Abstract: Provided are an ovary-targeting polypeptide, a derivative of the polypeptide, and the use of the polypeptide in the preparation of a drug or reagent for treating ovarian related reproductive diseases and preventing and treating the in-vivo or in-vitro aging of oocytes. The diseases comprise menstrual cycle disorder, polycystic ovary syndrome, androgenic phenotype, hair loss, abnormal metabolism, ovarian insufficiency, premature ovarian failure, ovulation failure, abnormal glucose metabolism, and abnormal lipid metabolism, preferably, hyperglycemia and insulin resistance. In addition, the polypeptide is expected to prolong the preservation time and improve the preservation quality of oocytes or fertilized eggs in the field of assisted reproduction.

Abstract: Provided is a liquid crystal handwriting panel. The liquid crystal handwriting panel includes: a first substrate and a second substrate that are opposite to each other, and a liquid crystal layer between the first substrate and the second substrate; wherein the first substrate includes: a first base substrate, a touch electrode layer on a side of the first base substrate, and a first drive electrode layer on a side of the first base substrate; the second substrate includes: a second base substrate, a second drive electrode layer on a side of the second base substrate, and a shielding layer on a side of the second base substrate.

Abstract: A liquid crystal handwriting board is provided. The liquid crystal handwriting board includes a first substrate and a second substrate that are disposed opposite to each other, and a liquid crystal layer disposed between the first substrate and the second substrate; wherein the first substrate includes: a first base substrate, and a transistor and a pixel electrode disposed at a side, proximal to the second substrate, of the first base substrate, the transistor being electrically connected to the pixel electrode; wherein the transistor includes a channel region, wherein a ratio of an area of the channel region to an on-current of the transistor is greater than a ratio of an area of a channel region of a reference transistor to an on-current of the reference transistor.

Abstract: There are provided systems and methods for classifying a substructure in graph data using textual descriptions derived from the graph data and hash maps generated from the textual descriptions. One or more descriptions that describe a plurality of transactions are generated based on a sequence of nodes in a set of nodes identified in a corresponding transaction of the plurality of transactions. The set of nodes represents features of the corresponding transaction. A plurality of instances is identified from the descriptions, and each instance may include a substructure including two or more nodes connected via at least one edge. For each instance, a key and a value are generated based on a hash for the instance to generate a hash map. A specific transaction is classified as an abnormal transaction based on a particular key that is excluded from the hash map.

Abstract: The present disclosure is related to systems and methods for processing X-ray images. A method for processing an X-ray image may include obtaining an X-ray image; and determining a metal image based on the X-ray image by using a trained metal detection model. The metal image includes information of a metal object in the X-ray image.

Abstract: A method for preparing a supercritical fluid by deep-sea pressure is provided and belongs to the technical field of supercritical fluid preparation. The method includes the following steps of: placing a low-pressure fluid in a closed flexible container, sending the closed flexible container down to a location of a sea at a depth where a seawater pressure meets a requirement by using a powered or unpowered traction device, leaving the flexible container standing still until a volume of the flexible container does not change, wrapping the closed flexible container with a rigid pressure-bearing container, transferring the closed flexible container to the sea surface by the powered or unpowered traction device, and taking out the fluid in the flexible container as supercritical fluid. Then the supercritical fluid is produced. Therefore, the process of preparing supercritical (high pressure) liquid in the deep-sea is safer and more stable than the preparation way on land.

Abstract: A magnetic confinement fusion reactor includes a host hall, and a host including a Dewar system, a cold shield system, a superconducting magnet system, a vacuum chamber system, a divertor system, a blanket system, a remote operation system, and a maintenance system. The superconducting magnet system includes a central solenoid magnet, a poloidal field magnet, and a toroidal field magnet. The central solenoid magnet is configured to provide necessary volt-seconds. The poloidal field magnet is configured to generate a poloidal magnetic field. The toroidal field magnet is configured to generate a toroidal magnetic field. The plasma is confined by the toroidal magnetic field and the poloidal magnetic field. The vacuum chamber system is provided with a neutron shielding block to protect the superconducting magnets from being damaged by fusion neutrons.

Abstract: A magnetic confinement fusion reactor includes a host hall, and a host including a Dewar system, a cold shield system, a superconducting magnet system, a vacuum chamber system, a divertor system, a blanket system, a remote operation system, and a maintenance system. The superconducting magnet system includes a central solenoid magnet, a poloidal field magnet, and a toroidal field magnet. The central solenoid magnet is configured to provide necessary volt-seconds. The poloidal field magnet is configured to generate a poloidal magnetic field. The toroidal field magnet is configured to generate a toroidal magnetic field. The plasma is confined by the toroidal magnetic field and the poloidal magnetic field. The vacuum chamber system is provided with a neutron shielding block to protect the superconducting magnets from being damaged by fusion neutrons.

