Patents by Inventor Jialun Wang

Jialun Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enhancement of peptide cellular uptake
    Patent number: 6713280
    Abstract: Peptide conjugates of the formula are provided (R—X)n-peptide  (I) wherein: n is from 1 to 10; X is (a) C═O, when the R—X group is attached to: (i) the N-terminus of the peptide, or (ii) a side chain of the peptide where the functional group of the side chain to which the R—X group is attached is NH2 or OH; or (b) O or NH, when the R—X group is attached to (i) the C-terminus of the peptide, or (ii) a side chain of the peptide where the functional group of the side chain to which the R—X group is attached is COOH or CONH2; and R is selected from the group consisting of C2-18 alkyl; C2-18 alkoxy; C2-14 alkylenyl containing one or two double bonds; cyclobutyl; cyclopentyl; cyclohexyl optionally monosubstituted with a C1-5 straight or branched chain alkyl group; phenyl optionally monosubstituted with a C1-5 straight or branched chain alkyl group; and benzyl.
    Type: Grant
    Filed: April 6, 2000
    Date of Patent: March 30, 2004
    Assignee: Thomas Jefferson University
    Inventors: Ziwei Huang, Jialun Wang, Zhijia Zhang, Simei Shan, Zhixian Lu
  • Small molecule inhibitors of BCL-2 proteins
    Patent number: 6492389
    Abstract: Small molecule inhibitors of Bcl-2 function are used to induce apoptosis of cells which are subject to Bcl-2, which cells are otherwise subject to Bcl-2 mediated blockage of apoptosis. The compounds are useful for treating cancer, autoimmune disorders and viral infection.
    Type: Grant
    Filed: July 20, 1999
    Date of Patent: December 10, 2002
    Assignee: Thomas Jefferson University
    Inventors: Ziwei Huang, Dongxiang Liu, Xiaobing Han, Zhijia Zhang, Jialun Wang