Patents by Inventor Jian Yao

Jian Yao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-PD-L1 ANTIBODY AND APPLICATION THEREOF
    Publication number: 20190367618
    Abstract: An antibody or a functional fragment thereof that specifically bind to PD-L1 with high affinity, a nucleic acid molecule that encodes said antibody or the functional fragment thereof, an expression vector and a host cell for use in expressing said antibody or the functional fragment thereof, and a method for producing said antibody or the functional fragment thereof. An immunoconjugate and a pharmaceutical composition containing said antibody or the functional fragment thereof, and a method for using said antibody or the functional fragment thereof to enhance the function of a T cell so as to up-regulate a cell-mediated immune response, for use in treating diseases caused by T cell dysfunction.
    Type: Application
    Filed: February 13, 2018
    Publication date: December 5, 2019
    Inventors: HAI WU, Sheng YAO, Yuehua ZHOU, Jian YAO, Dan MENG, Hui FENG
  • PHOSPHOKETOLASES FOR IMPROVED PRODUCTION OF ACETYL COENZYME A-DERIVED METABOLITES, ISOPRENE, ISOPRENOID PRECURSORS, AND ISOPRENOIDS
    Publication number: 20190367896
    Abstract: This present invention relates to cultured recombinant cells comprising a heterologous phosphoketolase (PKL) polypeptide that are capable of increased production of acetyl coenzyme A-derived metabolites, as well as methods for producing and using the same. In some embodiments, the recombinant cells further comprise one or more mevalonate (MVA) pathway polypeptides for the production of isoprenoid precursors, isoprene and isoprenoids.
    Type: Application
    Filed: February 14, 2019
    Publication date: December 5, 2019
    Inventors: Zachary Q. BECK, Jeffrey W. Munos, Derek H. Wells, Jian Yao
  • POLYPEPTIDES WITH ENDOGLUCANASE ACTIVITY AND USES THEREOF
    Publication number: 20190367894
    Abstract: Disclosed herein are cellulase variants, or active fragments thereof, and polynucleotides encoding same, wherein the cellulase variants, or active fragments thereof, have endoglucanase activity. Also disclosed herein are compositions comprising said cellulase variants, or active fragments thereof; vectors and/or host cells comprising the polynucleotides encoding said cellulase variants, or active fragments thereof; and methods for making and/or using said cellulase variants, or active fragments thereof and/or compositions containing same; wherein said cellulase variants, or active fragments thereof, have endoglucanase activity.
    Type: Application
    Filed: December 14, 2017
    Publication date: December 5, 2019
    Inventors: Richard R. Bott, David A. Estell, Neeraj Pandey, Sina Pricelius, Jian Yao
  • SHEAR THICKENING MATERIALS AS LIGHTWEIGHT SURFACE ARMOR
    Publication number: 20190359853
    Abstract: A shear thickening composition is provided. The shear thickening composition includes polydimethylsiloxane (PDMS) and boron. The boron is cross-linked to an oxygen atom in the PDMS to yield boron-cross-linked PDMS (B-PDMS). Vehicle parts including the shear thickening composition and methods of coating vehicle parts with the thickening composition are also provided.