Abstract: The present invention relates to crystalline forms I and II of the compound 2-N-4,6-di-O-tributyryl-D-glucosamine, preparation methods and uses thereof, wherein the crystalline forms I and II obtained from the present invention have high water solubility, crystalline stability and can be better applied in pharmacy.

Abstract: The disclosure relates to bifunctional KRAS-modulating compounds having the structure K-L-T, where K is a targeting group that binds specifically to a KRAS protein (mutant or wild-type), T is an E3-ligase binding group, and L is absent or is a bivalent linking group that connects K and T together via a covalent linkage. Compounds and pharmaceutical compositions thereof can promote degradation of KRAS protein (mutant or wild-type) in a cell and are thus useful for treating, inhibiting, and preventing KRAS-associated diseases, disorders and conditions, including cancers.

Abstract: The disclosure relates to KRAS inhibitor compounds having the structure of Formula (I), pharmaceutical compositions thereof, and methods of use thereof for inhibiting, treating, and/or preventing KRAS-associated diseases, disorders and conditions.

Abstract: The disclosure relates to KRASG12D inhibitor compounds having the structure of Formula (A) or Formula (B), pharmaceutical compositions thereof, and methods of use thereof for inhibiting, treating, and/or preventing KRASG12D mutation-associated diseases, disorders and conditions.

Abstract: The disclosure relates to bifunctional KRAS-G12D-modulating compounds having the structure W-L-T, where W is a targeting group that binds specifically to KRAS-G12D protein, T is an E3-ligase binding group, and L is absent or is a bivalent linking group that connects W and T together via a covalent linkage. Compounds and pharmaceutical compositions thereof can promote degradation of the KRAS-G12D protein in a cell and are thus useful for treating, inhibiting, and preventing KRAS-G12D-associated diseases, disorders and conditions, including cancers.

Abstract: The disclosure relates to bifunctional CDK-modulating compounds having the structure W-L-T, where W is a targeting group that binds specifically to a CDK protein, T is an E3-ligase binding group, and L is absent or is a bivalent linking group that connects W and T together via a covalent linkage. Compounds and pharmaceutical compositions thereof can promote degradation of one or more CDK protein in a cell and are thus useful for treating, inhibiting, and preventing CDK-associated diseases, disorders and conditions, including cancers.

Abstract: A powder injection of a donepezil semi palmoxiric acid salt, a composition containing the same and a preparation method therefor. The powder injection contains donepezil semi palmoxiric acid salt crystals having an average particle size of 2-52 ?m.

Abstract: Disclosed is a salt form of an isoquinolinone type compound as a ROCK protein kinase inhibitor and a preparation method therefor, and use of the salt form in the preparation of a medicament for treating glaucoma or ocular hypertension is further included.

Abstract: The disclosure relates to bifunctional KRAS-G12D-modulating compounds having the structure W-L-T, where W is a targeting group that binds specifically to KRAS-G12D protein, T is an E3-ligase binding group, and L is absent or is a bivalent linking group that connects W and T together via a covalent linkage. Compounds and pharmaceutical compositions thereof can promote degradation of the KRAS-G12D protein in a cell and are thus useful for treating, inhibiting, and preventing KRAS-G12D-associated diseases, disorders and conditions, including cancers.

Abstract: The disclosure uses the Carter's coefficient to correct the equivalent electromagnetic air gap length. And the specific permeance on both sides of the primary core is obtained. Then, the permeance on both sides based on the structure of the primary core is calculated. An equation is established by using the continuity principle of flux, thereby obtaining the air gap magnetomotive force model of current-carrying conductor. The slot vector diagram of magnetomotive force in short primary linear machine is illustrated according to that in the rotating machine. Then, based on the winding arrangement and vector combination, the amplitude and phase of various spatial harmonic wave of the three-phase winding are obtained. Finally, the characteristics of average component distribution of the current-carrying conductor are adopted to obtain the pulsating magnetomotive force generated by the three-phase winding of the linear machine.

Abstract: Related are a JAK kinase inhibitor, a preparation method for same, and applications thereof in the field of medicine, related to the field of medicinal chemistry. Provided is a novel small molecule JAK inhibitor, which has the structure as represented by formula (II). The compound provides improved efficacy and safeness in preventing or treating a JAK-related indication.

Abstract: The disclosure uses the Carter's coefficient to correct the equivalent electromagnetic air gap length. And the specific permeance on both sides of the primary core is obtained. Then, the permeance on both sides based on the structure of the primary core is calculated. An equation is established by using the continuity principle of flux, thereby obtaining the air gap magnetomotive force model of current-carrying conductor. The slot vector diagram of magnetomotive force in short primary linear machine is illustrated according to that in the rotating machine. Then, based on the winding arrangement and vector combination, the amplitude and phase of various spatial harmonic wave of the three-phase winding are obtained. Finally, the characteristics of average component distribution of the current-carrying conductor are adopted to obtain the pulsating magnetomotive force generated by the three-phase winding of the linear machine.