Patents by Inventor Jianfei Yang

Jianfei Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for modulating lymphocyte activity
    Patent number: 8546541
    Abstract: The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies HVEM as interacting with BTLA. Methods and compositions for modulating BTLA-mediated signaling and interfering with the interaction of BTLA and HVEM for therapeutic, diagnostic and research purposes are also provided.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: October 1, 2013
    Assignee: Washington University
    Inventors: Kenneth M. Murphy, Theresa L. Murphy, John R. Sedy, Michelle A. Hurchla Pyles, Norihiko Watanabe, Jianfei Yang
  • COMPOSITIONS AND METHODS FOR MODULATING LYMPHOCYTE ACTIVITY
    Publication number: 20120322986
    Abstract: The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies HVEM as interacting with BTLA. Methods and compositions for modulating BTLA-mediated signaling and interfering with the interaction of BTLA and HVEM for therapeutic, diagnostic and research purposes are also provided.
    Type: Application
    Filed: May 17, 2012
    Publication date: December 20, 2012
    Applicant: THE WASHINGTON UNIVERSITY
    Inventors: Kenneth M. Murphy, Theresa L. Murphy, John R. Sedy, Michelle A. Hurchla Pyles, Norihiko Watanabe, Jianfei Yang
  • COMPOSITIONS AND METHODS FOR MODULATING LYMPHOCYTE ACTIVITY
    Publication number: 20120232259
    Abstract: The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies B7 family member B7x as interacting with BTLA to attenuate lymphocyte activity. Methods and compositions for modulating BTLA-mediated negative signaling and interfering with the interaction of BTLA and B7x for therapeutic, diagnostic and research purposes are also provided.
    Type: Application
    Filed: April 3, 2012
    Publication date: September 13, 2012
    Applicant: THE WASHINGTON UNIVERSITY
    Inventors: Kenneth Murphy, Norihiko Watanabe, Theresa Murphy, Jianfei Yang
  • COMPOSITIONS AND METHODS FOR MODULATING LYMPHOCYTE ACTIVITY
    Publication number: 20120214972
    Abstract: The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies B7 family member B7x as interacting with BTLA to attenuate lymphocyte activity. Methods and compositions for modulating BTLA-mediated negative signaling and interfering with the interaction of BTLA and B7x for therapeutic, diagnostic and research purposes are also provided.
    Type: Application
    Filed: October 20, 2010
    Publication date: August 23, 2012
    Applicant: THE WASHINGTON UNIVERSITY
    Inventors: Kenneth Murphy, Norihiko Watanabe, Theresa Murphy, Jianfei Yang
  • COMPOSITIONS AND METHODS FOR MODULATING LYMPHOCYTE ACTIVITY
    Publication number: 20120207759
    Abstract: The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies HVEM as interacting with BTLA. Methods and compositions for modulating BTLA-mediated signaling and interfering with the interaction of BTLA and HVEM for therapeutic, diagnostic and research purposes are also provided.
    Type: Application
    Filed: December 30, 2011
    Publication date: August 16, 2012
    Applicant: THE WASHINGTON UNIVERSITY
    Inventors: Kenneth M. Murphy, Theresa L. Murphy, John R. Sedy, Michelle A. Hurchla Pyles, Norihiko Watanabe, Jianfei Yang
  • T CELL PROTEINS AND NUCLEOTIDES ENCODING THE SAME
    Publication number: 20120178184
    Abstract: The present invention relates to mouse and human J12 polynucleotides, polypeptide and anti J12 antibody molecules. The J12 is a cytokine that is preferentially expressed in Th2 cells. The polypeptides and/or antibodies described herein can be used in methods for detection and treatment of certain autoimmune and inflammatory diseases including asthma.
    Type: Application
    Filed: March 29, 2012
    Publication date: July 12, 2012
    Applicant: BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.
