Abstract: Biological weapons are any infectious agent such as a bacteria or virus when used intentionally to inflict harm upon others. This definition is often expanded to include biologically-derived toxins and poisons. Biological warfare agents include both living microorganisms (bacteria, protozoa, rickettsia, viruses, and fungi), and toxins (chemicals) produced by microorganisms, plants, or animals. Ultraviolet (UV) light, which at select wavelengths of energy, is immensely germicidal. Chemicals also denature proteins and nucleic acids of all bacterial and virus. Set UV light and chemicals as disinfection's tool which against bacterial and viruses in inside of Mailbox to secure mails and posters which delivered by outside will be disinfected. The Safe Mailbox is a very important tool that protect innocent people from bioterrorism at individual family level.