Abstract: Provided herein are antibodies, masked antibodies (e.g., activatable antibodies), and antigen-binding fragments that target human CD47, polynucleotides encoding the same, therapeutic compositions thereof, and their use to treat CD47-positive diseases such as cancer. The masked antibodies described herein may comprise an IgG1 Fc region.

Abstract: The invention provides a carbon fiber reinforced plastic electrofusion fitting and a self-monitoring method of strain for the fitting. Carbon fiber filled polymer is used to fabricate the fitting to improve the mechanical strength of the fitting. The fitting comprises an electrofusion fitting body embedded with a resistance heating wire and two terminals arranged on the electrofusion fitting body and connected to the two ends of the resistance heating wire respectively. For the self-monitoring of strain, at least one pair of electrodes are set on the surface of the electrofusion fitting. The resistance change between electrodes caused by fitting deformation due to temperature change or mechanical loading during operation can be measured, and could be further used for structural health monitoring of the electrofusion fitting. The combination of mechanical enhancement and strain sensing of the electrofusion fitting can improve the performance and reliability of plastic pipelines.

Abstract: The present application relates to a boost circuit for driving a light-emitting diode. The boost circuit comprises: a first input terminal operably connected with an external power supply; a second input terminal operably connected with a pulse width modulation signal source; an output terminal operably connected with the light-emitting diode; a first capacitor, a positive electrode of which is coupled with the first input terminal and the output terminal, and a negative electrode of which is coupled with the second input terminal; and a second capacitor, a positive electrode of which is coupled with the positive electrode of the first capacitor and the output terminal, and a negative electrode of which is grounded, wherein, when an applied pulse width modulation signal is at low level, the external power supply charges the first capacitor with a first voltage.

Abstract: Methods, apparatus, and systems for monitoring damage of electrofusion joints of a non-metallic pipe are provided. In one aspect, a system includes: a data collector for collecting monitored resistance data of an electrofusion joint; one or more processors; and one or more memories having instructions executable by the one or more processors to perform operations including: storing a first damage critical value, a second damage critical value, and the monitored resistance data; processing the monitored resistance data to obtain a first monitored value and a second monitored value; comparing the first monitored value with the first damage critical value and the second monitored value with the second damage critical value; and determining the electrofusion joint is damaged in response to determining at least one of: the first monitored value being greater than the first damage critical value or the second monitored value being greater than the second damage critical value.

Abstract: Methods, devices, and systems for monitoring hydrogen leakage using a composite pipeline for transporting hydrogen are provided. In one aspect, a system of real-time whole-pipeline monitoring hydrogen leakage includes: a composite pipeline including a plastic pipe, a polyurethane foam layer, and a plastic protection layer that are disposed in sequence from inside to outside; joints for connecting sections of the composite pipeline; evacuation pipes; and hydrogen sensors. Each of the evacuation pipes is installed at a corresponding joint of the joints, and each hydrogen sensor is disposed in a corresponding evacuation pipe of the evacuation pipes.

Abstract: Methods, devices, and systems for monitoring hydrogen leakage using a composite pipeline for transporting hydrogen are provided. In one aspect, a system of real-time whole-pipeline monitoring hydrogen leakage includes: a composite pipeline including a plastic pipe, a polyurethane foam layer, and a plastic protection layer that are disposed in sequence from inside to outside; joints for connecting sections of the composite pipeline; evacuation pipes; and hydrogen sensors. Each of the evacuation pipes is installed at a corresponding joint of the joints, and each hydrogen sensor is disposed in a corresponding evacuation pipe of the evacuation pipes.

Abstract: Method, devices, and systems for transporting high pressure hydrogen over long distance using anti-hydrogen embrittlement wire reinforced composite pipes are provided. In one aspect, an anti-hydrogen embrittlement wire reinforced composite pipe includes a plastic outer layer, a plastic inner layer, and a wire winding layer. The plastic inner layer is provided in the plastic outer layer, and materials of the plastic inner layer and the plastic outer layer are a thermoplastic material. The wire winding layer is provided between the plastic inner layer and the plastic outer layer and bonded with the plastic inner layer and the plastic outer layer by a hot melt adhesive. The wire winding layer is formed by a plurality of wires spirally wound in left rotation or right rotation.

Abstract: Methods, apparatus, and systems for testing a hydrogen permeability of a non-metallic pipe are provided. In one aspect, an apparatus for testing a hydrogen permeability of a non-metallic pipe includes: pipe sealing pieces, a test cylinder, a high pressure gas source, a gas exhaust tube, a vacuum pump, and a pressure sensor. A plurality of circumferential reinforcement pieces are disposed on a circumferential inner wall surface of a cylindrical body of the test cylinder to be in contact with an outer surface of a to-be-tested pipe placed in the test cylinder and perform circumferential reinforcement on the to-be-tested pipe.

Abstract: Provided are heterodimeric proteins comprising polypeptides having CH3 domains with engineered residues that form disulfide bonds and/or salt bridges. Also provided are activatable antibodies targeting CD3 and/or HER2. Compositions, methods of manufacture and methods of treatment using the heterodimeric proteins and the activatable antibodies are further provided.

Abstract: An order delivery processing method includes: extracting target location information and merchant location information from a received order; determining whether the order is in a preset delivery range according to the target location information and the merchant location information; delivering the order based on a first preset rule when the order is not in the preset delivery range; sending first order-taking notification information to a merchant in response to receiving an order-taking operation of a deliverer in the target deliverer set; determining the order is effective in response to receiving an order-taking operation fed back by the merchant in response to the first order-taking notification information; and delivering the order based on a second preset rule when the order is in the preset delivery range.

