Patents by Inventor Jiandong Jiang

Jiandong Jiang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220326209
    Abstract: A rapid, low-cost, portable and reliable method for on-site detection of deoxynivalenol (DON), a representative mycotoxin predominantly occurring in grains, would be helpful to control mycotoxin contamination. Herein, a paper-based microfluidic chip capable of measuring deoxynivalenol (DON-Chip) in foods, feeds and feed ingredients was developed. As discussed herein, the DON-Chip incorporated a colorimetric competitive immunoassay into a paper microfluidic device and used gold nanoparticles as a signal indicator. Furthermore, a novel ratiometric analysis method was used to improve signal resolvability at low concentrations of DON. Detection of DON in aqueous extracts from solid foods, feeds or feed ingredients was successfully validated with a detection range from 0.01-20 ppm (using dilution factors from 10-104). Compared with conventional methods, the novel DON-Chip greatly reduces the cost and time of mycotoxin detection in the food and feed industry.
    Type: Application
    Filed: September 28, 2020
    Publication date: October 13, 2022
    Inventors: Qian Jiang, Jiandong Wu, Francis Lin, Chengbo Yang
  • Publication number: 20200230118
    Abstract: The present application relates to the use of berberine as shown in formula (I) or an active metabolite thereof and a pharmaceutically acceptable salt thereof in the preparation of a drug for preventing and/or treating phenylketonuria.
    Type: Application
    Filed: March 14, 2018
    Publication date: July 23, 2020
    Applicant: Institute of Materia Medica, Chinese Academy of Medical Sciences
    Inventors: Yan WANG, Jiandong JIANG, Zhenxiong ZHAO, Shurong MA, Jiawen SHOU, Xiaoyang LI
  • Patent number: 10252987
    Abstract: Provided are a new aromatic cyanogen compound and a preparation method thereof. The present invention also relates to the use of such compound in antiviral drugs, in particular the use thereof in anti-HCV drugs.
    Type: Grant
    Filed: August 17, 2016
    Date of Patent: April 9, 2019
    Assignee: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences
    Inventors: Yanping Li, Zhuorong Li, Zonggen Peng, Jianrui Li, Xinbei Jiang, Jinhua Chen, Jiandong Jiang
  • Patent number: 10146240
    Abstract: A voltage regulator having a pre-regulator circuit is disclosed. A low dropout (LDO) voltage regulator includes an amplifier circuit, a current buffer circuit, and a pre-regulator circuit. The current buffer circuit includes a transistor having a gate terminal coupled to the amplifier output. The current buffer provides a current based at least in part on the output signal generated by the amplifier. The pre-regulator circuit is coupled to provide a dynamic supply voltage to the current buffer. They dynamic supply voltage depends at least in part on a fixed supply voltage provided thereto, as well as the output voltage provided by the LDO voltage regulator.
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: December 4, 2018
    Assignee: Apple Inc.
    Inventors: Ruopeng Wang, Dashun Xue, Jiandong Jiang, Jay B. Fletcher
  • Publication number: 20180208549
    Abstract: Provided are a new aromatic cyanogen compound and a preparation method thereof. The present invention also relates to the use of such compound in antiviral drugs, in particular the use thereof in anti-HCV drugs.
    Type: Application
    Filed: August 17, 2016
    Publication date: July 26, 2018
    Inventors: Yanping Li, Zhuorong Li, Zonggen Peng, Jianrui Li, Xinbei Jiang, Jinhua Chen, Jiandong Jiang
  • Patent number: 9682954
    Abstract: The present invention relates to the pharmaceutical field, in particular to a phenanthridine derivative as shown in general formula (1) a pharmaceutical composition comprising the derivative, its preparation method, and its uses in manufacture of a medicament for the prevention or treatment of a disease related to the activity of Wnt signaling pathway, hepatitis C and hepatitis B.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: June 20, 2017
    Assignees: Kunming Institute of Botany, The Chinese Academy of Sciences, Shanghai Institutes for Biological Sciences, CAS, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences
    Inventors: Xiaojiang Hao, Duozhi Chen, Lin Li, Zonggen Peng, Jiandong Jiang, Yingtong Di, Junlin Yin, Sheng Wang, Jieyun Cai
  • Patent number: 9359298
    Abstract: Provided are cajanine structure analogous compounds, synthesis method and pharmacological effects thereof, the compounds of the present invention having the structure as represented by general formulas I, II, III, IV and V. Also provided are pharmaceutical compositions containing the compounds as active ingredient, and uses thereof; the compounds of the present invention having the pharmacological activities such as anti-virus, anti-virus-infection, nerve protection, anti-metabolic-diseases and the like. Also provided is a chemical total synthesis preparation method of the natural products cajanine, cajanine A and cajanine C. The present invention lays a foundation for the in-depth study and development of the compounds as clinical drugs in the future.
