Abstract: The disclosure relates to KRASG12D inhibitor compounds having the structure of Formula (A) or Formula (B), pharmaceutical compositions thereof, and methods of use thereof for inhibiting, treating, and/or preventing KRASG12D mutation-associated diseases, disorders and conditions.

Abstract: An approach for fatigue crack detection is described. In one example, a first image of a structure is captured at a first time, and a second image of the structure is captured at a second time. A feature-based image registration is performed to align features of the second image with the first image, and an intensity-based image registration is performed to further align features of the second image with the first image. A registration error map is determined by performing a pixel-by-pixel intensity comparison of the first image and the second image. Additionally, an edge-aware noise reduction process can be performed on the registration error map. The registration error map can be referenced to identify certain fatigue cracks in the structure.

Abstract: Systems and methods including identifying a physical intelligent moving object (IMO), the physical IMO associated with a current location and a service request; creating, from a digital representation template that is based on the service request, a digital representation instance of the physical IMO in a particular edge cloud of a distributed cloud computing environment that is closest to the current location of the physical IMO; in response to creating the digital representation instance, establishing a network connection between the digital representation and the physical IMO using the particular edge cloud; detecting a movement of the physical IMO from coverage of the particular edge cloud; in response to detecting the movement of the physical IMO: identifying a target edge cloud of the distributed cloud computing environment for coverage of the physical IMO; and establishing a network connection between the digital representation and the physical IMO using the target edge cloud.

Abstract: The present disclosure discloses a recombinant varicella-zoster virus (VZV) vaccine, including a fusion protein formed by an amino acid sequence of an extracellular domain of a recombinant glycoprotein gE of a live attenuated VZV strain (OKA strain) gene and an Fc fragment of human immunoglobulin. The present disclosure further provides preparation and use of the fusion protein, a corresponding recombinant gene, a eukaryotic expression vector, etc. The fusion protein of the present disclosure has prominent immunogenicity and can induce the high-level expression of neutralizing antibodies in serum.

Abstract: A transcutaneous nerve stimulation system includes a multifunctional earphone assembly that receives a sound signal from a sound source or other sources (such as a signal generator). An amplifier receiving the sound signal from the sound source or independent signal generator amplifies the sound signal to generate an amplified electrical signal. A stimulator, which includes multiple conductive electrode contacts, is coupled to the amplifier to receive the amplified electrical signal. The electrode contacts may protrude from an earbud/headphone or extend from an adjustable probe arm. The amplified electrical signal is used to apply electrical stimulation while the earphone assembly emits audible sounds according to the sound signal. The combined functionality enhances compliance with treatment regimens involving electrical stimulation of vagus nerves and other regions of a subject.

Abstract: A transcutaneous nerve stimulation system includes a multifunctional earphone assembly that receives a sound signal from a sound source or other sources (such as a signal generator). An amplifier receiving the sound signal from the sound source or independent signal generator amplifies the sound signal to generate an amplified electrical signal. A stimulator, which includes multiple conductive electrode contacts, is coupled to the amplifier to receive the amplified electrical signal. The electrode contacts may protrude from an earbud/headphone or extend from an adjustable probe arm. The amplified electrical signal is used to apply electrical stimulation while the earphone assembly emits audible sounds according to the sound signal. The combined functionality enhances compliance with treatment regimens involving electrical stimulation of vagus nerves and other regions of a subject.

Abstract: Disclosed are a scheduling-free transmission method and apparatus. The method comprises: monitoring a service interaction state to obtain a service requirement evaluation result; determining whether the service requirement evaluation result represents a low service load, and if so, allocating dedicated resources to a terminal, otherwise, allocating shared resources to the terminal; acquiring a transmission result of data transmission carried out by the terminal based on the allocated resources; and based on the transmission result, sending response information to the terminal according to a pre-set dynamic response rule. In this way, a terminal can transmit data by means of dedicated resources when a service load is low, and the terminal transmits data using shared resources when the service load is high, thereby reducing time delays, preventing resource conflicts, and increasing the transmission rate and reliability.

Abstract: Disclosed are a scheduling-free transmission method and apparatus. The method comprises: monitoring a service interaction stale to obtain a service requirement evaluation result; determining whether the service requirement evaluation result represents a low service load, and if so, allocating dedicated resources to a terminal, otherwise, allocating shared resources to the terminal; acquiring a transmission result of data transmission carried out by the terminal based on the allocated resources; and based on the transmission result, sending response information to the terminal according to a pre-set dynamic response rule. In this way, a terminal can transmit data by means of dedicated resources when a service load is low, and the terminal transmits data using shared resources when the service load is high, thereby reducing time delays, preventing resource conflicts, and increasing the transmission rate and reliability.

Abstract: Systems and methods including identifying a physical intelligent moving object (IMO), the physical IMO associated with a current location and a service request; creating, from a digital representation template that is based on the service request, a digital representation instance of the physical IMO in a particular edge cloud of a distributed cloud computing environment that is closest to the current location of the physical IMO; in response to creating the digital representation instance, establishing a network connection between the digital representation and the physical IMO using the particular edge cloud; detecting a movement of the physical IMO from coverage of the particular edge cloud; in response to detecting the movement of the physical IMO: identifying a target edge cloud of the distributed cloud computing environment for coverage of the physical IMO; and establishing a network connection between the digital representation and the physical IMO using the target edge cloud.

