Patents by Inventor Jian Xing

Jian Xing has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11447452
    Abstract: Benzyl derivative compounds having peroxisome proliferator-activated receptor ? (PPAR?) agonistic activity, compositions containing such compounds, and methods of their use in enhancing PPAR? activity for treating diseases and/or conditions involving inflammation and/or angiogenesis, particularly ocular diseases and/or conditions such as but not limited to retinal inflammation, retinal neovascularization, retinal vascular leakage, retinopathy of prematurity, diabetic retinopathy, age-related macular degeneration, and diabetic macular edema are disclosed.
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: September 20, 2022
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Adam Duerfeldt, Jian-xing Ma, Xiaozheng Dou, Dinesh Nath, Young-Hwa Shin
  • Patent number: 11435144
    Abstract: A heat dissipation device includes a base seat having a first chamber. The first chamber has multiple partitioning sections to partition the first chamber into multiple rooms without communicating with each other. A first working fluid is disposed in the rooms. Multiple two-phase fluid radiating fins are disposed on upper side of the base seat. Each of the two-phase fluid radiating fins is formed with an internal second chamber in communication with the rooms or not in communication with the rooms. The heat dissipation device can achieve better heat dissipation effect.
    Type: Grant
    Filed: August 5, 2019
    Date of Patent: September 6, 2022
    Assignee: Asia Vital Components (China) Co., Ltd.
    Inventors: Han-Min Liu, Jian Zhang, Xing-Xing Lyu
  • Patent number: 11396020
    Abstract: In one aspect, the present disclosure provides an integrated microfluidic device for nucleic acid amplification and microarray detection. In one aspect, the device comprises: (1) a microchip configured to process reagents, comprising a plurality of reservoirs, channels, valves, and/or fluid interfaces; (2) an amplification chamber for PCR, carried out in a detachable tube assembled on the microchip through a joint; and (3) a microarray chamber comprising a microarray and a reaction chamber. In some embodiments, these features are interconnected to allow transportation of reagents for nucleic acid amplification and hybridization detection functions in a closed system. In one aspect, the integrate device herein overcomes the problem of contamination during the amplification and hybridization reactions.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: July 26, 2022
    Assignees: CapitalBio Corporation, Tsinghua University
    Inventors: Yan Liu, Guohao Zhang, Jiang Zhu, Zhengde Feng, Hongju Guo, Jian Gao, Wanli Xing, Jing Cheng
  • Publication number: 20220204518
    Abstract: The present invention relates to a pyrimido[5,4-b]pyrrolizin compound represented by general formula I, an optical isomer thereof, a preparation method therefor, a pharmaceutical composition containing same, and a use thereof. The compound according to the present invention has good inhibitory activity on the kinase BTK at both the molecular level and the cellular level. Meanwhile, the compound also has good anti-tumor activity and pharmacokinetic properties in vivo.
    Type: Application
    Filed: April 24, 2020
    Publication date: June 30, 2022
    Inventors: Ao ZHANG, Jian DING, Hua XIE, Zilan SONG, Yu XUE, Li XING, Linjiang TONG, Meiyu GENG
  • Patent number: 11369575
    Abstract: Pharmaceutical particles having an inner portion comprising an agonist of peroxisome proliferator-activated receptor ? (PPAR?) and a biodegradable polymer; and an outer coating comprising an emulsifier which surrounds the inner portion, wherein the agonist may be a fibrate, and the particle contains at least about 5 wt % to about 25 wt % of the agonist, and wherein the particle has a sustained delayed release of the agonist in a range of at least about 1 to 12 months when in an aqueous solution or physiological environment. The pharmaceutical particles may be used, for example, to treat diseases and conditions such as ocular disorders which benefit from PPAR? agonism.
