Patents by Inventor Jian Wu Li

Jian Wu Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Double-stranded RNAS directed to IKK-2
    Patent number: 7759476
    Abstract: Compositions and methods are provided for treating NF-?B-related conditions. In particular, the invention provides a stimulus-inducible IKK signalsome, and components and variants thereof. An IKK signalsome or component thereof may be used, for example, to identify antibodies and other modulating agents that inhibit or activate signal transduction via the NF-?B cascade. IKK signalsome, components thereof and/or modulating agents may also be used for the treatment of diseases associated with NF-?B activation.
    Type: Grant
    Filed: October 22, 2007
    Date of Patent: July 20, 2010
    Assignee: Signal Pharmaceuticals
    Inventors: Frank Mercurio, Hengyi Zhu, Miguel Barbosa, Jian Wu Li, Brion W. Murray
  • Stimulus Inducible Protein Kinase Complex and Methods of Use Therefor
    Publication number: 20090169564
    Abstract: Compositions and methods are provided for treating NF-?B-related conditions. In particular, the invention provides a stimulus-inducible IKK signalsome, and components and variants thereof. An IKK signalsome or component thereof may be used, for example, to identify antibodies and other modulating agents that inhibit or activate signal transduction via the NF-?B cascade. IKK signalsome, components thereof and/or modulating agents may also be used for the treatment of diseases associated with NF-?B activation.
    Type: Application
    Filed: October 22, 2007
    Publication date: July 2, 2009
    Inventors: Frank Mercurio, Hengyi Zhu, Miguel Barbosa, Jian Wu Li, Brion W. Murray
  • Stimulus-inducible protein kinase complex and methods of use therefor
    Patent number: 7285654
    Abstract: Compositions and methods are provided for treating NF-?B-related conditions. In particular, the invention provides a stimulus-inducible IKK signalsome, and components and variants thereof. An IKK signalsome or component thereof may be used, for example, to identify antibodies and other modulating agents that inhibit or activate signal transduction via the NF-?B cascade. IKK signalsome, components thereof and/or modulating agents may also be used for the treatment of diseases associated with NF-?B activation.
    Type: Grant
    Filed: January 8, 2003
    Date of Patent: October 23, 2007
    Assignee: Signal Pharmaceuticals
    Inventors: Frank Mercurio, Hengyi Zhu, Miguel Barbosa, Jian Wu Li, Brion W. Murray
  • Stimulus-inducible protein kinase complex and methods of use therefor
    Patent number: 6576437
    Abstract: Compositions and methods are provided for treating NF-&kgr;B-related conditions. In particular, the invention provides a stimulus-inducible IKK signalsome, and components and variants thereof. An IKK signalsome or component thereof may be used, for example, to identify antibodies and other modulating agents that inhibit or activate signal transduction via the NF-&kgr;B cascade. IKK signalsome, components thereof and/or modulating agents may also be used for the treatment of diseases associated with NF-&kgr;B activation.
    Type: Grant
    Filed: April 27, 2001
    Date of Patent: June 10, 2003
    Assignee: Signal Pharmaceuticals, Inc.
    Inventors: Frank Mercurio, Hengyi Zhu, Miguel Barbosa, Jian Wu Li, Brion W. Murray
  • Stimulus-inducible protein kinase complex and methods of use therefor
    Publication number: 20030100026
    Abstract: Compositions and methods are provided for treating NF-&kgr;B-related conditions. In particular, the invention provides a stimulus-inducible IKK signalsome, and components and variants thereof. An IKK signalsome or component thereof may be used, for example, to identify antibodies and other modulating agents that inhibit or activate signal transduction via the NF-&kgr;B cascade. IKK signalsome, components thereof and/or modulating agents may also be used for the treatment of diseases associated with NF-&kgr;B activation.
    Type: Application
    Filed: January 8, 2003
    Publication date: May 29, 2003
    Inventors: Frank Mercurio, Hengyi Zhu, Miguel Barbosa, Jian Wu Li, Brion W. Murray
  • Stimulus-inducible protein kinase complex and methods of use therefor
    Publication number: 20020151021
    Abstract: Compositions and methods are provided for treating NF-&kgr;B-related conditions. In particular, the invention provides a stimulus-inducible IKK signalsome, and components and variants thereof. An IKK signalsome or component thereof may be used, for example, to identify antibodies and other modulating agents that inhibit or activate signal transduction via the NF-&kgr;B cascade. IKK signalsome, components thereof and/or modulating agents may also be used for the treatment of diseases associated with NF-&kgr;B activation.
    Type: Application
    Filed: April 27, 2001
    Publication date: October 17, 2002
    Inventors: Frank Mercurio, Hengyi Zhu, Miguel Barbosa, Jian Wu Li, Brion W. Murray
  • Stimulus-inducible protein kinase complex and methods of use therefor
    Patent number: 6258579
    Abstract: Compositions and methods are provided for treating NF-&kgr;B-related conditions. In particular, the invention provides a stimulus-inducible IKK signalsome, and components and variants thereof. An IKK signalsome or component thereof may be used, for example, to identify antibodies and other modulating agents that inhibit or activate signal transduction via the NF-&kgr;B cascade. IKK signalsome, components thereof and/or modulating agents may also be used for the treatment of diseases associated with NF-&kgr;B activation.
    Type: Grant
    Filed: August 13, 1997
    Date of Patent: July 10, 2001
    Assignee: Signal Pharmaceuticals, Inc.
    Inventors: Frank Mercurio, Hengyi Zhu, Miguel Barbosa, Jian Wu Li, Brion W. Murray