    Type: Application
    Filed: May 24, 2018
    Publication date: November 28, 2019
    Applicant: GM GLOBAL TECHNOLOGY OPERATIONS LLC
    Inventors: Qiangfeng XIAO, Ming YANG, Neeraj S. SHIDORE, Jingyan WAN, Wen-Chiao LIN, Jian YAO
  • Method of controlling clamping of wedge-actuated CVT and powertrain with wedge-actuated CVT
    Patent number: 10473213
    Abstract: A method of controlling a continuously variable transmission includes monitoring powertrain operating conditions, and calculating, via an electronic controller, a commanded clamping force based on the powertrain operating conditions, wherein the commanded clamping force includes a commanded clamping force of an input pulley and a commanded clamping force of an output pulley on the endless rotatable device. The method also includes activating, via the electronic controller, at least one of the input actuator and the output actuator such that an axial component of the input wedge force and the axial force of the input actuator together provide the commanded clamping force of the input pulley, and an axial component of the output wedge force and the axial force of the output actuator together provide the commanded clamping force of the output pulley.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: November 12, 2019
    Assignee: GM Global Technology Operations LLC
    Inventors: Ying Huang, Chunhao J. Lee, Jian Yao, Chengwu Duan
  • Continuously variable transmission with wedge actuation mechanism
    Patent number: 10473200
    Abstract: A continuously variable transmission (CVT) comprises a shaft rotatable about an axis, and variator assembly, and an actuator mechanism. The variator assembly includes a pulley supported on the shaft and having a ramp surface, and an endless rotatable device frictionally engaged with the pulley. The ramp surface inclines in an axial direction along the axis toward the endless rotatable device. The CVT further comprises an actuator mechanism that includes a wedge component that has a wedge surface interfacing with the ramp surface, and a rotary piston operatively connected to the wedge component. The rotary piston defines a first fluid chamber pressurizable to apply a rotational force that provides relative motion between the ramp surface and the wedge surface resulting in a wedge force on the ramp surface and a clamping force of the endless rotatable device on the pulley.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: November 12, 2019
    Assignee: GM Global Technology Operations LLC
    Inventors: Chengwu Duan, Chunhao J. Lee, Jian Yao, Ying Huang, Derek F. Lahr, Farzad Samie
  • Continuously-variable transmission
    Patent number: 10473195
    Abstract: A continuously-variable transmission (CVT) assembly is employed for transmitting a torque from an external power-source. The CVT includes a variable-diameter input pulley and a variable-diameter output pulley, each having a respective range of adjustment. The CVT also includes a continuous torque-transmitting element extending between the variable-diameter input pulley and the variable-diameter output pulley, and thereby operatively connecting the input pulley to the output pulley. The CVT additionally includes a first elastic element having a first zero stiffness over the range of adjustment of the variable-diameter input pulley and configured to apply a first constant spring clamping force via the input pulley to the continuous torque-transmitting element.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: November 12, 2019
    Assignee: GM Global Technology Operations LLC
    Inventors: Chengwu Duan, Farzad Samie, Jian Yao, Chi-Kuan Kao
  • WEARABLE DEVICES AND METHODS FOR MANUFACTURING A WEARABLE DEVICE
    Publication number: 20190341005
    Abstract: According to various embodiments, a wearable device may be provided. The wearable device may include: a display panel having integrally formed a first display portion and a second display portion; and a driver circuit configured to control the first display portion with a first frequency and to control the second display portion with a second frequency.
    Type: Application
    Filed: May 23, 2016
    Publication date: November 7, 2019
    Inventors: Chee Oei CHAN, Jian Yao LIEN, Kah Yong LEE, Joel Sze Wei HONG, Farrukh Raza RIZVI
  • Cycle lock system and method
    Patent number: 10458490
    Abstract: Systems and methods are provided for locking a cycle. A clutch system of the cycle includes a forward lock system configured to alternatively prevent or allow operation of the cycle in a forward direction. A shaft extends through the clutch system. An actuator is configured to move the forward lock system along the shaft between a lock position and a free position. A controller is configured to shift the actuator, via a signal from a processor, between the lock position and the free position. The cycle is configured to be locked against forward operation by the clutch system.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: October 29, 2019
    Assignee: GM GLOBAL TECHNOLOGY OPERATIONS LLC
    Inventors: Zhen Gao, Chengwu Duan, Jian Yao, Chunhao J. Lee
  • Composite cable
    Patent number: 10446292
    Abstract: The present disclosure relates to a composite cable, which comprises a first wire assembly and a second wire assembly, and each wire of the second wire assembly is surrounded by an insulating layer. The composite cable further comprises: a sheath made of insulating material and configured to enclose the first wire assembly and the second wire assembly; and a shield comprising different kinds of metal wires and configured to surround the first wire assembly, wherein the first wire assembly is capable of transmitting signals, and the second wire assembly is capable of transmitting power supply. The composite cable according to the present disclosure is excellent in shielding performance for different requirements.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: October 15, 2019
    Assignee: Heyi Intelligent Technology (Shenzhen) Co., Ltd
    Inventors: Chao Ning, Qian Cao, Wenhua Su, Jian Yao, Baiyu Pan, Ji Wang
  • DETERMINING DRIVABLE FREE-SPACE FOR AUTONOMOUS VEHICLES
    Publication number: 20190286153
    Abstract: In various examples, sensor data may be received that represents a field of view of a sensor of a vehicle located in a physical environment. The sensor data may be applied to a machine learning model that computes both a set of boundary points that correspond to a boundary dividing drivable free-space from non-drivable space in the physical environment and class labels for boundary points of the set of boundary points that correspond to the boundary. Locations within the physical environment may be determined from the set of boundary points represented by the sensor data, and the vehicle may be controlled through the physical environment within the drivable free-space using the locations and the class labels.
