Abstract: Disclosed is a switching power supply circuit and a control circuit and a control method thereof. The control circuit comprises a control unit and a driving unit. The control unit controls the driving unit to provide a driving signal with different driving strengths according to a comparison result between a switching voltage and a preset voltage, so as to adjust a speed of turning the power switch off. By controlling the driving strength of the driving signal, a rising rate of the switching voltage can be improved, a spike of the switching voltage can be reduced, various components in the circuit can be protected from being damaged by the spike, and service life and reliability of the circuit can be improved.

Abstract: Technologies are described for suppressing the collection of activity data by an operating system. An operating system provides an application programming interface (“API”) through which applications can submit activity data. The activity data can be exposed to users through a UI that includes UI controls that can be selected to resume previously performed activities. The operating system also provides another UI that includes UI controls for specifying that collection of activity data by the operating system is to be suppressed. When the UI control is selected, the API will discard activity data received from applications. Another selection of the UI control will instruct the API to resume collection and storage of activity data provided by the applications. The UI for suppressing the collection of activity data can also include another UI control which, when selected, will cause activity data previously obtained by the API and stored to be discarded.

Abstract: Technologies are described for suppressing the collection of activity data by an operating system. An operating system provides an application programming interface (“API”) through which applications can submit activity data. The activity data can be exposed to users through a UI that includes UI controls that can be selected to resume previously performed activities. The operating system also provides another UI that includes UI controls for specifying that collection of activity data by the operating system is to be suppressed. When the UI control is selected, the API will discard activity data received from applications. Another selection of the UI control will instruct the API to resume collection and storage of activity data provided by the applications. The UI for suppressing the collection of activity data can also include another UI control which, when selected, will cause activity data previously obtained by the API and stored to be discarded.

Abstract: The invention provides a transgenic non-human animal expressing von Willebrand Factor A1 protein containing at least one mutation selected from the group consisting of: 1263P>S, 1269N>D, 1274K>R, 1287M>R, 1302G>D, 1308H>R, 1313R>W, 1314I>V, 1326R>H, 1329L>I, 1330E>G, 1333A>D, 1344T>A, 1347I>V, 1350T>A, 1370G>S, 1379H>R, 1381T>A, 1385T>M 1391P>Q, 1394A>S, 1397L>F, 1421S>N, 1439L>V, 1442G>S, 1449R>Q, 1466A>P, 1469Q>L, 1472Q>H, 1473V>M, 1475H>Q, 1479S>G, and any combination thereof.

Abstract: The invention provides a transgenic non-human animal expressing von Willebrand Factor A1 protein containing at least one mutation selected from the group consisting of: 1263P>S, 1269N>D, 1274K>R, 1287M>R, 1302G>D, 1308H>R, 1313R>W, 1314I>V, 1326R>H, 1329L>I, 1330E>G, 1333A>D, 1344T>A, 1347I>V, 1350T>A, 1370G>S, 1379H>R, 1381T>A, 1385T>M 1391P>Q, 1394A>S, 1397L>F, 1421S>N, 1439L>V, 1442G>S, 1449R>Q, 1466A>P, 1469Q>L, 1472Q>H, 1473V>M, 1475H>Q, 1479S>G, and any combination thereof.

Abstract: The present invention provides, inter alia, transgenic non-human animals, such as transgenic mice. The animals contain in their genome a polynucleotide encoding a von Willebrand factor (VWF) polypeptide, which polypeptide forms a thrombus when in the presence of human platelets. Nucleic acid sequences and vectors for generating the transgenic non-human animals, and methods for using the transgenic non-human animals are provided as well. Chimeric VWF proteins are also provided.

Abstract: The invention provides a transgenic non-human animal expressing von Willebrand Factor A1 protein containing at least one mutation selected from the group consisting of: 1263P>S, 1269N>D, 1274K>R, 1287M>R, 1302G>D, 1308H>R, 1313R>W, 1314I>V, 1326R>H, 1329L>I, 1330E>G, 1333A>D, 1344T>A, 1347I>V, 1350T>A, 1370G>S, 1379H>R, 1381T>A, 1385T>M 1391P>Q, 1394A>S, 1397L>F, 1421S>N, 1439L>V, 1442G>S, 1449R>Q, 1466A>P, 1469Q>L, 1472Q>H, 1473V>M, 1475H>Q, 1479S>G, and any combination thereof.