Patents by Inventor Jianfeng Wen

Jianfeng Wen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250109134
    Abstract: Disclosed are a crystalline form or an amorphous form of a macrocyclic compound or a salt or solvate thereof, as well as a preparation method therefor and an application thereof. The structure of the macrocyclic compound is represented by formula I.
    Type: Application
    Filed: January 29, 2023
    Publication date: April 3, 2025
    Inventors: Yanqiong LIN, Jianfeng WEN, Jianpeng FENG, Weidong LI, Chuanshen WANG, Zongbin LI
  • Publication number: 20250057834
    Abstract: The present invention relates to a pharmaceutical composition containing alkynyl compound, a preparation method thereof and its application. The present invention discloses a pharmaceutical composition comprising an active pharmaceutical ingredient and an available pharmaceutical excipient; The active pharmaceutical ingredient is 3-((1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide, or its pharmaceutical acceptable salt; The available pharmaceutical excipients includes diluents and lubricants. The pharmaceutical composition can effectively improve the bioavailability of the alkynyl compound, has good dissolution and stability, and improve the drug safety.
    Type: Application
    Filed: August 23, 2024
    Publication date: February 20, 2025
    Inventors: Yanqiong LIN, Jianfeng WEN, Feng XU, Jiaan HUANG, Shixiong LI, Xiaoling HE, Shihe LIANG
  • Patent number: 12152025
    Abstract: Disclosed herein are a process for preparing alkynyl-containing compound and intermediate thereof.
    Type: Grant
    Filed: February 26, 2020
    Date of Patent: November 26, 2024
    Assignees: Ascentage Pharma (Suzhou) Co., Ltd., Ascentage Pharma Goup Corp Limited, GUANGZHOU HEALTHQUEST PHARMA CO., LTD.
    Inventors: Ming Guo, Jianfeng Wen, Shangjun Teng, Tianzhu Wu, Jianpeng Feng
  • Patent number: 12097195
    Abstract: The present invention relates to a pharmaceutical composition containing alkynyl compound, a preparation method thereof and its application. The present invention discloses a pharmaceutical composition comprising an active pharmaceutical ingredient and an available pharmaceutical excipient; The active pharmaceutical ingredient is 3-((1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide, or its pharmaceutical acceptable salt; The available pharmaceutical excipients includes diluents and lubricants. The pharmaceutical composition can effectively improve the bioavailability of the alkynyl compound, has good dissolution and stability, and improve the drug safety.
    Type: Grant
    Filed: December 9, 2019
    Date of Patent: September 24, 2024
    Assignees: Ascentage Pharma (Suzhou) Co., Ltd., Ascentage Pharma Group Corp Limited, Guangzhou Healthquest Pharma Co., Ltd.
    Inventors: Yanqiong Lin, Jianfeng Wen, Feng Xu, Jiaan Huang, Shixiong Li, Xiaoling He, Shihe Liang
  • Publication number: 20240116829
    Abstract: Disclosed in the present application are a concrete protection material, and a preparation method and a construction method therefor. The concrete protection material consists of 50%-90% of a component A and 10%-50% of a component B in percentage by weight, where the component A is prepared from 30%-65% of organic silicon, 2%-5% of nano-silicon dioxide and the balance of an organic solvent in percentage by weight; and the component B is prepared from 20%-50% of an organic base and the balance of water in percentage by weight. The present application not only can form nano-particles having a strengthening effect in capillary channels of a concrete surface layer, but also can achieve a technical effect of superhydrophobicity on the concrete surface layer.