    Inventors: Jianfei YANG, Frank James KING, Jun LI, Zhen Hao QI, Ming XUE
  • T cell proteins and nucleotides encoding the same
    Patent number: 8168752
    Abstract: The present invention relates to mouse and human J12 polynucleotides, polypeptide and anti J12 antibody molecules. The J12 is a cytokine that is preferentially expressed in Th2 cells. The polypeptides and/or antibodies described herein can be used in methods for detection and treatment of certain autoimmune and inflammatory diseases including asthma.
    Type: Grant
    Filed: October 6, 2009
    Date of Patent: May 1, 2012
    Assignee: Boehringer Ingelheim Pharmaceutical, Inc.
    Inventors: Jianfei Yang, Frank James King, Jun Li, Zhenhao Qi, Ming Xue
  • Methods for modulating IKK? activity
    Patent number: 8088915
    Abstract: A method for modulating NF-?B dependent gene transcription in a cell comprised of modulating IKK? protein activity in the cell. The present invention also provides siRNA compositions and methods thereof for modulating NF-?B dependent gene transcription.
    Type: Grant
    Filed: October 13, 2010
    Date of Patent: January 3, 2012
    Assignee: Boehringer Ingelheim Pharmaceuticals Inc.
    Inventors: Jun Li, Xiang Li, Jianfei Yang, Kenneth B. Marcu
  • COMPOSITIONS AND METHODS FOR MODULATING LYMPHOCYTE ACTIVITY
    Publication number: 20110230647
    Abstract: The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies HVEM as interacting with BTLA. Methods and compositions for modulating BTLA-mediated signaling and interfering with the interaction of BTLA and HVEM for therapeutic, diagnostic and research purposes are also provided.
    Type: Application
    Filed: December 23, 2010
    Publication date: September 22, 2011
    Applicant: THE WASHINGTON UNIVERSITY
    Inventors: Kenneth M. Murphy, Theresa L. Murphy, John R. Sedy, Michelle A. Hurchla Pyles, Norihiko Watanabe, Jianfei Yang
  • METHODS FOR MODULATING IKKALPHA ACTIVITY
    Publication number: 20110112284
    Abstract: A method for modulating NF-?B dependent gene transcription in a cell comprised of modulating IKK? protein activity in the cell. The present invention also provides siRNA compositions and methods thereof for modulating NF-?B dependent gene transcription.
    Type: Application
    Filed: October 13, 2010
    Publication date: May 12, 2011
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Jun LI, Xiang LI, Jianfei YANG, Kenneth MARCU
  • Methods for modulating IKK? activity
    Patent number: 7838268
    Abstract: A method for modulating NF-?B dependent gene transcription in a cell comprised of modulating IKK? protein activity in the cell. The present invention also provides siRNA compositions and methods thereof for modulating NF-?B dependent gene transcription.
    Type: Grant
    Filed: April 26, 2007
    Date of Patent: November 23, 2010
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Jun Li, Xiang Li, Jianfei Yang, Kenneth Marcu
  • T CELL PROTEINS AND NUCLEOTIDES ENCODING THE SAME
    Publication number: 20100036100
    Abstract: The present invention relates to mouse and human J12 polynucleotides, polypeptide and anti J12 antibody molecules. The J12 is a cytokine that is preferentially expressed in Th2 cells. The polypeptides and/or antibodies described herein can be used in methods for detection and treatment of certain autoimmune and inflammatory diseases including asthma.
    Type: Application
    Filed: October 6, 2009
    Publication date: February 11, 2010
    Applicant: Boehringer Ingelheim Phamaceuticals, Inc.
    Inventors: Jianfei Yang, Frank James King, Jun Li, Zhen Hao Qi, Ming Xue
  • COMPOSITIONS AND METHODS FOR MODULATING LYMPHOCTE ACTIVITY
    Publication number: 20080269464
    Abstract: The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies B7 family member B7x as interacting with BTLA to attenuate lymphocyte activity. Methods and compositions for modulating BTLA-mediated negative signaling and interfering with the interaction of BTLA and B7x for therapeutic, diagnostic and research purposes are also provided.
