Abstract: The present disclosure provides a crystalline polythiocarbonate and a preparation method thereof. The crystalline polythiocarbonate is a random copolymer and includes five structural units L1 to L5 as shown in the following formula. The method includes carrying out a polymerization reaction natively or in solution using carbon disulfide, ethylene oxide, selectively added third monomer, initiator, Lewis acid, selectively added chain transfer agent, and selectively added solvent as raw materials. This method provides a new way for high value-added application of carbon disulfide and ethylene oxide by using inexpensive carbon disulfide and ethylene oxide as monomers; the product is a random copolymerized crystalline polythiocarbonate with novel structure, which has various chain link structures and excellent mechanical properties, processing properties and degradability.

Abstract: The present disclosure provides a crystalline polythiocarbonate and a preparation method thereof. The crystalline polythiocarbonate is a random copolymer and includes five structural units L1 to L5 as shown in the following formula. The method includes carrying out a polymerization reaction natively or in solution using carbon disulfide, ethylene oxide, selectively added third monomer, initiator, Lewis acid, selectively added chain transfer agent, and selectively added solvent as raw materials. This method provides a new way for high value-added application of carbon disulfide and ethylene oxide by using inexpensive carbon disulfide and ethylene oxide as monomers; the product is a random copolymerized crystalline polythiocarbonate with novel structure, which has various chain link structures and excellent mechanical properties, processing properties and degradability.

Abstract: The present disclosure provides a Lewis acid-base pair catalytic initiator and an application thereof. The Lewis acid-base pair catalytic initiator includes a Lewis acid and a Lewis base, the Lewis acid having a structural general formula as shown in formula (I) and the Lewis base having a structural general formula as shown in formula (II); wherein: the A is selected from element Baron or element Aluminum; the R1, R2, R3, R4 are independently selected from alkyl, alkoxy, aryl or halogen groups; the alkyl or alkoxy have a carbon number being equal to or greater than 1 to equal to or less than 16; the aryl contains substituents with the number being equal to or less than 5, the substituents being selected from methyl, methoxy or halogen; n is selected from an integer from 1 to 16.

Abstract: It is provided an Antarctic Krill trawl with a centralized sinker and a self-expandable mouth structure, including a beam, an upper border rope, a lower border rope, a lateral line, a cover net, a flank net and a body net. A length of the beam is 18 to 20 meters. The beam enables the mouth to be expanded horizontally, a sinker is provided at each of two sides of a belly net at a front end of a first mouth of the body net. A component force of a sinking force by the sinker is transmitted through the lateral line and a sewing edge so as to cause the lower border rope in a tensioning state due to the transmitted force. The body net comprises a back net, a lateral net and a belly net. Taper ratios of the back net and the lateral net are 2-1.

Abstract: The present disclosure provides a Lewis acid-base pair catalytic initiator and an application thereof. The Lewis acid-base pair catalytic initiator includes a Lewis acid and a Lewis base, the Lewis acid having a structural general formula as shown in formula (I) and the Lewis base having a structural general formula as shown in formula (II); wherein: the A is selected from element Baron or element Aluminum; the R1, R2, R3, R4 are independently selected from alkyl, alkoxy, aryl or halogen groups; the alkyl or alkoxy have a carbon number being equal to or greater than 1 to equal to or less than 16; the aryl contains substituents with the number being equal to or less than 5, the substituents being selected from methyl, methoxy or halogen; n is selected from an integer from 1 to 16.

Abstract: The invention provides a method of inhibiting the catalytic activity of a protein kinase comprising contacting said protein kinase with a compound of formula (I), or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition containing the same, and also provides a method of treating a protein kinase related disorder comprising a step of administering to a patient in need thereof a therapeutically effective amount of the compound of formula (I) or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition containing the same, wherein each substituent in formula (I) is same as defined in the description.

Abstract: The invention provides new pyrrolo-nitrogenous heterocyclic derivatives represented by formula (I) or their salts, the preparation thereof, pharmaceutical compositions containing such derivatives and the use of such derivatives as therapeutic agents, especially as protein kinase inhibitors, wherein each substituent in formula (I) is same as defined in the description.

Abstract: Pyrrolo[3,2-c]pyridine-4-one-2-indolinone compounds, especially 2-(2-oxoindoline-3-ylidene)methyl-5-(2-hydroxy-3-morpholin-4-yl-propyl)-6,7-dihydro-1H-pyrrol[3,2-c]pyridine-4(5H)-one compounds. Their preparation and pharmaceutical composition, and pharmaceutical use as protein kinase inhibitors.

Abstract: Pyrrolo[3,2-c]pyridine-4-one-2-indolinone compounds, especially 2-(2-oxoindoline-3-ylidene)methyl-5-(2-hydroxy-3-morpholin-4-yl-propyl)-6,7-dihydro-1H-pyrrol[3,2-c]pyridine-4(5H)-one compounds. Their preparation and pharmaceutical composition, and pharmaceutical use as protein kinase inhibitors.

Abstract: The invention provides new pyrrolo-nitrogenous heterocyclic derivatives represented by formula (I) or their salts, the preparation thereof, pharmaceutical compositions containing such derivatives and the use of such derivatives as therapeutic agents, especially as protein kinase inhibitors, wherein each substituent in formula (I) is same as defined in the description.

Abstract: The present invention relates to new dicyclooctane derivates represented by general formula (I), preparation processes and pharmaceutical compositions containing them, and to uses for treatment especially for dipeptidyl peptidase inhibitor (DPPIV), in which each substituent group of general formula (I) is as defined in specification.