Abstract: The present invention relates to a compound of formula (I) capable of inhibiting plasmin activity and having blood coagulation and hemostasis activity, and a pharmaceutically acceptable salt, hydrate, isomer, prodrug and mixture thereof, wherein R1 to R3 are as defined in the description.

Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.

Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.

Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for minimally invasive collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.

Abstract: In a general aspect, chemical compounds (e.g., drugs, agrochemicals, and explosives) are detected. In some examples, a chemical detection system includes a container, an ionization system, a mass spectrometer, one or more computer systems, a sampling probe, and a control system. The sampling probe is configured to receive a liquid solvent from the container; to hold a fixed volume of the liquid solvent in direct contact with a sample surface for a period of time to form an analyte in the sampling probe; and to deliver the analyte to the ionization system. The ionization system is configured to ionize the analyte. The mass spectrometer is configured to produce mass spectrometry data by processing the ionized analyte provided by the ionization system. The one or more computer systems are configured to analyze the mass spectrometry data to detect a chemical compound present on the sample surface.

Abstract: In a general aspect, microorganisms [e.g., bacteria, etc.) are identified and detected. In some examples, a liquid solvent is supplied through a first channel of a sampling probe to an internal reservoir of the sampling probe; a fixed volume of the liquid solvent in the internal reservoir is held in direct contact with a sample surface for a period of time to form a liquid analyte; gas is supplied to the internal reservoir through a second channel of the sampling probe; the liquid analyte is extracted from the internal reservoir through a third channel of the sampling probe; the liquid analyte is transferred to a mass spectrometer; the mass spectrometer processes the liquid analyte to produce mass spectrometry data; and the mass spectrometry data are analyzed to detect and identify a microorganism [e.g., acteria, fungi, or another type of microorganism) present at the sample surface.

Abstract: In a general aspect, a swab sample is analyzed, for example, to test for disease. In some examples, a swab head of a swab sample is inserted through an opening into an internal reservoir of a sampling device. The sampling device includes the opening, an inlet channel, an outlet channel, and the internal reservoir. The internal reservoir is in fluid communication with the inlet channel, the outlet channel, and the opening. A liquid solvent is supplied to the swab head in the internal reservoir via the inlet channel of the sampling device. The swab head is held in the liquid solvent for a period of time to form an analyte in the internal reservoir. The analyte is extracted from the internal reservoir via the outlet channel of the sampling device. The analyte is transferred to and processed by a mass spectrometer to obtain mass spectrometry data.

Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.

Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for minimally invasive collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.

Abstract: In a general aspect, methods and devices are provided for using mass spectrometry to identify endometriosis. In some aspects, a fixed or discrete volume of a solvent is applied to a tissue site including possible endometriosis tissue. The applied solvent is collected to obtain a liquid sample. The liquid sample is subjected to mass spectrometry analysis. The liquid sample is collected from a tissue site in vivo during a medical procedure. The mass spectrometry data are analyzed to identify whether the tissue site comprises endometriosis.

Abstract: Methods and apparatus are provided for cleaning or exchanging medical devices. Certain embodiments may include a cassette comprising a plurality of medical devices, where the orientation of the cassette can be changed while the cassette is coupled to a processing instrument.

Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.

Abstract: Method and devices are provided for imaging a surface, such as a biological tissue sample, by mass spectrometry. In certain aspects, devices of the embodiments allow for the placement and collection of a plurality of spatially separated liquid droplets on a sample and delivery of the droplets with extracted sample analytes for mass spectrometry analysis.

Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.

Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.

Abstract: Methods and devices are provided for assessing biological samples using molecular analysis. In certain aspects, methods and devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry. In certain aspects, the results of the mass spectrometry can be analyzed to determine tissue type, sample quality, or disease state of the sample.

Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for minimally invasive collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.

Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.

Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.

Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.