Abstract: This disclosure relates to methods of treating a copper metabolism-associated disease or disorder, such as Wilson disease (WD). This disclosure also relates to methods of sequestering copper in a subject or of mobilizing copper into plasma in a subject.

Abstract: Provided are an anti-bedsore adjusting and monitoring system and method. The system includes an air pressure determination module, an electric mattress and a visualization module. The air pressure determination module is configured to determine a body mass index according to a height and a weight of a target object, determine a target mattress air pressure according to the body mass index and send the target mattress air pressure to the electric mattress. The electric mattress is configured to perform inflation or deflation processing according to the target mattress air pressure, acquire a pressure value corresponding to each target position and send the pressure value to the visualization module, where the each target position is a position where a corresponding pressure sensor in the electric mattress contacts the target object. The visualization module is configured to determine guidance information corresponding to the pressure value according to the pressure value and display the guidance information.

Abstract: A superconducting quantum computing system includes a control system and a superconducting quantum chip. The superconducting quantum chip includes at least two connection regions and a first central exchange region. Each of the at least two connection regions includes a first suspended superconducting bit and at least one superconducting bit. The first central exchange region includes the first suspended superconducting bit, and is used to transfer a quantum operation between superconducting bits in different connection regions. A control circuit is configured to control a coupling strength between the first suspended superconducting bit and the superconducting bit. Therefore, a single connection region or a central exchange region can be isolated by controlling the coupling strength between the first suspended superconducting bit and the superconducting bit, thereby effectively obtaining a divided subspace.

Abstract: Disclosed are methods of treating a copper metabolism-associated disease or disorder, such as Wilson disease (WD) in a subject, particularly in a subject who is from about 3 years old to less than about 18 years old. Also disclosed are compositions comprising bis-choline tetrathiomolybdate for use in the treatment of a copper metabolism-associated disease or disorder, such as Wilson disease (WD) in a subject, particularly in a subject who is from about 3 years old to less than about 18 years old. Also disclosed are uses of a composition comprising bis-choline tetrathiomolybdate for the manufacture of a medicament for treating a copper metabolism-associated disease or disorder, such as Wilson disease (WD) in a subject, particularly in a subject who is from about 3 years old to less than about 18 years old.

Abstract: Methods, systems and techniques for multivariate time series forecasting are provided. A dataset is obtained that corresponds to a multivariate time series data for a multivariate time series forecasting task. A particular machine learning architecture is used for the forecasting using an artificial neural network and deep learning. The machine learning architecture includes an autoencoder configured and trained on itself moved forward in time to generate autoencoder layers to analyse seasonality and co-variance information of the multivariate input dataset in a future time frame and an autoregressor to generate autoregressor layers to analyse trend information of the multivariate input dataset in a future time frame; and a layer merger for merging the one or more autoregressor layers and one or more autoencoder layers to form a set of merged layers representative of a multivariate time series forecast using the machine learning model in the future time frame.

Abstract: Provided in the embodiments of the present disclosure are an information display method, apparatus, electronic device and storage medium. The method comprises: acquiring audio data of a recommended video of a target object; determining audio clip information of a target audio clip in the recommended video according to the audio data, wherein, the audio clip information comprises identification information and association information, and the target audio clip includes a preset keyword; and when an information acquisition request for the recommended video has been received, sending the audio clip information to a client terminal, such that the client terminal displays the association information if a target video clip corresponding to the target audio clip is played on the client terminal, wherein, the information acquisition request is sent by the client terminal.

Abstract: A lifting column includes a drive unit, a lifting tube, and a transmission assembly. The lifting tube includes a first tube, a second tube, a third tube, a fourth tube, and a fifth tube. The transmission assembly includes a first screw rod, a second screw rod, a third screw rod, and a fourth screw rod. The drive unit is in transmission fit with the first screw rod and drives the first screw rod to rotate. A lower end of the second screw rod has a first nut in transmission with the first screw rod, a lower end of the third screw rod has a second nut in transmission with the second screw rod, a lower end of the fourth screw rod has a third nut in transmission with the third screw rod, and a lower end of the first tube has a fourth nut in transmission with the fourth screw rod.