Abstract: The invention provides a carbon fiber reinforced plastic electrofusion fitting and a self-monitoring method of strain for the fitting. Carbon fiber filled polymer is used to fabricate the fitting to improve the mechanical strength of the fitting. The fitting comprises an electrofusion fitting body embedded with a resistance heating wire and two terminals arranged on the electrofusion fitting body and connected to the two ends of the resistance heating wire respectively. For the self-monitoring of strain, at least one pair of electrodes are set on the surface of the electrofusion fitting. The resistance change between electrodes caused by fitting deformation due to temperature change or mechanical loading during operation can be measured, and could be further used for structural health monitoring of the electrofusion fitting. The combination of mechanical enhancement and strain sensing of the electrofusion fitting can improve the performance and reliability of plastic pipelines.

Abstract: A method for joint data-pilot tracking of navigation signal, including: multiplying a digital intermediate frequency signal with a local carrier to accomplish carrier removal; multiplying a signal after the carrier removal with a data baseband signal and a pilot baseband signal respectively to accomplish code removal; processing a signal after the code removal with integration-and-dump to obtain a coherent integration result of each branch; using the coherent integration results to accomplish data-bit flip detection and calculation of probability-weighting factor; acquiring a data-pilot joint carrier tuning-amount, and tuning the carrier numerically controlled oscillator by the carrier tuning-amount to realize data-pilot joint signal carrier tracking; and acquiring a data-pilot joint code tuning-amount, and tuning the code numerically controlled oscillator to realize baseband signal tracking.

Abstract: A method for joint data-pilot tracking of navigation signal, including: multiplying a digital intermediate frequency signal with a local carrier to accomplish carrier removal; multiplying a signal after the carrier removal with a data baseband signal and a pilot baseband signal respectively to accomplish code removal; processing a signal after the code removal with integration-and-dump to obtain a coherent integration result of each branch; using the coherent integration results to accomplish data-bit flip detection and calculation of probability-weighting factor; acquiring a data-pilot joint carrier tuning-amount, and tuning the carrier numerically controlled oscillator by the carrier tuning-amount to realize data-pilot joint signal carrier tracking; and acquiring a data-pilot joint code tuning-amount, and tuning the code numerically controlled oscillator to realize baseband signal tracking.

Abstract: The present disclosure is directed to a system and method for generating an output oscillating signal using an input oscillating signal that is subject to missing pulses and/or distortions. The output oscillating signal can be generated at a desired frequency by a frequency-locked loop (FLL) that uses the input oscillating signal as a reference clock. Because the input oscillating signal is used as a reference clock, missing pulses and/or distortions in the input oscillating signal can adversely affect the continued, stable generation of the output oscillating signal. To this end, the system and method of the present disclosure use an input oscillating signal error detector to open the FLL upon detecting a missing pulse in the input oscillating signal and/or a distortion in the input oscillating signal.

Abstract: The present disclosure is directed to a method and apparatus for providing an output oscillating signal at a desired frequency. In at least one example, the apparatus includes a weak inversion structure configured to set a small reference current. A current mirror configured to provide a replica current based on the small reference current and a tuning word. A ring oscillator is configured to be powered by a supply at a voltage determined based on the replica current. The tuning word is adjustable to change the voltage such that the ring oscillator provides the output oscillating signal at the desired frequency.

Abstract: The present disclosure is directed to a method and apparatus for providing an output oscillating signal at a desired frequency. In at least one example, the apparatus includes a weak inversion structure configured to set a small reference current. A current mirror configured to provide a replica current based on the small reference current and a tuning word. A ring oscillator is configured to be powered by a supply at a voltage determined based on the replica current. The tuning word is adjustable to change the voltage such that the ring oscillator provides the output oscillating signal at the desired frequency.

Abstract: A communication device (100) is provided with a technique (400) for self-diagnosing an air leak. The leak is determined without having to open the communication device by applying a temporary excitation signal to the speaker terminals (402) to produce a damped response (404) and then monitoring the damped response (406) of the speaker.

Abstract: Methods for the racemization of an enantiomer of a 2,3-benzodiazepine molecule into the corresponding racemic mixture under either basic or acidic conditions are described. Furthermore, the invention relates to the conversion of an enantiomer of tofisopam or its metabolites to the corresponding opposite enantiomer.

Abstract: A system and method are provided for resynchronizing backplane link management credit counters in a packet communications switch fabric. The method comprises: at an input port card ingress port, accepting information packets including cells and cell headers with destination information; modifying the destination information in the received cell headers; routing information packets between the input port card and output port cards on backplane data links through an intervening crossbar; at the input port card, maintaining a credit counter for each output port card channel; decrementing the counter in response to transmitting cells from the input port card; generating credits in response to transmitting cells from an output port card channel; sending the generated credits to increment the counter, using the modified destination information; and, using the generated credit flow to resynchronize the credit counter.

Abstract: A credit-based system and method are provided for managing backplane traffic flow in a packet communications switch fabric. The method comprises: accepting information packets including cells and cell headers with destination information; modifying the destination information in the received cell headers; routing information packets between an input port card and output port cards on backplane data links through an intervening crossbar; at the input port card, maintaining a credit counter for each output port card channel; decrementing the counter in response to transmitting cells from the input port card; generating credits in response to transmitting cells from an output port card channel; and, using modified destination information, sending the generated credits to increment the counter. In some aspects, modifying the destination information in the received packet headers includes: extracting the output port card termination from the card field; and, inserting the input port card source in the card field.