    Type: Grant
    Filed: March 18, 2020
    Date of Patent: June 28, 2022
    Assignees: The Board of Regents of the University of Oklahoma, Virginia Commonwealth University, Intellectual Property Foundation
    Inventors: Jian-xing Ma, Fangfang Qiu, Qingguo Xu, Tuo Meng
  • Patent number: 11337968
    Abstract: Compositions containing a phenylquinoline derivative compound having peroxisome proliferator-activated receptor a (PPAR?) agonistic activity, and methods of their use in enhancing PPAR? activity in retinal cells, and in treating ocular disorders or conditions, such as but not limited to retinal inflammation, retinal neovascularization, retinal vascular leakage, retinopathy of prematurity, diabetic retinopathy, age-related macular degeneration, and diabetic macular edema are disclosed.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: May 24, 2022
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Jian-xing Ma, Elizabeth Moran, Guotao Deng, Adam S. Duerfeldt
  • Patent number: 11178246
    Abstract: The disclosed embodiments disclose techniques for managing cloud-based storage using a time-series database. A distributed cloud data management system (DCDMS) manages objects stored in a cloud storage system. The DCDMS leverages a distributed time-series database to track objects accessed via the DCDMS. During operation, the DCDMS receives a request to access an object using a path identifier and an object identifier. The DCDMS determines from the path identifier that the request is associated with one of its supported extended capabilities, and uses the previously tracked object operations that are stored in the time-series database to determine the actual target bucket in the cloud storage system that contains the requested object; the target bucket that contains the object may be different from the bucket identified in the path identifier that is received. The object identifier is then used to access the requested object from the target bucket to service the request.
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: November 16, 2021
    Assignee: Panzura, LLC
    Inventors: Jian Xing, Qian Zhang, Pu Paul Zhang
  • Publication number: 20210141981
    Abstract: A structural non-gradient topology optimization method based on a sequential Kriging surrogate model mainly comprises three parts: reduced series expansion of a material field of design domain, building of a non-gradient topology optimization model and solving optimization model using a sequential Kriging surrogate model algorithm. Design variables of the topology optimization problem are considerably reduced through the series expansion of a material-field function, and then the topology optimization problem involving fewer than 50 design variables can be effectively solved using the sequential Kriging surrogate model algorithm with an adaptive design space adjustment strategy. Without requiring the information of design sensitivity of a performance function, this method is suitable for solving complex multi-physical, multidisciplinary and highly nonlinear topology optimization problems.
    Type: Application
    Filed: March 17, 2020
    Publication date: May 13, 2021
    Inventors: Yangjun LUO, Jian XING, Zhan KANG
  • Publication number: 20210024469
    Abstract: Benzyl derivative compounds having peroxisome proliferator-activated receptor ? (PPAR?) agonistic activity, compositions containing such compounds, and methods of their use in enhancing PPAR? activity for treating diseases and/or conditions involving inflammation and/or angiogenesis, particularly ocular diseases and/or conditions such as but not limited to retinal inflammation, retinal neovascularization, retinal vascular leakage, retinopathy of prematurity, diabetic retinopathy, age-related macular degeneration, and diabetic macular edema are disclosed.
    Type: Application
    Filed: March 15, 2019
    Publication date: January 28, 2021
    Inventors: Adam Duerfeldt, Jian-xing Ma, Xiaozheng Dou, Dinesh Nath, Young-Hwa Shin
  • Patent number: 10798427
    Abstract: The present invention relates to a system and method for providing a failover of storage for media content, including media content used for broadcasting in cinema. One embodiment of the invention stores copies of digital cinema packages (“DCPs”) to both a central storage facility as well as a local storage facility. When a server module reading DCPs in central storage module encounters abnormalities, it switches reading operations to the local storage module, at the same frame location from which interruption occurred. The present invention provides a multi-layered storage system for cinema broadcasting of a movie to decrease likelihood of interruptions during a broadcast that may be caused by failure of the central storage facility.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: October 6, 2020
    Assignee: GDC TECHNOLOGY (SHENZHEN) LIMITED
    Inventors: Man Nang Chong, Pranay Kumar, Chern Yue Kwok, Jing Zheng Tan, Jian Xing Huang
  • Publication number: 20200297651
    Abstract: Pharmaceutical particles having an inner portion comprising an agonist of peroxisome proliferator-activated receptor ? (PPAR?) and a biodegradable polymer; and an outer coating comprising an emulsifier which surrounds the inner portion, wherein the agonist may be a fibrate, and the particle contains at least about 5 wt % to about 25 wt % of the agonist, and wherein the particle has a sustained delayed release of the agonist in a range of at least about 1 to 12 months when in an aqueous solution or physiological environment. The pharmaceutical particles may be used, for example, to treat diseases and conditions such as ocular disorders which benefit from PPAR? agonist.
