Patents by Inventor Jiaming Zhuang

Jiaming Zhuang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROTEIN-TEMPLATED SELF-ASSEMBLY OF A COVALENT POLYMER NETWORK FOR INTRACELLULAR TRAFFICKING AND TRACELESS RELEASE
    Publication number: 20230405142
    Abstract: The invention provides polymers and polymer-based nano-structures, in particular, polymers and polymer network to which biomolecules (e.g., proteins, antibodies, peptide aptamers) can be covalently conjugated and stably encapsulated therein and be controllably delivered and released upon degradation of the nano-structures in response to specific microenvironment, and compositions and methods of preparation and use thereof.
    Type: Application
    Filed: June 12, 2023
    Publication date: December 21, 2023
    Inventors: Sankaran Thayumanavan, Jiaming Zhuang
  • Protein-templated self-assembly of a covalent polymer network for intracellular trafficking and traceless release
    Patent number: 11672867
    Abstract: The invention provides polymers and polymer-based nano-structures, in particular, polymers and polymer network to which biomolecules (e.g., proteins, antibodies, peptide aptamers) can be covalently conjugated and stably encapsulated therein and be controllably delivered and released upon degradation of the nano-structures in response to specific microenvironment, and compositions and methods of preparation and use thereof.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: June 13, 2023
    Assignee: University of Massachusetts
    Inventors: Sankaran Thayumanavan, Jiaming Zhuang
  • SURFACE FUNCTIONALIZED, HOST-GUEST POLYMER NANO-ASSEMBLIES AND METHODS THEREOF
    Publication number: 20220133639
    Abstract: The invention generally relates to polymer-based nano-structures. More particularly, the invention relates to novel, surface-functionalized, guest-host polymer nano-assemblies and nano-delivery vehicles useful in diverse fields including drug delivery, diagnostics and specialty materials. The nano-assemblies and nano-delivery vehicles of the invention are afforded via simplify and reliable approaches.
    Type: Application
    Filed: July 31, 2021
    Publication date: May 5, 2022
    Inventors: Sankaran Thayumanavan, Jiaming Zhuang, Hui Wang
  • COMPOSITIONS AND METHODS FOR PROTEIN LABELING, MODIFICATION, ANALYSIS, AND TARGETED DELIVERY
    Publication number: 20210380635
    Abstract: The invention relates to chemically reactive and/or biologically active compounds, reagents and compositions thereof. More particularly, the invention provides novel reagents that are useful in chemical synthesis, functionalization, delivery, probing and/or analytical measurements of small molecule drugs, proteins, antibodies and other biomolecules. The invention provides novel biologically active agents useful as diagnostics or therapeutics, and related composition and methods of uses thereof.
    Type: Application
    Filed: June 28, 2019
    Publication date: December 9, 2021
    Inventors: Sankaran Thayumanavan, Richard W. Vachet, Jiaming Zhuang, Bo Zhao
  • PROTEIN-TEMPLATED SELF-ASSEMBLY OF A COVALENT POLYMER NETWORK FOR INTRACELLULAR TRAFFICKING AND TRACELESS RELEASE
    Publication number: 20200282066
    Abstract: The invention provides polymers and polymer-based nano-structures, in particular, polymers and polymer network to which biomolecules (e.g., proteins, antibodies, peptide aptamers) can be covalently conjugated and stably encapsulated therein and be controllably delivered and released upon degradation of the nano-structures in response to specific microenvironment, and compositions and methods of preparation and use thereof.
    Type: Application
    Filed: March 30, 2018
    Publication date: September 10, 2020
    Inventors: Sankaran Thayumanavan, Jiaming Zhuang
  • SURFACE FUNCTIONALIZED, HOST-GUEST POLYMER NANO-ASSEMBLIES AND METHODS THEREOF
    Publication number: 20160243047
    Abstract: The invention generally relates to polymer-based nano-structures. More particularly, the invention relates to novel, surface-functionalized, guest-host polymer nano-assemblies and nano-delivery vehicles useful in diverse fields including drug delivery, diagnostics and specialty materials. The nano-assemblies and nano-delivery vehicles of the invention are afforded via simplify and reliable approaches.
    Type: Application
    Filed: October 2, 2014
    Publication date: August 25, 2016
    Inventors: Sankaran Thayumanavan, Jiaming Zhuang, Hui Wang