Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Abstract: Methods of synthesizing chondroitin sulfate oligosaccharides are provided. Enzymatic schematic approaches to synthesizing structurally defined homogenous chondroitin sulfate oligosaccharides at high yields are provided. Synthetic chondroitin sulfate oligosaccharides ranging from 3-mers to 15-mers are provided.

Abstract: A barrier structure for bearing a high-energy impact and construction method thereof are provided. The barrier structure includes a supporting pile array arranged between two opposite mountain slope surfaces. The supporting pile array is arranged in a straight line and includes two or more supporting piles. The two or more supporting piles are fixed at a lower part of a mountain. A barrier net is connected to the two or more supporting piles. The barrier net passes through the supporting pile array and extends to the two opposite mountain slope surfaces. The barrier net is fixed on the two opposite mountain slope surfaces. Pull plates are disposed on the two opposite mountain slope surfaces, and one side of each of the pull plates is fixed to a corresponding slope surface of the two opposite mountain slope surfaces through reverse prestressed anchor cables.

Abstract: A low-carbon and low-alloy dual-phase steel and hot-dip galvanized dual-phase steel having tensile strength greater than or equal to 980 MPa and a method for manufacturing by means of rapid heat treatment. The steel has the following chemical components in percentage by mass: C: 0.05-0.17%, Si: 0.1-0.7%, Mn: 1.4-2.8%, P?0.020%, S?0.005%, B?0.005%, and Al: 0.02-0.055%, and may further contain two or more of Nb, Ti, Cr, Mo, and V, Cr+Mo+Ti+Nb+V?1.1%, the balance is Fe and other inevitable impurities. The method for manufacturing the steel comprises: smelting, casting, hot rolling, cold rolling and rapid heat treatment procedures. According to the present invention, the recovery, recrystallization and austenite transformation process of a deformed structure is changed, the nucleation rate is increased, the grain growth time is shortened, grains are refined, the strength of the material is improved, and the performance range of the material is expanded.

Abstract: A high-formability hot galvanized aluminum-zinc or hot galvanized aluminum-magnesium dual-phase steel having a tensile strength of ?590 MPa and a rapid heat treatment hot dipping fabrication method, the steel comprising the following components in mass percentage: C: 0.045-0.12%; Si: 0.1-0.5%; Mn: 1.0-2.0%; P: ?0.02%; S: ?0.006%; and Al: 0.02-0.055%. The steel may also contain one or two among Cr, Mo, Ti, Nb, and V, wherein the Cr+Mo+Ti+Nb+V?0.5%, and the remainder is Fe and other inevitable impurities. The present invention changes the recovery of a deformed structure, ferrite recrystallization and austenite transformation processes during annealing by means of rapid heat treatment, and the nucleation point of a crystal is increased, grain growth time is shortened, the strength and formability (n90 value) of the material is improved while heat treatment efficiency is improved, which thus extends the performance range of the material.

Abstract: Provided are a low-carbon low-alloy Q&P steel or hot-dip galvanized Q&P steel with a tensile strength greater than or equal to 1180 MPa, and a manufacturing method therefor. The steel comprises the chemical components by mass percent: C: 0.16-0.23%, Si: 1.1-2.0%, Mn: 1.6-3.0%, P?0.015%, S?0.005%, Al: 0.02-0.05%; and the steel can further comprise one or two of Cr, Mo, Ti, Nb and V, and Cr+Mo+Ti+Nb+V? 0.5%, and the balance being Fe and other unavoidable impurities. The manufacturing method comprises the processes of smelting, casting, hot rolling, cold rolling, and a rapid heat treatment or a rapid heat treatment hot dip process.

Abstract: A method for storing metadata and a configuration schema for each of a plurality of capabilities, and storing a plurality of catalogs, each catalog identifying the metadata and configuration schema associated with at least one of the plurality of capabilities. The method also includes receiving a request for implementation of one of the plurality of capabilities on a pluggable system, and associating, by a lifecycle manager and based on a catalog of the plurality of catalogs related to the request, the metadata and configuration schema related to the requested one of the plurality of capabilities with a domain specific capabilities controller compatible with the pluggable system.

Abstract: The present disclosure provides a light-emitting substrate and a manufacturing method thereof, a backlight and a display device. The light-emitting substrate includes a substrate including a plurality of light-emitting regions arranged in an array, each of the plurality of light-emitting regions including a driving circuit and at least one light-emitting unit connected to the driving circuit, a first electrically conductive portion on the substrate and connected to the driving circuit and the at least one light-emitting unit in each light-emitting region, and a second electrically conductive portion on the substrate and including a plurality of pads. The first electrically conductive portion and the second electrically conductive portion are on a same layer.

Abstract: A combined platform for testing fireproof materials for cables includes a main frame for providing operating space; an air circulation system including a fresh air supply unit for supplying fresh air into the operating space and an exhaust gas treatment unit for treating the gas in the operating space under set conditions; an open flame system for providing an open flame for testing cables; a water circulation system for supplying water at least to the exhaust gas treatment unit and the operating space; and a control system for collecting at least the temperature and gas concentration in the operating space, and performing process control based on the collected results. The actual working conditions of scenarios such as fire-resistant cable tunnels and fire-resistant cable trenches can be simulated, and multiple tests such as combustion performance test and physical and chemical performance test can be carried out under various working conditions.