    Type: Application
    Filed: March 18, 2020
    Publication date: September 24, 2020
    Inventors: Jian-xing Ma, Fangfang Qiu, Qingguo Xu, Tuo Meng
  • Publication number: 20200201775
    Abstract: The disclosed embodiments disclose techniques for managing a distributed cache in a cloud-based distributed computing environment (CBDCE). During operation, an instance of a data processing layer service (DPL) receives a data request from a client that specifies an address and an operation for a target data block. The DPL instance uses these to determine a first cache instance of the distributed cache that is assigned to cache a metadata entry that links the address with a data block fingerprint for the target data block. The DPL instance then uses the data block fingerprint and the cache mapping to determine a second cache instance that is assigned to store the target data block, and then accesses the second cache instance to complete the operation for the target data block.
    Type: Application
    Filed: February 29, 2020
    Publication date: June 25, 2020
    Applicant: Panzura, Inc.
    Inventors: Qian Zhang, Jian Xing, Pu Paul Zhang
  • Publication number: 20200204626
    Abstract: The disclosed embodiments disclose techniques for accessing a scale-out block interface in a cloud-based distributed computing environment (CBDCE). During operation, an instance of a block device service (BDS) receives a data request from a client. The BDS instance translates the data request into a set of data block accesses, and then sends the translated data request to a data processing layer service (DPL). The DPL instance services the data request using a set of data operations that leverage one or more of a distributed cache, a distributed database, and a cloud storage system. The BDS service leverages the DPL instance to provide to the client an abstraction of a highly-available block storage device with unlimited storage space via the scale-out block interface.
    Type: Application
    Filed: March 3, 2020
    Publication date: June 25, 2020
    Applicant: Panzura, Inc.
    Inventors: Qian Zhang, Jian Xing, Pu Paul Zhang
  • Patent number: 10663750
    Abstract: Apparatus and methods for super-resolution imaging of extended objects utilize a scanned illumination source with a small spot size. Sub-images composed of highly-overlapping point spread functions are captured and each sub-image is iteratively compared to a series of brightness combinations of template point spread functions in a dictionary. The dictionary is composed of highly-overlapping point spread functions. Each sub-image is associated with a best-match template combination solution, and the best-match reconstructions created by best-match solutions are combined into a super-resolution image of the object.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: May 26, 2020
    Assignee: The Regents of the University of Colorado, a body
    Inventors: Juin-Yann Yu, Carol J. Cogswell, Simeng Chen, Robert H. Cormack, Jian Xing
  • Publication number: 20200068010
    Abstract: The disclosed embodiments disclose techniques for managing a cloud-based distributed computing environment (CBDCE) that comprises multiple geographically-distributed compute nodes. Multiple services simultaneously execute on the CBDCE compute nodes, with each service comprising multiple service instances that simultaneously execute on multiple distinct compute nodes of the CBDCE. During operation, the system uses a distributed database to track the status of the CBDCE to ensure the ongoing stability and scalability of the CBDCE. Upon receiving a request that is associated with the configuration of the CBDCE, a service accesses CBDCE status information from the distributed database to respond to the request.
    Type: Application
    Filed: July 13, 2019
    Publication date: February 27, 2020
    Applicant: Panzura, Inc.
    Inventors: Jian Xing, Qian Zhang, Pu Paul Zhang
  • Publication number: 20200065199
    Abstract: The disclosed embodiments disclose techniques for journaling data received in a cloud-based distributed computing environment (CBDCE). Multiple services simultaneously execute on the CBDCE compute nodes, with each service comprising multiple service instances that simultaneously execute on multiple, distinct compute nodes of the CBDCE. The CBDCE includes a distributed database that enables coordination between the service instances of services that execute in the CBDCE; this distributed database also includes multiple distributed database instances that simultaneously executing on multiple different CBDCE compute nodes. During operation, a service instance executing on one of these compute nodes receives a client request. The service instance submits this client request to a distributed database instance and, in parallel, also submits the client request and its associated user data to a distributed journaling service.
