Abstract: A culture medium is provided which is capable of establishing expanded potential stem cell (EPSC) lines which resemble naïve or ground state ES cells, but are also able to differentiate into placenta trophoblasts and the embryo proper. Methods are provided using the medium for the in vitro conversion and maintenance of cells, including pluripotent cells into EPSCs.

Abstract: A child safety seat device is provided and includes a child safety seat, a trigger mechanism and a driving portion. The child safety seat is for a child to be seated therein. The child safety seat includes a buckle assembly. The trigger mechanism is switchable between an open state and a closed state. When the buckle assembly is buckled, the driving portion is operated to switch the trigger mechanism from the open state to the closed state. The trigger mechanism of the child safety seat device is switchable between different states by buckling and unbuckling operations of the buckle assembly for preventing a dangerous scenario where the child is left in the car.

Abstract: Heparin compounds and synthetic heparin analogues having short acting anticoagulant activity are provided. Methods of synthesizing such heparin compounds, including chemoenzymatic pathways using sulfotransferase enzymes are provided. Methods of treating subjects in need of anticoagulant activity are provided.

Abstract: An apparatus includes a body defining an aperture. The apparatus also includes an image sensor including an array of sensing elements. The apparatus further includes an ambient light sensor. The image sensor and the ambient light sensor are each arranged to receive radiation from the aperture.

Abstract: An electric bicycle includes a drive unit, a control unit for controlling or regulating the electric bicycle, and a communications unit for transmitting and/or receiving data, wherein the communications unit has a first radio interface for connection to a radio mast. It is proposed that the communications unit have a second radio interface for connection to a radio mast.

Abstract: The present disclosure provides a self-driven water collecting surface having a superhydrophilic-superhydrophobic structure, and a method for preparing the same, belonged to the technical field of water harvesting and superhydrophobic surfaces. The water collecting surface is a superhydrophobic surface with the distributed superhydrophilic region. The superhydrophilic region is a venation channel network structure consisting of hierarchical superhydrophilic channels. In the method, a pulsed laser is firstly adopted to form periodically distributed peak-pit microstructures and nanostructures, which is then modified with a low-surface-energy substance. Then, the low-surface-energy substance layer is removed by a pulsed laser again according to a venation channel network pattern. The laser scanned region is superhydrophilic, while the other regions are superhydrophobic. So that, the self-driven water collecting surface with the superhydrophobic-superhydrophilic structure is obtained.

Abstract: Provided herein are small molecule compounds, including non-anticoagulant heparan sulfate oligosaccharide molecules, having anti-inflammatory properties and capable of interacting with high mobility group box 1 (HMGB1) proteins in a manner sufficient to affect an interaction between the HMGB1 protein and a receptor for advanced glycation end products (RAGE). Also provided herein are methods of treating Paracetamol (APAP) overdose in subjects.

Abstract: The present invention is directed to 3-amino pyrrolidine and piperidine macrocyclic compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.

Abstract: An automatic locking device for assembling a part to a workpiece is provided. The device includes a feeding mechanism, a fixture mechanism, a loading and unloading mechanism, a lifting mechanism, a rotating mechanism, and a locking mechanism. The feeding mechanism feeds the part to the fixture mechanism. The loading and unloading mechanism places the workpiece on the part. The lifting mechanism lifts up the fixture mechanism together with the part and the workpiece. The rotating mechanism rotates the fixture mechanism. The locking mechanism locks the part to the workpiece after the part and the workpiece are rotated by the rotating mechanism. The automatic locking device integrates multiple functions in a single station, reduces the number of the work stations and operatives, lowers the cost, and improves accuracy of the assembly. An assembling apparatus including the automatic locking device is also provided.

