Abstract: Provided herein are proteins that include different combinations of structural and nonstructural proteins from SARS-CoV-2 and MERS-CoV. Also provided are polynucleotides encoding the proteins of the present disclosure. In one embodiment, a polynucleotide encoding a protein is present as a viral vector, such as adenovirus. In one embodiment, a polynucleotide encoding a protein is present as a mRNA. Also provided are methods for using the proteins and polynucleotides of the present disclosure.

Abstract: Provided herein is a genetically modified Y. pestis that includes three alterations compared to a control Y. pestis. Two alterations include decreased mRNA, decreased protein, or a combination thereof, encoded by a lpp coding region and encoded by a msbB coding region. The third alteration is selected from an alteration of an intergenic region between the coding regions ypo1119 and ypo1120, and decreased mRNA, decreased protein, or a combination thereof, encoded by a coding region selected from pla, ypol717, ypmt1.80c, rbsA (ypo2500), ypo0498, vasK (ypo3603), ypo3164, hxuB (ypo3248), ypo1616, ypo1119, ypo1120, and ail. Also provided are compositions that include the genetically modified Y. pestis, and methods of using the genetically modified Y. pestis.

Abstract: Provided herein is a genetically modified Y. pestis that includes three alterations compared to a control Y. pestis. Two alterations include decreased mRNA, decreased protein, or a combination thereof, encoded by a lpp coding region and encoded by a msbB coding region. The third alteration is selected from an alteration of an intergenic region between the coding regions ypo1119 and ypo1120, and decreased mRNA, decreased protein, or a combination thereof, encoded by a coding region selected from pla, ypol717, ypmt1.80c, rbsA (ypo2500), ypo0498, vasK (ypo3603), ypo3164, hxuB (ypo3248), ypo1616, ypo1119, ypo1120, and ail. Also provided are compositions that include the genetically modified Y. pestis, and methods of using the genetically modified Y. pestis.

Abstract: In a method for improving call performance of a mobile device, the strength of received signals is sent to a base station when the mobile device receives signals from the base station. The method obtains a path balance value sent by the base station, and determines whether the path balance value is greater than a predefined threshold value. The path balance value is obtained according to the strength of the received signals of the mobile device and an emission intensity of the mobile device. When the path balance value is greater than the predefined threshold value, the method obtains a transmitting power of the mobile device, and increases the transmitting power of the mobile device according to the path balance value to improve call performance of the mobile device.

Abstract: A dual-mode mobile device comprises two mode systems. If both of two mode systems of the dual-mode mobile device are in a working status, the mobile device uses a first mode system to control a first power amplifier of the first mode system to transmit power signals, informs a second mode system that the first power amplifier is transmitting power signals, and controls the second mode system to enter into a mixed mode. If the second mode system is in a working status and the first mode system is in a required to work status, the mobile device uses the first mode system to inform the second mode system enter into the mixed mode, and controls the first mode system to inform a second power amplifier of the second mode system to transmit power signals causing both of the first and second mode systems to work synchronously.

Abstract: In a method for improving call performance of a mobile device, the strength of received signals is sent to a base station when the mobile device receives signals from the base station. The method obtains a path balance value sent by the base station, and determines whether the path balance value is greater than a predefined threshold value. The path balance value is obtained according to the strength of the received signals of the mobile device and an emission intensity of the mobile device. When the path balance value is greater than the predefined threshold value, the method obtains a transmitting power of the mobile device, and increases the transmitting power of the mobile device according to the path balance value to improve call performance of the mobile device.

Abstract: A dual-mode mobile device comprises two mode systems. If both of two mode systems of the dual-mode mobile device are in a working status, the mobile device uses a first mode system to control a first power amplifier of the first mode system to transmit power signals, informs a second mode system that the first power amplifier is transmitting power signals, and controls the second mode system to enter into a mixed mode. If the second mode system is in a working status and the first mode system is in a required to work status, the mobile device uses the first mode system to inform the second mode system enter into the mixed mode, and controls the first mode system to inform a second power amplifier of the second mode system to transmit power signals causing both of the first and second mode systems to work synchronously.

Abstract: The present invention concerns the use of methods and compositions to prophylactically or therapeutically vaccinate a subject against a pathogen or disease. Embodiments of the invention include the production of an attenuated bacterium from the family Enterobacteriaceae with a non-functional lipoprotein for use as a vaccine or as a vaccine vector for delivering antigens to a subject to be vaccinated. In certain embodiments, a bacterium of the Enterobacteriaceae family lacking a wild type LP, for example Salmonella typhimurium lacking a wild type LP, may be produced and used as a vaccine or vaccine vector.

Abstract: The present invention concerns the use of methods and compositions to prophylactically or therapeutically vaccinate a subject against a pathogen or disease. Embodiments of the invention include the production of an attenuated bacterium from the family Enterobacteriaceae with a non-functional lipoprotein for use as a vaccine or as a vaccine vector for delivering antigens to a subject to be vaccinated. In certain embodiments, a bacterium of the Enterobacteriaceae family lacking a wild type LP, for example Salmonella typhimurium lacking a wild type LP, may be produced and used as a vaccine or vaccine vector.