Abstract: Provided herein are compounds of Formula (I), their pharmaceutically acceptable salts, and their pharmaceutical compositions: wherein R1, R2, R3a, R3b, R4, R5, and A are defined in the present disclosure. The compounds are potent inhibitors of the main protease (Mpro) of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), and they are useful in treating or preventing COVID-19 in a subject.

Abstract: A heterogeneous computing terminal for task scheduling is provided, including a processing unit and multiple computing units. The heterogeneous computing terminal generates a task scheduling strategy. The target computing unit acquires a target upgrade program, is upgrade based on the target upgrade program, processes a target task and sends a processing result to the processing unit. The processing unit combines processing results sent by multiple target computing units to obtain a processing result of an initial task set. The heterogeneous computing terminal can upgrade the computing unit online, that is, dynamically update the computing unit, thereby greatly expanding the versatility of the computing unit of hardware. Scheduling strategy adapted to the task can be generated, and the computing unit can dynamically provide better task processing capabilities. The computing efficiency of the heterogeneous computing terminal is improved.

Abstract: The present invention relates to a transdermal photocuring forming hydrogel with biological activity. The hydrogel can release recombinant collagen with biological activity, the recombinant collagen includes a sequence as shown in SEQ ID No. 1, an amino acid sequence of the recombinant collagen includes N basic repetitive units, and each basic repetitive unit includes n1 of the following characteristic amino acid sequences: “G-Xaa1-Xaa2-G-E-Xaa3”; the 3? end and the 5? end of the basic repetitive unit are connected to form the above characteristic amino acid sequence. The recombinant collagen provided by the present invention has relatively obvious integrin binding activity, and has the effects of promoting cell adhesion, proliferation and differentiation. The hydrogel of the present invention has good biocompatibility and stable quality, which can be cured and formed in situ in a transdermal photo-crosslinking manner after injection, with simple, convenient and controllable operation.

Abstract: Disclosed herein is a hybrid inorganic-organic light emitting device that can include a cathode; an anode; at least one organic layer disposed between the cathode and the anode, wherein the at least one organic layer comprises an emissive material; at least one additional layer selected from the group consisting of an electron injection layer, an electron transport layer, and a hole blocking layer; wherein the at least one additional layer is disposed between the cathode and the at least one organic layer; and wherein the at least one additional layer comprises at least one metal oxide. Also disclosed are consumer products comprising this hybrid inorganic-organic light emitting device.

Abstract: Disclosed is an integrated sealed micro-mesh nebulization module, which includes: an nebulization device and a nozzle mechanism disposed on the nebulization device, the nozzle mechanism disposed on the nebulization device is detachably connected with the nebulization device; the nebulization module comprises an annular base, a lower shell disposed in the annular base, an upper shell disposed on the lower shell, a micro-mesh nebulization sheet disposed on the lower shell, a first sealing ring and a second sealing ring respectively disposed on both sides of the micro-mesh nebulization sheet, and a metal contact disposed between the lower shell and the upper shell, with one end connected with the micro-mesh nebulization sheet through a wire, and the other end extending to an exterior of the lower shell and connected with an external driving circuit.

Abstract: A skin layer of a superconducting tape has a woven mesh structure and is disposed on a surface of a superconducting tape. The skin layer of a superconducting tape solves the problem where a vapor layer generated when a superconductor is in a normal resistive state greatly reduces the efficiency of a heat exchange between the superconductor and liquid nitrogen. Further provided are the superconducting tape and a superconducting coil.

Abstract: A method and a system for calculating tumor neoantigen burden (TNB) are provided. The method includes: step S1: processing a normal sample and a tumor sample, sequencing a specific region and detecting somatic mutations in the sample; step S2: annotating and filtering the somatic mutations, and translating to obtain mutant peptide sequences of a patient; step S3: filtering the mutant peptide sequences to obtain neopeptide sequences based on a proteome of the normal sample; step S4, performing a human leukocyte antigen (HLA) typing analysis based on alignment data of the normal sample to obtain HLA genotypes of the sample; step S5, predicting binding affinities between the neopeptide sequences and the HLA genotypes to obtain specific neoantigens of the sample, and performing a weighted scoring on each of the specific neoantigens and calculating the TNB of the sample.

Abstract: A buffer assembly is provided that includes a first mounting seat, a second mounting seat, a hinge assembly, and an elastic member. One of the first mounting seat or the second mounting seat is configured to be connected to a mechanical arm and the other one is configured to be connected to an end picker. The hinge assembly is connected between the first mounting seat and the second mounting seat and includes a first ball joint mounted in the first mounting seat and a guide rod, one of the second mounting seat or the first ball joint is connected to the guide rod, and the other one is slidably sleeved outside the guide rod. The elastic member is configured to apply a force to enable the second mounting seat to approach the first mounting seat. Further provided is a manipulator.

Abstract: A quick connection mechanism includes a truncated-cone-shaped quick release plate, a base, and a locking structure. A tapered clamping groove is provided in a larger bottom surface of the quick release plate. A sliding groove is provided in the base, and the quick release plate is clamped in the sliding groove. The locking structure is configured to fix the quick release plate that enters the sliding groove. The locking structure includes a rotating shaft, a locking arm rotatably provided on the rotating shaft, and a first elastic member connected to the locking arm and configured to apply, to the locking arm, a force in a direction for locking the quick release plate. One end of the locking arm abuts against an inner side wall of the clamping groove and is configured to enable locking of the quick release plate in the sliding groove by the abutment.

