Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: The present invention discloses macrocyclic compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: The present invention discloses substituted pyrrolo[1,2-c]pyrimidines, such as the compound which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: The present invention discloses compounds of Formula (Ia), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (Ia) or a pharmaceutically acceptable slat thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (Ia) or a pharmaceutically acceptable salt thereof.

Abstract: The present invention discloses compounds of Formula (Ia), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (Ia) or a pharmaceutically acceptable slat thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (Ia) or a pharmaceutically acceptable salt thereof.

Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof: which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: The present disclosure provides a method and apparatus for processing a heterogeneous cluster-oriented task. The method comprises: receiving a task request and a basic execution environment; scheduling a heterogeneous device according to the task request; compiling the basic execution environment into an execution environment corresponding to the scheduled heterogeneous device, and deploying on the scheduled heterogeneous device; triggering the scheduled heterogeneous device to execute the task request. It is only necessary for the user to provide the basic execution environment with respect to the task, and unnecessary for the user to respectively write a version of execution environment for each type of hardware platform, thereby implementing quick development of the heterogeneous device code and reducing the development and maintenance costs.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof: which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof: which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof: which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: The present disclosure provides a method and apparatus for processing a heterogeneous cluster-oriented task. The method comprises: receiving a task request and a basic execution environment; scheduling a heterogeneous device according to the task request; compiling the basic execution environment into an execution environment corresponding to the scheduled heterogeneous device, and deploying on the scheduled heterogeneous device; triggering the scheduled heterogeneous device to execute the task request. It is only necessary for the user to provide the basic execution environment with respect to the task, and unnecessary for the user to respectively write a version of execution environment for each type of hardware platform, thereby implementing quick development of the heterogeneous device code and reducing the development and maintenance costs.

Abstract: A server cabinet, including: a cabinet body having a plurality of regions including a first region to store a server, a power supply region to store a power supply, a second region to store the server and a switch; and a cabinet backboard positioned at a back side of the cabinet body, and including a plurality of management backboards and a plurality of fans, in which each of the plurality of management backboards is respectively connected with the server and a central management module of the server cabinet, the server is connected with the corresponding management backboard via a connector and controlled by the central management module via the cabinet backboard. The server cabinet according to embodiments of the present disclosure can achieve a replacement of the management backboard and the server without powering off, thus greatly improving an operation and maintenance of the server cabinet.

Abstract: The present disclosure provides a heat-dissipating system and method of a whole cabinet server system. The system comprises: a whole cabinet server system, a water-cooling plate, a water-cooling coil pipe and a fan; the water-cooling plate is disposed on each designated heat-generating element in each server of the whole cabinet server system; the water-cooling plate is configured to use low-temperature water therein to take away heat generated by the designated heat-generating element; the fan is configured to produce low-temperature air stream which flows through the whole cabinet server system and the water-cooling coil pipe in turn; the water-cooling coil pipe is configured to cool air stream that have absorbed the heat of the whole cabinet server system as low-temperature air stream. The solutions of the present disclosure can be applied to improve the heat-dissipating efficiency and reduce the costs of implementation.

Abstract: A server cabinet, including: a cabinet body having a plurality of regions including a first region to store a server, a power supply region to store a power supply, a second region to store the server and a switch; and a cabinet backboard positioned at a back side of the cabinet body, and including a plurality of management backboards and a plurality of fans, in which each of the plurality of management backboards is respectively connected with the server and a central management module of the server cabinet, the server is connected with the corresponding management backboard via a connector and controlled by the central management module via the cabinet backboard. The server cabinet according to embodiments of the present disclosure can achieve a replacement of the management backboard and the server without powering off, thus greatly improving an operation and maintenance of the server cabinet.

Abstract: A remote-controlled mobile triangle sign includes a triangle sign having at least one surface with a reflective area; a remote controller configured to transmit control signals; and a remote-controlled car. The remote-controlled car includes a power supply module; a drive motor powered by the power supply module; and a remote control receiving and execution module for receiving the control signals. The triangle sign is mounted on top of the remote-controlled car, and the remote control receiving and execution module is electrically connected to the drive motor and provides output signals.

Abstract: A remote-controlled mobile triangle sign includes a triangle sign having at least one surface with a reflective area; a remote controller configured to transmit control signals; and a remote-controlled car. The remote-controlled car includes a power supply module; a drive motor powered by the power supply module; and a remote control receiving and execution module for receiving the control signals. The triangle sign is mounted on top of the remote-controlled car, and the remote control receiving and execution module is electrically connected to the drive motor and provides output signals.

Abstract: Embodiments of the invention provide a method of de-rate matching without NULL bits skipping. Date is received without NULLs and inputted into a LLR combining block. The history data without NULLs is buffered. Log-likelihood ratio (LLR) combining is called before de-rate matching. The output of LLR combining is de-interleaved. The reading pointer is offset to forge NULLs. Finally, de-interleaving output without NULLs is sent to a turbo decoder.

Abstract: Methods, systems, and computer-readable media that allow a user to select and add subsections of multiple websites to a single aggregated website that will automatically retrieve updated content corresponding to the selected subsection are provided. The content from the selected subsections may be displayed on the aggregated website. The aggregated website will periodically check a source website and update the content displayed on the aggregated site if the source website has been updated. The application generating the source website determines which subsection of the updated website corresponds with the subsection originally selected for display by comparing the document object model (“DOM”) for both the updated web page and the original version of the web page at the time the subsection selection was made by the user. Condensed DOM trees may be generated for the updated web page and the original version of the web page, prior to comparing the two DOM trees.