Patents by Inventor Jiandong Jiang
Jiandong Jiang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240000880Abstract: The disclosure relates to a pharmaceutical composition having the efficacy of preventing and treating lung injury, a preparation method therefor and a use thereof. The composition comprises a grape powder with a content of 1-25% (w/w), a grape seed extract with a content of 0.5-15% (w/w) and a pharmaceutically acceptable carrier. The composition of the disclosure has the efficacy of preventing and treating lung injury, oxidative injury, inhibiting pulmonary fibrosis, regulating lipid metabolism, and the like.Type: ApplicationFiled: December 3, 2021Publication date: January 4, 2024Inventors: Hongtao JIN, Peicheng ZHANG, Jinlan ZHANG, Jiandong JIANG, Ping ZHANG, Yangyang LI
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Publication number: 20230365632Abstract: This disclosure related to a group of peptide derivative Omicsynins with antiviral activity against influenza virus and coronavirus. It also related uses of these derivatives, the chemical formula of the peptide derivative Omicsynins is shown in formula (1): R1—R4 are shown in the following table. NO. substituent1 substituent2 substituent3 R1 Basic amino-acid side chains including lysine, histidine, citrulline residues, and etc. R2 —CH(CH3)2, —CH(CH3)CH2CH3 —CH2CH(CH3)2 Neutral amino-acid side chain including tryptophan, serine, threonine, cysteine residues and etc. R3 R3 including tyrosine, lysine, histidine, citrulline residues, and etc. R4 —CH2OH —CHO R4 including —CH2NH2, —CH?NH,— CH?NOH, —COOH, —COOR5 (R5 represents alkyl groups containing 1-3 carbons), -CONH2 and etc.Type: ApplicationFiled: February 10, 2021Publication date: November 16, 2023Inventors: Shuyi SI, Bin HONG, Yuhuan LI, Hongmin SUN, Jiandong JIANG, Xingxing LI, Minghua CHEN, Rongmei GAO, Yongsheng CHE, Xin ZHEN, Liyan YU, Hongyu LIU, Ming ZHONG, YeXiang WU, Yuanyuan SHI
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Publication number: 20230277576Abstract: The present invention relates to a method for preventing or treating a coronavirus infectious disease, comprising administering to a patient in need thereof a therapeutically or prophylactically effective amount of a compound represented by formula (I) or pharmaceutically acceptable salts thereof. The compound represented by formula (I) is used for treating patients with novel coronavirus pneumonia, and shows obvious advantages in all of the clearance rate by viral nucleic acid test, the course of clearance, and the cure and discharge time.Type: ApplicationFiled: February 20, 2021Publication date: September 7, 2023Inventors: Junbiao CHANG, Jinfa DU, Jiandong JIANG, Yuhuan LI
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Publication number: 20200230118Abstract: The present application relates to the use of berberine as shown in formula (I) or an active metabolite thereof and a pharmaceutically acceptable salt thereof in the preparation of a drug for preventing and/or treating phenylketonuria.Type: ApplicationFiled: March 14, 2018Publication date: July 23, 2020Applicant: Institute of Materia Medica, Chinese Academy of Medical SciencesInventors: Yan WANG, Jiandong JIANG, Zhenxiong ZHAO, Shurong MA, Jiawen SHOU, Xiaoyang LI
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Patent number: 10252987Abstract: Provided are a new aromatic cyanogen compound and a preparation method thereof. The present invention also relates to the use of such compound in antiviral drugs, in particular the use thereof in anti-HCV drugs.Type: GrantFiled: August 17, 2016Date of Patent: April 9, 2019Assignee: Institute of Medicinal Biotechnology, Chinese Academy of Medical SciencesInventors: Yanping Li, Zhuorong Li, Zonggen Peng, Jianrui Li, Xinbei Jiang, Jinhua Chen, Jiandong Jiang
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Patent number: 10146240Abstract: A voltage regulator having a pre-regulator circuit is disclosed. A low dropout (LDO) voltage regulator includes an amplifier circuit, a current buffer circuit, and a pre-regulator circuit. The current buffer circuit includes a transistor having a gate terminal coupled to the amplifier output. The current buffer provides a current based at least in part on the output signal generated by the amplifier. The pre-regulator circuit is coupled to provide a dynamic supply voltage to the current buffer. They dynamic supply voltage depends at least in part on a fixed supply voltage provided thereto, as well as the output voltage provided by the LDO voltage regulator.Type: GrantFiled: February 1, 2018Date of Patent: December 4, 2018Assignee: Apple Inc.Inventors: Ruopeng Wang, Dashun Xue, Jiandong Jiang, Jay B. Fletcher
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Publication number: 20180208549Abstract: Provided are a new aromatic cyanogen compound and a preparation method thereof. The present invention also relates to the use of such compound in antiviral drugs, in particular the use thereof in anti-HCV drugs.Type: ApplicationFiled: August 17, 2016Publication date: July 26, 2018Inventors: Yanping Li, Zhuorong Li, Zonggen Peng, Jianrui Li, Xinbei Jiang, Jinhua Chen, Jiandong Jiang