    Type: Application
    Filed: November 21, 2022
    Publication date: April 11, 2024
    Applicants: NATIONAL ENGINEERING RESEARCH CENTER OF HIGH-SPEED RAILWAY CONSTRUCTION TECHNOLOGY, CHINA RAILWAY NO.4 ENGINEERING GROUP CO., LTD, ANHUI ENGINEERING MATERIAL TECHNOLOGY CO, LTD OF CTCE GROUP
    Inventors: Dongdong FAN, Hai HUANG, Jianfeng WEN, Jianwei PENG, Zhiyong WANG, Yitao CHEN, Chenhao WU, Jianan YAO, Jie TANG, Juan CHEN, Chunhong LIN, Xianzhu HU, Zhiwu YU
  • Publication number: 20230382800
    Abstract: The invention provides a modified dolomite powder, a preparation method thereof, and a concrete. The modified dolomite powder is prepared from 98% to 99% of a dolomite powder, 0.2% to 0.5% of a chaotropic agent, 0.6% to 1.0% of a dihydrogen phosphate, and 0.2% to 0.5% of a capillary filler according to the mass percentage. The chaotropic agent is one or more of sodium sulfate, potassium sulfate, and ammonium sulfate. By promoting the dissolution of the surface of the dolomite powder, participating in the hydration reaction, and filling capillary pores, the triple modification solves the problems of bleeding, strength, and durability of the dolomite powder concrete in the related art. The obtained modified dolomite powder has good solubility and high chemical activity, and the prepared concrete has high strength and compactness, low porosity, and good durability.
    Type: Application
    Filed: May 16, 2023
    Publication date: November 30, 2023
    Applicants: ANHUI ZHONGTIE ENGINEERING MATERIAL TECHNOLOGY CO., LTD., CHINA TIESIJU CIVIL ENGINEERING GROUP CO., LTD.
    Inventors: Jianwei Peng, Dongdong Fan, Hai Huang, Jie Tang, Chenghao Wu, Jianfeng Wen, Yucheng Tang, Chunsong Yu, Yitao Chen, Jianan Yao
  • Patent number: 11787814
    Abstract: Disclosed is a method for preparing 2-indolinospirone compound and intermediate thereof, specifically disclosed is a method for preparing a compound of formula 5. The method is relatively simple and has high stereoselectivity and yield.
    Type: Grant
    Filed: July 10, 2020
    Date of Patent: October 17, 2023
    Assignees: Ascentage Pharma (Suzhou) Co., Ltd., Ascentage Pharma Group Corp Limited
    Inventors: Ming Guo, Jianfeng Wen, Jianpeng Feng, Tianzhu Wu, Huirong Lu
  • Publication number: 20230271986
    Abstract: Disclosed herein are a crystalline or amorphous form of a Bcl-2/Bcl-xL inhibitor compound or a salt thereof, and a preparation method and application thereof.
    Type: Application
    Filed: July 12, 2021
    Publication date: August 31, 2023
    Inventors: Jianfeng WEN, Yanqiong LIN, Jianpeng FENG, Zhenzhong SHAO, Huirong LU, Weidong LI
  • Publication number: 20230257384
    Abstract: Crystallines form or amorphous forms of bisdiazabicyclic compounds or salts thereof for the treatment and/or prevention of diseases or disorders related to hepatitis virus, and a preparation method and application thereof are provided. The crystalline forms or amorphous forms involved provide important reference value for the development and utilization of drugs in the future.
    Type: Application
    Filed: July 16, 2021
    Publication date: August 17, 2023
    Inventors: Jianfeng Wen, Yanqiong Lin, Tianzhu Wu, Minmin Cai, Zongbin Li, Weidong Li
  • Publication number: 20230159518
    Abstract: The present invention provides crystalline forms or amorphous forms of N-(phenylsulfonyl) benzoamide compound or its salts or solvates used as a Bcl-2 inhibitor, and the preparation method and the application thereof.