    Type: Application
    Filed: October 19, 2007
    Publication date: October 30, 2008
    Applicant: WASHINGTON UNIVERSITY IN ST. LOUIS
    Inventors: Kenneth M. Murphy, Norihiko Watanabe, Theresa Murphy, Jianfei Yang, Xingxing Zang
  • BTLA nucleic acids
    Patent number: 7304149
    Abstract: The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies B7 family member B7x as interacting with BTLA to attenuate lymphocyte activity. Methods and compositions for modulating BTLA-mediated negative signaling and interfering with the interaction of BTLA and B7x for therapeutic, diagnostic and research purposes are also provided.
    Type: Grant
    Filed: June 20, 2003
    Date of Patent: December 4, 2007
    Assignee: Washington University in St. Louis
    Inventors: Kenneth P. Murphy, Norihiko Watanabe, Theresa L. Murphy, Jianfei Yang
  • Methods for Modulating IKKalpha Activity
    Publication number: 20070191300
    Abstract: A method for modulating NF-?B dependent gene transcription in a cell comprised of modulating IKK? protein activity in the cell. The present invention also provides siRNA compositions and methods thereof for modulating NF-?B dependent gene transcription.
    Type: Application
    Filed: April 26, 2007
    Publication date: August 16, 2007
    Inventors: Jun Li, Xiang Li, Jianfei Yang, Kenneth Marcu
  • Methods for modulating IKK? activity
    Patent number: 7235654
    Abstract: A method for modulating NF-?B dependent gene transcription in a cell comprised of modulating IKK? protein activity in the cell. The present invention also provides siRNA compositions and methods thereof for modulating NF-?B dependent gene transcription.
    Type: Grant
    Filed: December 8, 2003
    Date of Patent: June 26, 2007
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Jun Li, Xiang Li, Jianfei Yang
  • T cell protein and nucleotides encoding the same
    Publication number: 20060269991
    Abstract: The present invention relates to mouse and human J12 polynucleotides, polypeptide and anti J12 antibody molecules. The J12 is a cytokine that is preferentially expressed in Th2 cells. The polypeptides and/or antibodies described herein can be used in methods for detection and treatment of certain autoimmune and inflammatory diseases including asthma.
    Type: Application
    Filed: October 31, 2005
    Publication date: November 30, 2006
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Jianfei Yang, Frank King, Jun Li, Zhen Qi, Ming Xue
  • Method to identify and analyze genes having modified expression in stimulated T cells
    Publication number: 20060019303
    Abstract: A method of identifying genes involved in the stimulation of primary T cells comprising the steps of: a) contacting experimental cells with a stimulating agent; b) preparing RNA from said experimental cells at one or more stimulation phases; c) measuring the level of gene expression in the cells; d) comparing the levels of gene expression of said experimental cells to the level of gene expression in control cells that have not been exposed to an stimulation agent; e) identifying genes that are up regulated or down regulated in said experimental cells relative to said control cells.
    Type: Application
    Filed: July 22, 2005
    Publication date: January 26, 2006
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Brian Castle, Jianfei Yang, Xiang Li, Jun Li
  • Methods for modulating IKKalpha activity
    Publication number: 20050043257
    Abstract: A method for modulating NF-?B dependent gene transcription in a cell comprised of modulating IKK? protein activity in the cell. The present invention also provides siRNA compositions and methods thereof for modulating NF-?B dependent gene transcription.
    Type: Application
    Filed: December 8, 2003
    Publication date: February 24, 2005
    Inventors: Jun Li, Xiang Li, Jianfei Yang, Kenneth Marcu
  • Compositions and methods for modulating lymphocyte activity
    Publication number: 20040175380
    Abstract: The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies B7 family member B7x as interacting with BTLA to attenuate lymphocyte activity. Methods and compositions for modulating BTLA-mediated negative signaling and interfering with the interaction of BTLA and B7x for therapeutic, diagnostic and research purposes are also provided.
    Type: Application
    Filed: June 20, 2003
    Publication date: September 9, 2004
    Inventors: James P. Allison, Kenneth P. Murphy, Norihiko Watanabe, Theresa L. Murphy, Jianfei Yang, Xingxing Zang