutical composition containing the same as an active ingredient. Compared to existing drugs, the guanidine derivative according to the present invention shows excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence even with small doses, and may thus be effectively used in preventing or treating various cancers such as uterine cancer, breast cancer, stomach cancer, brain cancer, rectal cancer, colorectal cancer, lung cancer, skin cancer, blood cancer, liver cancer, etc., inhibiting cancer cell proliferation and cancer metastasis.Type: ApplicationFiled: November 20, 2015Publication date: February 15, 2018Applicant: ImmunoMet Therapeutics Inc.Inventors: Hong Woo KIM, Jae Kap JEONG, Ji Sun LEE, Hye Jin HEO, Hong Bum LEE, Ji Ae KOOK, Sung Wuk KIM
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Publication number: 20170073331Abstract: The present invention relates to guanidine compounds for inhibiting mitochondrial oxidative phosphorylation (OXPHOS) and use thereof. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating a OXPHOS-related disease, particularly cancer, by inhibiting mitochondrial oxidative phosphorylation and reprogramming cellular metabolism.Type: ApplicationFiled: April 17, 2015Publication date: March 16, 2017Applicant: IMMUNOMET THERAPEUTICS INC.Inventors: Sung Wuk Kim, Hong Woo Kim, Sang Hee Yoo, Ji Sun Lee, Hye Jin Heo, Hong Bum Lee, Ji Ae Kook, Young Woo Lee, Mi Jeong Kim, Woong Cho
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Publication number: 20160101112Abstract: The present invention provides a novel use of N1-cyclic amine-N5-substituted biguanide derivatives for preparing a medicine for preventing or treating fibrosis. The N1-cyclic amine-N5-substituted biguanide derivatives according to the present invention are capable of effectively inhibiting fibrosis by effectively suppressing the EMT.Type: ApplicationFiled: May 20, 2014Publication date: April 14, 2016Applicant: IMMUNOMET THERAPEUTICS INCInventors: Sung Wuk Kim, Soon Im Lee, Yeon Jung Song, Min Jae Shin, Kook Hwan Oh, Kyung Don Ju, Eun Kyoung Shin, Ji Sun Lee, Hye Jin Heo, Hong Bum Lee, Ji Ae Kook, Min Jeong Kim, Hye Soun Eum