Patents by Inventor Jiaguo HUANG

Jiaguo HUANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MEANS AND METHODS FOR VISUALIZATION OF TISSUE STRUCTURES
    Publication number: 20230092002
    Abstract: The present invention relates to a chemical compound comprising (i) a polycationic polymer, coupled to (ii) a dye. The present invention further relates to a method for visualizing a glycosamine-containing structure in a biological sample comprising a) contacting an inner lumen of said biological sample with a dye-conjugated polycationic polymer, preferably with the chemical compound according to the present invention; b) tissue-clearing said biological sample; and, thereby, c) visualizing an internal glycosamine-containing structure in said biological sample. The present invention also relates to a method for determining the number and/or size of glomeruli in a kidney or a sample thereof making use of the method for visualizing a glycosamine-containing structure; and also relates to kits and uses related to said chemical compounds and said methods.
    Type: Application
    Filed: August 31, 2022
    Publication date: March 23, 2023
    Inventors: Norbert Gretz, Ruediger Rudolf, Stepfanie Weinfurter, Cinzia Brenna, Jiaguo Huang, Arif ul Maula Khan
  • MOLECULAR RENAL PROBES FOR DETECTING ACUTE KIDNEY INJURY
    Publication number: 20220096662
    Abstract: Disclosed herein are compounds or salts and/or solvates of formula I, II and III, where the compounds or salts and/or solvates have the following structures: (X)a—Y—(Z)b I; II; or X?—Y? III; where X, Y, Z, Y?, a, b, R4, R6 and R7 are as defined herein.
    Type: Application
    Filed: January 31, 2020
    Publication date: March 31, 2022
    Inventors: Kanyi Pu, Jiaguo Huang
  • NOVEL TRICARBOCYANINE-CYCLODEXTRIN(S) CONJUGATES AND USE THEREOF
    Publication number: 20220047724
    Abstract: The invention relates to novel tricarbocyanine-cyclodextrin(s) conjugates useful as markers in the diagnosis of kidney diseases, diagnostic compositions comprising the conjugates, their use, and their production.
    Type: Application
    Filed: October 29, 2021
    Publication date: February 17, 2022
    Inventors: Leopoldo DELLA CIANA, Norbert GRETZ, Rossana PERCIACCANTE, Federica RODEGHIERO, Stefania GERACI, Jiaguo HUANG, Zeneida HERRERA PÉREZ, Johannes PILL, Stefanie WEINFURTER
  • Tricarbocyanine-cyclodextrin(s) conjugates and use thereof
    Patent number: 11179481
    Abstract: The present invention relates to novel tricarbocyanine-cyclodextrin(s) conjugates useful as markers in the diagnosis of kidney diseases, a diagnostic composition comprising said conjugates, their use and their production.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: November 23, 2021
    Assignee: CYANAGEN S.R.L.
    Inventors: Leopoldo Della Ciana, Norbert Gretz, Rossana Perciaccante, Federica Rodeghiero, Stefania Geraci, Jiaguo Huang, Zeneida Herrera Pérez, Johannes Pill, Stefanie Weinfurter
  • NOVEL TRICARBOCYANINE-CYCLODEXTRIN(S) CONJUGATES AND USE THEREOF
    Publication number: 20190381196
    Abstract: The present invention relates to novel tricarbocyanine-cyclodextrin(s) conjugates useful as markers in the diagnosis of kidney diseases, a diagnostic composition comprising said conjugates, their use and their production.
    Type: Application
    Filed: August 30, 2019
    Publication date: December 19, 2019
    Inventors: Leopoldo DELLA CIANA, Norbert GRETZ, Rossana PERCIACCANTE, Federica RODEGHIERO, Stefania GERACI, Jiaguo HUANG, Zeneida HERRERA PÉREZ, Johannes PILL, Stefanie WEINFURTER
  • MEANS AND METHODS FOR VISUALIZATION OF TISSUE STRUCTURES
    Publication number: 20190353565
    Abstract: The present invention relates to a chemical compound comprising (i) a polycationic polymer, coupled to (ii) a dye. The present invention further relates to a method for visualizing a glycosamine-containing structure in a biological sample comprising a) contacting an inner lumen of said biological sample with a dye-conjugated polycationic polymer, preferably with the chemical compound according to the present invention; b) tissue-clearing said biological sample; and, thereby, c) visualizing an internal glycosamine-containing structure in said biological sample. The present invention also relates to a method for determining the number and/or size of glomeruli in a kidney or a sample thereof making use of the method for visualizing a glycosamine-containing structure; and also relates to kits and uses related to said chemical compounds and said methods.
    Type: Application
    Filed: November 30, 2017
    Publication date: November 21, 2019
    Inventors: Norbert GRETZ, Ruediger RUDOLF, Stefanie WEINFURTER, Cinzia BRENNA, Jiaguo HUANG, Arif ul Maula KHAN
  • Tricarbocyanine-cyclodextrin(s) conjugates and use thereof
    Patent number: 10441666
    Abstract: The present invention relates to novel tricarbocyanine-cyclodextrin(s) conjugates useful as markers in the diagnosis of kidney diseases, a diagnostic composition comprising said conjugates, their use and their production.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: October 15, 2019
    Assignee: CYANAGEN S.R.L.
    Inventors: Leopoldo Della Ciana, Norbert Gretz, Rossana Perciaccante, Federica Rodeghiero, Stefania Geraci, Jiaguo Huang, Zeneida Herrera Pérez, Johannes Pill, Stefanie Weinfurter
  • NOVEL TRICARBOCYANINE-CYCLODEXTRIN(S) CONJUGATES AND USE THEREOF
    Publication number: 20150328342
    Abstract: The present invention relates to novel tricarbocyanine-cyclodextrin(s) conjugates useful as markers in the diagnosis of kidney diseases, a diagnostic composition comprising said conjugates, their use and their production.
    Type: Application
    Filed: May 15, 2015
    Publication date: November 19, 2015
    Inventors: Leopoldo DELLA CIANA, Norbert GRETZ, Rossana PERCIACCANTE, Federica RODEGHIERO, Stefania GERACI, Jiaguo HUANG, Zeneida HERRERA PÉREZ, Johannes PILL, Stefanie WEINFURTER