Abstract: Systems and methods for defending against volumetric attacks, implemented in a cloud-based system. Embodiments include steps of, monitoring flows and a rate of requests to a Data Center (DC); receiving a request from an address to the DC, the request being for a service in a cloud-based system; determining if the address has been successfully authenticated within a past predetermined time period; responsive to the address not having been successfully authenticated within the past time period, and one of (i) the rate of requests being above a threshold or (ii) the number of flows being above a threshold, placing the address in a penalty box for a predetermined amount of time; and blocking requests from the address in the penalty box for the predetermined amount of time.

Abstract: This application provides example communication methods and devices to improve wireless local area network (WLAN) communication efficiency. In an example method, an access point (AP) sends first indication information. The first indication information indicates a first resource unit (RU) of a station (STA). The AP sends second indication information. The second indication information indicates whether the STA is allowed to send a physical layer protocol data unit (PPDU) based on a part of the first RU, and when the second indication information indicates that the STA is allowed to send the PPDU based on the part of the first RU. The PPDU includes a low density parity check (LDPC) extra symbol segment. The AP receives a first PPDU. A second RU occupied by the first PPDU is the part of the first RU. The first PPDU includes the LDPC extra symbol segment.

Abstract: Disclosed in the present invention are a series of fused polycyclic substituted 5-carboxylic acid thienopyrimidine dione compounds and the use thereof. Specifically disclosed are a compound represented by formula (H) and a pharmaceutically acceptable salt thereof.

Abstract: A polypeptide compound having a structure shown in formula I, or a stereoisomer, mixture or pharmaceutically acceptable salt thereof Experimental results show that the polypeptide compound can effectively exhibit high agonistic activity to GHSR-1a.

Abstract: A method, an apparatus, a terminal and a storage medium for display control is provided by the disclosure. The disclosure provides a method of display control which includes: displaying, in a display area of a target application, at least part of pages opened in the target application, if a number of pages opened in the target application exceeds n, displaying n opened pages in the display area of the target application and hiding other pages, and displaying a page identifier of a hidden page, n being not less than 1; and in response to a triggering operation on the page identifier, displaying a page corresponding to the triggered page identifier in the display area of the target application.

Abstract: This application relates to the field of liquid cooling technologies, and provides a gas collection apparatus, configured to collect bubbles generated due to loss of a working medium in a liquid cooling apparatus. The gas collection apparatus includes a cooling plate. The cooling plate includes at least one gas collection structure disposed inside the cooling plate, a first flow channel disposed inside the cooling plate, a second flow channel disposed inside the gas collection structure, and at least one connecting channel configured to connect the first flow channel and the second flow channel. The at least one connecting channel is configured to transfer, to the second flow channel, bubbles carried when the working medium flows in the first flow channel. The at least one gas collection structure is configured to collect the bubbles from the second flow channel.

Abstract: The present invention discloses a heteroatom- and cycloalkyl-containing organic compound and an organic electroluminescent device containing the compound. The general structural formula of the organic compound is as represented by Formula I. The organic compound has a boron-nitrogen structure with multiple resonance effect, wherein a cycloalkyl-containing fluorenyl structure is introduced on the basis of the boron-nitrogen structure. The molecular size is greatly expanded by means of the cycloalkyl group, thereby effectively avoiding a concentration quenching effect, while the molecular orientation is enhanced due to the planarity of the fluorenyl group.

Abstract: A barrier structure for bearing a high-energy impact and construction method thereof are provided. The barrier structure includes a supporting pile array arranged between two opposite mountain slope surfaces. The supporting pile array is arranged in a straight line and includes two or more supporting piles. The two or more supporting piles are fixed at a lower part of a mountain. A barrier net is connected to the two or more supporting piles. The barrier net passes through the supporting pile array and extends to the two opposite mountain slope surfaces. The barrier net is fixed on the two opposite mountain slope surfaces. Pull plates are disposed on the two opposite mountain slope surfaces, and one side of each of the pull plates is fixed to a corresponding slope surface of the two opposite mountain slope surfaces through reverse prestressed anchor cables.

Abstract: This application relates to the wireless communications field, for example, is applicable to a wireless local area network supporting the 802.11be standard, and in particular, to a PPDU uplink bandwidth indication method and a related apparatus. The method includes: An AP generates and sends a trigger frame. The trigger frame carries first indication information, where the first indication information directly indicates or jointly indicates an EHT TB PPDU bandwidth or an uplink PPDU total transmission bandwidth. The trigger frame carries second indication information, where the second indication information indicates distribution of an HE TB PPDU and/or an EHT TB PPDU in the uplink PPDU total transmission bandwidth, or directly indicate whether an EHT station transmits an HE TB PPDU or an EHT TB PPDU.

Abstract: An array substrate includes: a first substrate (10), including a plurality of sub-pixel regions (101) arranged in an array along a row direction (X) and a column direction (Y); a pixel circuit layer, including a plurality of sub-pixel circuits; a planarization layer (17), provided with a first via hole (170) located in the sub-pixel regions (101), and includes at least one pattern portion (171), the pattern portion (171) includes a plurality of pattern units (171a) arranged in an array along the row direction (X) and the column direction (Y); and a reflective electrode layer, wherein the reflective electrode layer includes a plurality of reflective electrodes (18) that are mutually disconnected, each of the reflective electrodes (18) is located in one of the sub-pixel regions (101) and is electrically connected to the sub-pixel circuit through the first via hole (170).

Abstract: The present invention relates to an S-configuration-containing amino benzamide pyridazinone compound, a preparation method therefor, and a pharmaceutical composition and application thereof. Specifically, the present invention relates to a compound represented by the following general formula I or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition and application thereof. The S-configuration compound of the present application has very strong binding activity on class I histone deacetylase (HDAC1), and shows inhibitory activity on in-vitro proliferation of various tumor cells.