    Type: Application
    Filed: July 13, 2019
    Publication date: February 27, 2020
    Applicant: Panzura, Inc.
    Inventors: Jian Xing, Qian Zhang, Pu Paul Zhang
  • Publication number: 20200065447
    Abstract: A method for fixture shape optimization design of a space membrane structure for inhibiting wrinkling, and solves the problem that the space membrane structure is easy to generate a wrinkling phenomenon under the stretching effect of a traditional fixture. By optimizing the shape of the fixture and changing the loading boundary conditions, the minor principal stress of the unit in the membrane region is maximized and the distribution of the principal stress of the membrane is regulated. A global optimization algorithm is used to find a global optimal design, and then novel fixture forms with “arch” and “convex” boundaries are obtained, to achieve the purpose of completely simulating the wrinkling. The present invention not only inhibits the generation of the wrinkling in the membrane, but also avoids cutting the membrane and ensures that the membrane has large enough working area.
    Type: Application
    Filed: December 20, 2018
    Publication date: February 27, 2020
    Inventors: Yangjun LUO, Jian XING, Zhan KANG, Ming LI
  • Publication number: 20200068038
    Abstract: The disclosed embodiments disclose techniques for managing cloud-based storage using a time-series database. A distributed cloud data management system (DCDMS) manages objects stored in a cloud storage system. The DCDMS leverages a distributed time-series database to track objects accessed via the DCDMS. During operation, the DCDMS receives a request to access an object using a path identifier and an object identifier. The DCDMS determines from the path identifier that the request is associated with one of its supported extended capabilities, and uses the previously tracked object operations that are stored in the time-series database to determine the actual target bucket in the cloud storage system that contains the requested object; the target bucket that contains the object may be different from the bucket identified in the path identifier that is received. The object identifier is then used to access the requested object from the target bucket to service the request.
    Type: Application
    Filed: December 11, 2018
    Publication date: February 27, 2020
    Applicant: Panzura, Inc.
    Inventors: Jian Xing, Qian Zhang, Pu Paul Zhang
  • Patent number: 10516974
    Abstract: Disclosed are methods for equipment networking, and equipment. Equipment acquires at least one of first information indicating a state of the equipment or second information indicating a state of peer equipment. The equipment determines whether a pre-set condition is met by at least one of the first information or the second information. When the pre-set condition is met by at least one of the first information or the second information, the equipment forms a group with the peer equipment. The equipment monitors data characterizing a signal transmitted by the peer equipment. When a first pre-set condition is not met by the data characterizing the signal transmitted by the peer equipment, the equipment quits the group formed with the peer equipment.
    Type: Grant
    Filed: August 6, 2019
    Date of Patent: December 24, 2019
    Assignee: Beijing Xiaoniao Tingting Technology Co., LTD.
    Inventors: Xiaolei Lou, Jian Xing, Weijie Li
  • Patent number: 10494619
    Abstract: Mutant mammalian RPE65 proteins and portions thereof, and nucleic acids encoding the mutants, for use in treating a condition related to retinal degeneration in a subject, the mutant mammalian RPE65 proteins or portions thereof having isomerohydrolase activity. A gene therapy method of treating a condition related to retinal degeneration in a mammalian subject in need of such treatment, comprising administering to the subject a therapeutically-effective amount of a vector comprising a nucleic acid encoding a mutant mammalian RPE65 protein or a portion thereof. A method of treating a condition related to retinal degeneration in a subject in need of such treatment, comprising administering to the subject a therapeutically-effective amount of at least one of a mutant mammalian RPE65 protein or a portion thereof.
    Type: Grant
    Filed: July 27, 2015
    Date of Patent: December 3, 2019
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Jian-Xing Ma, Yusuke Takahashi, Gennadiy Moiseyev