Patents by Inventor Jiajia Hou

Jiajia Hou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phenyl c-glucoside derivative containing deoxyglucose structure, preparation method and use thereof
    Patent number: 10294259
    Abstract: The present invention provides a phenyl C-glucoside derivative containing a deoxyglucose structure as represented by formula I, preparation method thereof, a pharmaceutical composition comprising the same, and uses thereof in the preparation of medicaments for treating diabetes, wherein substituents R1-R7 are as defined in the specification. The present invention also provides a method for synthesizing the phenyl C-glucoside derivative containing a deoxyglucose structure and an intermediate product. The method has advantages of being simple to manage and of low cost, which is suitable for large-scale industrial production. The present invention further provides a cocrystal of (1S)-1-[4-chloro-3-(4-ethoxybenzyl)phenyl]-1,6-dideoxy-D-glucose and L-proline, and preparation method and uses thereof.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: May 21, 2019
    Assignee: Tianjin Institute of Pharmaceutical Research
    Inventors: Guilong Zhao, Yuli Wang, Bingni Liu, Yafei Xie, Yuqiang Liu, Peng Liu, Jiang Wu, Jiajia Hou, Wei Wei, Wen Du, Weiren Xu, Lida Tang, Meixiang Zou
  • PHENYL C-GLUCOSIDE DERIVATIVE CONTAINING DEOXYGLUCOSE STRUCTURE, PREPARATION METHOD AND USE THEREOF
    Publication number: 20170057989
    Abstract: The present invention provides a phenyl C-glucoside derivative containing a deoxyglucose structure as represented by formula I, preparation method thereof, a pharmaceutical composition comprising the same, and uses thereof in the preparation of medicaments for treating diabetes, wherein substituents R1-R7 are as defined in the specification. The present invention also provides a method for synthesizing the phenyl C-glucoside derivative containing a deoxyglucose structure and an intermediate product. The method has advantages of being simple to manage and of low cost, which is suitable for large-scale industrial production. The present invention further provides a cocrystal of (1S)-1-[4-chloro-3-(4-ethoxybenzyl)phenyl]-1,6-dideoxy-D-glucose and L-proline, and preparation method and uses thereof.
    Type: Application
    Filed: November 11, 2016
    Publication date: March 2, 2017
    Applicant: Tianjin Institute of Pharmaceutical Research
    Inventors: Guilong Zhao, Yuli Wang, Bingni Liu, Yafei Xie, Yuqiang Liu, Peng Liu, Jiang Wu, Jiajia Hou, Wei Wei, Wen Du, Weiren Xu, Lida Tang, Meixiang Zou
  • Phenyl C-glucoside derivative containing deoxyglucose structure, preparation method and use thereof
    Patent number: 9505734
    Abstract: The present invention provides a phenyl C-glucoside derivative containing a deoxyglucose structure as represented by formula I, preparation method thereof, a pharmaceutical composition comprising the same, and uses thereof in the preparation of medicaments for treating diabetes, wherein substituents R1-R7 are as defined in the specification. The present invention also provides a method for synthesizing the phenyl C-glucoside derivative containing a deoxyglucose structure and an intermediate product. The method has advantages of being simple to manage and of low cost, which is suitable for large-scale industrial production. The present invention further provides a cocrystal of (1S)-1-[4-chloro-3-(4-ethoxybenzyl)phenyl]-1,6-dideoxy-D-glucose and L-proline, and preparation method and uses thereof.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: November 29, 2016
    Assignee: Tianjin Institute of Pharmaceutical Research
    Inventors: Guilong Zhao, Yuli Wang, Bingni Liu, Yafei Xie, Yuqiang Liu, Peng Liu, Jiang Wu, Jiajia Hou, Wei Wei, Wen Du, Weiren Xu, Lida Tang, Meixiang Zou
  • PHENYL C-GLUCOSIDE DERIVATIVE CONTAINING DEOXYGLUCOSE STRUCTURE, PREPARATION METHOD AND USE THEREOF
    Publication number: 20160046595
    Abstract: The present invention provides a phenyl C-glucoside derivative containing a deoxyglucose structure as represented by formula I, preparation method thereof, a pharmaceutical composition comprising the same, and uses thereof in the preparation of medicaments for treating diabetes, wherein substituents R1-R7 are as defined in the specification. The present invention also provides a method for synthesizing the phenyl C-glucoside derivative containing a deoxyglucose structure and an intermediate product. The method has advantages of being simple to manage and of low cost, which is suitable for large-scale industrial production. The present invention further provides a cocrystal of (1S)-1-[4-chloro-3-(4-ethoxybenzyl)phenyl]-1,6-dideoxy-D-glucose and L-proline, and preparation method and uses thereof.
    Type: Application
    Filed: December 5, 2013
    Publication date: February 18, 2016
    Applicant: Tianjin Institute of Pharmaceutical Research
    Inventors: Guilong Zhao, Yuli Wang, Bingni Liu, Yafei Xie, Yuqiang Liu, Peng Liu, Jiang Wu, Jiajia Hou, Wei Wei, Wen Du, Weiren Xu, Lida Tang, Meixiang Zou