Patents by Inventor Jian Q. Yao
Jian Q. Yao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 10646326Abstract: The present disclosure relates, in some aspects, to orthopaedic implants for securing soft tissue to bone and methods for using the same. One particular implant comprises a first exposed porous surface region, having pores for promoting bone ingrowth, and a second exposed porous surface, having pores for promoting soft tissue ingrowth. At least some of the pores of the first exposed porous surface region may be seeded with osteocytic factors and at least some of the pores of the second exposed porous surface region may be seeded with fibrocytic factors. Such orthopaedic implants can advantageously facilitate regeneration of the soft tissue to bone interface.Type: GrantFiled: September 20, 2017Date of Patent: May 12, 2020Assignee: Zimmer, Inc.Inventors: Tao Jiang, Jian Q. Yao, Hali Wang, Timothy A. Hoeman, Ray Zubok, John Chernosky, Keith A. Roby
-
Patent number: 10167447Abstract: The present disclosure provides tissue supports and methods for preparing a cartilage composition for repairing cartilage defects, which is prepared by expanding and integrating small cartilage tissue pieces derived from donor or engineered tissue. The methods and supports described herein promote cell migration and integration of neighboring tissue pieces in culture to form the cartilage composition. Methods of cartilage repair using the cartilage composition are also described.Type: GrantFiled: June 9, 2014Date of Patent: January 1, 2019Assignee: Zimmer, Inc.Inventors: Jian Q. Yao, Hali Wang
-
Publication number: 20180008399Abstract: The present disclosure relates, in some aspects, to orthopaedic implants for securing soft tissue to bone and methods for using the same. One particular implant comprises a first exposed porous surface region, having pores for promoting bone ingrowth, and a second exposed porous surface, having pores for promoting soft tissue ingrowth. At least some of the pores of the first exposed porous surface region may be seeded with osteocytic factors and at least some of the pores of the second exposed porous surface region may be seeded with fibrocytic factors. Such orthopaedic implants can advantageously facilitate regeneration of the soft tissue to bone interface.Type: ApplicationFiled: September 20, 2017Publication date: January 11, 2018Inventors: Tao Jiang, Jian Q. Yao, Hali Wang, Timothy A. Hoeman, Ray Zubok, John Chernosky, Keith A. Roby
-
Patent number: 9827087Abstract: The present disclosure relates, in some aspects, to orthopedic implants for securing soft tissue to bone and methods for using the same. One particular implant comprises a first exposed porous surface region, having pores for promoting bone ingrowth, and a second exposed porous surface, having pores for promoting soft tissue ingrowth. At least some of the pores of the first exposed porous surface region may be seeded with osteocytic factors and at least some of the pores of the second exposed porous surface region may be seeded with fibrocytic factors. Such orthopedic implants can advantageously facilitate regeneration of the soft tissue to bone interface.Type: GrantFiled: June 1, 2015Date of Patent: November 28, 2017Assignee: Zimmer, Inc.Inventors: Tao Jiang, Jian Q. Yao, Hali Wang, Timothy A. Hoeman, Ray Zubok, John Chernosky, Keith A. Roby
-
Patent number: 9339587Abstract: Compositions and methods for repairing a ruptured connective tissue are disclosed. The composition may include a first biocompatible material to provide a scaffold for connective tissue cell growth and tissue repair. This first biocompatible material may withstand a tensile load of up to 250 N. The composition may also include a second biocompatible material including at least one bioactive agent that can stimulate connective tissue cell growth and tissue repair. The method may include positioning a first end of the first biocompatible material adjacent a first end of a ruptured connective tissue, positioning a second end of the first biocompatible material adjacent a second end of the ruptured connective tissue, and anchoring the first biocompatible material to the first and second tendon ends. The method may alternatively comprise or further include positioning a second biocompatible material between the first and second ends of the ruptured connective tissue.Type: GrantFiled: December 22, 2008Date of Patent: May 17, 2016Assignee: Zimmer Orthobiologics, Inc.Inventors: Hali Wang, Jian Q. Yao
-
Patent number: 9138318Abstract: Implants for repairing tissue defects, such as cartilage tissue defects, and methods of their preparation and use are disclosed. A mold of a tissue defect is prepared by pressing upon the defect a substrate having shape memory, such as aluminum foil. The mold, which has contours substantially conforming to those of the defect, is removed from the defect, and tissue particles are added to the mold ex vivo. A biological carrier such as biocompatible glue is also added to the mold. The combination of tissue particles and the biological carrier thereby form an implant, which retains its shape after separation from the mold. The implant can be transferred to the tissue defect, with contours of the mold matching corresponding contours of the defect.Type: GrantFiled: December 15, 2011Date of Patent: September 22, 2015Assignee: Zimmer, Inc.Inventors: Jian Q. Yao, Ben Walthall, Jizong Gao, Victor Zaporojan
-