    Type: Application
    Filed: March 5, 2021
    Publication date: May 25, 2023
    Applicants: ASCENTAGE PHARMA (SUZHOU) CO., LTD., ASCENTAGE PHARMA GROUP CORP LIMITED
    Inventors: Jianfeng WEN, Jianpeng FENG, Tianzhu WU, Weidong LI, Yanqiong LIN
  • Publication number: 20230159524
    Abstract: Disclosed is a method for synthesizing N-(phenylsulfonyl)benzamide compound and intermediate thereof. The method comprises a method for synthesizing a compound 1, comprising conducting a Buchwald-Hartwig coupling reaction as shown below with compound A and compound B in a solvent and in the presence of a base and a palladium catalyst to obtain the compound 1; wherein R is C1-C8 alkyl. The present disclosure synthesizes three intermediate compounds required by the target compound and their preparation methods for the first time. Using the method disclosed in the present disclosure to synthesize the target compound 3 has the advantages of high yield, good purity, easy-to-obtain reaction raw materials, suitable for industrial production.
    Type: Application
    Filed: July 1, 2021
    Publication date: May 25, 2023
    Applicants: ASCENTAGE PHARMA (SUZHOU) CO., LTD., ASCENTAGE PHARMA GROUP CORP LIMITED
    Inventors: Jianfeng WEN, Jianyong CHEN, Yunlong ZHOU, Jianpeng FENG, Ming GUO, Tianzhu WU, Minmin CAI, Yu JING, Lingling JIAO
  • Patent number: 11636341
    Abstract: This disclosure relates to processing sequential interaction data through machine learning. In one aspect, a method includes obtaining a dynamic interaction graph constructed based on a dynamic interaction sequence. The dynamic interaction sequence includes interaction feature groups corresponding to interaction events. Each interaction feature group includes a first object, a second object, and an interaction time of an interaction event that involved the first object and the second object. The dynamic interaction graph includes multiple nodes including, for each interaction feature group, a first node that represents the first object of the interaction feature group and a second node that represents the second object of the interaction feature group. A current sequence corresponding to a current node to be analyzed is determined. The current sequence is input into a Transformer-based neural network model. The neural network model determines a feature vector corresponding to the current node.
    Type: Grant
    Filed: March 1, 2021
    Date of Patent: April 25, 2023
    Assignee: Advanced New Technologies Co., Ltd.
    Inventors: Xiaofu Chang, Jianfeng Wen, Le Song
  • Publication number: 20230106142
    Abstract: The invention discloses the crystal form, preparation method and application of an alkynyl compound, its salt and solvent compound. The invention specifically discloses 3-((1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazine-1-yl)methyl)-3-(trifluoromethyl)phenyl) benzamide crystal form I and 3-((1H-pyrazolo [3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazine-1-yl)methyl)-3-(trifluoromethyl)phenyl) benzamide fumarate crystal form II. The crystal form of the invention has good stability and has important value for drug optimization and development.
    Type: Application
    Filed: July 1, 2021
    Publication date: April 6, 2023
    Inventors: Jianfeng WEN, Yanqiong LIN, Jianpeng FENG, Tianzhu WU, Zhenzhong SHAO, Weidong LI
  • Publication number: 20230064976
    Abstract: Amorphous form or crystalline form of a 2-indolinolinololylspironone compound or its salt and solvate used as an MDM2 inhibitor, a preparation method and an application thereof. The amorphous form or crystalline form of the invention has good stability and is of great value for drug development, preparation development and production.
    Type: Application
    Filed: January 22, 2021
    Publication date: March 2, 2023
    Applicants: ASCENTAGE PHARMA (SUZHOU) CO., LTD., ASCENTAGE PHARMA GROUP CORP LIMITED
    Inventors: Jianfeng WEN, Jianpeng FENG, Tianzhu WU, Weidong LI, Yanqiong LIN, Zongbin LI
  • Publication number: 20220296587
    Abstract: The present invention relates to a pharmaceutical composition containing alkynyl compound, a preparation method thereof and its application. The present invention discloses a pharmaceutical composition comprising an active pharmaceutical ingredient and an available pharmaceutical excipient; The active pharmaceutical ingredient is 3-((1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide, or its pharmaceutical acceptable salt; The available pharmaceutical excipients includes diluents and lubricants. The pharmaceutical composition can effectively improve the bioavailability of the alkynyl compound, has good dissolution and stability, and improve the drug safety.
