Abstract: The present disclosure provides a kit for detecting an anti-vinculin-immunoglobulin G (IgG) antibody, including the antigen protein vinculin, a solid phase carrier, a labeled antibody, an antigen diluent, a sample dilution buffer, an antibody diluent, a substrate color development reagent, a washing solution, a standard, a positive quality control, and negative quality control. In the present disclosure, the kit can detect the anti-Vinculin-IgG antibody in a sample to be tested by indirect reaction combined with magnetic particle-based chemiluminescence immunoassay. Autoantibodies against the target antigen vinculin are identified in the serum of a patient with autoimmune nephrotic syndrome for the first time, and a detection kit is provided for the autoantibodies. The present disclosure provides a basis for molecular mechanism research and clinical diagnosis and treatment of autoimmune nephrotic syndrome related to vinculin and vinculin-IgG autoantibodies at home and abroad.

Abstract: The present disclosure provides a kit for detecting an anti-proteasome subunit alpha type 1-immunoglobulin G (IgG) antibody, including an antigen protein proteasome subunit alpha type 1, a solid phase carrier, a labeled antibody, an antigen diluent, a sample dilution buffer, an antibody diluent, a substrate color development reagent, a washing solution, a standard, a positive quality control, and a negative quality control. In the present disclosure, the kit is capable of detecting the anti-proteasome subunit alpha type 1-IgG antibody in serum to be tested by indirect reaction combined with magnetic particle-based chemiluminescence immunoassay. Autoantibodies against the target antigen protein proteasome subunit alpha type 1 are identified in the serum of a patient with autoimmune nephrotic syndrome for the first time.

Abstract: Disclosed is a method for preparing compound S-1 (S-1) comprising resolving compound rac-2 (rac-2) with a compound of Formula 3 wherein R1, R4, m and n are as defined in the disclosure.

Abstract: Disclosed are methods for preparing compound S-1 (S-1) from (R)-2-bromobutanoic acid prepared by treating (R)-2-aminobutanoic acid with an alkali metal nitrite compound and hydrobromic acid.

Abstract: Disclosed is a method for preparing compound Formula S-1, comprising resolving compound Formula rac-2 with a compound of Formula 3 wherein R1·R4, m and n are as defined in the disclosure.

Abstract: Described herein are novel methods of synthesizing 2-amino-5-chloro-N,3-dimethylbenzamide. Compounds prepared by the methods disclosed herein are useful for preparation of certain anthranilamide compounds that are of interest as insecticides, such as, for example, the insecticides chlorantraniliprole and cyantraniliprole.

Abstract: The integrated dual-motor controller includes a controller housing, a bus magnetic ring component, an all-in-one module, a control plate, an isolation plate and a drive plate. The bus magnetic ring component, the all-in-one module, the control plate, the isolation plate and the drive plate are all integrated in the controller housing. The integrated dual-motor controller is designed to achieve a high level of integration, and a modular design is used inside to facilitate mounting and reduce the size.

Abstract: Described herein are novel methods of synthesizing Ethyl 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylate.

Abstract: Described herein are novel methods of synthesizing (3-chloro-2-pyridyl)hydrazine. Compounds prepared by the methods disclosed herein are useful for preparation of certain anthranilamide compounds that are of interest as insecticides, such as, for example, the insecticides chlorantraniliprole and cyantraniliprole.

Abstract: Disclosed are an IGBT package heat dissipation structure and a motor controller applying the same. The IGBT package heat dissipation structure includes a heat dissipation substrate body, heat dissipation fins and electrodes respectively fixed on two sides of the heat dissipation substrate body. Each heat dissipation fin is provided with an inner cavity, a wafer, a first DBC layer and a second DBC layer are arranged in the inner cavity, an electrode is extended through the heat dissipation substrate body, and connected with the wafer through the first DBC layer and the second DBC layer.

Abstract: Described herein are novel methods of synthesizing 2-amino-5-chloro-N,3-dimethylbenzamide. Compounds prepared by the methods disclosed herein are useful for preparation of certain anthranilamide compounds that are of interest as insecticides, such as, for example, the insecticides chlorantraniliprole and cyantraniliprole.

Abstract: Described herein are novel methods of synthesizing 5-Bromo-2-(3-chloro-pyridin-2-yl)-2H-pyrazole-3-carboxylic acid from pyrazole or pyrazole derivatives. Also described herein are novel reaction intermediates.

Abstract: The water channel structure for connecting a controller to a motor includes a controller main housing and a motor body that are connected and fastened to each other. A water-cooling plate is fastened in the controller main housing. A water inlet and a water outlet are respectively provided at two ends of the controller main housing. A heat dissipation water channel communicating the water inlet with the water outlet inside the controller main housing is formed in the water-cooling plate. A motor water channel is provided inside the motor body. A transition water joint is provided at the water outlet of the controller main housing. The transition water joint is directly connected to a water inlet of the motor water channel.

Abstract: Disclosed a method for preparing compound of Formula (I) and (II) wherein R1, R2, R3, X and n are as defined in the disclosure.

Abstract: Described herein are novel methods of synthesizing 5-Bromo-2-(3-chloro-pyridin-2-yl)-2H-pyrazole-3-carboxylic acid from pyrazole or pyrazole derivatives. Also described herein are novel reaction intermediates.

Abstract: Described herein are novel methods of synthesizing 5-Bromo-2-(3-chloro-pyridin-2-yl)-2H-pyrazole-3-carboxylic acid from pyrazole or pyrazole derivatives. Also described herein are novel reaction intermediates.

Abstract: Described herein are novel methods of synthesizing 5-Bromo-2-(3-chloro-pyridin-2-yl)-2H-pyrazole-3-carboxylic acid from pyrazole or pyrazole derivatives. Also described herein are novel reaction intermediates.

Abstract: Described herein are novel methods of synthesizing 2-amino-5-chloro-N,3-dimethylbenzamide. Compounds prepared by the methods disclosed herein are useful for preparation of certain anthranilamide compounds that are of interest as insecticides, such as, for example, the insecticides chlorantraniliprole and cyantraniliprole.

Abstract: The integrated dual-motor controller includes a controller housing, a bus magnetic ring component, an all-in-one module, a control plate, an isolation plate and a drive plate. The bus magnetic ring component, the all-in-one module, the control plate, the isolation plate and the drive plate are all integrated in the controller housing. The integrated dual-motor controller is designed to achieve a high level of integration, and a modular design is used inside to facilitate mounting and reduce the size.

Abstract: A water-cooled motor controller includes a capacitor, a water-cooled plate, and a power module stacked in a controller housing. The power module is fixedly connected to the water-cooled plate. The water-cooled plate is provided with a cooling medium flow channel on one side facing the power module, and the other side of the water-cooling plate on which the cooling medium flow channel faces away from the power module side contacts the capacitor through an insulating and thermally conductive material for heat exchange. The water-cooled plate and the controller housing are fixedly connected to each other with a cooling medium passage provided therebetween. A cooling medium flows in from the controller housing, and then flows out of the controller housing after being heat exchanged by the water-cooled plate. The present invention utilizes upper and lower surfaces of the water-cooled plate to dissipate heat from the capacitor and the power module simultaneously.