Abstract: In a general aspect, a method for inferring one or more biomolecule-to-biomolecule interaction sites includes receiving data representative of a plurality of prediction models. Each prediction model is associated with a different atom type of a plurality of atom types and characterizes biomolecule-to-biomolecule interaction site specific patterns common to a plurality of three dimensional probability density maps. Each three dimensional probability density map is associated with a corresponding biomolecule of a plurality of biomolecules included in a training data set and represents a probability of a non-covalent interacting atom on a surface of the corresponding biomolecule interacting with the atom type associated with the prediction model. Data representative of a query biomolecule is received, the data including one or more unknown biomolecule-to-biomolecule interaction sites.

Abstract: An ultrasonic puncture method including the following steps: mounting a probe beam direction indicator on a probe by an indicator holder, with the orientation of the probe beam direction indicator the same as that of the probe, and enabling a light beam emitted by the probe beam direction indicator to rotate in a plane perpendicular to a beam plane of the probe; rotating the probe beam direction indicator to allow the light beam to coincide with the beam plane of the probe, and locking the probe beam direction indicator; and placing the probe on the body surface, and inserting a puncture needle along the light beam after a focus is found. The method can solve the problem of having difficulty in accurately and rapidly displaying the puncture needle on an ultrasonogram in free-hand puncture of a superficial tissue or superficial organ at present. An ultrasonic puncture device is also disclosed.

Abstract: The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.

Abstract: A method of suppressing ripple can include: (i) coupling a switching converter and a load in series between output terminals of a signal source; and (ii) controlling a difference voltage between an input voltage signal and an output voltage signal of the switching converter to vary with a voltage signal generated by the signal source to maintain a load current signal flowing through the load as a DC signal.

Abstract: Provided are a method of delivering downlink signaling and a device supporting the method. According to one embodiment of the present invention, a method in which a first base station (BS) delivers downlink signaling to a user equipment (UE) in a wireless communication system includes: receiving the downlink signaling from an upper layer entity; requesting a second BS for paging on the UE; and delivering the downlink signaling to the UE via the second BS if a paging response of the UE is received from the second BS.

Abstract: The present disclosure provides a method for manufacturing a display substrate, a display substrate, and a display device. The method for manufacturing a display substrate comprises: providing a container, which is positioned horizontally and which contains a curable liquid, and the bottom of which is flat; immersing a side of the substrate parallel to the bottom of the container in the horizontal direction into the curable liquid; and performing curing treatment of the curable liquid until the curable liquid is solidified on the side of the substrate to form a film layer.

Abstract: The present provides a waste heat boiler and a hammering device, a heating tube mounting structure thereof. The waste heat boiler which a boiler, heating tubes provided in the boiler and a hammering device; the boiler is provided with an exhaust gas inlet and an exhaust gas outlet; the heating tubes are in a horizontal grid tube arrangement; a surface of the heating tubes is provided with fins, and the heating tubes are connected to support assemblies in an unfixed way.

Abstract: Disclosed is a method for synthesizing a sitagliptin intermediate, the method comprising: in the presence of hydrogen and a transition metal catalyst having a chiral phosphine ligand, subjecting a compound of formula II to an asymmetric reductive amination with ammonia or ammonium salt in a proper organic solvent under the condition of adding an acidic additive to produce a compound of formula I, wherein, an R- or S-configuration of a stereocenter is represented by *; the compound of formula I of R configuration can be used to prepare sitagliptin, and a reaction formula is as follows: R1 and R2 are each independently selected from hydrogen, C1-C12 linear or branched alkyl, C3-C12 cycloalkyl, C2-C12 alkenyl, C2-C12 alkynyl and C7-C12 arylalkyl. The method has a high yield and a high ee % value, a mild reaction condition and a low production cost, and is simple to operate, convenient to purify, environmental friendly and suitable for industrial production.

Abstract: Techniques for utilizing data mining technology to extract universal topics with multilingual representations from a multilingual database, and to organize existing or new documents in different languages by analyzing their respective topic distributions.

Abstract: A switching power supply apparatus of a current-resonance type, including a first switching element and a second switching element connected in series, a series circuit of a resonant reactor and a resonant capacitor connected in parallel to the first switching element or the second switching element, a control circuit configured to alternately turn on and off the first switching element and the second switching element, and a load detection circuit. The load detection circuit includes a shunt circuit which shunts a resonant current flowing through the resonant reactor and resonant capacitor connected in series to obtain a shunted current, converts the shunted current to a first voltage signal, and outputs the first voltage signal, a switching circuit which switches between the first voltage signal and a second voltage signal of a ground level to generate a third voltage signal, and an averaging circuit which averages the third voltage signal.

Abstract: The present invention is applied to the technical field of solid-state storage, and provided are a solid state disk and a data management method and system. The data management method for a solid state disk comprises: saving the written data in a solid state disk after adding a timestamp to written data; receiving a mark command for marking the data to be invalid, marking an address range corresponding to the invalid data, and saving the marked information in the solid state disk after adding a timestamp to the marked information; comparing the timestamp of the marked information with the timestamp of the data in the marked address range after starting the solid state disk; if the timestamp of the data in the marked address range is earlier than the timestamp of the marked information, marking the address range as invalid, otherwise not marking the address range as invalid.

