Patents by Inventor Jian X. Zhang

Jian X. Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Composition and method for the restoration and preservation of transplant organs procured from DCD donors
    Patent number: 8802361
    Abstract: The present invention provides a perfusion solution comprising specific metabolic agents, antioxidant agents, and membrane stabilizer agents that can help improve preservation, organ viability, and in some cases recover organs that would otherwise being unusable for transplantation. In a further embodiment, the perfusion solution can be used in combination with hypothermic machine perfusion. It has been found that combination of the perfusion solution and hypothermic machine perfusion can help prevent or reduce further damage to the organ and restore the organ's anti-oxidant system, stabilize the cellular cytoskeleton and cellular membranes, inhibit arachidonic acid pathway, provide oncotic support, reduce interstitial edema formation, and help restore energy stores within the organ. As a result, the method can be used to improve the viability of otherwise marginal donor organs.
    Type: Grant
    Filed: June 8, 2011
    Date of Patent: August 12, 2014
    Assignee: University of North Carolina at Charlotte
    Inventors: Charles Y. Lee, Mark G. Clemens, Jian X. Zhang, Shailendra Jain
  • Composition and Method for the Restoration and Preservation of Transplant Organs Procured From DCD Donors
    Publication number: 20110236875
    Abstract: The present invention provides a perfusion solution comprising specific metabolic agents, antioxidant agents, and membrane stabilizer agents that can help improve preservation, organ viability, and in some cases recover organs that would otherwise being unusable for transplantation. In a further embodiment, the perfusion solution can be used in combination with hypothermic machine perfusion. It has been found that combination of the perfusion solution and hypothermic machine perfusion can help prevent or reduce further damage to the organ and restore the organ's anti-oxidant system, stabilize the cellular cytoskeleton and cellular membranes, inhibit arachidonic acid pathway, provide oncotic support, reduce interstitial edema formation, and help restore energy stores within the organ. As a result, the method can be used to improve the viability of otherwise marginal donor organs.
    Type: Application
    Filed: June 8, 2011
    Publication date: September 29, 2011
    Inventors: Charles Y. Lee, Mark G. Clemens, Jian X. Zhang, Shailendra Jain
  • Composition and method for the restoration and preservation of transplant organs procured from DCD donors
    Patent number: 7977042
    Abstract: The present invention provides a perfusion solution comprising specific metabolic agents, antioxidant agents, and membrane stabilizer agents that can help improve preservation, organ viability, and in some cases recover organs that would otherwise being unusable for transplantation. In a further embodiment, the perfusion solution can be used in combination with hypothermic machine perfusion. It has been found that combination of the perfusion solution and hypothermic machine perfusion can help prevent or reduce further damage to the organ and restore the organ's anti-oxidant system, stabilize the cellular cytoskeleton and cellular membranes, inhibit arachidonic acid pathway, provide oncotic support, reduce interstitial edema formation, and help restore energy stores within the organ. As a result, the method can be used to improve the viability of otherwise marginal donor organs.
    Type: Grant
    Filed: July 27, 2006
    Date of Patent: July 12, 2011
    Assignee: University of North Carolina at Charlotte
    Inventors: Charles Y. Lee, Mark G. Clemens, Jian X. Zhang, Shailendra Jain