Patents by Inventor Jian Jeffrey Chen

Jian Jeffrey Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 6-Substituted pyrido-pyrimidines
    Publication number: 20030171584
    Abstract: The present invention provides compounds of the Formula I and II: 1
    Type: Application
    Filed: February 11, 2002
    Publication date: September 11, 2003
    Inventors: Jian Jeffrey Chen, James Patrick Dunn, David Michael Goldstein, Christoph Martin Stahl
  • 7-oxo-pyridopyrimidines (I)
    Publication number: 20030153586
    Abstract: The present invention provides compounds of the formula: 1
    Type: Application
    Filed: August 29, 2002
    Publication date: August 14, 2003
    Applicant: Syntex (U.S.A) LLC
    Inventors: Jian Jeffrey Chen, James Patrick Dunn, David Michael Goldstein, Julie Anne Lim
  • 7-oxo-pyridopyrimidines (II)
    Publication number: 20030144307
    Abstract: The present invention provides compounds of the formula: 1
    Type: Application
    Filed: December 10, 2002
    Publication date: July 31, 2003
    Inventors: Humberto Bartolome Arzeno, Jian Jeffrey Chen, James Patrick Dunn, David Michael Goldstein, Julie Anne Lim
  • 7-oxo-pyridopyrimidines (II)
    Patent number: 6518276
    Abstract: The present invention provides compounds of the formula: wherein R1, R3, and Ar1 are those defined herein, and R2 is —CR′R″—Ra (where R′ and R″ are hydrogen, hydroxyalkyl or alkyl with at least one being alkyl or hydroxyalkyl and Ra is hydroxyalkyl), Rx—S—Ry— (where Rx is alkyl and Ry is alkylene), alkoxy-substituted alkyl, heterocyclylalkyl or C4-C5 cycloalkyl, wherein each of the hydroxy group present in R2 can be independently Ra—C(═O)—O, RaRbN—C(═O)—O, or Ra—S(O)2—O—, wherein Ra and Rb are independently hydrogen, alkyl, aryl, or aralkyl, and methods for preparation and uses thereof.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: February 11, 2003
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Humberto Bartolome Arzeno, Jian Jeffrey Chen, James Patrick Dunn, David Michael Goldstein, Julie Anne Lim
  • 7-oxo-pyridopyrimidines (I)
    Patent number: 6506749
    Abstract: The present invention provides compounds of the formula: wherein R2 is substituted cycloalkyl, heterosubstituted cycloalkyl, heteroalkylsubstituted cycloalkyl, heterosubstituted cycloalkyl-alkyl, optionally substituted heterocyclyl, spiro-substituted cycloalkyl, aralkoxy, alkoxy, -alkylene-S(O)n-alkyl (wherein n is 1 or 2), or —SO2Ar2; and R1, R3, and Ar1 are those defined herein, and methods for preparation and uses thereof.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: January 14, 2003
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Jian Jeffrey Chen, James Patrick Dunn, David Michael Goldstein, Julie Anne Lim
  • Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
    Patent number: 6495699
    Abstract: The present invention is directed to compound of the formula I: wherein R1, R2, R3, R4, R5, X, Y, and are as defined herein. These compounds are useful for inhibiting the activity of a metalloproteinase by contacting the metalloproteinase with an effective amount of the inventive compounds.
    Type: Grant
    Filed: August 6, 2001
    Date of Patent: December 17, 2002
    Assignee: Agouron Pharmaceuticals Inc.
    Inventors: Steven L. Bender, Arlindo L. Castelhano, Wesley K. M. Chong, Melwyn A. Abreo, Roland J. Billedeau, Jian Jeffrey Chen, Judith G. Deal
  • Sulfonamide hydroxamates
    Patent number: 6492394
    Abstract: A compound of the Formula (I): wherein Z, R1, R, and Ar2 are as defined in the specification. This invention also relates to sulfonamide compounds of the Formula (I) that are inhibitors of procollagen C-proteinase, pharmaceutical compositions containing them, methods for their use, and methods for preparing the compounds.
    Type: Grant
    Filed: December 22, 1999
    Date of Patent: December 10, 2002
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Roland Joseph Billledeau, Chris Allen Broka, Jeffrey Allen Campbell, Jian Jeffrey Chen, Sharon Marie Dankwardt, Nancy Delaet, Leslie Ann Robinson, Keith Adrian Murray Walker
  • 7-oxo-pyridopyrimidines (I)
    Publication number: 20020137756
    Abstract: The present invention provides compounds of the formula: 1
    Type: Application
    Filed: August 30, 2001
    Publication date: September 26, 2002
    Inventors: Jian Jeffrey Chen, James Patrick Dunn, David Michael Goldstein, Julie Anne Lim
  • 7-oxo-pyridopyrimidines (II)
    Publication number: 20020055513
    Abstract: The present invention provides compounds of the formula: 1
    Type: Application
    Filed: August 30, 2001
    Publication date: May 9, 2002
    Inventors: Humberto Bartolome Arzeno, Jian Jeffrey Chen, James Patrick Dunn, David Michael Goldstein, Julie Anne Lim
  • Sulfamide-metalloprotease inhibitors
    Patent number: 6376506
    Abstract: This invention relates to sulfamides of formula (I) that are inhibitors of metalloproteases, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Grant
    Filed: December 22, 1999
    Date of Patent: April 23, 2002
    Assignees: Syntex (U.S.A.) LLC, Agouron Pharmaceuticals, Inc.