Abstract: A compound enzyme, comprising L-histidine methylase, halogen methyltransferase and trimethylhistidine sulfurylase. L-histidine is catalyzed by L-histidine methylase and halogen methyltransferase to obtain trimethylhistidine, and then is catalyzed by trimethylhistidine sulfurase to obtain the L-ergothioneine. The method can realize conversion from L-histidine to L-ergothioneine only in two steps. Moreover, SAM enzyme is regenerated, such that the usage amount of the SAM enzyme is greatly reduced. Therefore, the method greatly reduces the raw material cost. Moreover, the method is high in reaction concentration (about 30 g/L), simple in process and good in industrial production prospect.

Abstract: Metal Organic Frameworks (MOFs), methods of using the MOFs for harvesting water from air, and methods of making the MOFs are provided. The water-harvesting MOFs include a metal organic framework molecule having positively charged, linker unsaturated nodes and a net positive electrical charge and charge-compensating anions contained within pores of the metal organic framework molecules. The charge-compensating ions are not anchored to the metal organic framework molecules via coordination bonds and, therefore, are able to move through the porous MOF structure when they are solvated in liquid water contained within the pores.

Abstract: The present invention provides an application of a small-molecule compound in preparation of an antitumor drug. A series of small-molecule drugs with high brain tumor growth activity inhibitory properties are obtained, are docked to pharmacodynamic analysis of the small-molecule drugs, and do not need to be transferred to other testing platforms.

Abstract: Disclosed is a membrane-type metalloprotease inhibitory protein T1Pr?TACE and use thereof, which can be used for preparing drugs targeting MT1-MMP or TACE endonuclease. Also disclosed are an antitumor pharmaceutical composition comprising BHK-21 cells and an artificial basal membrane which expresses T1Pr?TACE protein.

Abstract: The present invention relates to the technical field of biochemistry. Disclosed are a mutant enzyme, the use thereof and a process for preparing a tripeptide by using an enzymatic method. The mutant enzyme comprises: glycine and L-histidine ligase GHS, and tripeptide ligase HKS; or a fusion enzyme of the two. Glycine and L-histidine ligase activity is achieved by means of modifying an Lal enzyme, so as to obtain the GHS enzyme; and the ability for synthesizing dipeptide glycine-L-histidine and L-lysine is achieved by means of using a gshB enzyme, so as to obtain the HKS enzyme. On this basis, the GHS enzyme is further fused with the HKS enzyme by means of using a polypeptide chain, and then a bifunctional enzyme GHKS that links glycine, L-histidine and L-lysine in one step can be constructed, so that a tripeptide is conveniently prepared with a high yield.

Abstract: A polymer having a dispersing function, a preparation method therefor and use thereof as a cement dispersant are provided. The polymer has a structural unit (a), a structural unit (b) and a structural unit (c). The structural unit (a) is provided by an unsaturated polyether, the structural unit (b) is provided by an unsaturated acid and/or a salt thereof and/or an anhydride thereof, and the structural unit (c) is provided by a silane and/or siloxane having a polymerizable group and no less than five carbon atoms. The molar ratio of the structural unit (a), the structural unit (b) and the structural unit (c) is 1:(1-20):(0.01-0.5); and the polymer has a weight average molecular weight of 20,000-90,000 g/mol.

Abstract: The present invention is directed to macrocyclic urea compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.

Abstract: Methods, apparatus, computer program products for tracking sensitive data are provided. A method for tracking sensitive data comprises identifying, by one or more processing units, for a type of sensitive data, at least one key interface that carries the type of sensitive data and recording the at least one key interface. The method further comprises generating, by one or more processing units, for the type of sensitive data, for each type of sensitive data, a series of service nodes based on the at least one key interface, and monitoring, by one or more processing units, for the type of sensitive data, corresponding data traffic flowing through corresponding series of service nodes, based on the identified at least one key interface.

Abstract: A slider includes: a first coupling section; a second coupling section; and an impedance conversion line, which is connected between the first coupling section and the second coupling section, and includes a series portion and a parallel portion connected in series, wherein the series portion includes only one first connection line, and the parallel portion includes at least two second connection lines connected in parallel.