Abstract: A quantum rod film for a backlight unit of a liquid crystal display is disclosed herein. The quantum rod film includes a first barrier layer, a sub-wavelength microstructure on the first barrier layer, and a plurality of quantum rods, wherein the sub-wavelength microstructure includes gratings aligned in a parallel direction, an alignment microstructure disposed in grooves between the gratings in a direction perpendicular to the gratings, and a reflective layer on upper surfaces of the gratings. A plurality of quantum rods are arranged in the alignment microstructure of the sub-wavelength microstructure, and major axes of the quantum rods are aligned in a direction perpendicular to the gratings.

Abstract: A method and apparatus for transmitting an indication in a wireless communication system is provided. A relay node (RN) transmits an indication which indicates that the RN is either a fixed relay node or a mobile relay node, and receives initial parameters from an operation, administration, and maintenance (OAM) according on the indication. If the RN is the mobile relay node, the initial parameters includes a list of donor eNodeB (DeNB) cells at a trajectory of the RN.

Abstract: A system may receive tag information, associated with media content, that includes a tag and a tag time. The system may generate, based on the tag information, clip information that includes a start time and an end time for a media content clip associated with the media content. The system may determine, based on the tag information, advertisement information that identifies an advertisement to be displayed with the media content clip, and indicates how the advertisement is to be displayed. The system may provide the tag information for display via a social media application, and may receive, via the social media application, an indication that the media content clip is to be provided for display to a user. The system may provide the advertisement information and the clip information such that the advertisement and the media content clip are provided for display to the user based on the advertisement information.

Abstract: Generating an optimized supplier allocation plan includes identifying parts and suppliers associated with an allocation problem, where each supplier can supply at least one part. One or more objective functions are selected. Each objective function has part variables, and each part variable represents a quantity of a part to be procured from a supplier. At least one constraint constraining at least one part variable is received. The one or more objective functions are optimized with respect to the at least one constraint to yield a value for each part variable. A quantity of each part to be procured from at least one supplier is determined according to the values to generate the optimized supplier allocation plan.

Abstract: A device intercepts a request that includes a network address or a universal resource locator (URL) for a landing page and determines whether special handling is applicable when forwarding the landing page to the requesting device. When the special handling is applicable, the request is automatically redirected to a validation device, which determines whether the requesting device is eligible for the special handling. The validation device signs based on the determination and returns the signed request to the requesting device. The requesting device forwards the signed request to request the landing page and the special handling is selectively applied based on the signed request.

Abstract: A method and apparatus for deriving a scaled motion vector (MV) for a current block based on a candidate MV associated with a candidate block determines a first picture distance between a current picture corresponding to the current block and a target reference picture pointed to by a current motion vector of the current block, and then determines a second picture distance between a candidate picture corresponding to the candidate block and a candidate reference picture pointed to by the candidate MV of the candidate block. The method further determines a pre-scaled distance division having a first value related to dividing a pre-scaling factor by the second picture distance, and determines an intermediate scaling factor by right-shifting a multiplication result associated with the first picture distance and the pre-scaled distance division by q bits, wherein q is a positive integer.

Abstract: Aspects of the disclosure provide an apparatus that includes a navigation signal receiver and a processing circuit. The navigation signal receiver is to receive, from a plurality of satellites, first ephemeris data. The first ephemeris data is effective for a first time duration. The processing circuit is to predict, based on the first ephemeris data, second ephemeris data. The second ephemeris data is effective for a second time duration that is extended beyond the first time duration. The second ephemeris data is used by the navigation signal receiver to acquire satellite signals for positioning the apparatus during the second time duration.

Abstract: A process for the joint preparation of 1,3,3,3-tetrafluoropropene and 2,3,3,3-tetrafluoropropene, comprising: (a) starting materials comprising at least one compound having the structure of formula I, II or III are reacted with hydrogen fluoride, producing 1,2,3-trichloro-3,3-difluoropropene, 1,2,3-trichloro-1,1,2-trifluoropropane, and 1,2,3-trichloro-1,1,3-trifluoropropane; in the compounds of said formulae CF2-mClm?CCl—CHF2-nCln (Formula I), CF3-pClpCHCl?CH2Cl (Formula II), and CF3-xClxCF2-yClyCHF2-zClz (Formula III), m=0, 1, 2; n=1, 2; p=2, 3; x=1, 2, 3; y=1, 2; z=1, 2 and 4?x+y+z?6; (b) the 1,2,3-trichloro-3,3-difluoropropene, 1,2,3-trichloro-1,1,2-trifluoropropane and 1,2,3-trichloro-1,1,3-trifluoropropane undergo dechlorination, producing 3-chloro-3,3-difluoropropyne, 3-chloro-2,3,3-trifluoropropene and 3-chloro-1,3,3-trifluoropropene; and (c) the 3-chloro-3,3-difluoropropyne, 3-chloro-2,3,3-trifluoropropene and 3-chloro-1,3,3-trifluoropropene are reacted with hydrogen fluoride, simultaneously yielding

Abstract: Semiconductor device components and methods are disclosed. In one embodiment, a semiconductor device component includes a conductive segment having a first surface, a second surface opposite the first surface, a first end, and a second end opposite the first end. A first via is coupled to the second surface of the conductive segment at the first end. A second via is coupled to the first surface of the conductive segment at the second end, and a third via is coupled to the second surface of the conductive segment at the second end.