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Patent number: 9682954Abstract: The present invention relates to the pharmaceutical field, in particular to a phenanthridine derivative as shown in general formula (1) a pharmaceutical composition comprising the derivative, its preparation method, and its uses in manufacture of a medicament for the prevention or treatment of a disease related to the activity of Wnt signaling pathway, hepatitis C and hepatitis B.Type: GrantFiled: February 28, 2014Date of Patent: June 20, 2017Assignees: Kunming Institute of Botany, The Chinese Academy of Sciences, Shanghai Institutes for Biological Sciences, CAS, Institute of Medicinal Biotechnology, Chinese Academy of Medical SciencesInventors: Xiaojiang Hao, Duozhi Chen, Lin Li, Zonggen Peng, Jiandong Jiang, Yingtong Di, Junlin Yin, Sheng Wang, Jieyun Cai
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Patent number: 9359298Abstract: Provided are cajanine structure analogous compounds, synthesis method and pharmacological effects thereof, the compounds of the present invention having the structure as represented by general formulas I, II, III, IV and V. Also provided are pharmaceutical compositions containing the compounds as active ingredient, and uses thereof; the compounds of the present invention having the pharmacological activities such as anti-virus, anti-virus-infection, nerve protection, anti-metabolic-diseases and the like. Also provided is a chemical total synthesis preparation method of the natural products cajanine, cajanine A and cajanine C. The present invention lays a foundation for the in-depth study and development of the compounds as clinical drugs in the future.Type: GrantFiled: December 18, 2012Date of Patent: June 7, 2016Assignee: INSTITUTE OF MEDICINAL BIOTECHNOLOGY, CHINESE ACADEMY OF MEDICAL SCIENCESInventors: Zhuorong Li, Xingyue Ji, Situ Xue, Guanghui Zheng, Yuhuan Li, Peizhen Tao, Jiandong Jiang
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Patent number: 9325233Abstract: DC to DC converters and PWM controllers are presented in which a slope compensation ramp signal is provided for current control operation via a frequency adaptive compensation circuit with a phase locked loop that provides a control output signal having an amplitude generally proportional to the frequency of a clock signal, and a slope generator circuit generating the slope compensation ramp signal with an amplitude generally proportional to the control output signal amplitude.Type: GrantFiled: July 1, 2014Date of Patent: April 26, 2016Assignee: TEXAS INSTRUMENTS INCORPORATEDInventors: Paul Thomas Bennett, Robert Henry Bell, Sang Yong Lee, Robert Kenneth Oppen, Jiandong Jiang
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Publication number: 20160083364Abstract: The present invention relates to the pharmaceutical field, in particular to a phenanthridine derivative as shown in general formula (1) a pharmaceutical composition comprising the derivative, its preparation method, and its uses in manufacture of a medicament for the prevention or treatment of a disease related to the activity of Wnt signaling pathway, hepatitis C and hepatitis B.Type: ApplicationFiled: February 28, 2014Publication date: March 24, 2016Inventors: Xiaojiang Hao, Duozhi Chen, Lin Li, Zonggen Peng, Jiandong Jiang, Yingtong Di, Junlin Yin, Sheng Wang, Jieyun Cai
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Publication number: 20160006336Abstract: DC to DC converters and PWM controllers are presented in which a slope compensation ramp signal is provided for current control operation via a frequency adaptive compensation circuit with a phase locked loop that provides a control output signal having an amplitude generally proportional to the frequency of a clock signal, and a slope generator circuit generating the slope compensation ramp signal with an amplitude generally proportional to the control output signal amplitude.Type: ApplicationFiled: July 1, 2014Publication date: January 7, 2016Applicant: Texas Instruments IncorporatedInventors: Paul Thomas Bennett, Robert Henry Bell, Sang Yong Lee, Robert Kenneth Oppen, Jiandong Jiang
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Publication number: 20140371232Abstract: Provided are cajanine structure analogous compounds, synthesis method and pharmacological effects thereof, the compounds of the present invention having the structure as represented by general formulas I, II, III, IV and V. Also provided are pharmaceutical compositions containing the compounds as active ingredient, and uses thereof; the compounds of the present invention having the pharmacological activities such as anti-virus, anti-virus-infection, nerve protection, anti-metabolic-diseases and the like. Also provided is a chemical total synthesis preparation method of the natural products cajanine, cajanine A and cajanine C. The present invention lays a foundation for the in-depth study and development of the compounds as clinical drugs in the future.Type: ApplicationFiled: December 18, 2012Publication date: December 18, 2014Inventors: Zhuorong Li, Xingyue Ji, Situ Xue, Guanghui Zheng, Yuhuan Li, Peizhen Tao, Jiandong Jiang
