Patents by Inventor Jian Hua Gu

Jian Hua Gu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical formulations comprising anti-RANKL antibodies and an aromatic amino acid comprising a phenyl or an indole
    Patent number: 11873343
    Abstract: Disclosed herein are aqueous pharmaceutical formulations comprising denosumab or another human anti-RANKL monoclonal antibody or portion thereof, and characteristics of pH, buffer systems, and amino acid aggregation inhibitors. Also disclosed are presentation of the formulation for use, e.g. in a single-use vial, single-use syringe, or glass container, methods of using the formulations and articles for preventing or treating diseases, and related kits.
    Type: Grant
    Filed: November 18, 2021
    Date of Patent: January 16, 2024
    Assignee: AMGEN INC.
    Inventors: Stephen Robert Brych, Lyanne M. Wong, Jaymille Fallon, Monica Michelle Goss, Jian Hua Gu, Pavan K. Ghattyvenkatakrishna
  • FORMULATIONS OF HUMAN ANTI-RANKL ANTIBODIES, AND METHODS OF USING THE SAME
    Publication number: 20220143181
    Abstract: Disclosed herein are aqueous pharmaceutical formulations comprising denosumab or another human anti-RANKL monoclonal antibody or portion thereof, and characteristics of pH, buffer systems, and amino acid aggregation inhibitors. Also disclosed are presentation of the formulation for use, e.g. in a single-use vial, single-use syringe, or glass container, methods of using the formulations and articles for preventing or treating diseases, and related kits.
    Type: Application
    Filed: November 18, 2021
    Publication date: May 12, 2022
    Applicant: AMGEN INC.
    Inventors: Stephen Robert BRYCH, Lyanne M. WONG, Jaymille FALLON, Monica Michelle GOSS, Jian Hua GU, Pavan K. GHATTYVENKATAKRISHNA
  • Formulations comprising human anti-RANKL monoclonal antibodies, and methods of using the same
    Patent number: 11192952
    Abstract: Disclosed herein are aqueous pharmaceutical formulations comprising denosumab or another human anti-RANKL monoclonal antibody or portion thereof, and characteristics of pH, buffer systems, and amino acid aggregation inhibitors. Also disclosed are presentation of the formulation for use, e.g. in a single-use vial, single-use syringe, or glass container, methods of using the formulations and articles for preventing or treating diseases, and related kits.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: December 7, 2021
    Assignee: Amgen Inc.
    Inventors: Stephen Robert Brych, Lyanne M. Wong, Jaymille Fallon, Monica Michelle Goss, Jian Hua Gu, Pavan Ghattyvenkatakrishna
  • FORMULATIONS OF HUMAN ANTI-RANKL ANTIBODIES, AND METHODS OF USING THE SAME
    Publication number: 20200354463
    Abstract: Disclosed herein are aqueous pharmaceutical formulations comprising denosumab or another human anti-RANKL monoclonal antibody or portion thereof, and characteristics of pH, buffer systems, and amino acid aggregation inhibitors. Also disclosed are presentation of the formulation for use, e.g. in a single-use vial, single-use syringe, or glass container, methods of using the formulations and articles for preventing or treating diseases, and related kits.
    Type: Application
    Filed: April 27, 2018
    Publication date: November 12, 2020
    Inventors: Stephen Robert Brych, Lyanne M. Wong, Jaymille Fallon, Monica Michelle Goss, Jian Hua Gu, Pavan Ghattyvenkatakrishna
  • EXCIPIENTS TO REDUCE THE VISCOSITY OF ANTIBODY FORMULATIONS AND FORMULATION COMPOSITIONS
    Publication number: 20200352857
    Abstract: This invention concerns a series of excipients capable of effectively reducing the viscosity of protein formulations. The viscosity reducing excipients are oligopeptides (e.g., dipeptides, tripeptides) comprising at least one arginine. The peptides may also include basic or acidic or hydrophilic or hydrophobic/aromatic amino acids. An arginine residue may be either at the amino or the carboxyl end of the oligopeptide.
    Type: Application
    Filed: April 24, 2018
    Publication date: November 12, 2020
    Applicant: AMGEN INC.
    Inventors: Jian Hua GU, Robert Matthew FESINMEYER, Rulin QIAN
  • Sustained release formulations
    Patent number: 7732399
    Abstract: The present invention relates broadly to the field of sustained release formulations. More specifically, the invention describes compositions and methods relating to formulating proteins and/or peptides with purified gallic acid esters. In one example, the gallic acid ester is PentaGalloylGlucose (PGG) and in anther example the gallic acid ester is epigallocatechin gallate (EGCG).
