Abstract: Provided are a federated graph clustering method based on distributed graph embedding, a device, and a readable storage medium.

Abstract: Disclosed are new small molecules having a substituted pyrimidine or substituted fused pyrimidine core structure and the uses thereof for modulating glucocerebrosidase activity. Also disclosed are pharmaceutical compositions comprising the small molecules which may be administered in methods of treating diseases or disorders associated with glucocerebrosidase activity, including Gaucher's disease and neurological diseases and disorders such as genetic and sporadic synucleinopathies, including Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy associated with aberrant glucocerebrosidase activity. The small molecules may contain a fluorophore or may be conjugated to a fluorophore in order to prepare a fluorescent probe for use in high throughput screening methods to identify new modulators of glucocerebrosidase activity via fluorescence polarization.

Abstract: Provided herein are compounds that modulate glucocerebrosidase (GCase), an enzyme whose activity is associated with neurological diseases and disorders (e.g., Gaucher's disease, Parkinson's disease). Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating GCase-related diseases and disorders (e.g., Gaucher's disease, Parkinson's disease) with the compounds in a subject, by administering the compounds and/or compositions described herein.

Abstract: A method for sample alignment is applied to a first participant system, where a first trusted execution environment is deployed at the first participant system. The method includes, in the first trusted execution environment, obtaining at least one first sample identifier of the first participant system; through the first trusted execution environment, obtaining at least one second sample identifier of the second participant system from the second trusted execution environment, where the second trusted execution environment is deployed at the second participant system; in the first trusted execution environment, determining the first initial intersection of the at least one first sample identifier and the at least one second sample identifier and performing the shuffle processing on all first target sample identifiers in the first initial intersection to obtain the first target intersection; and based on the first target intersection, determining the first sample alignment result.

Abstract: Provided herein are compounds that modulate glucocerebrosidase (GCase), an enzyme whose activity is associated with neurological diseases and disorders (e.g., Gaucher's disease. Parkinson's disease). Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating GCase-related diseases and disorders (e.g., Gaucher's disease. Parkinson's disease) with the compounds in a subject, by administering the compounds and/or compositions described herein.

Abstract: Provided herein are compounds that modulate glucocerebrosidase (GCase), an enzyme whose activity is associated with neurological diseases and disorders (e.g., Gaucher's disease, Parkinson's disease). Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating GCase-related diseases and disorders (e.g., Gaucher's disease, Parkinson's disease) with the compounds in a subject, by administering the compounds and/or compositions described herein.

Abstract: The present invention provides a high radiation rate platinum complex based on 1,8-substituted carbazole and an application thereof. The luminescent material of the present invention can efficiently control the excited state properties of material molecules by introducing substituents at 1-, 8-position of carbazole, which increases components of metal-to-ligand charge transfer state (MLCT), and improves the intersystem crossing rate of molecules; at the same time, the introduction of substituents at the 1-, 8-position of carbazole can increase the dihedral angle thereof with a pyridine ring, which can improve the rigidity of molecules, effectively reduce the energy consumed by the vibration and rotation of the carbazole ring in the molecules, and reduce non-radiative attenuation. The described factors can jointly increase the radiation rate of material molecules and shorten the lifetime of the excited state.

Abstract: A method of recycling fibers from post-consumer nylon fabrics is performed as follows. Post-consumer nylon textiles are crushed to obtain crushed textiles, which are fed to a two-stage screw machine, and transported to a compression zone, a melting zone, and a metering zone in sequence. Then the crushed textiles are subjected to water cooling, air cooling, granulation and drying to obtain nylon fabric chips, which are subjected to secondary granulation. The nylon fabric chips and a nylon-6 masterbatch are fed into a composite core screw and a skin screw to obtain a mixed melt, which is fed into a spinning box and compounded to obtain a coated filament bundle. The coated filament bundle is ejected for monomer suction, and subjected to primary cooling by lateral blowing, cluster oiling, secondary cooling, stretched shaping and winding to obtain recycled fibers.

Abstract: The invention provides substituted pyrrolo[1,2-a]pyrimidines and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., Gaucher disease, Parkinson's disease, Lewy body disease, dementia, or multiple system atrophy, in a patient. Exemplary substituted pyrrolo[1,2-a]pyrimidines compounds described herein include substituted 2,4-dimethyl-N-phenylpyrrolo[1,2-a]pyrimidine-8-carboxamide compounds and variants thereof.

Abstract: A fraudulent transaction detection method comprises: performing feature mapping processing on each of a plurality of transaction data to generate corresponding feature vectors; converting the feature vectors of a transaction to be detected into integrated feature vectors based on a first self-learning model; respectively converting the feature vectors respectively of at least one time sequence transaction into time sequence feature vectors based on a second self-learning model; combining the integrated feature vectors and each of the time sequence feature vectors corresponding to each of the time sequence transactions to form depth feature vectors; classifying the depth feature vectors based on a third self-learning model to determine whether the transaction to be detected is a normal transaction or a fraudulent transaction.

