Abstract: The present disclosure provides an isolated or purified SARS-CoV-2 Receptor Binding Domain (RBD) polypeptide and cells for producing such a polypeptide, as well as compositions and methods thereof.

Abstract: The present disclosure provides virus like nanoparticles (VLPs), which are capable of displaying multiple copies of a SARS-CoV-2 antigen, for eliciting protective immunity against a SARS-CoV-2 infection, as well as polypeptides, compositions and methods thereof.

Abstract: A route navigation method, include: at a first terminal in communication with a second terminal via a navigation server: obtaining a starting point and a destination that are set by a user; displaying, on a navigation interface, the starting point and the destination; drawing, on the navigation interface, route information from the starting point to the destination according to a swipe gesture of the user on the navigation interface; and sending route forwarding instruction to the navigation server, wherein sending the route forwarding instruction includes: sending the route information to the navigation server, wherein the navigation server is configured to determine a navigation path from the starting point to the destination according to the route information, and sending a request for the navigation server to forward the navigation path to the second terminal to prompt another user to arrive at the destination from the starting point in accordance with the navigation path.

Abstract: A route navigation method, include: at a first terminal in communication with a second terminal via a navigation server: obtaining a starting point and a destination that are set by a user; displaying, on a navigation interface, the starting point and the destination; drawing, on the navigation interface, route information from the starting point to the destination according to a swipe gesture of the user on the navigation interface; and sending route forwarding instruction to the navigation server, wherein sending the route forwarding instruction includes: sending the route information to the navigation server, wherein the navigation server is configured to determine a navigation path from the starting point to the destination according to the route information, and sending a request for the navigation server to forward the navigation path to the second terminal to prompt another user to arrive at the destination from the starting point in accordance with the navigation path.

Abstract: The invention affords C2-symmetrical ruthenocene diphosphine ligands with surface chirality and their manufacture. The present invention uses (S)-(S)-1,1?-2(diphenylphosphino)-2,2?-2[(S)-4-isopropyloxazolinyl] ruthenocene as raw material and the product is prepared through two or three steps of reaction. At the action of trifluoroacetic acid, (S)-(S)-1,1?-2(diphenylphosphino)-2,2?-2[(S)-4-isopropyloxazolinyl] ruthenocene first removes oxazoline and gets ester amides compound which then carries out ester exchange or reduction alkylation and gets the product of ruthenocene diphosphine ligand with surface chirality. The ligands prepared with the structure as follows from the invention can be used in all kinds of metallic catalysis asymmetric reaction and has good reaction activity and stereoselectivity, wherein R is methyl or ethyl, R1 is linear or branched alkyl, cycloalkyl, alkoxy, aryl, aralkyl and alkyl amino.

Abstract: The invention affords C2-symmetrical ruthenocene diphosphine ligands with surface chirality and their manufacture. The present invention uses (S)—(S)-1,1?-2(diphenylphosphino)-2,2?-2[(S)-4-isopropyloxazolinyl]ruthenocene as raw material and the product is prepared through two or three steps of reaction. At the action of trifluoroacetic acid, (S)—(S)-1,1?-2(diphenylphosphino)-2,2?-2[(S)-4-isopropyloxazolinyl]ruthenocene first removes oxazoline and gets ester amides compound which then carries out ester exchange or reduction alkylation and gets the product of ruthenocene diphosphine ligand with surface chirality. The ligands prepared with the structure as follows from the invention can be used in all kinds of metallic catalysis asymmetric reaction and has good reaction activity and stereoselectivity, wherein R is methyl or ethyl, R1 is linear or branched alkyl, cycloalkyl, alkoxy, aryl, aralkyl and alkyl amino.

Abstract: A rotary piston internal combustion engine comprises a substantially circular-cylindrical compression space (3) and a substantially circular-cylindrical working space (4), rotary pistons (7, 8) which can rotate together about an axis of the compression space (3) and the working space (4), being disposed in the compression space (3) and the working space (4) are slides (19) which are arranged so as to be movable in the radial direction in order to abut sealingly the surface of the respective rotary piston (7, 8). The periphery of the working space has a first exhaust aperture (26). The working space has further exhaust apertures (27) which can be closed by exhaust valves (15) which can be closed and opened successively by means of an adjusting arrangement (17).