Publication number: 20150257871Abstract: The present disclosure relates, in some aspects, to orthopaedic implants for securing soft tissue to bone and methods for using the same. One particular implant comprises a first exposed porous surface region, having pores for promoting bone ingrowth, and a second exposed porous surface, having pores for promoting soft tissue ingrowth. At least some of the pores of the first exposed porous surface region may be seeded with osteocytic factors and at least some of the pores of the second exposed porous surface region may be seeded with fibrocytic factors. Such orthopaedic implants can advantageously facilitate regeneration of the soft tissue to bone interface.Type: ApplicationFiled: June 1, 2015Publication date: September 17, 2015Inventors: Tao Jiang, Jian Q. Yao, Hali Wang, Timothy A. Hoeman, Ray Zubok, John Chernosky, Keith A. Roby
-
Patent number: 9055977Abstract: The present disclosure relates, in some aspects, to orthopaedic implants for securing soft tissue to bone and methods for using the same. One particular implant comprises a first exposed porous surface region, having pores for promoting bone ingrowth, and a second exposed porous surface, having pores for promoting soft tissue ingrowth. At least some of the pores of the first exposed porous surface region may be seeded with osteocytic factors and at least some of the pores of the second exposed porous surface region may be seeded with fibrocytic factors. Such orthopaedic implants can advantageously facilitate regeneration of the soft tissue to bone interface.Type: GrantFiled: November 16, 2012Date of Patent: June 16, 2015Assignee: Zimmer, Inc.Inventors: Tao Jiang, Jian Q. Yao, Hali Wang, Timothy A. Hoeman, Ray Zubok, John Chernosky, Keith A. Roby
-
Publication number: 20140335612Abstract: The present disclosure provides tissue supports and methods for preparing a cartilage composition for repairing cartilage defects, which is prepared by expanding and integrating small cartilage tissue pieces derived from donor or engineered tissue. The methods and supports described herein promote cell migration and integration of neighboring tissue pieces in culture to form the cartilage composition. Methods of cartilage repair using the cartilage composition are also described.Type: ApplicationFiled: June 9, 2014Publication date: November 13, 2014Inventors: Jian Q. Yao, Hali Wang
-
Publication number: 20140178343Abstract: The present disclosure provides tissue supports and methods for preparing a cartilage composition for repairing cartilage defects, which is prepared by expanding and integrating small cartilage tissue pieces derived from donor or engineered tissue. The methods and supports described herein promote cell migration and integration of neighboring tissue pieces in culture to form the cartilage composition. Methods of cartilage repair using the cartilage composition are also described.Type: ApplicationFiled: March 13, 2013Publication date: June 26, 2014Inventors: Jian Q. Yao, Hali Wang
-
Patent number: 8608759Abstract: Medical devices for cutting and suturing biological tissue generally include a shaft and first and second guide members each including a first portion coupled to the shaft at a first location and a second portion coupled to the shaft at a second location. The first portions are movable along the shaft relative to the second portions, and the first and second guide members define an arcuate profile and are configured to flex in response to such movement. When used to cut tissue, the medical device may further include a blade positioned between the first and second guide members. When used to suture tissue, one or more suture guides may be provided on the first guide member for directing a suture needle through tissue proximate the first guide member. Methods of repairing and replacing a meniscus using the medical devices are also provided.Type: GrantFiled: March 21, 2012Date of Patent: December 17, 2013Assignee: Zimmer Orthobiologics, Inc.Inventors: Victor Zaporojan, Jian Q. Yao, Rodney E. Bristol, Hui Liu, Hali Wang, Hai-Qing Xian
-
Publication number: 20130330415Abstract: The invention provides a composition including isolated small living tissue particles, a method of making the tissue particles, and a method of using the composition to ameliorate a tissue defect. The tissue particles are composed of cells and their associated extracellular molecules and are sized, in certain embodiments, to be smaller than about 1 mm. Another aspect of the inventive tissue particles is the large percentage of viable cells. In certain embodiments, the tissue particles are made from cartilage and the composition may also contain additives such as adhesives, solutions, and bioactive agents.Type: ApplicationFiled: July 26, 2013Publication date: December 12, 2013Applicant: Zimmer Orthobiologics, Inc.Inventors: Jian Q. Yao, Victor Zaporojan
-
Patent number: 8497121Abstract: The invention provides a composition including isolated small living tissue particles, a method of making the tissue particles, and a method of using the composition to ameliorate a tissue defect. The tissue particles are composed of cells and their associated extracellular molecules and are sized, in certain embodiments, to be smaller than about 1 mm. Another aspect of the inventive tissue particles is the large percentage of viable cells. In certain embodiments, the tissue particles are made from cartilage and the composition may also contain additives such as adhesives, solutions, and bioactive agents.Type: GrantFiled: March 23, 2012Date of Patent: July 30, 2013Assignee: Zimmer Orthobiologics, Inc.Inventors: Jian Q. Yao, Victor Zaporojan
-
Publication number: 20130131699Abstract: The present disclosure relates, in some aspects, to orthopaedic implants for securing soft tissue to bone and methods for using the same. One particular implant comprises a first exposed porous surface region, having pores for promoting bone ingrowth, and a second exposed porous surface, having pores for promoting soft tissue ingrowth. At least some of the pores of the first exposed porous surface region may be seeded with osteocytic factors and at least some of the pores of the second exposed porous surface region may be seeded with fibrocytic factors. Such orthopaedic implants can advantageously facilitate regeneration of the soft tissue to bone interface.Type: ApplicationFiled: November 16, 2012Publication date: May 23, 2013Applicant: Zimmer, Inc.Inventors: Tao Jiang, Jian Q. Yao, Hali Wang, Timothy A. Hoeman, Ray Zubok, John Chernosky, Keith A. Roby
