Patents by Inventor Jiake Che

Jiake Che has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation method and use of liposome encapsulating polypeptide, suberoylanilide hydroxamic acid (SAHA), and vitamin A
    Patent number: 12766117
    Abstract: A preparation method of a liposome encapsulating a polypeptide, suberoylanilide hydroxamic acid (SAHA), and vitamin A is provided, including the following steps: dissolving choline, cholesterol, an anti-angiogenic lytic peptide, the SAHA, and the vitamin A in a chloroform-methanol solution and mixing evenly, and subjecting an obtained mixed solution to spin drying under reduced pressure to form a film; and subjecting the film to hydration with a phosphate-buffered saline (PBS) solution or ddH2O to obtain the liposome. Use of the preparation method is further provided, where a liposome prepared by the preparation method is used as a drug for treating hepatic fibrosis. An “anti-hepatic fibrosis drug” is combined with “liver-targeted vitamin A” to construct a “target liposome encapsulating the anti-hepatic fibrosis drug”.
    Type: Grant
    Filed: September 12, 2024
    Date of Patent: October 20, 2026
    Assignee: UNION HOSPITAL, TONGJI MEDICAL COLLEGE, HUAZHONG UNI. OF SCIENCE AND TECH.
    Inventors: Huikuan Chu, Dongyuan Wang, Wenkang Gao, Ling Yang, Yue Chen, Yuanqing Zhu, Hang Yuan, Zilu Cheng, Jiake Che, Yupin Tan, Shengqi Yan, Wei Li, Zexuan Li, Ao Liu
  • PREPARATION METHOD AND USE OF LIPOSOME ENCAPSULATING POLYPEPTIDE, SUBEROYLANILIDE HYDROXAMIC ACID (SAHA), AND VITAMIN A
    Publication number: 20250161244
    Abstract: A preparation method of a liposome encapsulating a polypeptide, suberoylanilide hydroxamic acid (SAHA), and vitamin A is provided, including the following steps: dissolving choline, cholesterol, an anti-angiogenic lytic peptide, the SAHA, and the vitamin A in a chloroform-methanol solution and mixing evenly, and subjecting an obtained mixed solution to spin drying under reduced pressure to form a film; and subjecting the film to hydration with a phosphate-buffered saline (PBS) solution or ddH2O to obtain the liposome. Use of the preparation method is further provided, where a liposome prepared by the preparation method is used as a drug for treating hepatic fibrosis. An “anti-hepatic fibrosis drug” is combined with “liver-targeted vitamin A” to construct a “target liposome encapsulating the anti-hepatic fibrosis drug”.
    Type: Application
    Filed: September 12, 2024
    Publication date: May 22, 2025
    Inventors: Huikuan CHU, Dongyuan Wang, Wenkang Gao, Ling Yang, Yue Chen, Yuanqing Zhu, Hang Yuan, Zilu Cheng, Jiake Che, Yupin Tan, Shengqi Yan, Wei Li, Zexuan Li, Ao Liu