    Inventors: Chris Allen Broka, Jeffrey Allen Campbell, Arlindo Lucas Castelhano, Jian Jeffrey Chen, Robert Than Hendricks, Michael Joseph Melnick, Keith Adrian Murray Walker
  • Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
    Publication number: 20020019429
    Abstract: The present invention is directed to compound of the formula I: 1
    Type: Application
    Filed: August 6, 2001
    Publication date: February 14, 2002
    Inventors: Steven L. Bender, Arlindo L. Castelhano, Wesley K.M. Chong, Melwyn A. Abreo, Roland J. Billedeau, Jian Jeffrey Chen, Judith G. Deal
  • Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
    Patent number: 6306892
    Abstract: The present invention is directed to compound of the formula I: wherein R1, R2, R3, R4, R 5, X, Y, and are as defined herein. These compounds are useful for inhibiting the activity of a metalloproteinase by contacting the metalloproteinase with an effective amount of the inventive compounds.
    Type: Grant
    Filed: June 21, 2000
    Date of Patent: October 23, 2001
    Assignees: Agouron Pharmaceuticals, Inc., Syntex Inc.
    Inventors: Steven L. Bender, Arlindo L. Castelhano, Wesley K. M. Chong, Melwyn A. Abreo, Roland J. Billedeau, Jian Jeffrey Chen, Judith G. Deal
  • Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
    Patent number: 6174915
    Abstract: The present invention is directed to compound of the formula I: wherein R1, R2, R3, R4, R5, X, Y, and  are as defined herein. These compounds are useful for inhibiting the activity of a metalloproteinase by contacting the metalloproteinase with an effective amount of the inventive compounds.
    Type: Grant
    Filed: May 11, 1999
    Date of Patent: January 16, 2001
    Assignees: Agouron Pharmaceuticals, Inc., Syntex (U.S.A.) Inc.
    Inventors: Steven L. Bender, Arlindo L. Castelhano, Wesley K. M. Chong, Melwyn A. Abreo, Roland J. Billedeau, Jian Jeffrey Chen, Judith G. Deal
  • Sulfamide-metalloprotease inhibitors
    Patent number: 6143744
    Abstract: This invention relates to sulfamides of formula (I) ##STR1## that are inhibitors of metalloproteases, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Grant
    Filed: August 5, 1999
    Date of Patent: November 7, 2000
    Assignees: Syntex (U.S.A.) Inc., Agouron Pharmaceuticals, Inc.
    Inventors: Chris Allen Broka, Jeffrey Allen Campbell, Arlindo Lucas Castelhano, Jian Jeffrey Chen, Robert Than Hendricks, Michael Joseph Melnick, Keith Adrian Murray Walker
  • Sulfamide-metalloprotease inhibitors
    Patent number: 6130220
    Abstract: This invention relates to sulfamides of formula (I) ##STR1## that are inhibitors of metalloproteases, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Grant
    Filed: August 5, 1999
    Date of Patent: October 10, 2000
    Assignees: Syntex (USA) Inc., Agouron Pharmaceuticals, Inc.
    Inventors: Chris Allen Broka, Jeffrey Allen Campbell, Arlindo Lucas Castelhano, Jian Jeffrey Chen, Robert Than Hendricks, Michael Joseph Melnick, Keith Adrian Murray Walker
  • Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
    Patent number: 6008243
    Abstract: The present invention is directed to compound of the formula I: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, X, Y, and ##STR2## are as defined herein. These compounds are useful for inhibiting the activity of a metalloproteinase by contacting the metalloproteinase with an effective amount of the inventive compounds.
    Type: Grant
    Filed: March 25, 1997
    Date of Patent: December 28, 1999
    Assignees: Agouron Pharmaceuticals, Inc., Syntex (U.S.A.), Inc.
    Inventors: Steven L. Bender, Arlindo L. Castelhano, Wesley K. M. Chong, Melwyn A. Abreo, Jian Jeffrey Chen, Judith G. Deal
  • Sulfamide-metalloprotease inhibitors
    Patent number: 5998412
    Abstract: This invention relates to sulfamides of formula (I) ##STR1## that are inhibitors of metalloproteases, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Grant
    Filed: January 21, 1998
    Date of Patent: December 7, 1999
    Assignees: Syntex (U.S.A.) Inc., Agouron Pharmaceuticals, Inc.
    Inventors: Chris Allen Broka, Jeffrey Allen Campbell, Arlindo Lucas Castelhano, Jian Jeffrey Chen, Robert Than Hendricks, Michael Joseph Melnick, Keith Adrian Murray Walker
  • Matrix metalloprotease inhibitors
    Patent number: 5773428
    Abstract: Compounds of formula (I): ##STR1## as single stereoisomers or mixtures thereof and their pharmaceutically acceptable salts inhibit matrix metalloproteases, such as interstitial collagenases, and are useful in the treatment of mammals having disease states alleviated by the inhibition of such matrix metalloproteases, for example arthritic diseases or bone resorption diseases, such as osteoporosis.
    Type: Grant
    Filed: February 5, 1996
    Date of Patent: June 30, 1998
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Arlindo Lucas Castelhano, Teng Jiam Liak, Stephen Horne, Alexander Krantz, Zhengyu Yuan, Jian Jeffrey Chen, Paul David Cannon, Hal Van Wart