Abstract: A superconducting magnet may include magnet coils including at least one group of outer coils and at least one group of inner coils, a container including an accommodating space, at least one first chamber that is disposed within the accommodating space and houses the at least one group of the inner coils, and at least one second chamber that is disposed within the accommodating space and houses the at least one group of the outer coils. The at least one first chamber and the at least one second chamber may be configured to be filled with a cooling medium and are in fluid communication with each other. The cooling medium may be configured to cool the magnet coils to a superconducting state.

Abstract: A rock direct tensile test platform suitable for all material test machines includes a support frame. A top of the support frame is fixed with a top plate, and a bearing plate is provided above the top plate. The bearing plate is provided with a plurality of vertical force transferring rods. The force transferring rods vertically penetrate through the top plate and have a sliding fit with the top plate. Lower ends of the force transferring rods are provided with a tensile base. A top of the tensile base is provided with a lower clamp holder. A bottom of the top plate is provided with an upper clamp holder, and a clamp center of the upper clamp holder coincides with a clamp center of the lower clamp holder.

Abstract: A direct tensile and acoustic testing machine under rock seepage includes a sample and a support frame. A top of the support frame is fixed with a top plate, a bearing plate is provided above the top plate, the bearing plate is provided with a plurality of vertical force transferring rods, the force transferring rods vertically penetrate through the top plate and sliding fit with the top plate, lower ends of the force transferring rods are provided with a tensile base, a top of the tensile base is provided with a lower clamp holder, a bottom of the top plate is provided with an upper clamp holder, and a clamp center of the upper clamp holder overlaps with a clamp center of the lower clamp holder. An acoustic component and a seepage component are provided in the upper clamp holder and the lower clamp holder.

Abstract: An integrated acoustic detection and rock direct tensile test machine includes a support frame. A top of the support frame is provided with a top plate and a bearing plate is provided above the top plate. The bearing plate is provided with force transferring rods, lower ends of which are provided with a tensile base. A top of the tensile base is provided with a lower clamp holder and a bottom of the top plate is provided with an upper clamp holder. An upper channel is provided inside the upper clamp holder. The upper channel is provided with an acoustic transmitting probe. A lower channel is provided inside the lower clamp holder. One end of the lower channel is communicated with the outside, the other end is provided with an acoustic receiving probe. The lower channel extends to a bottom of a clamping chamber of the lower clamp holder.

Abstract: Provided herein are novel VEGF mimics, pharmaceutical compositions thereof, and methods of their use in increasing or reducing angiogenesis.

Abstract: Provided are novel bis-cyclic guanidine compounds, and the use thereof for treating bacterial infection.

Abstract: Provided herein are novel VEGF mimics, pharmaceutical compositions thereof, and methods of their use in increasing or reducing angiogenesis.

Abstract: Provided are cyclic peptidomimetics that can, e.g., antagonize the extracellular domain of EGFR, and methods of use thereof.

Abstract: Provided are cyclic peptidomimetics that can, e.g., enhance activation of EGFR, and methods of use thereof.

Abstract: Disclosed are cyclic ?-amino acid peptide compounds, methods of using said compounds, and kits comprising said compounds. More specifically, disclosed are human epidermal growth factor receptor 2 (HER2) specific cyclic ?-amino acid peptide compounds, methods of using said compounds in the treatment of cell proliferative diseases or disorders, methods of detecting HER2 using the compounds, and kits comprising the compounds.

Abstract: Systems and methods for data storage are provided. The systems may include one or more storage modules and one or more computing modules. The systems may obtain data to be processed. The systems may determine a required storage bandwidth based on the data to be processed. The systems may determine a distribution mode of a current computing bandwidth of the one or more computing modules based on a current storage bandwidth of the one or more storage modules and the required storage bandwidth.

Abstract: Disclosed herein is a series of helical sulfono-?-AApeptides that mimic the binding mode of the ?-helical HD2 domain of B-Cell Lymphoma 9 (BCL9). As disclosed herein, sulfono-?-AApeptides can structurally and functionally mimic the ?-helical domain of BCL9, and selectively disrupt ?-catenin/BCL9 PPIs with even higher potency. More intriguingly, these sulfono-?-AApeptides can enter cancer cells, bind with ?-catenin and disrupt ?-catenin/BCL PPI, and exhibit excellent cellular activity, which is much more potent than the BCL9 peptide. Furthermore, enzymatic stability studies demonstrated the remarkable stability of the helical sulfono-?-AApeptides, with no degradation in the presence of pronase for 24 h, augmenting their biological potential.

Abstract: Provided herein are compounds, compositions, pharmaceutical compositions, kits, and methods relating to novel sulfono-?-AA peptides. Novel sulfono-?-AA peptides as described herein can have the structure according to Formula 1: In embodiments according to the present disclosure, novel sulfono-?-AA peptides as described herein have minimal toxicity, can repair neuronal damage, inhibit Amyloid beta aggregation, and promote cellular growth and viability.

Abstract: Described herein are assays, methods, and devices for diagnosing/prognosing Alzheimer's disease (AD) and/or a neurodegenerative disease in a subject. The assays, methods, and/or devices described herein can be configured to detect GAS5 long-coding RNAs and/or expression thereof in a sample from a subject.

Abstract: Provided are novel bis-cyclic guanidine compounds, and the use thereof for treating bacterial infection.

Abstract: Provided herein are compounds that can bind GAS5 long non-coding RNA, compositions thereof, and uses thereof.

Abstract: Disclosed herein is a system for providing a test environment, composed of one or more virtual machines, to a developer instantly in response to a checkout request from the developer. To do this, a sandbox service implements a smart, tiered approach to creating and provisioning virtual machines that compose the test environments. The approach is flexible and elastic in nature, so that the developers do not have to wait an extended period of time for a test environment, yet the costs associated with configuring the virtual machines (e.g., storage and compute costs) are minimized. For example, the sandbox service can use historical data to predict a number of checkout requests expected for a first time interval (e.g., one day), a second time interval (e.g., thirty minutes), and a third time interval (e.g., five minutes). The sandbox service can then configure virtual machines into different states based on the predicted numbers.

Abstract: Disclosed herein are compounds for the treatment of neurodegenerative diseases and compositions comprising the same.

Abstract: Described herein are assays, methods, and devices for diagnosing/prognosing Alzheimer's disease (AD) and/or a neurodegenerative disease in a subject. The assays, methods, and/or devices described herein can be configured to detect GAS5 long-coding RNAs and/or expression thereof in a sample from a subject.

Abstract: Provided are novel bis-cyclic guanidine compounds, and the use thereof for treating bacterial infection.