Patents by Inventor Jialiu Zeng

Jialiu Zeng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ACIDIC NANOPARTICLES FOR RESTORATION OF AUTOPHAGY
    Publication number: 20240252675
    Abstract: In various embodiments novel biodegradable acid-activated acid releasing nanoparticles (acNPs) are provided that are used as a targeted strategy to manipulate lysosomal acidity and autophagy. These acNPs based, in certain embodiments, on fluorinated polyesters are degraded at pH 6.0 (pH reported in dysfunctional lysosomes), and release component acids that further lower the lysosomal pH, and thereby increasing autophagic flux and cellular function of hepatocytes under LT. The acNPs can serve as a therapeutic in restoring liver-diseases.
    Type: Application
    Filed: April 12, 2024
    Publication date: August 1, 2024
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Orian SHIRIHAI, Mark GRINSTAFF, Jialiu ZENG
  • ACIDIC NANOPARTICLES FOR RESTORATION OF AUTOPHAGY
    Publication number: 20230140315
    Abstract: In various embodiments novel biodegradable acid-activated acid releasing nanoparticles (acNPs) are provided that are used as a targeted strategy to manipulate lysosomal acidity and autophagy. These acNPs based, in certain embodiments, on fluorinated polyesters are degraded at pH 6.0 (pH reported in dysfunctional lysosomes), and release component acids that further lower the lysosomal pH, and thereby increasing autophagic flux and cellular function of hepatocytes under LT. The acNPs can serve as a therapeutic in restoring liver-diseases.
    Type: Application
    Filed: December 21, 2022
    Publication date: May 4, 2023
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Orian SHIRIHAI, Mark GRINSTAFF, Jialiu ZENG
  • ACIDIC NANOPARTICLES FOR RESTORATION OF AUTOPHAGY
    Publication number: 20220273812
    Abstract: In various embodiments novel biodegradable acid-activated acid releasing nanoparticles (acNPs) are provided that are used as a targeted strategy to manipulate lysosomal acidity and autophagy. These acNPs based, in certain embodiments, on fluorinated polyesters are degraded at pH 6.0 (pH reported in dysfunctional lysosomes), and release component acids that further lower the lysosomal pH, and thereby increasing autophagic flux and cellular function of hepatocytes under LT. The acNPs can serve as a therapeutic in restoring liver-diseases.
    Type: Application
    Filed: May 13, 2022
    Publication date: September 1, 2022
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Orian SHIRIHAI, Mark GRINSTAFF, Jialiu ZENG
  • Acidic nanoparticles for restoration of autophagy
    Patent number: 10925975
    Abstract: In various embodiments novel biodegradable acid-activated acid releasing nanoparticles (acNPs) are provided that are used as a targeted strategy to manipulate lysosomal acidity and autophagy. These acNPs based, in certain embodiments, on fluorinated polyesters are degraded at pH 6.0 (pH reported in dysfunctional lysosomes), and release component acids that further lower the lysosomal pH, and thereby increasing autophagic flux and cellular function of hepatocytes under LT. The acNPs can serve as a therapeutic in restoring liver-diseases.
    Type: Grant
    Filed: January 21, 2019
    Date of Patent: February 23, 2021
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Orian Shirihai, Mark Grinstaff, Jialiu Zeng
  • ACIDIC NANOPARTICLES FOR RESTORATION OF AUTOPHAGY
    Publication number: 20190224336
    Abstract: In various embodiments novel biodegradable acid-activated acid releasing nanoparticles (acNPs) are provided that are used as a targeted strategy to manipulate lysosomal acidity and autophagy. These acNPs based, in certain embodiments, on fluorinated polyesters are degraded at pH 6.0 (pH reported in dysfunctional lysosomes), and release component acids that further lower the lysosomal pH, and thereby increasing autophagic flux and cellular function of hepatocytes under LT. The acNPs can serve as a therapeutic in restoring liver-diseases.
    Type: Application
    Filed: January 21, 2019
    Publication date: July 25, 2019
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, TRUSTEES OF Boston University
    Inventors: Orian Shirihai, Mark Grinstaff, Jialiu Zeng