Abstract: The present invention particularly discloses a novel feedback circuit, mainly comprising: a signal sampling unit, a feedback unit, a signal concerting unit, and a signal adjusting unit. During the operation of the feedback circuit, a current-mode error amplifier unit is configured to output a current error signal based on a current sampling signal and a dimming signal outputted by the signal converting unit, so as to activate a PWM controlling unit to stabilize an output current of a LED driver circuit. In the meantime, a voltage-mode error amplifier unit cooperates with the PWM controlling unit to adaptively regulate an output voltage of the LED driver circuit based on a voltage sampling signal and an adjustment signal outputted by the signal adjusting unit, in order to facilitate the LED driver circuit provides a constant output power.

Abstract: The present disclosure relates to 2-arylamino pyridine, pyrimidine, or triazine derivatives, and the preparation method and use thereof. The 2-arylamino pyridine, pyrimidine, or triazine derivatives may act on certain mutated forms of epidermal growth factor receptor, for example the L858R activating mutant, the delE746_A750 mutant, the Exon19 deletion activating mutant, and the T790M resistance mutant, so as to be used for treatment and prevention of diseases and medical conditions. The 2-arylamino pyridine, pyrimidine, or triazine derivatives may be used for treatment and prevention of cancer. The present disclosure also relates to a pharmaceutical composition comprising 2-arylamino pyridine, pyrimidine, or triazine derivatives, intermediates useful in the manufacture of 2-arylamino pyridine, pyrimidine, or triazine derivatives, and to methods of treatment of diseases mediated by various different forms of EGFR using 2-arylamino pyridine, pyrimidine, or triazine derivatives.

Abstract: A method used in a flash memory module having a plurality of storage blocks is disclosed. Each storage block can be used as a first block or a second block wherein a cell of the first block is arranged for storing data of 1 bit and a cell of the second block is arranged for storing data of at least 2 bits. The method includes: classifying data to be programmed into a plurality of groups of data; executing error code encoding to generate a corresponding parity check code to store the groups of data and the corresponding parity check code to at least one block of first blocks; and after completing storing the groups of data, performing an internal copy operation upon the groups of data and the corresponding parity check code from the at least one block of the first blocks to at least one second block.

Abstract: A method used for a flash memory module having a plurality of storage blocks each can be used as a first block or a second block includes: classifying data into a plurality of groups of data; respectively executing error code encoding to generate a first corresponding parity check code to store the groups of data and the first corresponding parity check code into the flash memory module as first blocks; reading out the groups of data from the first blocks; executing error correction and de-randomize operation upon read out data to generate de-randomized data; executing randomize operation upon the de-randomized data according to a set of seeds to generate randomized data; performing error code encoding upon the randomized data to generate a second corresponding parity check code; and storing the randomized data and the second corresponding parity check code into the flash memory module as the second block.

Abstract: A system is configured to shield an interior chamber of a structure. The system may include a power source, an outer shield assembly operatively connected to the power source and coupled to an outer wall of the structure, and an inner shield assembly surrounding the internal chamber. The outer shield assembly generates a magnetic field through and around the structure. The inner shield assembly deflects radiation particles away from the interior chamber and re-directs portions of the magnetic field around the interior chamber.

Abstract: Described are organosilicon electrolyte compositions having improved thermostability and electrochemical properties and electrochemical devices that contain the organosilicon electrolyte compositions.

Abstract: A method used for a flash memory module having a plurality of storage blocks each can be used as a first block or a second block includes: classifying data into a plurality of groups of data; respectively executing error code encoding to generate a first corresponding parity check code to store the groups of data and the first corresponding parity check code into the flash memory module as first blocks; reading out the groups of data from the first blocks; executing error correction and de-randomize operation upon read out data to generate de-randomized data; executing randomize operation upon the de-randomized data according to a set of seeds to generate randomized data; performing error code encoding upon the randomized data to generate a second corresponding parity check code; and storing the randomized data and the second corresponding parity check code into the flash memory module as the second block.

Abstract: A method used in a flash memory module having a plurality of storage blocks is disclosed. Each storage block can be used as a first block or a second block wherein a cell of the first block is arranged for storing data of 1 bit and a cell of the second block is arranged for storing data of at least 2 bits. The method includes: classifying data to be programmed into a plurality of groups of data; executing error code encoding to generate a corresponding parity check code to store the groups of data and the corresponding parity check code to at least one block of first blocks; and after completing storing the groups of data, performing an internal copy operation upon the groups of data and the corresponding parity check code from the at least one block of the first blocks to at least one second block.

Abstract: The present invention is based, in part, on our studies of molecular pathways that include the deubiquitinase CYLD. Accordingly, the present invention features, inter alia, nucleic acid constructs that express CYLD or a biologically active variant thereof (e.g., a variant including the catalytic domain), nucleic acids that inhibit the expression of a negative regulator of CYLD (e.g., PDE4B or LNK2), nucleic acids that modulate the expression of downstream CYLD targets (e.g., Akt, by inhibiting or promoting the expression of the downstream target), compositions including one or more of these types of constructs (e.g., pharmaceutical compositions), kits including one or more of the compositions described herein and instructions for use, screening methods to identify therapeutic agents {e.g., anti-inflammatory agents) that upregulate CYLD, downregulate a negative regulatory of CYLD, or modulate (e.g., inhibit) a downstream CYLD target (e.g.

Abstract: Described herein are liquid, organosilicon compounds that including a substituent that is a cyano (—CN), cyanate (—OCN), isocyanate (—NCO), thiocyanate (—SCN) or isothiocyanate (—NCS). The organosilicon compounds are useful in electrolyte compositions and can be used in any electrochemical device where electrolytes are conventionally used.