Abstract: The invention provides substituted pyrrolo[1,2-a]pyrimidines and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., Gaucher disease, Parkinson's disease, Lewy body disease, dementia, or multiple system atrophy, in a patient. Exemplary substituted pyrrolo[1,2-a]pyrimidines compounds described herein include substituted 2,4-dimethyl-N-phenylpyrrolo[1,2-a]pyrimidine-8-carboxamide compounds and variants thereof.

Abstract: Disclosed are new small molecules having a substituted quinazoline core structure and the uses thereof for modulating glucocerebrosidase activity. Also disclosed are pharmaceutical compositions comprising the small molecules or activated glucocerebrosidase conjugated to the small molecules, which compositions may be administered in methods of treating diseases or disorders associated with glucocerebrosidase activity, including neurological diseases and disorders such as Gaucher's disease and Parkinson's disease.

Abstract: A fraudulent transaction detection method comprises: performing feature mapping processing on each of a plurality of transaction data to generate corresponding feature vectors; converting the feature vectors of a transaction to be detected into integrated feature vectors based on a first self-learning model; respectively converting the feature vectors respectively of at least one time sequence transaction into time sequence feature vectors based on a second self-learning model; combining the integrated feature vectors and each of the time sequence feature vectors corresponding to each of the time sequence transactions to form depth feature vectors; classifying the depth feature vectors based on a third self-learning model to determine whether the transaction to be detected is a normal transaction or a fraudulent transaction.

Abstract: Disclosed are new small molecules having a pyrrolopyrimidine core structure and the uses thereof for modulating glucocerebrosidase activity. Also disclosed are pharmaceutical compositions comprising the small molecules which may be administered in methods of treating diseases or disorders associated with glucocerebrosidase activity, including neurological diseases and disorders such as Gaucher's disease and Parkinson's disease. The small molecules may be utilized to generate activated glucocerebrosidase. The activated glucocerebrosidase thusly generated can be administered in enzyme replacement therapy and/or utilized in screening assays for new small molecules that bind to the activated glucocerebrosidase and/or modulate the activity of the activated glucocerebrosidase.

Abstract: The present invention relates to an off-line PIN authentication and an off-line PIN authentication system. The method comprises: inputting an off-line PIN1 to a POS terminal, the POS terminal generating a dynamic challenge code, and transmitting the dynamic challenge code and the off-line PIN1 to a card application; the card application verifying the first off-line PIN1 and the second off-line PIN2 are consistent with each other or not; if consistent, a digital signature being made on the first off-line PIN1 and the second off-line PIN2 to return signature data and a success status code to the POS terminal; the POS terminal verifying the signature data in case of receiving the success status code, and starting the subsequent transaction procedure if the signature data is verified successfully. According to the present invention, it not only can realize the verification of the IC card to the off-line PIN, but also can realize the verification of the terminal to the off-line PIN.

Abstract: The invention provides substituted pyrrolo[1,2-a]pyrimidines and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., Gaucher disease, Parkinson's disease, Lewy body disease, dementia, or multiple system atrophy, in a patient. Exemplary substituted pyrrolo[1,2-a]pyrimidines compounds described herein include substituted 2,4-dimethyl-N-phenylpyrrolo[1,2-a]pyrimidine-8-carboxamide compounds and variants thereof.

Abstract: Disclosed are new small molecules having a pyrrolopyrimidine core structure and the uses thereof for modulating glucocerebrosidase activity. Also disclosed are pharmaceutical compositions comprising the small molecules which may be administered in methods of treating diseases or disorders associated with glucocerebrosidase activity, includin neurological diseases and disorders such as Gaucher's disease and Parkinson's disease. The small molecules may be utilized to generate activated glucocerebrosidase. The activated glucocerebrosidase thusly generated can be administered in enzyme replacement therapy and/or utilized in screening assays for new small molecules that bind to the activated glucocerebrosidase and/or modulate the activity of the activated glucocerebrosidase.

Abstract: Disclosed are new small molecules having a substituted quinazoline core structure and the uses thereof for modulating glucocerebrosidase activity. Also disclosed are pharmaceutical compositions comprising the small molecules or activated glucocerebrosidase conjugated to the small molecules, which compositions may be administered in methods of treating diseases or disorders associated with glucocerebrosidase activity, including neurological diseases and disorders such as Gaucher's disease and Parkinson's disease.

Abstract: The invention provides substituted pyrrolo[1,2-a]pyrimidines and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., Gaucher disease, Parkinson's disease, Lewy body disease, dementia, or multiple system atrophy, in a patient. Exemplary substituted pyrrolo[1,2-a]pyrimidines compounds described herein include substituted 2,4-dimethyl-N-phenylpyrrolo[1,2-a]pyrimidine-8-carboxamide compounds and variants thereof.

Abstract: Disclosed are new small molecules having a 4-methylpyrrolo[1,2-a]pyrimidine-8-carboxamide core structure and the uses thereof for modulating glucocerebrosidase activity. Also disclosed are pharmaceutical compositions comprising the small molecules which may be administered in methods of treating diseases or disorders associated with glucocerebrosidase activity, including neurological diseases and disorders such as Gaucher's disease and Parkinson's disease. The small molecules may contain a fluorophore or may be conjugated to a fluorophore in order to prepare a fluorescent probe for use in high throughput screening methods to identify new modulators of glucocerebrosidase activity via fluorescence polarization.