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Publication number: 20130190345Abstract: The present invention relates to a N-substituted matrinic acid derivative or matrine derivative, and its preparation method and uses. Specifically, the present invention relates to a compound of Formula (I) or (II) (wherein all the definitions of substituted groups are those mentioned in the specification), or a pharmaceutically acceptable salt, geometric isomer, stereoisomer, solvate, ester or prodrug thereof. The present invention further relates to a method for preparing the compound of the present invention, a pharmaceutical composition containing the compound, and uses thereof in manufacture of a medicament. The compound of the present invention can be used for prophylaxis and/or treatment of a disease or disorder associated with viral infection such as hepatitis B and/orhepatitis C and/or AIDS.Type: ApplicationFiled: April 29, 2011Publication date: July 25, 2013Applicants: CSPC Zongqi Pharmaceutical Technology (Shijiahuang) Co., Ltd., Institute of Medicinal Biotechnology, Chinese Academy of Medical SciencesInventors: Jiandong Jiang, Danqing Song, Nana Du, Zonggen Peng, Yuping Wang, Limei Gao, Yanxing Han, Xin Li, Chunxin Li
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Publication number: 20100311694Abstract: A set of geldanamycin derivatives and their preparation methods. Pharmaceutical compositions comprising the said compounds as an active ingredient which are used as antivirus and antitumor agents. The said derivatives are used in the manufacture of heat shock protein 90 (Hsp 90) inhibiting agents which have the utility as antivirus and antitumor agents.Type: ApplicationFiled: January 19, 2009Publication date: December 9, 2010Applicant: Institute of Medicinal Biotechnology, Chinese Academy of Medical SciencesInventors: Zhuorong Li, Zonggen Peng, Yanping Li, Jianhua Zhu, Peizhen Tao, Bo Fan, Yuping Wang, Guangzhi Shan, Shuqin Wang, Tian Zhang, Jiandong Jiang
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Patent number: 7224218Abstract: A pre-charge apparatus and method for controlling startup transients in a capacitively-coupled switching power stage provide lower cost and improved startup transient performance in Class D amplifiers, as well as in other AC power converter applications. A charging source is activated at startup to control the charging of an external capacitor from a single power supply rail to an operating point voltage equal to the average DC output of the switching circuit, while a control circuit disables the output power stage of the switching converter. The current source may be a constant-current source and/or may be controlled via feedback from the voltage or current at the output terminal of the converter to taper the current level to more accurately control the charging. A discharge circuit can also be provided to discharge the output terminal to an opposite power supply rail before commencing the controlled charging.Type: GrantFiled: June 24, 2005Date of Patent: May 29, 2007Assignee: Cirrus Logic, Inc.Inventors: Jiandong Jiang, Lingli Zhang, Johann Gaboriau, John L. Melanson
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Patent number: 6952356Abstract: Disclosed are methods and apparatus for over-current detection in PWM power stages. Disclosed methods and apparatus provide over-current detection with adaptive filtering according to the pulse width of the PWM input signal. Methods and apparatus for their implementation are described for detecting the pulse width of a PWM signal in the PWM circuit. According to the detected pulse width, a digital delay less than the pulse width of the PWM signal is selected from among a plurality of available digital delays. Further, an over-current condition in the PWM power stage is detected. The detected over-current signal is filtered by means of the selected digital delay and an over-current detection result is output.Type: GrantFiled: August 27, 2003Date of Patent: October 4, 2005Assignee: Texas Instruments IncorporatedInventor: Jiandong Jiang
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Publication number: 20050047178Abstract: Disclosed are methods and apparatus for over-current detection in PWM power stages. Disclosed methods and apparatus provide over-current detection with adaptive filtering according to the pulse width of the PWM input signal. Methods and apparatus for their implementation are described for detecting the pulse width of a PWM signal in the PWM circuit. According to the detected pulse width, a digital delay less than the pulse width of the PWM signal is selected from among a plurality of available digital delays. Further, an over-current condition in the PWM power stage is detected. The detected over-current signal is filtered by means of the selected digital delay and an over-current detection result is output.Type: ApplicationFiled: August 27, 2003Publication date: March 3, 2005Inventor: Jiandong Jiang