Abstract: Described are electrolyte compositions having at least one salt and at least one compound selected from the group consisting of: wherein “a” is from 1 to 3; “b” is 1 or 2; 4?“a”+“b”?2; X is a halogen; R can be alkoxy or substituted alkoxy, among other moieties, and R1 is alkyl, substituted alkyl, aryl, substituted aryl, alkoxy, or substituted alkoxy. Also described are electrochemical devices that use the electrolyte composition.

Abstract: An system can include a server that includes or is associated with a keyword price recommendation module. The module can be configured to recommend an optimal price for a keyword, per referral event, in a search engine marketing campaign. For making such a recommendation, the module can be configured to determine revenue generated per referral event for the keyword according to a number of referral events for the keyword for a plurality of users and revenue generated for the keyword by the plurality of users. It can also be configured to select a return on investment percentage for the keyword, and determine the optimal price for the keyword according to the revenue generated per referral event and the return on investment percentage. Additionally or alternatively, the keyword price recommendation module can be configured to calculate the return on investment percentage for the keyword according to at least one market condition.

Abstract: The present invention features, inter alia, pharmaceutical compositions and their use in the preparation of a medicament (e.g., a medicament for inflammation, such as an inflammatory lung disease) or in a therapeutic regimen. The compositions can include at least two active agents: a first agent that inhibits PDE4 (e.g., roflumilast) and a second active agent that inhibits the expression or activity of one or more PDE4B variants (e.g., PDE4B2). The compositions and methods will attenuate an unwanted up-regulation of a PDE4B (e.g., PDE4B2) and may thereby improve treatment with the first agent (e.g., roflumilast). For example, the second agent may improve the efficacy of the first agent, decrease the effective dose of the first agent, ameliorate the tolerance to the first agent that would otherwise develop (e.g., in patients with COPD exacerbation), reduce unwanted side effects caused by the first agent, or otherwise improve treatment regimes including a PDE4 inhibitor.

Abstract: A multi-functional composite structure has a modular design that can be altered depending on an extreme environment in which the structure will be exposed such as hazardous radiation, micro-meteoroid and orbital debris impacts, extreme temperature changes, etc. The material combinations employed in the multi-functional composite structure provide a supporting structure with low weight and maximum protection from radiation, debris impacts and temperature variations.

Abstract: Simplification of trajectory representation is provided. Trajectories represented by a set of points on a map are obtained. Common route elements are identified for the trajectories based on the set of points. Each of the common route elements represents a geospatial area in which at least a predetermined number of the trajectories are identical. Simplified representations of the trajectories are generated based on the identified common route elements.

Abstract: Described herein are liquid, organosilicon compounds that including a substituent that is a cyano (—CN), cyanate (—OCN), isocyanate (—NCO), thiocyanate (—SCN) or isothiocyanate (—NCS). The organosilicon compounds are useful in electrolyte compositions and can be used in any electrochemical device where electrolytes are conventionally used.

Abstract: An example system can include a server that includes or is associated with a keyword recommendation module. The keyword recommendation module can be configured to select keywords for a search engine for use in a search engine marketing campaign, wherein the search engine provides more traffic to Internet content of a publisher than other search engines, for the keywords. The module can also be configured to determine, per keyword, user engagement with the Internet content resulting from the traffic provided by the search engine for the keywords, according to one or more of time spent viewing the Internet content, page views of the Internet content, and dwell times. The module can also be configured to score, per keyword, the keywords according to the determined user engagement with the Internet content, and generate keyword recommendations according to the scoring of the keywords.

Abstract: A fan and a motor drive device thereof are provided. The motor drive device is configured to drive a motor and includes a control management unit and a voltage converter. The control management unit classifies target rotation speed signals provided by an ECU into multiple rotation speed ranges, each corresponding to a specific output duty ratio. The control management unit receives a target rotation speed signal transmitted from the ECU in a real-time manner, and output a voltage regulating signal, which is a pulse width modulation signal having a duty ratio corresponding to one of the rotation speed ranges in which the target rotation speed signal transmitted from the ECU falls. The voltage converter is connected between a power source and the motor, and is configured to regulate a voltage outputted to the motor in response to the voltage regulating signal having the specific duty ratio outputted from the control management unit, to regulate a rotation speed of the motor.

Abstract: Described are compounds of the structure R4—a—Si—(Sp-Y)a—Zb, wherein “a” is integer from 1 to 4; “b” is an integer from 0 to (3×a); “Z,” which is absent when “b”“R” or formula (II), wherein each “R” is halogen, C1-6 linear or branched alkyl, alkenyl, or alkynyl or C1-6 linear or branched halo-alkyl, halo-alkenyl, or halo-alkynyl; each “Sp” C1-15 linear or branched alkylenyl or CMS linear or branched halo-alkylenyl; and each “Y” an organic polar group. Also described are electrolyte compositions containing one or more of these compounds.

Abstract: An example system can include a server that includes or is associated with a keyword recommendation module. The keyword recommendation module can be configured to select keywords for a search engine for use in a search engine marketing campaign, wherein the search engine provides more traffic to Internet content of a publisher than other search engines, for the keywords. The module can also be configured to determine, per keyword, user engagement with the Internet content resulting from the traffic provided by the search engine for the keywords, according to one or more of time spent viewing the Internet content, page views of the Internet content, and dwell times. The module can also be configured to score, per keyword, the keywords according to the determined user engagement with the Internet content, and generate keyword recommendations according to the scoring of the keywords.