    Type: Grant
    Filed: December 18, 2012
    Date of Patent: June 7, 2016
    Assignee: INSTITUTE OF MEDICINAL BIOTECHNOLOGY, CHINESE ACADEMY OF MEDICAL SCIENCES
    Inventors: Zhuorong Li, Xingyue Ji, Situ Xue, Guanghui Zheng, Yuhuan Li, Peizhen Tao, Jiandong Jiang
  • Patent number: 9325233
    Abstract: DC to DC converters and PWM controllers are presented in which a slope compensation ramp signal is provided for current control operation via a frequency adaptive compensation circuit with a phase locked loop that provides a control output signal having an amplitude generally proportional to the frequency of a clock signal, and a slope generator circuit generating the slope compensation ramp signal with an amplitude generally proportional to the control output signal amplitude.
    Type: Grant
    Filed: July 1, 2014
    Date of Patent: April 26, 2016
    Assignee: TEXAS INSTRUMENTS INCORPORATED
    Inventors: Paul Thomas Bennett, Robert Henry Bell, Sang Yong Lee, Robert Kenneth Oppen, Jiandong Jiang
  • Publication number: 20160083364
    Abstract: The present invention relates to the pharmaceutical field, in particular to a phenanthridine derivative as shown in general formula (1) a pharmaceutical composition comprising the derivative, its preparation method, and its uses in manufacture of a medicament for the prevention or treatment of a disease related to the activity of Wnt signaling pathway, hepatitis C and hepatitis B.
    Type: Application
    Filed: February 28, 2014
    Publication date: March 24, 2016
    Inventors: Xiaojiang Hao, Duozhi Chen, Lin Li, Zonggen Peng, Jiandong Jiang, Yingtong Di, Junlin Yin, Sheng Wang, Jieyun Cai
  • Publication number: 20160006336
    Abstract: DC to DC converters and PWM controllers are presented in which a slope compensation ramp signal is provided for current control operation via a frequency adaptive compensation circuit with a phase locked loop that provides a control output signal having an amplitude generally proportional to the frequency of a clock signal, and a slope generator circuit generating the slope compensation ramp signal with an amplitude generally proportional to the control output signal amplitude.
    Type: Application
    Filed: July 1, 2014
    Publication date: January 7, 2016
    Applicant: Texas Instruments Incorporated
    Inventors: Paul Thomas Bennett, Robert Henry Bell, Sang Yong Lee, Robert Kenneth Oppen, Jiandong Jiang
  • Publication number: 20140371232
    Abstract: Provided are cajanine structure analogous compounds, synthesis method and pharmacological effects thereof, the compounds of the present invention having the structure as represented by general formulas I, II, III, IV and V. Also provided are pharmaceutical compositions containing the compounds as active ingredient, and uses thereof; the compounds of the present invention having the pharmacological activities such as anti-virus, anti-virus-infection, nerve protection, anti-metabolic-diseases and the like. Also provided is a chemical total synthesis preparation method of the natural products cajanine, cajanine A and cajanine C. The present invention lays a foundation for the in-depth study and development of the compounds as clinical drugs in the future.