-
Publication number: 20120183586Abstract: The invention provides a composition including isolated small living tissue particles, a method of making the tissue particles, and a method of using the composition to ameliorate a tissue defect. The tissue particles are composed of cells and their associated extracellular molecules and are sized, in certain embodiments, to be smaller than about 1 mm. Another aspect of the inventive tissue particles is the large percentage of viable cells. In certain embodiments, the tissue particles are made from cartilage and the composition may also contain additives such as adhesives, solutions, and bioactive agents.Type: ApplicationFiled: March 23, 2012Publication date: July 19, 2012Applicant: Zimmer Orthobiologics, Inc.Inventors: Jian Q. Yao, Victor Zaporojan
-
Publication number: 20120179173Abstract: Medical devices for cutting and suturing biological tissue generally include a shaft and first and second guide members each including a first portion coupled to the shaft at a first location and a second portion coupled to the shaft at a second location. The first portions are movable along the shaft relative to the second portions, and the first and second guide members define an arcuate profile and are configured to flex in response to such movement. When used to cut tissue, the medical device may further include a blade positioned between the first and second guide members. When used to suture tissue, one or more suture guides may be provided on the first guide member for directing a suture needle through tissue proximate the first guide member. Methods of repairing and replacing a meniscus using the medical devices are also provided.Type: ApplicationFiled: March 21, 2012Publication date: July 12, 2012Applicant: Zimmer Orthobiologics, Inc.Inventors: Victor Zaporojan, Jian Q. Yao, Rodney Bristol, Hui Liu, Hali Wang, Hai-Qing Xian
-
Publication number: 20120107384Abstract: Implants for repairing tissue defects, such as cartilage tissue defects, and methods of their preparation and use are disclosed. A mold of a tissue defect is prepared by pressing upon the defect a substrate having shape memory, such as aluminum foil. The mold, which has contours substantially conforming to those of the defect, is removed from the defect, and tissue particles are added to the mold ex vivo. A biological carrier such as biocompatible glue is also added to the mold. The combination of tissue particles and the biological carrier thereby form an implant, which retains its shape after separation from the mold. The implant can be transferred to the tissue defect, with contours of the mold matching corresponding contours of the defect.Type: ApplicationFiled: December 15, 2011Publication date: May 3, 2012Applicants: ZIMMER, INC., ISTO TECHNOLOGIES, INC.Inventors: Jian Q. Yao, Ben Walthall, Jizong Gao, Victor Zaporojan
-
Patent number: 8163549Abstract: The invention provides a composition including isolated small living tissue particles, a method of making the tissue particles, and a method of using the composition to ameliorate a tissue defect. The tissue particles are composed of cells and their associated extracellular molecules and are sized, in certain embodiments, to be smaller than about 1 mm. Another aspect of the inventive tissue particles is the large percentage of viable cells. In certain embodiments, the tissue particles are made from cartilage and the composition may also contain additives such as adhesives, solutions, and bioactive agents.Type: GrantFiled: December 20, 2006Date of Patent: April 24, 2012Assignee: Zimmer Orthobiologics, Inc.Inventors: Jian Q Yao, Victor Zaporojan
-
Patent number: 8162961Abstract: Medical devices for cutting and suturing biological tissue generally include a shaft and first and second guide members each including a first portion coupled to the shaft at a first location and a second portion coupled to the shaft at a second location. The first portions are movable along the shaft relative to the second portions, and the first and second guide members define an arcuate profile and are configured to flex in response to such movement. When used to cut tissue, the medical device may further include a blade positioned between the first and second guide members. When used to suture tissue, one or more suture guides may be provided on the first guide member for directing a suture needle through tissue proximate the first guide member. Methods of repairing and replacing a meniscus using the medical devices are also provided.Type: GrantFiled: July 23, 2007Date of Patent: April 24, 2012Assignee: Zimmer Orthobiologies, Inc.Inventors: Victor Zaporojan, Jian Q. Yao, Rodney Bristol, Hui Liu, Hali Wang, Hai-Qing Xian
-
Publication number: 20120020932Abstract: A hydrogel-forming composition is provided that comprises an extracellular matrix protein, hyaluronic acid, and a thermosensitive biocompatible polymer such as methylcellulose. The hydrogels can provide a therapeutic effect; further, the hydrogels may comprise an optional therapeutic agent such as cells or a pharmaceutical composition. The composition may be injected to an area in need of treatment by the therapeutic agent. The composition may form a gel at about 37° C., such that the gel maintains the therapeutic agent in the area of the body in need of such treatment.Type: ApplicationFiled: June 30, 2011Publication date: January 26, 2012Applicant: Zimmer Orthobiologics, Inc.Inventors: Jian Q. Yao, Jizong Gao, Xiao Huang, Archit Sanghvi