Abstract: Disclosed are a display panel and a driving method therefor, and a display device. Two adjacent rows of sub-pixels are taken as a row group, and the row group is provided with a first sub row group and a second sub row group that are arranged in a column direction; a gate electrode of a first transistor in the first sub row group is electrically connected to a first gate line; a gate electrode of a second transistor in the second sub row group is electrically connected to a second gate line; two adjacent sub-pixels in the column direction share one third transistor, and a gate electrode of the third transistor in the row group is electrically connected to a third gate line; and the first transistor and the second transistor in one column of sub-pixels are electrically connected to a data line by means of the shared third transistor.

Abstract: This application describes examples of a data processing method and apparatus. In one example, the method includes: If a target buffer that is corresponding to a target priority and that is on a network device reaches a first threshold, the network device sends a pause message to an upstream device, so that the upstream device stops sending a first data packet corresponding to the target priority. If a duration in which the network device stops buffering a second data packet is greater than a preset duration, and the target buffer falls back below a second threshold, the network device sends a sending resumption message to the upstream device, so that the upstream device sends a third data packet corresponding to the target priority.

Abstract: The present application relates to the field of handling apparatus technologies, in particular to an end pickup device, a manipulator and a robot. The end pickup device includes: a mounting seat, a pickup mechanism and a driving mechanism. The pickup mechanism is disposed on the mounting seat and includes at least two pickup apparatuses are movable relative to each other, and the pickup apparatus includes a pickup part for picking up articles. The driving mechanism is disposed on the mounting seat and is in driving connection with the pickup mechanism, and the driving mechanism drives the at least two pickup apparatuses to move relatively, so that the at least two pickup apparatuses pick up the articles in a switching way. Based on this, the replacement time of the pickup parts can be shortened and the working efficiency of the end pickup device can be improved.

Abstract: A hot-plugging edge computing system includes at least an elastic database, a data processing module, and hot-plugging computing modules. The elastic database is configured to store data through an SSD array with a configurable number of SSDs. The data processing module is connected to the elastic database and each of the hot-plugging computing modules, and controls data storage in the elastic database, monitors and assigns a task to each of the hot-plugging computing modules. Each of the hot-plugging computing modules performs data computing based on the corresponding task assigned by the data processing module, and returns a computing result to the corresponding data processing module.

Abstract: The invention provides a rapid, sensitive and specific nucleic acid detection system which utilizes isothermal nucleic acid amplification in combination with a lateral flow chromatographic device, or DNA dipstick, for DNA-hybridization detection. The system of the invention requires no complex instrumentation or electronic hardware, and provides a low cost nucleic acid detection system suitable for highly sensitive pathogen detection. Hybridization to single-stranded DNA amplification products using the system of the invention provides a sensitive and specific means by which assays can be multiplexed for the detection of multiple target sequences.

Abstract: An apparatus of a first communication node is provide that includes: means for synchronising a common reference timing with a second communication node; means for obtaining an indication of a time window that specifies a period of time between first and second time instances; and means for configuring a machine learning-based function at the first communication node, wherein the configuration of the machine learning-based function is common between the first and second communication nodes. The apparatus further includes means for executing the machine learning-based function; and means for obtaining information by measuring a performance metric, for the machine learning-based function, during the time window.

Abstract: An electronic device includes a semiconductor die having a multilevel metallization structure including stacked levels with respective dielectric layers and metal lines, and a low leakage, low hydrogen diffusion barrier layer on one of the stacked levels. The diffusion barrier layer contacts a side of the dielectric layer and the metal line of the one of the stacked levels, and the diffusion barrier layer includes silicon nitride material having a first bond percentage ratio of ammonia to silicon nitride that is greater than a second bond percentage ratio of silicon hydride to silicon nitride.

Abstract: A quick connection mechanism includes a truncated-cone-shaped quick release plate, a base, and a locking structure. A tapered clamping groove is provided in a larger bottom surface of the quick release plate. A sliding groove is provided in the base, and the quick release plate is clamped in the sliding groove. The locking structure is configured to fix the quick release plate that enters the sliding groove. The locking structure includes a rotating shaft, a locking arm rotatably provided on the rotating shaft, and a first elastic member connected to the locking arm and configured to apply, to the locking arm, a force in a direction for locking the quick release plate. One end of the locking arm abuts against an inner side wall of the clamping groove and is configured to enable locking of the quick release plate in the sliding groove by the abutment.

Abstract: A service flow scheduling method and apparatus, and a system. When transmission quality of a service flow with a higher priority does not meet a service level requirement corresponding to the service flow, a first network device adjusts, to a first threshold, a transmission rate threshold of an HQoS model for a service flow with a lower priority, where the first threshold is less than a current data transmission rate of the service flow with a lower priority. By performing traffic shaping on the service flow with a lower priority, a bandwidth resource of a downlink port of the first network device may give way to the service flow with a higher priority, to ensure that the service flow with a higher priority meets the service level requirement of the service flow with a higher priority.

Abstract: An integrated circuit package is formed by positioning an integrated circuit die on a die pad of a leadframe; connecting a bond wire between the die and a bond pad of the leadframe; encapsulating the bond wire, die, and bond pad with an encapsulant material to form a first mold cap of the integrated circuit package; after the encapsulating, bending one or more leads of the leadframe to form one or more bent leads; and encapsulating the first mold cap and a portion of a bend of the one or more bent leads with the encapsulant material to form a second mold cap.

Abstract: This application discloses an information display method and apparatus and user equipment, and belongs to the field of computer technologies. The method includes: if the user equipment is not connected to the first network and the second network at the same time, if the user equipment does not receive indication information, the user equipment obtains history information, where the indication information is used to indicate that the current cell supports dual connectivity of the first network and the second network; and displays, according to the history information, an identifier matching the network that can be connected by the user equipment.