    Type: Application
    Filed: December 18, 2012
    Publication date: December 18, 2014
    Inventors: Zhuorong Li, Xingyue Ji, Situ Xue, Guanghui Zheng, Yuhuan Li, Peizhen Tao, Jiandong Jiang
  • Publication number: 20130190345
    Abstract: The present invention relates to a N-substituted matrinic acid derivative or matrine derivative, and its preparation method and uses. Specifically, the present invention relates to a compound of Formula (I) or (II) (wherein all the definitions of substituted groups are those mentioned in the specification), or a pharmaceutically acceptable salt, geometric isomer, stereoisomer, solvate, ester or prodrug thereof. The present invention further relates to a method for preparing the compound of the present invention, a pharmaceutical composition containing the compound, and uses thereof in manufacture of a medicament. The compound of the present invention can be used for prophylaxis and/or treatment of a disease or disorder associated with viral infection such as hepatitis B and/orhepatitis C and/or AIDS.
    Type: Application
    Filed: April 29, 2011
    Publication date: July 25, 2013
    Applicants: CSPC Zongqi Pharmaceutical Technology (Shijiahuang) Co., Ltd., Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences
    Inventors: Jiandong Jiang, Danqing Song, Nana Du, Zonggen Peng, Yuping Wang, Limei Gao, Yanxing Han, Xin Li, Chunxin Li
  • Publication number: 20100311694
    Abstract: A set of geldanamycin derivatives and their preparation methods. Pharmaceutical compositions comprising the said compounds as an active ingredient which are used as antivirus and antitumor agents. The said derivatives are used in the manufacture of heat shock protein 90 (Hsp 90) inhibiting agents which have the utility as antivirus and antitumor agents.
    Type: Application
    Filed: January 19, 2009
    Publication date: December 9, 2010
    Applicant: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences
    Inventors: Zhuorong Li, Zonggen Peng, Yanping Li, Jianhua Zhu, Peizhen Tao, Bo Fan, Yuping Wang, Guangzhi Shan, Shuqin Wang, Tian Zhang, Jiandong Jiang
  • Patent number: 7224218
    Abstract: A pre-charge apparatus and method for controlling startup transients in a capacitively-coupled switching power stage provide lower cost and improved startup transient performance in Class D amplifiers, as well as in other AC power converter applications. A charging source is activated at startup to control the charging of an external capacitor from a single power supply rail to an operating point voltage equal to the average DC output of the switching circuit, while a control circuit disables the output power stage of the switching converter. The current source may be a constant-current source and/or may be controlled via feedback from the voltage or current at the output terminal of the converter to taper the current level to more accurately control the charging. A discharge circuit can also be provided to discharge the output terminal to an opposite power supply rail before commencing the controlled charging.
    Type: Grant
    Filed: June 24, 2005
    Date of Patent: May 29, 2007
    Assignee: Cirrus Logic, Inc.
    Inventors: Jiandong Jiang, Lingli Zhang, Johann Gaboriau, John L. Melanson
  • Patent number: 6952356
    Abstract: Disclosed are methods and apparatus for over-current detection in PWM power stages. Disclosed methods and apparatus provide over-current detection with adaptive filtering according to the pulse width of the PWM input signal. Methods and apparatus for their implementation are described for detecting the pulse width of a PWM signal in the PWM circuit. According to the detected pulse width, a digital delay less than the pulse width of the PWM signal is selected from among a plurality of available digital delays. Further, an over-current condition in the PWM power stage is detected. The detected over-current signal is filtered by means of the selected digital delay and an over-current detection result is output.
    Type: Grant
    Filed: August 27, 2003
    Date of Patent: October 4, 2005
    Assignee: Texas Instruments Incorporated
    Inventor: Jiandong Jiang
  • Publication number: 20050047178
    Abstract: Disclosed are methods and apparatus for over-current detection in PWM power stages. Disclosed methods and apparatus provide over-current detection with adaptive filtering according to the pulse width of the PWM input signal. Methods and apparatus for their implementation are described for detecting the pulse width of a PWM signal in the PWM circuit. According to the detected pulse width, a digital delay less than the pulse width of the PWM signal is selected from among a plurality of available digital delays. Further, an over-current condition in the PWM power stage is detected. The detected over-current signal is filtered by means of the selected digital delay and an over-current detection result is output.
    Type: Application
    Filed: August 27, 2003
    Publication date: March 3, 2005
    Inventor: Jiandong Jiang