    Type: Application
    Filed: March 15, 2019
    Publication date: September 19, 2019
    Inventors: Mansi Rankawat, Jian Yao, Dong Zhang, Chia-Chih Chen
  • NOVEL METALLOPROTEASES
    Publication number: 20190264187
    Abstract: Aspects of the present compositions and methods relate to novel metalloproteases polynucleotides encoding the novel metalloprotease, compositions and methods for use thereof.
    Type: Application
    Filed: May 7, 2019
    Publication date: August 29, 2019
    Inventors: Lilia M Babe, Roopa Santosh Ghirnikar, Frits Goedegebuur, Xiaogang Gu, Marc Anton Bernhard Kolkman, Jian Yao, Shukun Yu
  • ANTI-PCSK9 ANTIBODY AND USE THEREOF
    Publication number: 20190233540
    Abstract: The present invention provides an antibody or a functional fragment thereof that specifically binds to PCSK9 with high affinity, also provides a nucleic acid molecule encoding the antibody of the invention or the functional fragment thereof, for expressing an expression vector and a host cell of the antibody or the functional fragment thereof, and also provides a method for producing the antibody or the functional fragment thereof. The present invention provides that the antibody or the functional fragment thereof is used for treating diseases such as dyslipidemia.
    Type: Application
    Filed: November 24, 2016
    Publication date: August 1, 2019
    Inventors: Hai WU, Bo CHEN, Hui FENG, Sheng YAO, Jian YAO, Hongchuan LIU, Libo ZHANG, Jing ZHANG, Dan MENG
  • METHODS AND SYSTEMS FOR ASSISTING OPERATION OF A ROAD VEHICLE WITH AN AERIAL DRONE
    Publication number: 20190227555
    Abstract: Methods and systems for assisting operation of a road vehicle with an aerial drone are provided. In an exemplary embodiment, a method for assisting operation of a road vehicle with an aerial drone includes flying the aerial drone on a route ahead of the road vehicle and sensing an object at a location on the route ahead of the road vehicle with the aerial drone. Further, the method includes communicating data associated with the object and/or the location to the road vehicle. Also, the method includes utilizing the data to operate the road vehicle.
    Type: Application
    Filed: January 22, 2018
    Publication date: July 25, 2019
    Applicant: GM GLOBAL TECHNOLOGY OPERATIONS LLC
    Inventors: David Sun, Peggy Wang, Jian Yao, Chengwu Duan, Jiang L. Du
  • 3-D air pollution transmission path identification
    Patent number: 10359280
    Abstract: A system, method and computer program product for tracking and identifying a polluted air mass's transmission trajectory in real 3-D space. In one aspect, a polluted air mass's transmission path identification is based on a monitoring of PM2.5 concentration in cubic volumes of an air mass. The method computes a transmission path of polluted air that considers wind-pressure conversion, the displacement estimation with mass concentration, and planetary boundary layer (PBLP height constraint) for 3-D cubic grids. The resultant determination of a polluted air mass's transmission trajectory in real 3-D space generates more practical and reliable results for intensive knowledge of the transport pathways and potential pollution sources in real 3-D space.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: July 23, 2019
    Assignee: International Business Machines Corporation
    Inventors: Xin Xin Bai, Xin Jie Lv, Xiao Guang Rui, Xi Xia, Jian Yao, Wen Jun Yin, Wei Zhao, Yu Xin Zhao
  • ELECTRICALLY-ASSISTED TURBOCHARGER
    Publication number: 20190186348
    Abstract: A turbocharging system for an internal combustion engine includes a turbocharger having a shaft supported for rotation about an axis. The turbocharger also includes a turbine wheel mounted on the shaft and configured to be rotated about the axis by the exhaust gas, and a compressor assembly mounted on the shaft and configured to pressurize an airflow received from the ambient for delivery to the cylinder. The turbocharging system additionally includes an electric motor configured to generate electric motor torque. The turbocharging system further includes a one-way clutch configured to selectively connect the electric motor to the compressor assembly, such that the electric motor torque assists the turbocharger in generating boost pressure. An internal combustion engine employing such a turbocharging system is also disclosed.
