Patents by Inventor Jian-Qiang Fan
Jian-Qiang Fan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9937165Abstract: The invention relates to methods of enhancing normal melanocortin-4 receptor (MC4R) activity, and to enhancing activity of an MC4R having a mutation which affects protein folding and/or processing of the MC4R. The invention provides a method of treating an individual having a condition in which increased activity of an MC4R at the cell surface would be beneficial, for example in obesity, by administering an effective amount of a pharmacological chaperone for the MC4R. The invention provides MC4R pharmacological chaperones which enhance the activity of MC4R. The invention further provides a method of screening to identify pharmacological chaperones which enhance folding of an MC4R in the endoplasmic reticulum (ER), in order to enhance the activity of the MC4R at the cell surface.Type: GrantFiled: May 6, 2016Date of Patent: April 10, 2018Assignees: Amicus Therapeutics, Inc., Universite de MontrealInventors: Jian-Qiang Fan, Kenneth Valenzano, Gary Lee, Michel Bouvier, Patricia René
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Publication number: 20180085437Abstract: This application provides methods of improving protein replacement therapy by combining protein replacement therapy with active site-specific chaperones (ASSC) to increase the stability and efficiency of the protein being administered. The application further provides stable compositions comprising the purified protein and an ASSC, and methods of treatment by administering the compositions.Type: ApplicationFiled: August 14, 2017Publication date: March 29, 2018Applicant: Mount Sinai School of Medicine of New York UniversityInventor: Jian-Qiang FAN
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Patent number: 9597377Abstract: This application provides methods of improving protein replacement therapy by combining protein replacement therapy with active site-specific chaperones (ASSC) to increase the stability and efficiency of the protein being administered. The application further provides stable compositions comprising the purified protein and an ASSC, and methods of treatment by administering the compositions.Type: GrantFiled: December 23, 2005Date of Patent: March 21, 2017Assignee: MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITYInventor: Jian-Qiang Fan
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Publication number: 20160346262Abstract: A method of enhancing the activity of lysosomal ?-Galactosidase A (?-Gal A) in mammalian cells and for treatment of Fabry disease by administration of 1-deoxy-galactonojirimycin and related compounds.Type: ApplicationFiled: January 25, 2016Publication date: December 1, 2016Inventors: Jian-Qiang Fan, Satoshi Ishii
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Publication number: 20160287581Abstract: The invention relates to methods of enhancing normal melanocortin-4 receptor (MC4R) activity, and to enhancing activity of an MC4R having a mutation which affects protein folding and/or processing of the MC4R. The invention provides a method of treating an individual having a condition in which increased activity of an MC4R at the cell surface would be beneficial, for example in obesity, by administering an effective amount of a pharmacological chaperone for the MC4R. The invention provides MC4R pharmacological chaperones which enhance the activity of MC4R. The invention further provides a method of screening to identify pharmacological chaperones which enhance folding of an MC4R in the endoplasmic reticulum (ER), in order to enhance the activity of the MC4R at the cell surface.Type: ApplicationFiled: May 6, 2016Publication date: October 6, 2016Inventors: Jian-Qiang Fan, Kenneth Valenzano, Gary Lee, Michel Bouvier, Patricia René
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Patent number: 9381194Abstract: The invention relates to methods of enhancing normal melanocortin-4 receptor (MC4R) activity, and to enhancing activity of an MC4R having a mutation which affects protein folding and/or processing of the MC4R. The invention provides a method of treating an individual having a condition in which increased activity of an MC4R at the cell surface would be beneficial, for example in obesity, by administering an effective amount of a pharmacological chaperone for the MC4R. The invention provides MC4R pharmacological chaperones which enhance the activity of MC4R. The invention further provides a method of screening to identify pharmacological chaperones which enhance folding of an MC4R in the endoplasmic reticulum (ER), in order to enhance the activity of the MC4R at the cell surface.Type: GrantFiled: August 3, 2009Date of Patent: July 5, 2016Assignee: Amicus Therapeutics, Inc.Inventors: Jian-Qiang Fan, Kenneth Valenzano, Gary Lee, Michel Bouvier, Patricia René