Abstract: Computational systems and methods are provided to automatically assess residual characteristics of an existing machine learning model to identify and determine suboptimal pockets and augmentation strategies. A computing system, device and method for optimizing a machine learning model for performing predictions is provided. The computing device performs sub-optimal pocket identification on an existing machine learning algorithm by residual analysis to calculate an error. The computing device utilizes the residual as a target for an ensemble tree model and automatically generates a set of interpretable rules from the tree based ensemble model that contribute to the suboptimal pockets. The rules indicating relationships between features and interactions as well as values for the sub-optimal pockets. The computing device determines optimizations for improving the machine learning model based on the interpretable computer-implemented rules.

Abstract: A method for preparing a cementing material by sintering and activating coal gangue is provided. The method includes the following steps: (1) crushing coarse-grained coal gangue to predetermined particle size; (2) fully and evenly mixing the crushed coal gangue, the composite additive and water according to a set proportion, and granulating the obtained mixture; (3) distributing, igniting and exhausting the granulated pellets in the sintering machine to obtain decarburized coal gangue sinter; (4) cooling the decarburized coal gangue sinter in a cooler; (5) crushing and finely grinding the cooled coal gangue sinter to obtain a coal gangue active mixture; and (6) mixing the coal gangue active admixture, the fly ash, the quicklime and the gypsum according to a predetermined ratio, and then carrying out injection moulding, mold removal and curing to obtain the coal gangue-based cementitious material.

Abstract: Provided are a box, a battery, an electrical device, and a method for manufacturing the battery, which belong to the technical field of energy storage devices. The box is applicable to a battery, the battery includes a battery cell, in which the box includes a plurality of box walls, in which the plurality of box walls enclose a first chamber for accommodating the battery cell, and at least one of the box walls is internally provided with a second chamber for accommodating fire-fighting agent, in which the first chamber and the second chamber are configured to be able to communicate with each other when the battery cell is thermal-runaway, so that the fire-fighting agent releases fire-fighting medium into the first chamber. The box, the battery, the electrical device and the method for manufacturing the battery can improve the safety performance of the battery.

Abstract: An electric vehicle includes in-vehicle multimedia set in a rotatable manner, and the rotatable in-vehicle multimedia is used for providing a charge operation interface and a discharge operation interface. The charge and discharge control method includes: receiving a wake-up instruction input by a user, where the wake-up instruction is generated by rotating the in-vehicle multimedia by the user, and the wake-up instruction includes a charge wake-up instruction and a discharge wake-up instruction; waking up the in-vehicle multimedia in a sleep mode according to the wake-up instruction, so that the in-vehicle multimedia correspondingly displays the charge operation interface or the discharge operation interface; receiving a setting instruction input by the user through an operation interface, where the setting instruction includes a charge setting instruction and a discharge setting instruction; and controlling the electric vehicle to execute the setting instruction.

Abstract: A lifting column includes a drive unit, a lifting tube, and a transmission assembly. The lifting tube includes a first tube, a second tube, a third tube, a fourth tube, and a fifth tube. The transmission assembly includes a first screw rod, a second screw rod, a third screw rod, and a fourth screw rod. The drive unit is in transmission fit with the first screw rod and drives the first screw rod to rotate. A lower end of the second screw rod has a first nut in transmission with the first screw rod, a lower end of the third screw rod has a second nut in transmission with the second screw rod, a lower end of the fourth screw rod has a third nut in transmission with the third screw rod, and a lower end of the first tube has a fourth nut in transmission with the fourth screw rod.

Abstract: Example ion trap chips and quantum computing methods are described. One example ion trap chip includes a plurality of first ion traps and a plurality of second ion traps. Each first ion trap is configured to store an operation ion, where two adjacent first ion traps form one ion trap group. Each second ion trap corresponds to one ion trap group. Each second ion trap is configured to perform quantum operations of operation ions stored in a corresponding ion trap group, and each second ion trap is located between two first ion traps in a corresponding ion trap group. Operation ions stored in first ion traps in an ion trap group are transported to a corresponding second ion trap along a straight line.