Abstract: The present invention relates to a bispecific antibody that binds to human CD19 and CD3, wherein the bispecific antibody is composed of a Fab fragment which specifically recognizes a cell membrane antigen and a single-chain antibody which recognizes a CD3 molecule, where the single-chain antibody which recognizes the CD3 molecule is linked to the C-terminus of the CH1-region peptide fragment of the Fab fragment through a hydrophilic linker peptide-linker; and where the Fab fragment which specifically recognizes a cell membrane antigen contains a Fab structure which specifically recognizes a human CD19 antigen, and the bispecific antibody has the following structure: where the linker peptide-linker is composed of 8-20 hydrophilic amino acids.

Abstract: Disclosed in embodiments of the present invention are an MCS index determination method and base station equipment. The method comprises: calculating, by a base station equipment and according to a first SINR obtained by measuring an SRS signal at time k0, a second SINR of a PUSCH signal; determining, by the base station equipment and according to the second SINR, a first MCS index; and calculating, by the base station equipment and according to the first MCS index and data volume actually required to be transmitted by a user, an actually scheduled PRB amount, and a second MCS index actually used.

Abstract: A transcutaneous nerve stimulation system includes a multifunctional earphone assembly that receives a sound signal from a sound source or other sources (such as a signal generator). An amplifier receiving the sound signal from the sound source or independent signal generator amplifies the sound signal to generate an amplified electrical signal. A stimulator, which includes multiple conductive electrode contacts, is coupled to the amplifier to receive the amplified electrical signal. The electrode contacts may protrude from an earbud/headphone or extend from an adjustable probe arm. The amplified electrical signal is used to apply eleceltrical stimulation while the earphone assembly emits audible sounds according to the sound signal. The combined functionality enhances compliance with treatment regimens involving electrical stimulation of vagus nerves and other regions of a subject.

Abstract: A keyword input by a first user is received by a server. User characteristics are determined using the keyword. A first region is identified that comprises plural second regions. Based at least on location information of users in the first region, quantities of second users in respective second regions are determined that have the user characteristics. Candidate regions are determined from the plural regions based on the quantities of the second users. The candidate regions are provided for presentation to the first user.

Abstract: Disclosed in embodiments of the present invention are an MCS index determination method and base station equipment. The method comprises: calculating, by a base station equipment and according to a first SINR obtained by measuring an SRS signal at time k0, a second SINR of a PUSCH signal; determining, by the base station equipment and according to the second SINR, a first MCS index; and calculating, by the base station equipment and according to the first MCS index and data volume actually required to be transmitted by a user, an actually scheduled PRB amount, and a second MCS index actually used.

Abstract: The present invention discloses a bactericidal composition containing fluazinam. Active ingredients of the bactericidal composition are formed by fluazinam (A) and eugenol (B). The weight ratio of A to that of B is from 1:50 to 100:1. The composition has a significant synergistic effect and a high control effect. The composition is adapted for preventing and curing various diseases of fruits and vegetables, and is particularly adapted for preventing and curing pepper phytophthora blight.

Abstract: In one approach a method for operating an engine including a DPF is provided. The method includes adjusting a post fuel injection amount based on a rate of change of engine torque during DPF regeneration. As one example, the adjusting includes reducing the amount when the rate of change is positive, and increasing the amount when the rate of change is negative. Furthermore, the method may also include delivering exhaust gas to a turbocharger turbine, to an oxidation catalyst, and then a DPF, the adjusting of the post fuel injection further based on thermal inertia of the turbocharger.

Abstract: Methods for monitoring and detecting undesired exotherms which may occur in an exhaust aftertreatment system coupled to a lean burning combustion engine are described. In one particular approach, an undesired exotherm may be indicated based on an expected oxygen depletion along a length of an exhaust aftertreatment system in the direction of exhaust gas flow of exhaust gas. For example, during DPF regeneration, a certain amount of oxygen is expected to be utilized for removing soot. If less oxygen is actually found in the exhaust downstream of the exhaust system, then an undesired exotherm may be present, as unintended reductant may be present in the exhaust and reacting exothermically with oxygen. Various mitigation actions may then be initiated in response to the indication of an undesired exotherm.

Abstract: Methods for monitoring and detecting undesired exotherms which may occur in an exhaust aftertreatment system coupled to a lean burning combustion engine are described. In one particular approach, an undesired exotherm may be indicated based on an expected oxygen depletion along a length of an exhaust aftertreatment system in the direction of exhaust gas flow of exhaust gas. For example, during DPF regeneration, a certain amount of oxygen is expected to be utilized for removing soot. If less oxygen is actually found in the exhaust downstream of the exhaust system, then an undesired exotherm may be present, as unintended reductant may be present in the exhaust and reacting exothermically with oxygen. Various mitigation actions may then be initiated in response to the indication of an undesired exotherm.

Abstract: As such in one approach a method for operating an engine including a DPF is provided. The method including adjusting a post fuel injection amount based on a rate of change of engine torque during DPF regeneration. As one example, the adjusting includes reducing the amount when the rate of change is positive, and increasing the amount when the rate of change is negative. Furthermore, the method may also include delivering exhaust gas to a turbocharger turbine, to an oxidation catalyst, and then a DPF, the adjusting of the post fuel injection further based on thermal inertia of the turbocharger.

Abstract: Methods for monitoring and detecting undesired exotherms which may occur in an exhaust aftertreatment system coupled to a lean burning combustion engine are described. In one particular approach, an undesired exotherm may be indicated based on an expected oxygen depletion along a length of an exhaust aftertreatment system in the direction of exhaust gas flow of exhaust gas. For example, during DPF regeneration, a certain amount of oxygen is expected to be utilized for removing soot. If less oxygen is actually found in the exhaust downstream of the exhaust system, then an undesired exotherm may be present, as unintended reductant may be present in the exhaust and reacting exothermically with oxygen. Various mitigation actions may then be initiated in response to the indication of an undesired exotherm.