Abstract: Provided are methods and compositions for preparing a library of target nucleic acid sequences that are useful for assessing gene mutations for oncology biomarker profiling of samples. In particular, a target-specific primer panel is provided that allows for selective amplification of oncology biomarker target sequences in a sample. In one aspect, the invention relates to target-specific primers useful for selective amplification of one or more target sequences associated with oncology biomarkers from two or more sample types. In some aspects, amplified target sequences obtained using the disclosed methods, and compositions can be used in various processes including nucleic acid sequencing and used to detect the presence of genetic variants of one or more targeted sequences associated with oncology.

Abstract: A method for detecting a gene fusion includes amplifying a nucleic acid sample in the presence of primer pool to produce a plurality of amplicons. The primer pool includes primers targeting a plurality of exon-exon junctions of a driver gene. The amplicons correspond to the exon-exon junctions. The amplicons are sequenced and aligned to a reference sequence. The number of reads corresponding to each amplicon is normalized to give a normalized read count. A baseline correction is applied to the normalized read counts for the amplicons to form corrected read counts. A binary segmentation score is calculated for each corrected read count. A predicted breakpoint for the gene fusion is determined based on the amplicon index corresponding to the maximum absolute binary segmentation score. Gene fusion events may be detected in a partner agnostic manner, i.e. without prior knowledge of the specific fusion partner genes or specific breakpoint information.

Abstract: Provided herein are methods and related devices for preprocessing a biological sample during transit. The method may comprise the steps of: storing a biological sample in a storage container having walls that defines a storage volume; transporting the storage container with the stored biological sample to a sample processing facility; controlling one or more storage container parameters during the transporting step to initiate preprocessing of the biological sample; wherein the controlling step improves a processing parameter at the sample processing facility.

Abstract: A method includes: receiving, at a first layer of a protocol stack, multiple code blocks from a base station, the multiple code blocks is a portion of a transport block and is associated with an error rate; transmitting, to a second layer of the protocol stack, the multiple code blocks; and determining, at the second layer and based on the error rate, whether to (1) store the multiple code blocks in memory or (2) process the multiple code blocks. A method for saving power in a physical (PHY) layer-to-medium access (MAC) layer interface and a network device, and a system are also provided.

Abstract: A method for detecting a gene fusion includes amplifying a nucleic acid sample in the presence of primer pool to produce a plurality of amplicons. The primer pool includes primers targeting a plurality of exon-exon junctions of a driver gene. The amplicons correspond to the exon-exon junctions. The amplicons are sequenced and aligned to a reference sequence. The number of reads corresponding to each amplicon is normalized to give a normalized read count. A baseline correction is applied to the normalized read counts for the amplicons to form corrected read counts. A binary segmentation score is calculated for each corrected read count. A predicted breakpoint for the gene fusion is determined based on the amplicon index corresponding to the maximum absolute binary segmentation score. Gene fusion events may be detected in a partner agnostic manner, i.e. without prior knowledge of the specific fusion partner genes or specific breakpoint information.

Abstract: A superconducting magnet may include magnet coils including at least one group of outer coils and at least one group of inner coils, a container including an accommodating space, at least one first chamber that is disposed within the accommodating space and houses the at least one group of the inner coils, and at least one second chamber that is disposed within the accommodating space and houses the at least one group of the outer coils. The at least one first chamber and the at least one second chamber may be configured to be filled with a cooling medium and are in fluid communication with each other. The cooling medium may be configured to cool the magnet coils to a superconducting state.

Abstract: The present disclosure may provide a system. The system may include a magnetic resonance imaging (MRI) device configured to perform an imaging of a subject. The MRI device may includes a cryostat. The cryostat may include a first cooling chamber and a second cooling chamber that are in fluid communication through a connection conduit. The connection conduit may be located on a side of a central axis of the first cooling chamber or a central axis of the second cooling chamber. The system may include a radiation source configured to emit a radiation beam toward the subject. The radiation source may be positioned between the first cooling chamber and the second cooling chamber such that the first cooling chamber and the second cooling chamber are outside of a radiation range of the radiation beam.

Abstract: Introduced here is at least one technique to better estimate interference at a receiver. The technique includes receiving a plurality of reference signals, which each have information indicative of noise. Thus, the technique further includes, for each reference signal, determining a noise estimation and determining a distance metric and log-likelihood ratio (LLR) of the noise estimation. Once the distance metric and LLR of each reference signal is determined, the receiver can determine a final LLR based on the distance metric and LLR of each reference signal. In this manner, a final LLR is determined. This technique can be applied by any device operating on MIMO technology.

Abstract: According to one aspect of the present disclosure, a baseband chip may be configured to receive a data stream associated with a channel. The baseband chip may be configured to select a first anchor point from the first constellation points of the first transmission layer. The baseband chip may be configured to select a first subset of constellation points from the first constellation points and the second constellation points. The baseband chip may be configured to perform a first iteration of a recursive tree search. The baseband chip may be configured to determine a first path metric based at least in part on the first iteration of the recursive tree search operation. The baseband chip may be configured to select a second anchor point from the second constellation points of the second transmission layer. The second anchor point may be associated with a second iteration of the recursive tree search.