Abstract: The invention relates to products and methods for treating psoriasis. The products relate to antibodies that inhibit native human IL-23 while sparing IL-12. One example describes a Phase 1, randomized, double-blind, placebo-controlled, ascending single dose study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of an anti-IL-23 antibody (AMG 139) in healthy subjects and subjects with moderate to severe psoriasis.

Abstract: A sliding sleeve opening tool includes an engaging element, a ball seat and a guiding head connected in sequence, as disclosed herein. The engaging element includes at least two elastic pawls uniformly disposed in a circumferential direction and at least one engaging part disposed on an external circumferential surface of an elastic pawl, and the engaging element is further provided with a first fluid channel which runs through the engaging element. The ball seat is provided with a second fluid channel which runs through the ball seat, and within the second fluid channel a taper hole section for bearing a sealing ball is disposed, the second fluid channel being in communication with the first fluid channel. The guiding head is provided with a third fluid channel which runs through the guiding head, and the third fluid channel is in communication with the second fluid channel.

Abstract: The disclosure features methods for treating hypophosphatasia (HPP) in a patient (e.g., an adult having HPP, such as an adult having pediatric-onset HPP, or an adolescent having HPP) exhibiting decreased pyrophosphate (PPi) or pyridoxal 5?-phosphate (PLP) concentrations in, e.g., a plasma sample, physical impairments, or decreased walking ability by administering a soluble alkaline phosphatase (sALP) to the patient.

Abstract: A field-effect-transistor includes forming a fin structure on a substrate, a gate structure formed across each fin structure and covering a portion of top and sidewall surfaces of the fin structure, a first doped layer, made of a first semiconductor material and doped with first doping ions, in each fin structure on one side of the corresponding gate structure, and a second doped layer, made of a second semiconductor material, doped with second doping ions, and having doping properties different from the first doped layer, in each fin structure on another side of the corresponding gate structure.

Abstract: A method for preventing AMR in a human kidney transplant recipient is provided. The method comprises: selecting a deceased donor; selecting a kidney transplant recipient; transplanting the kidney from the donor to the recipient; and administering a therapeutically effective dose of an anti-C5 antibody or fragment thereof to the recipient. The recipient is generally sensitized to the donor. Also provided is a method for treating AMR in a kidney transplant patient. The method comprises: selecting a kidney transplant patient having symptoms of AMR; and administering a therapeutically effective dose of an anti-C5 antibody or fragment thereof to the patient; wherein the dose of the anti-C5 antibody or fragment thereof reduces the symptoms of AMR.

Abstract: A sliding sleeve opening tool includes an engaging element, a ball seat and a guiding head connected in sequence, as disclosed herein. The engaging element includes at least two elastic pawls uniformly disposed in a circumferential direction and at least one engaging part disposed on an external circumferential surface of an elastic pawl, and the engaging element is further provided with a first fluid channel which runs through the engaging element. The ball seat is provided with a second fluid channel which runs through the ball seat, and within the second fluid channel a taper hole section for bearing a sealing ball is disposed, the second fluid channel being in communication with the first fluid channel. The guiding head is provided with a third fluid channel which runs through the guiding head, and the third fluid channel is in communication with the second fluid channel.

Abstract: An electric vehicle includes in-vehicle multimedia set in a rotatable manner, and the rotatable in-vehicle multimedia is used for providing a charge operation interface and a discharge operation interface. The charge and discharge control method includes: receiving a wake-up instruction input by a user, where the wake-up instruction is generated by rotating the in-vehicle multimedia by the user, and the wake-up instruction includes a charge wake-up instruction and a discharge wake-up instruction; waking up the in-vehicle multimedia in a sleep mode according to the wake-up instruction, so that the in-vehicle multimedia correspondingly displays the charge operation interface or the discharge operation interface; receiving a setting instruction input by the user through an operation interface, where the setting instruction includes a charge setting instruction and a discharge setting instruction; and controlling the electric vehicle to execute the setting instruction.