    Type: Application
    Filed: December 9, 2019
    Publication date: September 22, 2022
    Inventors: Yanqiong LIN, Jianfeng WEN, Feng XU, Jiaan HUANG, Shixiong LI, Xiaoling HE, Shihe LIANG
  • Patent number: 11414400
    Abstract: The present invention relates to a method for preparing sulfonamides which are inhibitors of Bcl-2/Bcl-xL, comprising the compound (3R)-1-(3-(4-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-4-methylsulfonyl-5-methyl-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)-phenylaminosulfonyl)-2-trifluoro methylsulfonyl-anilino)-4-phenylthio-butyl)-4-hydroxyl-piperidine, and the present invention also relates to intermediates for the preparation of the sulfonamides, a new final product and its therapeutic use, and pharmaceutical use.
    Type: Grant
    Filed: January 3, 2020
    Date of Patent: August 16, 2022
    Assignees: ASCENTAGE PHARMA (SUZHOU) CO., LTD., ASCENTAGE PHARMA GROUP CORP LIMITED
    Inventors: Ming Guo, Jianfeng Wen, Tianzhu Wu, Huirong Lu, Feng Xu
  • Patent number: 11370807
    Abstract: The present invention relates to a process for preparing a sulfonamide compound which is an inhibitor of Bcl-2/Bcl-xL, including the compound (3R)-1-(3-(4-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-4-methylsulfonyl-5-methyl-1H-pyrrol-3-yl)-5-fluorophenyl)piperazine-1-yl)-phenylaminosulfonyl)-2-trifluoromethanesulfonyl-anilino)-4-phenylthio-butyl)-piperidine-4-carboxylic acid 3-phosphonopropyl ester. The present invention also relates to an intermediate for preparing the sulfonamide compound and a preparation process thereof.
    Type: Grant
    Filed: January 3, 2020
    Date of Patent: June 28, 2022
    Assignees: Ascentage Pharma (Suzhou) Co., Ltd., Ascentage Pharma Group Corp Limited
    Inventors: Ming Guo, Jianfeng Wen, Huirong Lu, Jianpeng Feng, Jing Zhang, Ming Jin, Qianlei Cao
  • Publication number: 20220112186
    Abstract: Disclosed herein are a process for preparing alkynyl-containing compound and intermediate thereof.
    Type: Application
    Filed: February 26, 2020
    Publication date: April 14, 2022
    Inventors: Ming Guo, Jianfeng Wen, Shangjun Teng, Tianzhu Wu, Jianpeng Feng
  • Patent number: 11250088
    Abstract: Computer-implemented methods, computer-implemented systems, and non-transitory, computer-readable media for processing interaction sequence data are disclosed. One computer-implemented method includes: obtaining a dynamic interaction graph is obtained, where the dynamic interaction graph is constructed based on a dynamic interaction sequence, including a plurality of interactions arranged in a chronological order, where each interaction includes two objects involved in the interaction and a time of the interaction. In the dynamic interaction graph, a sub-graph corresponding to a target node is determined, where nodes in the sub-graph comprise the target node and connection nodes connected to the target node through a predetermined amount of edges originating from the target node. A feature vector corresponding to the target node is determined based on a node feature of each of the nodes of the sub-graph and directions of edges of the sub-graph.
    Type: Grant
    Filed: April 5, 2021
    Date of Patent: February 15, 2022
    Assignee: Advanced New Technologies Co., Ltd.
    Inventors: Xiaofu Chang, Jianfeng Wen, Xuqin Liu, Le Song, Yuan Qi
  • Patent number: D1029097
    Type: Grant
    Filed: June 11, 2022
    Date of Patent: May 28, 2024
    Inventor: Jianfeng Wen