    Type: Application
    Filed: December 15, 2017
    Publication date: June 20, 2019
    Applicant: GM Global Technology Operations LLC
    Inventors: Jim Liu, Bin Zhu, Jian Yao, Claus Juergen Glahn
  • METHOD OF CONTROLLING CLAMPING OF WEDGE-ACTUATED CVT AND POWERTRAIN WITH WEDGE-ACTUATED CVT
    Publication number: 20190170249
    Abstract: A method of controlling a continuously variable transmission includes monitoring powertrain operating conditions, and calculating, via an electronic controller, a commanded clamping force based on the powertrain operating conditions, wherein the commanded clamping force includes a commanded clamping force of an input pulley and a commanded clamping force of an output pulley on the endless rotatable device. The method also includes activating, via the electronic controller, at least one of the input actuator and the output actuator such that an axial component of the input wedge force and the axial force of the input actuator together provide the commanded clamping force of the input pulley, and an axial component of the output wedge force and the axial force of the output actuator together provide the commanded clamping force of the output pulley.
    Type: Application
    Filed: December 1, 2017
    Publication date: June 6, 2019
    Applicant: GM GLOBAL TECHNOLOGY OPERATIONS LLC
    Inventors: Ying Huang, Chunhao J. Lee, Jian Yao, Chengwu Duan
  • CONTINUOUSLY VARIABLE TRANSMISSION WITH WEDGE ACTUATION MECHANISM
    Publication number: 20190170231
    Abstract: A continuously variable transmission (CVT) comprises a shaft rotatable about an axis, and variator assembly, and an actuator mechanism. The variator assembly includes a pulley supported on the shaft and having a ramp surface, and an endless rotatable device frictionally engaged with the pulley. The ramp surface inclines in an axial direction along the axis toward the endless rotatable device. The CVT further comprises an actuator mechanism that includes a wedge component that has a wedge surface interfacing with the ramp surface, and a rotary piston operatively connected to the wedge component. The rotary piston defines a first fluid chamber pressurizable to apply a rotational force that provides relative motion between the ramp surface and the wedge surface resulting in a wedge force on the ramp surface and a clamping force of the endless rotatable device on the pulley.
    Type: Application
    Filed: December 1, 2017
    Publication date: June 6, 2019
    Applicant: GM Global Technology Operations LLC
    Inventors: Chengwu Duan, Chunhao J. Lee, Jian Yao, Ying Huang, Derek F. Lahr, Farzad Samie
  • PAENIBACILLUS SP. MANNANASES
    Publication number: 20190153417
    Abstract: Disclosed herein are mannanases from Paenibacillus sp., polynucleotides encoding the mannanases, compositions containing the mannanases, and methods of use thereof. Compositions containing mannanases are suitable for use as detergents and for cleaning fabrics and hard surfaces, as well as in a variety of other industrial applications.
    Type: Application
    Filed: November 7, 2016
    Publication date: May 23, 2019
    Inventors: Christian D. Adams, Viktor Yuryevich Aleksetev, David Marquez, Miles Christopher Scotcher, Richard Bott, Jian Yao
  • SENSOR DEVICES AND METHODS FOR CONTROLLING A SENSOR DEVICE
    Publication number: 20190142302
    Abstract: According to various embodiments, a sensor device may be provided. The sensor device may include: an airflow sensor configured to generate a voltage based on an airflow; and an output circuit configured to output measurement data based on the voltage; wherein the airflow sensor is configured to provide the voltage as a power supply to the output circuit.
    Type: Application
    Filed: June 16, 2016
    Publication date: May 16, 2019
    Inventors: Sze Wei Joel HONG, Jian Yao LIEN