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Patent number: 9295670Abstract: The present invention relates to methods for treating obstructive sleep apnea (OSA), alleviating a negative OSA symptom, reducing snoring, or improving quality of life in a subject, comprising administering to the subject an effective amount of a pharmaceutical composition comprising pyridostigmine before sleep. Also provided are related medicaments as well as methods for preparing the medicaments.Type: GrantFiled: May 5, 2014Date of Patent: March 29, 2016Assignee: PFANTASTIC MEDICAL RESEARCH INSTITUTE, LLCInventor: Jian-Qiang Fan
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Patent number: 9265780Abstract: A method of enhancing the activity of lysosomal ?-Galactosidase A (?-Gal A) in mammalian cells and for treatment of Fabry disease by administration of 1-deoxy-galactonojirimycin and related compounds.Type: GrantFiled: December 20, 2013Date of Patent: February 23, 2016Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAIInventors: Jian-Qiang Fan, Satoshi Ishii
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Publication number: 20150258129Abstract: Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method are imino sugars and related compounds. In particular, C8-12-alkyl derivatives of N-alkyl-deoxymojirimycin, isofagomine compounds, and calystegine compounds are effective to enhance glucocerebrosidase activity.Type: ApplicationFiled: August 18, 2014Publication date: September 17, 2015Inventors: Jian-Qiang Fan, Satoshi Ishii, Naoki Asano
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Patent number: 8841322Abstract: Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method are imino sugars and related compounds. In particular, C8-12-alkyl derivatives of N-alkyl-deoxynojirimycin, isofagomine compounds, and calystegine compounds are effective to enhance glucocerebrosidase activity.Type: GrantFiled: April 22, 2013Date of Patent: September 23, 2014Assignee: Mount Sinai School of Medicine of New York UniversityInventors: Jian-Qiang Fan, Satoshi Ishii, Naoki Asano
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Publication number: 20140238412Abstract: The present invention relates to methods for treating obstructive sleep apnea (OSA), alleviating a negative OSA symptom, reducing snoring, or improving quality of life in a subject, comprising administering to the subject an effective amount of a pharmaceutical composition comprising pyridostigmine before sleep. Also provided are related medicaments as well as methods for preparing the medicaments.Type: ApplicationFiled: May 5, 2014Publication date: August 28, 2014Applicant: Pfantastic Medical Research Institute, LLCInventor: Jian-Qiang FAN
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Publication number: 20140206718Abstract: A method of enhancing the activity of lysosomal ?-Galactosidase A (?-Gal A) in mammalian cells and for treatment of Fabry disease by administration of 1-deoxy-galactonojirimycin and related compounds.Type: ApplicationFiled: December 20, 2013Publication date: July 24, 2014Applicant: Mount Sinai School of Medicine of New York UniversityInventors: Jian-Qiang Fan, Satoshi Ishii
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Patent number: 8753327Abstract: The present invention relates to methods for treating obstructive sleep apnea (OSA), alleviating a negative OSA symptom, reducing snoring, or improving quality of life in a subject, comprising administering to the subject an effective amount of a pharmaceutical composition comprising pyridostigmine before sleep. Also provided are related medicaments as well as methods for preparing the medicaments.Type: GrantFiled: January 27, 2012Date of Patent: June 17, 2014Assignee: Pfantastic Medical Research Institute, LLCInventor: Jian-Qiang Fan
