Abstract: A compound midazolam-D3 and its preparation method as it's synthesized from 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one (Compound II), by ring closure reaction with ethyl isocyanoacetate, hydrolysis with base, ring-opening with acid, ring closure under high temperature, and reacted with trideuteromethyl reagent; the synthetic route has advantage of short synthetic route appropriate, accessible and affordable. The prepared midazolam-D3 has characteristic with high purity, high deuterium content and very good stability.

Abstract: The present disclosure discloses a mass spectrometry based method for detecting serum metabolite, and relates to the technical field of mass spectrometric detection.

Abstract: The present disclosure discloses a mass spectrometry based method for detecting serum metabolite, and relates to the technical field of mass spectrometric detection.

Abstract: A spring assembly is provided which decreases the fatigue and wear on the springs of the assembly. The spring assembly includes upper and lower pistons separated by a substantially incompressible fluid. The lower piston is attached to one or more springs. The surface area of the upper surface of the lower piston is greater than the surface area of the lower surface of the upper piston. As such, the springs are deflected by a distance less than the distance traveled by the upper piston. By decreasing the length the springs are compressed, the springs are subject to less fatigue and wear. As a result, the life span of the springs is increased and the maintenance required of the spring assembly is minimized relative to that of typical spring assemblies.

Abstract: Induction heating systems for metal food cans configured to deliver sufficient heat into the can to sterilize the food within the can are provided. The heating system includes an induction coil and a control system. The control system is configured to monitor and control heating of sealed food cans during induction heating and to control and/or confirm various aspects of can heating during induction heating.

Abstract: A temperature detection system for detecting temperature within a metallic can during heating is provided. The system includes an induction heating coil configured to generate an alternating magnetic field, and a hermetically sealed can positioned within the magnetic field generated by the induction coil. At least a portion of the sealed can is formed from a metallic material, and the sealed can includes a food product within the can. The magnetic field causes resistive heating of the metallic material of the sealed can. The system includes a temperature sensing element located within the sealed can configured to generate a signal indicative of the temperature of the food product during heating and a memory device communicably coupled to the temperature sensing element configured to store data related to the signal received from the temperature sensing element.

Abstract: An induction heating system configured to sequentially heat a plurality of filled and sealed food containers is provided. The system includes an induction heating coil defining a lumen having a longitudinal axis. The lumen is configured to receive the containers during heating, and the induction coil is configured to generate an alternating magnetic field causing resistive heating of the container. The system includes a container moving device configured to move containers into the induction heating coil lumen prior to heating, to move containers while within the induction heating coil lumen and to move containers out of the induction heating coil lumen after heating.

Abstract: A spring assembly is provided which decreases the fatigue and wear on the springs of the assembly. The spring assembly includes upper and lower pistons separated by a substantially incompressible fluid. The lower piston is attached to one or more springs. The surface area of the upper surface of the lower piston is greater than the surface area of the lower surface of the upper piston. As such, the springs are deflected by a distance less than the distance traveled by the upper piston. By decreasing the length the springs are compressed, the springs are subject to less fatigue and wear. As a result, the life span of the springs is increased and the maintenance required of the spring assembly is minimized relative to that of typical spring assemblies.

Abstract: Induction heating systems for metal food cans configured to deliver sufficient heat into the can to sterilize the food within the can are provided. The heating system includes an induction coil and a control system. The control system is configured to monitor and control heating of sealed food cans during induction heating and to control and/or confirm various aspects of can heating during induction heating.

Abstract: A metal food can including a metal sidewall is provided. The diameter of the sidewall varies at different axial positions along the sidewall. The can includes a can end coupled to an end of the metal sidewall, and a plurality of circumferential beads formed in the metal sidewall. The shape of each circumferential bead varies based upon the diameter of the section of the sidewall in which the beads are formed.