Patents by Inventor Jian-Dong Li

Jian-Dong Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis
    Publication number: 20040265296
    Abstract: Disclosed herein is a composition and a method for the treatment of otitis media and paranasal sinusitis using human defensins, lysozyme and/or lactoferrin as a new class of non-antibiotic antimicrobials. From studies of otitis media and paranasal sinusitis, it was observed that certain innate immune modulators were important in the bodies response to the infection. Therefore, these innate immune modulators, lysozyme, lactoferrin, and defensins were tested for use as a non-antibiotic treatment for infection, particularly infections such as otitis media and sinusitis.
    Type: Application
    Filed: April 6, 2004
    Publication date: December 30, 2004
    Inventors: David J. Lim, Haa-Yung Lee, Paul Webster, Ali Andalibi, Jian-Dong Li, Tomas Ganz
  • Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis
    Patent number: 6716813
    Abstract: Disclosed herein is a method for the treatment of otitis media and paranasal sinusitis using human defensins, lysozyme and/or lactoferrin as a new class of non-antibiotic antimicrobials. From studies of otitis media and paranasal sinusitis, it was observed that certain innate immune modulators were important in the bodies response to the infection. Therefore, these innate immune modulators, lysozyme, lactoferrin and defensins, were tested for use as a non-antibiotic treatment for infection, particularly infections such as otitis media and sinusitis.
    Type: Grant
    Filed: November 27, 2001
    Date of Patent: April 6, 2004
    Assignee: House Ear Institute
    Inventors: David J. Lim, Haa-Yung Lee, Paul Webster, Ali Andalibi, Jian-Dong Li, Tomas Ganz
  • Composition and method for treating the over-production of mucin in diseases such as otitis media using an inhibitor of MUC5AC
    Publication number: 20020151491
    Abstract: Disclosed herein is a method for the identification of a treatment for overproduction of mucin during otitis media (OM) and chronic obstructive pulmonary disease (COPD). The method uses a MUC5AC plasmid to identify novel cytoplasmic proteins of Nontypeable Haemophilus influenzae, a common mediator of OM and COPD, which up-regulate human MUC5AC mucin transcription via a positive p38 MAP kinase pathway and a negative PI 3-Kinase-Akt pathway. These proteins can be used to identify or design inhibitors of the p38 MAP kinase pathway and activators of the PI 3-kinase Akt pathway.
    Type: Application
    Filed: November 27, 2001
    Publication date: October 17, 2002
    Inventors: Jian-Dong Li, David Lim, Haidong Xu, Beinan Wang, Tsuyoshi Shuto, Carol Basbaum, Young S. Kim
  • Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis
    Publication number: 20020141986
    Abstract: Disclosed herein is a composition and a method for the treatment of otitis media and paranasal sinusitis using human defensins, lysozyme and/or lactoferrin as a new class of non-antibiotic antimicrobials. From studies of otitis media and paranasal sinusitis, it was observed that certain innate immune modulators were important in the bodies response to the infection. Therefore, these innate immune modulators, lysozyme, lactoferrin, and defensins were tested for use as a non-antibiotic treatment for infection, particularly infections such as otitis media and sinusitis.
    Type: Application
    Filed: November 27, 2001
    Publication date: October 3, 2002
    Inventors: David J. Lim, Haa-Yung Lee, Paul Webster, Ali Andalibi, Jian-Dong Li, Tomas Ganz