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Patent number: 8633221Abstract: A method of enhancing the activity of lysosomal ?-Galactosidase A (?-Gal A) in mammalian cells and for treatment of Fabry disease by administration of 1-deoxy-galactonojirimycin and related compounds.Type: GrantFiled: November 23, 2009Date of Patent: January 21, 2014Assignee: Mount Sinai School of Medicine of New York UniversityInventors: Jian-Qiang Fan, Satoshi Ishii
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Patent number: 8436018Abstract: Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method are imino sugars and related compounds. In particular, C8-12-alkyl derivatives of N-alkyl-deoxynojirimycin, isofagomine compounds, and calystegine compounds are effective to enhance glucocerebrosidase activity.Type: GrantFiled: September 24, 2010Date of Patent: May 7, 2013Assignee: Mount Sinai School of Medicine of New York UniversityInventors: Jian-Qiang Fan, Satoshi Ishii, Naoki Asano
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Publication number: 20120197235Abstract: The present invention relates to methods for treating obstructive sleep apnea (OSA), alleviating a negative OSA symptom, reducing snoring, or improving quality of life in a subject, comprising administering to the subject an effective amount of a pharmaceutical composition comprising pyridostigmine before sleep. Also provided are related medicaments as well as methods for preparing the medicaments.Type: ApplicationFiled: January 27, 2012Publication date: August 2, 2012Inventor: Jian-Qiang FAN
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Publication number: 20110076765Abstract: Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method are imino sugars and related compounds. In particular, C8-12-alkyl derivatives of N-alkyl-deoxynojirimycin, isofagomine compounds, and calystegine compounds are effective to enhance glucocerebrosidase activity.Type: ApplicationFiled: September 24, 2010Publication date: March 31, 2011Applicant: Mount Sinai School of Medicine of New York UniversityInventors: Jian-Qiang Fan, Satoshi Ishii, Naoki Asano
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Patent number: 7812033Abstract: Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method are imino sugars and related compounds. In particular, C8-12-alkyl derivatives of N-alkyl-deoxynojirimycin, isofagomine compounds, and calystegine compoiunds are effective to enhance glucocerebrosidase activity.Type: GrantFiled: September 27, 2006Date of Patent: October 12, 2010Assignee: Mount Sinai School of Medicine of New York UniversityInventors: Jian-Qiang Fan, Satoshi Ishii, Naoki Asano
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Publication number: 20100189708Abstract: The present invention provides novel hydroxy piperidine (HP) derivatives having (i) a positive charge at the position corresponding to the anomeric position of a pyranose ring; (ii) a short, flexible linker emanating from the corresponding position of the ring oxygen in a pyranose; and (iii) a lipophilic moiety connected to the linker and pharmaceutically acceptable salts thereof. The linker can be absent if the lipophilic moiety corresponds to a hydrocarbon chain with a linear length of 6 or more carbons. The present invention further provides a method for treating individuals having Gaucher disease by administering the novel HP derivative as “active-site specific chaperones” for the mutant glucocerebrosidase associated with the disease.Type: ApplicationFiled: April 8, 2010Publication date: July 29, 2010Applicant: AMICUS THERAPEUTICS, INC.Inventors: Jian-Qiang Fan, Xiaoxiang Zhu, Kamlesh Sheth
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Patent number: 7741340Abstract: The present invention provides novel hydroxy piperidine (HP) derivatives having (i) a positive charge at the position corresponding to the anomeric position of a pyranose ring; (ii) a short, flexible linker emanating from the corresponding position of the ring oxygen in a pyranose; and (iii) a lipophilic moiety connected to the linker and pharmaceutically acceptable salts thereof. The linker can be absent if the lipophilic moiety corresponds to a hydrocarbon chain with a linear length of 6 or more carbons. The present invention further provides a method for treating individuals having Gaucher disease by administering the novel HP derivative as “active-site specific chaperones” for the mutant glucocerebrosidase associated with the disease.Type: GrantFiled: November 12, 2004Date of Patent: June 22, 2010Assignee: Amicus Therapeutics, Inc.Inventors: Jian-Qiang Fan, Xiaoxiang Zhu, Kamlesh Sheth