Abstract: A superconducting magnet may include magnet coils including at least one group of outer coils and at least one group of inner coils, a container including an accommodating space, at least one first chamber that is disposed within the accommodating space and houses the at least one group of the inner coils, and at least one second chamber that is disposed within the accommodating space and houses the at least one group of the outer coils. The at least one first chamber and the at least one second chamber may be configured to be filled with a cooling medium and are in fluid communication with each other. The cooling medium may be configured to cool the magnet coils to a superconducting state.

Abstract: Provided are vertical flow detection devices and related methods. The devices may comprise a membrane having a first surface and a second surface with a plurality of porous structures extending between the first and second surfaces to form fluid conduits from a first fluid chamber formed by the first surface and a second fluid chamber formed by the second fluid surface. A capture agent is immobilized on and/or in the membrane. A rigid porous membrane support mechanically supports the membrane and to provide a relatively uniform flow across the membrane. Various gaskets or holder elements are positioned around an outer edge of the membrane to prevent fluid leakage around the membrane. A fluid pump is configured to force a fluid sample flow in a direction from the first fluid chamber to the second fluid chamber.

Abstract: A communication device is provided that includes a receiver configured to receive a radio frequency signal. The communication device further includes a processor configured to determine a shift frequency based on a component radio frequency signal. The processor is configured to determine a second signal based on the radio frequency signal. The component radio frequency signal is based on the radio frequency signal and associated with a frequency related to the radio frequency signal represented in the frequency domain. The second signal is determined based on shifting frequencies related to the radio frequency signal represented in the frequency domain by the shift frequency.

Abstract: Introduced here are techniques for reducing the latency at a terminal device. In particular, for reducing the latency of detecting the downlink control information (DCI) in a downlink signal such as the physical downlink control channel (PDCCH) signal. The techniques include determining a probability of each aggregation level of the control channel elements (CCE) in a signal carrying the DCI. The probability can be based on the packet error rate (PER) of the signal. The PER can vary based on factors such as the signal to noise ratio (SNR) and/or the fading measurements. Further, the probability can depend on the reception history of the terminal device. Based on these factors, the terminal device can decode the CCEs in an order indicative of the probability of the corresponding aggregation levels carrying the DCI.

Abstract: A method and system for error checking in a wireless communication are provided. The method includes: receiving a payload; determining a final decoding result of the payload, the final decoding result indicating a start state and an end state; determining whether the end state is identical to the start state based on a state circularity check; and determining to discard the final decoding result based on whether the end state is identical to the start state.

Abstract: A method performed by a receiver of a wireless communications system to reduce the latency of channel estimation. The method includes receiving a data signal and a sequence of reference signals communicated over a wireless communication channel. In response to determining that the data signal is time critical or that a threshold reliability of the channel estimation is not required, the receiver estimates a channel condition of the wireless communication channel based on a portion of the sequence of reference signals. The receiver performs demodulation and decoding of the data signal prior to processing the entirety of the sequence of reference signals. The demodulation and decoding are adapted based on the estimated channel condition of the wireless communication channel.

Abstract: A method includes: receiving, at a first layer of a protocol stack, multiple code blocks from a base station, the multiple code blocks is a portion of a transport block and is associated with an error rate; transmitting, to a second layer of the protocol stack, the multiple code blocks; and determining, at the second layer and based on the error rate, whether to (1) store the multiple code blocks in memory or (2) process the multiple code blocks. A method for saving power in a physical (PHY) layer-to-medium access (MAC) layer interface and a network device, and a system are also provided.

Abstract: The present disclosure relates to a contactor and an operation method thereof. The contactor includes a contact, a control device, a wear indication and reset device, and a memory. The control device generates and stores wear diagnosis alarm information when the contactor is disconnected; generates a switch control signal based on the wear diagnosis alarm information when the contactor is powered on. A switch unit in the wear indication and reset device enters a wear indication state based on the switch control signal, and receives a user's operation to enter a reset state. The control device receives switch state information of the switch unit, and stores it when the contactor is disconnected. When the contactor is powered on, the control device clears the wear diagnosis alarm information based on the received switch state information being the reset state and the switch state information stored being the wear indication state.

Abstract: Introduced here is at least one technique to better estimate interference at a receiver. The technique includes receiving a plurality of reference signals, which each have information indicative of noise. Thus, the technique further includes, for each reference signal, determining a noise estimation and determining a distance metric and log-likelihood ratio (LLR) of the noise estimation. Once the distance metric and LLR of each reference signal is determined, the receiver can determine a final LLR based on the distance metric and LLR of each reference signal. In this manner, a final LLR is determined. This technique can be applied by any device operating on MIMO technology.