Abstract: A full continuous-flow preparation method of (+)-biotin, including: subjecting a cyclic anhydride and a chiral biphenyl propylene glycol to asymmetric ring-opening reaction to produce a first intermediate, which undergoes selective reduction with a borohydride and cyclization with an inorganic mineral acid to produce (3aS, 6aR)-lactone; subjecting the (3aS, 6aR)-lactone and a sulfenylating reagent to sulfenylation to produce (3aS, 6aR)-thiolactone, which undergoes Fukuyama coupling with a zinc reagent in the presence of a palladium catalyst and elimination reaction in the presence of an inorganic mineral acid to produce an alkenyl valerate compound; subjecting the alkenyl valerate compound to reduction in the presence of a Pd/C catalyst to produce a valerate ester, which undergoes hydrolysis to produce a valeric acid salt; and subjecting the valeric acid salt to debenzylation in the presence of an inorganic mineral acid to produce the target product (+)-biotin.

Abstract: A method for tracing an agricultural product based on meta-universe, including the following steps: collecting, by a terminal data collecting apparatus, agricultural product data, and generating an uplinking application; verifying the legitimacy and authenticity of the uplinking application when the uplinking application is received by a blockchain network, and uplinking the uplinking application; verifying the uplinked agricultural product data, triggering a growth function of the agricultural product in a smart contract using the agricultural product data, a virtual agricultural product of a meta-universe visualization platform starting to grow; selling the agricultural product on a trading platform, and generating, by a blockchain network, a traceability code after a consumer purchases the agricultural product; verifying the legitimacy of identities and data of the meta-universe visualization platform and the consumer. The present method can retrieve data, and recover the data.

Abstract: The disclosure provides a safety production management system for a power plant, which belongs to the technical field of power systems, and includes a monitoring module used for real-time monitoring working state information of each electrical equipment and operating state information of workers in the power plant; a data analysis module used for analyzing the working state information and the operating state information obtained by the monitoring module; a production dispatching center module managing each electrical equipment and the workers based on analysis results of the data analysis module; a emergency management module used for receiving emergency management instruction sent by the production dispatching center module, and performing emergency closing or opening of each electrical equipment, reminding and standardizing behavior and operation of the workers.

Abstract: The disclosure provides a safety production management system for a power plant, which belongs to the technical field of power systems, and includes a monitoring module used for real-time monitoring working state information of each electrical equipment and operating state information of workers in the power plant; a data analysis module used for analyzing the working state information and the operating state information obtained by the monitoring module; a production dispatching center module managing each electrical equipment and the workers based on analysis results of the data analysis module; a emergency management module used for receiving emergency management instruction sent by the production dispatching center module, and performing emergency closing or opening of each electrical equipment, reminding and standardizing behavior and operation of the workers.

Abstract: A full continuous-flow preparation method of (+)-biotin, including: subjecting a cyclic anhydride and a chiral biphenyl propylene glycol to asymmetric ring-opening reaction to produce a first intermediate, which undergoes selective reduction with a borohydride and cyclization with an inorganic mineral acid to produce (3aS, 6aR)-lactone; subjecting the (3aS, 6aR)-lactone and a sulfenylating reagent to sulfenylation to produce (3aS, 6aR)-thiolactone, which undergoes Fukuyama coupling with a zinc reagent in the presence of a palladium catalyst and elimination reaction in the presence of an inorganic mineral acid to produce an alkenyl valerate compound; subjecting the alkenyl valerate compound to reduction in the presence of a Pd/C catalyst to produce a valerate ester, which undergoes hydrolysis to produce a valeric acid salt; and subjecting the valeric acid salt to debenzylation in the presence of an inorganic mineral acid to produce the target product (+)-biotin.

Abstract: A heat sink for an IC component and an IC heat sink assembly are provided. The heat sink for an IC component has a contact surface suitable for thermally contacting with the IC component. A groove is provided in the contact surface. The IC heat sink assembly includes: a heat sink for an IC component; an IC component thermally connected to the heat sink; and a thermally conductive interface material provided between the heat sink and the IC component.

Abstract: Novel mp53 rescue compounds and the pharmaceutical composition, and methods of treating a p53 disorder.

Abstract: Disclosed herein is a novel p53 complex and a collection of compounds that can tightly associate with p53 to efficiently rescue wildtype p53 structure and function, and the methods of making and using the complex and the compounds, including for diagnosis, prognosis, and treatment of p53 related disorders such as cancer and aging.