    Type: Grant
    Filed: August 30, 2007
    Date of Patent: June 8, 2010
    Assignee: Amgen Inc.
    Inventors: Merrill S. Goldenberg, Jian Hua Gu
  • Sustained release formulations
    Patent number: 7323169
    Abstract: The present invention relates broadly to the field of sustained release formulations. More specifically, the invention describes compositions and methods relating to formulating proteins and/or peptides with purified gallic acid esters. In one example, the gallic acid ester is PentaGalloylGlucose (PGG) and in anther example the gallic acid ester is epigallocatechin gallate (EGCG).
    Type: Grant
    Filed: April 25, 2005
    Date of Patent: January 29, 2008
    Assignee: Amgen Inc.
    Inventors: Merrill S. Goldenberg, Jian Hua Gu
  • Liquid-cooled heat sink assembly
    Patent number: 7224585
    Abstract: A liquid-cooled heat sink assembly for cooling down an electronic component includes a main body (20) defining a central chamber (21) therein and having a number of fins (22) on an outside thereof, liquid coolant received in the central chamber, a first fan (40) received in the central chamber, and a second fan (60) positioned over the main body and engaged with the first fan. The heat sink assembly couples forced liquid cooling and forced airflow cooling, and need not extra pipes to form a circuit for the liquid coolant. Thus, not only the volume of the heat sink assembly is lessened, but also facilitates matching with electronic components.
    Type: Grant
    Filed: July 27, 2004
    Date of Patent: May 29, 2007
    Assignees: Fu Zhun Precision Ind. (Shenzhen) Co., Ltd., Foxconn Technology Co., Ltd.
    Inventors: Tsung Lung Lee, Dong Wang, Li He, ShengHua Wang, Jian-Hua Gu, Zhi-Gang Liu
  • Liquid-cooled heat sink assembly
    Publication number: 20050024830
    Abstract: A liquid-cooled heat sink assembly for cooling down an electronic component includes a main body (20) defining a central chamber (21) therein and having a number of fins (22) on an outside thereof, liquid coolant received in the central chamber, a first fan (40) received in the central chamber, and a second fan (60) positioned over the main body and engaged with the first fan. The heat sink assembly couples forced liquid cooling and forced airflow cooling, and need not extra pipes to form a circuit for the liquid coolant. Thus, not only the volume of the heat sink assembly is lessened, but also facilitates matching with electronic components.
    Type: Application
    Filed: July 27, 2004
    Publication date: February 3, 2005
    Inventors: Tsung Lee, Dong Wang, Li He, ShengHua Wang, Jian-Hua Gu, Zhi-Gang Liu
  • Sustained-release delayed gels
    Publication number: 20030072803
    Abstract: The present invention relates to sustained-release formulations using alginate delayed gels and methods thereof.
    Type: Application
    Filed: November 20, 2002
    Publication date: April 17, 2003
    Applicant: Amgen Inc.
    Inventors: Merrill Seymour Goldenberg, Alice C. Beekman, Jian Hua Gu
  • Biodegradable sustained-release alginate gels
    Publication number: 20020168406
    Abstract: The present invention relates to sustained-release formulations using biodegradable alginate delayed gels or particles and methods thereof.
    Type: Application
    Filed: June 20, 2002
    Publication date: November 14, 2002
    Inventors: Merrill Seymour Goldenberg, Jian Hua Gu
  • Biodegradable sustained-release alginate gels
    Patent number: 6432449
    Abstract: The present invention relates to sustained-release formulations using biodegradable alginate delayed gels or particles and methods thereof.
    Type: Grant
    Filed: May 18, 1998
    Date of Patent: August 13, 2002
    Assignee: Amgen Inc.
    Inventors: Merrill Seymour Goldenberg, Jian Hua Gu
  • SUSTAINED-RELEASE DELAYED GELS
    Publication number: 20010007673
    Abstract: The present invention relates to sustained-release formulations using alginate delayed gels and methods thereof.
    Type: Application
    Filed: November 12, 1999
    Publication date: July 12, 2001
    Inventors: MERRILL SEYMOUR GOLDENBERG, ALICE C. BEEKMAN, JIAN HUA GU